Induction of myeloma-specific cytotoxic T lymphocytes ex vivo by CD40-activated B cells loaded with myeloma tumor antigens View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-11

AUTHORS

Sang-Ki Kim, Thanh-Nhan Nguyen Pham, Tuyet Minh Nguyen Hoang, Hyun-Kyu Kang, Chun-Ji Jin, Jong-Hee Nam, Sang-Young Chung, So-Jin-Na Choi, Deok-Hwan Yang, Yeo-Kyeoung Kim, Ik-Joo Chung, Hyeoung-Joon Kim, Je-Jung Lee

ABSTRACT

We investigated to establish CD40-activated B cells (CD40-B cells) as alternative antigen-presenting cells (APCs) for the induction of myeloma-specific cytotoxic T lymphocytes (CTLs). To generate CD40-B cells, peripheral blood mononuclear cells were co-cultured with CD40L-transfected J558 cells in the presence of IL-4, insulin, transferrin, and cyclosporine for 14 days, and pulsed with myeloma lysates. The CD40-B cells consistently expressed high levels of CD80, CD86, CD54, CCR7, and HLA-DR. The CD40-B cells produced IL-12, IFN-gamma, and IL-6 during the culture period, but not IL-10. In addition, the CD40-B cells showed potent allogeneic T-cell stimulatory capacities that depended on the dose ratio and had the potential to polarize naïve T cells into Th1 subsets. The CD40-B cells loaded with tumor lysates induced strong target-specific CTLs, based on large numbers of IFN-gamma secreting cells and higher cytotoxic activity against target cells compared to the CD40-B cells without the tumor lysates. These results suggest that CD40-B cells loaded with myeloma lysates might provide alternative APCs for cellular immunotherapy in patients with myeloma. More... »

PAGES

1113-1123

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00277-009-0721-y

DOI

http://dx.doi.org/10.1007/s00277-009-0721-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047709653

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19277657


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