Wnt and Notch signaling pathways selectively regulating hematopoiesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-03-10

AUTHORS

Kun Zhou, Lifang Huang, Zhigang Zhou, Caihong Hu, Wenli Liu, Jianfeng Zhou, Hanying Sun

ABSTRACT

Hematopoietic stem and progenitor cells (HSPCs) are the source of all blood cells in the adult body. The pool of HSPCs is formed during embryogenesis process through a well-characterized succession of intra-embryonic regions and organs. The spatial and temporal restrictions in definitive hematopoietic development and the signaling molecules involved are of great interest as these may prove useful for generating and expanding these clinically important cell populations ex vivo. To elucidate the mechanism by which definitive HSPCs expand during this limited developmental time frame, we analyzed the spatial and temporal programmed gene expression patterns of Wnt and Notch signaling members during hematopoietic development. Genes related to the Wnt signaling pathway were up-regulated in E10.5 aorta-gonad-mesonephros (AGM) and E14.5 fetal liver corresponding to the inherent proliferation potential of hematopoietic progenitors, whereas genes related to the Notch signaling pathway were identified as up-regulated in E10.5 AGM, and bone marrow coincides with the maintenance of undifferentiation state of hematopoietic progenitors. Our findings suggest that Wnt and Notch signalings are integrated and are selectively regulating hematopoiesis. The spatial and temporal balance between Wnt and Notch signaling orchestrates the precise progression of hematopoietic progenitors. More... »

PAGES

749-757

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-010-0923-3

DOI

http://dx.doi.org/10.1007/s00277-010-0923-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021258788

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20217087


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Developmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoiesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Notch", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Shanghai First People Hospital, Shanghai Jiao Tong University, 201620, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.412478.c", 
          "name": [
            "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, 430030, Wuhan, Hubei, China", 
            "Shanghai First People Hospital, Shanghai Jiao Tong University, 201620, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Kun", 
        "id": "sg:person.01226036275.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226036275.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, 430030, Wuhan, Hubei, China", 
          "id": "http://www.grid.ac/institutes/grid.33199.31", 
          "name": [
            "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, 430030, Wuhan, Hubei, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Lifang", 
        "id": "sg:person.0673226361.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673226361.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai First People Hospital, Shanghai Jiao Tong University, 201620, Shanghai, China", 
          "id": "http://www.grid.ac/institutes/grid.412478.c", 
          "name": [
            "Shanghai First People Hospital, Shanghai Jiao Tong University, 201620, Shanghai, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Zhigang", 
        "id": "sg:person.01210327406.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210327406.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, 430030, Wuhan, Hubei, China", 
          "id": "http://www.grid.ac/institutes/grid.33199.31", 
          "name": [
            "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, 430030, Wuhan, Hubei, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Caihong", 
        "id": "sg:person.01142214206.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142214206.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, 430030, Wuhan, Hubei, China", 
          "id": "http://www.grid.ac/institutes/grid.33199.31", 
          "name": [
            "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, 430030, Wuhan, Hubei, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Wenli", 
        "id": "sg:person.01247010066.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247010066.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, 430030, Wuhan, Hubei, China", 
          "id": "http://www.grid.ac/institutes/grid.33199.31", 
          "name": [
            "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, 430030, Wuhan, Hubei, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Jianfeng", 
        "id": "sg:person.01230112135.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230112135.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, 430030, Wuhan, Hubei, China", 
          "id": "http://www.grid.ac/institutes/grid.33199.31", 
          "name": [
            "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, 430030, Wuhan, Hubei, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Hanying", 
        "id": "sg:person.01055570161.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055570161.95"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nri1529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040945415", 
          "https://doi.org/10.1038/nri1529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029766632", 
          "https://doi.org/10.1038/nature03319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006272273", 
          "https://doi.org/10.1038/ni1560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00277-007-0297-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000454775", 
          "https://doi.org/10.1007/s00277-007-0297-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031768095", 
          "https://doi.org/10.1038/nature01611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018424763", 
          "https://doi.org/10.1038/ni1164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/18884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037595361", 
          "https://doi.org/10.1038/18884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019010156", 
          "https://doi.org/10.1038/nature01593"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-03-10", 
    "datePublishedReg": "2010-03-10", 
    "description": "Hematopoietic stem and progenitor cells (HSPCs) are the source of all blood cells in the adult body. The pool of HSPCs is formed during embryogenesis process through a well-characterized succession of intra-embryonic regions and organs. The spatial and temporal restrictions in definitive hematopoietic development and the signaling molecules involved are of great interest as these may prove useful for generating and expanding these clinically important cell populations ex vivo. To elucidate the mechanism by which definitive HSPCs expand during this limited developmental time frame, we analyzed the spatial and temporal programmed gene expression patterns of Wnt and Notch signaling members during hematopoietic development. Genes related to the Wnt signaling pathway were up-regulated in E10.5 aorta-gonad-mesonephros (AGM) and E14.5 fetal liver corresponding to the inherent proliferation potential of hematopoietic progenitors, whereas genes related to the Notch signaling pathway were identified as up-regulated in E10.5 AGM, and bone marrow coincides with the maintenance of undifferentiation state of hematopoietic progenitors. Our findings suggest that Wnt and Notch signalings are integrated and are selectively regulating hematopoiesis. The spatial and temporal balance between Wnt and Notch signaling orchestrates the precise progression of hematopoietic progenitors.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00277-010-0923-3", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4934037", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1358129", 
        "issn": [
          "0939-5555", 
          "1432-0584"
        ], 
        "name": "Annals of Hematology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "89"
      }
    ], 
    "keywords": [
      "hematopoietic development", 
      "hematopoietic progenitors", 
      "Notch signaling", 
      "definitive hematopoietic development", 
      "gene expression patterns", 
      "E14.5 fetal liver", 
      "definitive HSPCs", 
      "aorta-gonad", 
      "embryogenesis process", 
      "developmental time frame", 
      "expression patterns", 
      "adult body", 
      "important cell population", 
      "hematopoietic stem", 
      "Wnt", 
      "progenitor cells", 
      "proliferation potential", 
      "progenitors", 
      "cell populations", 
      "genes", 
      "fetal liver", 
      "pathway", 
      "signaling", 
      "temporal balance", 
      "HSPCs", 
      "hematopoiesis", 
      "Notch", 
      "precise progression", 
      "cells", 
      "temporal restrictions", 
      "mesonephros", 
      "stem", 
      "blood cells", 
      "vivo", 
      "pool", 
      "succession", 
      "members", 
      "maintenance", 
      "organs", 
      "molecules", 
      "great interest", 
      "development", 
      "mechanism", 
      "population", 
      "progression", 
      "region", 
      "AGM", 
      "patterns", 
      "frame", 
      "time frame", 
      "potential", 
      "liver", 
      "body", 
      "balance", 
      "process", 
      "coincide", 
      "findings", 
      "source", 
      "interest", 
      "restriction", 
      "state"
    ], 
    "name": "Wnt and Notch signaling pathways selectively regulating hematopoiesis", 
    "pagination": "749-757", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021258788"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00277-010-0923-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20217087"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00277-010-0923-3", 
      "https://app.dimensions.ai/details/publication/pub.1021258788"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_513.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00277-010-0923-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00277-010-0923-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00277-010-0923-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00277-010-0923-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00277-010-0923-3'


 

This table displays all metadata directly associated to this object as RDF triples.

246 TRIPLES      21 PREDICATES      105 URIs      89 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00277-010-0923-3 schema:about N13888c39461c4771af5da1d5efcc7579
2 N1779979eab6b4c5ab1b7e0f623105620
3 N19c79b925c554dc9842e9ededc6293b6
4 N32d421571e434360b0e5959e56b8fed8
5 N8add62a4fe7a438eb6828464bfa9c91a
6 N91384156a050407e9b902e4ac40a2e68
7 N91910c92d1e245d1ae77b9bc44e46898
8 Nb55f5dbbbd814320a5e5939b33d215f7
9 Nd5577b468e284cc99016b10cea20bb81
10 Nef91b1cd9190431bb634c141ebf47a02
11 Nf6bcd73be71a42a1a9fb5c2eb87bf4e2
12 anzsrc-for:11
13 anzsrc-for:1102
14 schema:author Nc9350f9af87d410d9a55e9f0969d1dc1
15 schema:citation sg:pub.10.1007/s00277-007-0297-3
16 sg:pub.10.1038/18884
17 sg:pub.10.1038/nature01593
18 sg:pub.10.1038/nature01611
19 sg:pub.10.1038/nature03319
20 sg:pub.10.1038/ni1164
21 sg:pub.10.1038/ni1560
22 sg:pub.10.1038/nri1529
23 schema:datePublished 2010-03-10
24 schema:datePublishedReg 2010-03-10
25 schema:description Hematopoietic stem and progenitor cells (HSPCs) are the source of all blood cells in the adult body. The pool of HSPCs is formed during embryogenesis process through a well-characterized succession of intra-embryonic regions and organs. The spatial and temporal restrictions in definitive hematopoietic development and the signaling molecules involved are of great interest as these may prove useful for generating and expanding these clinically important cell populations ex vivo. To elucidate the mechanism by which definitive HSPCs expand during this limited developmental time frame, we analyzed the spatial and temporal programmed gene expression patterns of Wnt and Notch signaling members during hematopoietic development. Genes related to the Wnt signaling pathway were up-regulated in E10.5 aorta-gonad-mesonephros (AGM) and E14.5 fetal liver corresponding to the inherent proliferation potential of hematopoietic progenitors, whereas genes related to the Notch signaling pathway were identified as up-regulated in E10.5 AGM, and bone marrow coincides with the maintenance of undifferentiation state of hematopoietic progenitors. Our findings suggest that Wnt and Notch signalings are integrated and are selectively regulating hematopoiesis. The spatial and temporal balance between Wnt and Notch signaling orchestrates the precise progression of hematopoietic progenitors.
26 schema:genre article
27 schema:isAccessibleForFree false
28 schema:isPartOf Naefaf253140944df9109c7b7372d9419
29 Ncbad94c234c747deaadd13f327ef2c1d
30 sg:journal.1358129
31 schema:keywords AGM
32 E14.5 fetal liver
33 HSPCs
34 Notch
35 Notch signaling
36 Wnt
37 adult body
38 aorta-gonad
39 balance
40 blood cells
41 body
42 cell populations
43 cells
44 coincide
45 definitive HSPCs
46 definitive hematopoietic development
47 development
48 developmental time frame
49 embryogenesis process
50 expression patterns
51 fetal liver
52 findings
53 frame
54 gene expression patterns
55 genes
56 great interest
57 hematopoiesis
58 hematopoietic development
59 hematopoietic progenitors
60 hematopoietic stem
61 important cell population
62 interest
63 liver
64 maintenance
65 mechanism
66 members
67 mesonephros
68 molecules
69 organs
70 pathway
71 patterns
72 pool
73 population
74 potential
75 precise progression
76 process
77 progenitor cells
78 progenitors
79 progression
80 proliferation potential
81 region
82 restriction
83 signaling
84 source
85 state
86 stem
87 succession
88 temporal balance
89 temporal restrictions
90 time frame
91 vivo
92 schema:name Wnt and Notch signaling pathways selectively regulating hematopoiesis
93 schema:pagination 749-757
94 schema:productId N0c8c1fe502fc4ffab0cf6f134cd69dd7
95 Nd3db9a5b01304e99a6f6603b8ff49bf6
96 Nf3623d1ddce8437b81a41708243cc66a
97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021258788
98 https://doi.org/10.1007/s00277-010-0923-3
99 schema:sdDatePublished 2022-12-01T06:28
100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
101 schema:sdPublisher Na2d509718205453290a4894b9cc5ce0d
102 schema:url https://doi.org/10.1007/s00277-010-0923-3
103 sgo:license sg:explorer/license/
104 sgo:sdDataset articles
105 rdf:type schema:ScholarlyArticle
106 N0c8c1fe502fc4ffab0cf6f134cd69dd7 schema:name dimensions_id
107 schema:value pub.1021258788
108 rdf:type schema:PropertyValue
109 N13888c39461c4771af5da1d5efcc7579 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Hematopoietic Stem Cells
111 rdf:type schema:DefinedTerm
112 N16c9fefeda3e4546ab2a0619091978ad rdf:first sg:person.01055570161.95
113 rdf:rest rdf:nil
114 N1779979eab6b4c5ab1b7e0f623105620 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Biomarkers
116 rdf:type schema:DefinedTerm
117 N19c79b925c554dc9842e9ededc6293b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Gene Expression Regulation, Developmental
119 rdf:type schema:DefinedTerm
120 N29d30aaa15ae4afcbcdc8604ec5d658c rdf:first sg:person.01210327406.91
121 rdf:rest N40042576b72f4f7ca87fdeddfa6dd8fc
122 N32d421571e434360b0e5959e56b8fed8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Wnt Proteins
124 rdf:type schema:DefinedTerm
125 N40042576b72f4f7ca87fdeddfa6dd8fc rdf:first sg:person.01142214206.92
126 rdf:rest N77c1cd62e6d747909cf427ab0ba1d62f
127 N77c1cd62e6d747909cf427ab0ba1d62f rdf:first sg:person.01247010066.06
128 rdf:rest Nded3e2adbb03493aae8087ae24b284a2
129 N8add62a4fe7a438eb6828464bfa9c91a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Mice
131 rdf:type schema:DefinedTerm
132 N91384156a050407e9b902e4ac40a2e68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Hematopoiesis
134 rdf:type schema:DefinedTerm
135 N91910c92d1e245d1ae77b9bc44e46898 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Signal Transduction
137 rdf:type schema:DefinedTerm
138 Na2d509718205453290a4894b9cc5ce0d schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 Naefaf253140944df9109c7b7372d9419 schema:issueNumber 8
141 rdf:type schema:PublicationIssue
142 Nb55f5dbbbd814320a5e5939b33d215f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Receptors, Notch
144 rdf:type schema:DefinedTerm
145 Nc379ad1ccfda43e6aed61b62fdaa05bf rdf:first sg:person.0673226361.58
146 rdf:rest N29d30aaa15ae4afcbcdc8604ec5d658c
147 Nc9350f9af87d410d9a55e9f0969d1dc1 rdf:first sg:person.01226036275.89
148 rdf:rest Nc379ad1ccfda43e6aed61b62fdaa05bf
149 Ncbad94c234c747deaadd13f327ef2c1d schema:volumeNumber 89
150 rdf:type schema:PublicationVolume
151 Nd3db9a5b01304e99a6f6603b8ff49bf6 schema:name doi
152 schema:value 10.1007/s00277-010-0923-3
153 rdf:type schema:PropertyValue
154 Nd5577b468e284cc99016b10cea20bb81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Humans
156 rdf:type schema:DefinedTerm
157 Nded3e2adbb03493aae8087ae24b284a2 rdf:first sg:person.01230112135.59
158 rdf:rest N16c9fefeda3e4546ab2a0619091978ad
159 Nef91b1cd9190431bb634c141ebf47a02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Animals
161 rdf:type schema:DefinedTerm
162 Nf3623d1ddce8437b81a41708243cc66a schema:name pubmed_id
163 schema:value 20217087
164 rdf:type schema:PropertyValue
165 Nf6bcd73be71a42a1a9fb5c2eb87bf4e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Mice, Inbred BALB C
167 rdf:type schema:DefinedTerm
168 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
169 schema:name Medical and Health Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
172 schema:name Cardiorespiratory Medicine and Haematology
173 rdf:type schema:DefinedTerm
174 sg:grant.4934037 http://pending.schema.org/fundedItem sg:pub.10.1007/s00277-010-0923-3
175 rdf:type schema:MonetaryGrant
176 sg:journal.1358129 schema:issn 0939-5555
177 1432-0584
178 schema:name Annals of Hematology
179 schema:publisher Springer Nature
180 rdf:type schema:Periodical
181 sg:person.01055570161.95 schema:affiliation grid-institutes:grid.33199.31
182 schema:familyName Sun
183 schema:givenName Hanying
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055570161.95
185 rdf:type schema:Person
186 sg:person.01142214206.92 schema:affiliation grid-institutes:grid.33199.31
187 schema:familyName Hu
188 schema:givenName Caihong
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142214206.92
190 rdf:type schema:Person
191 sg:person.01210327406.91 schema:affiliation grid-institutes:grid.412478.c
192 schema:familyName Zhou
193 schema:givenName Zhigang
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210327406.91
195 rdf:type schema:Person
196 sg:person.01226036275.89 schema:affiliation grid-institutes:grid.412478.c
197 schema:familyName Zhou
198 schema:givenName Kun
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226036275.89
200 rdf:type schema:Person
201 sg:person.01230112135.59 schema:affiliation grid-institutes:grid.33199.31
202 schema:familyName Zhou
203 schema:givenName Jianfeng
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230112135.59
205 rdf:type schema:Person
206 sg:person.01247010066.06 schema:affiliation grid-institutes:grid.33199.31
207 schema:familyName Liu
208 schema:givenName Wenli
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247010066.06
210 rdf:type schema:Person
211 sg:person.0673226361.58 schema:affiliation grid-institutes:grid.33199.31
212 schema:familyName Huang
213 schema:givenName Lifang
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673226361.58
215 rdf:type schema:Person
216 sg:pub.10.1007/s00277-007-0297-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000454775
217 https://doi.org/10.1007/s00277-007-0297-3
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/18884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037595361
220 https://doi.org/10.1038/18884
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/nature01593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019010156
223 https://doi.org/10.1038/nature01593
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/nature01611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031768095
226 https://doi.org/10.1038/nature01611
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nature03319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029766632
229 https://doi.org/10.1038/nature03319
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/ni1164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018424763
232 https://doi.org/10.1038/ni1164
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/ni1560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006272273
235 https://doi.org/10.1038/ni1560
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nri1529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040945415
238 https://doi.org/10.1038/nri1529
239 rdf:type schema:CreativeWork
240 grid-institutes:grid.33199.31 schema:alternateName Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, 430030, Wuhan, Hubei, China
241 schema:name Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, 430030, Wuhan, Hubei, China
242 rdf:type schema:Organization
243 grid-institutes:grid.412478.c schema:alternateName Shanghai First People Hospital, Shanghai Jiao Tong University, 201620, Shanghai, China
244 schema:name Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, 430030, Wuhan, Hubei, China
245 Shanghai First People Hospital, Shanghai Jiao Tong University, 201620, Shanghai, China
246 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...