Bortezomib, doxorubicin, and dexamethasone combination therapy followed by thalidomide and dexamethasone consolidation as a salvage treatment for relapsed or refractory ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-09

AUTHORS

Sung Sook Lee, Cheolwon Suh, Bong-Seog Kim, Jooseop Chung, Young-Don Joo, Hun-Mo Ryoo, Young Rok Do, Jong-Youl Jin, Hye Jin Kang, Gyeong-Won Lee, Moon Hee Lee, Hyeok Shim, Kihyun Kim, Sung-Soo Yoon, Soo Mee Bang, Ho Young Kim, Je-Jung Lee, Jinny Park, Dong Soon Lee, Jae-Hoon Lee, the Korean Multiple Myeloma Working Party (KMMWP)

ABSTRACT

We conducted a phase 2 study with bortezomib, doxorubicin, and dexamethasone (PAD) followed by thalidomide and dexamethasone (TD) in patients with relapsed multiple myeloma (MM). Forty patients were enrolled between November 2005 and October 2007, with follow-up continuing until January 2009. Efficacy could be assessed in 37 patients. The overall response rate to PAD followed by TD was 83.6%: complete response 51.4%, near-complete response 13.4%, very good partial remission 5.4%, and partial response 13.4%. The median follow-up was 27 months (range 13-39). The median progression-free survival (PFS) from the start of treatment was 18 months (95% CI, 9.7-26.2 months), with a 1-year PFS rate of 56.9% and 3-year PFS rate of 25.7%. Median overall survival was 35.1 months (95% CI, 18.5-51.7), with a 1-year survival rate of 75% and 3-year survival rate of 27.3%. One hundred seventy-eight PAD cycles (median 6, range 1-6) in 38 patients were assessable for safety. The most common hematologic toxicity was thrombocytopenia, with grade 3-4 in 35.8%. Sensory neuropathy occurred at grade 2 in 26.3% and grade 3 in 10.3%. Two hundred TD treatment cycles (median 4, range 0-12 cycles) were administered. Most adverse events were of mild degree and manageable. PAD followed by TD in patients with relapsed MM is very effective and tolerable. More... »

PAGES

905-912

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-010-0943-z

DOI

http://dx.doi.org/10.1007/s00277-010-0943-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044303429

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20349060


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