Mechanisms of platelet recovery in ITP associated with therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-07

AUTHORS

Sophie J. Y. Pang, Alan H. Lazarus

ABSTRACT

Immune thrombocytopenia (ITP) is an autoimmune disease primarily characterized by increased clearance of auto-antibody-sensitized platelets by Fc-receptor-bearing macrophages in the spleen and liver. It has been classically accepted that antibody-mediated platelet destruction is Fc dependent. Recent studies, however, may also indicate the involvement of Fc-independent pathways of platelet destruction. Current treatment options work by immunosuppression (e.g., corticosteroids), immunomodulation (e.g., IVIg and anti-D), or removal of the platelet destruction site (splenectomy) in ITP. This review will discuss the mechanisms of action of these and other treatments for ITP. More... »

PAGES

31-35

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-010-0916-2

DOI

http://dx.doi.org/10.1007/s00277-010-0916-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035687547

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20179926


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