Alpha-type 1-polarized dendritic cells loaded with apoptotic allogeneic myeloma cell line induce strong CTL responses against autologous myeloma cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-08

AUTHORS

Deok-Hwan Yang, Mi-Hyun Kim, Cheol Yi Hong, Youn-Kyung Lee, Chun-Ji Jin, Thanh-Nhan Nguyen Pham, Jae-Sook Ahn, Woo-Kyun Bae, Yeo-Kyeoung Kim, Ik-Joo Chung, Hyeoung-Joon Kim, Pawel Kalinski, Je-Jung Lee

ABSTRACT

To induce a potent cytotoxic T lymphocyte (CTL) response, various tumor antigens should be loaded onto dendritic cells (DCs). In multiple myeloma (MM), it is difficult to obtain a sufficient number of autologous tumor cells as a source of tumor antigens in the clinical setting. We investigated the feasibility of immunotherapy in patients with MM, using myeloma-specific CTLs generated in vitro by alpha-type 1-polarized DCs (alphaDC1s) loaded with the ultraviolet B-irradiated allogeneic myeloma cell line, ARH77. alphaDC1s significantly increased the expression of several costimulatory molecules without differences in loading with tumor antigens. alphaDC1s showed a high production of interleukin-12 during maturation and after subsequent stimulation with CD40L but were not significantly affected by loading tumor antigens. Myeloma-specific CTLs against autologous myeloma cells from MM patients were induced by alphaDC1s pulsed with apoptotic ARH77 cells. Our data indicate that autologous DCs loaded with an allogeneic myeloma cell line can generate potent myeloma-specific CTL responses against autologous myeloma cells and might provide a practical method for cellular immunotherapy in patients with MM. More... »

PAGES

795-801

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-010-0931-3

DOI

http://dx.doi.org/10.1007/s00277-010-0931-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001959253

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20238114


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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-010-0931-3'


 

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