Local Intraarterial Thrombolysis: In Vitro Comparison of Various Infusion Catheters View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-09

AUTHORS

Jens J. Froelich, Martin Hoppe, Christina Freymann, Thomas Thiel, Hans-Joachim Wagner, Klemens H. Barth, Klaus J. Klose

ABSTRACT

PURPOSE: Catheters are compared in vitro to evaluate the efficacy of thrombolysis during urokinase infusion within the thrombus. METHODS: Six catheters were introduced individually into human thrombus within a stenotic flow model. Urokinase was infused continuously into the thrombus. To quantify the efficacy of thrombolysis, pressure gradients were recorded proximal and distal to the thrombus and during the course of infusion. Uniformity of lysis was assessed radiographically. RESULTS: The fastest and most homogeneous thrombolysis was achieved with the EDM and the straight-flush catheter, shown by decreasing transthrombotic pressure gradients. All other catheter designs showed less homogeneous and delayed thrombolysis (p 0.7). CONCLUSION: The EDM catheter and the straight flush catheter achieved the most homogeneous and fastest thrombolysis, apparently due to the best urokinase distribution within the thrombus. More... »

PAGES

369-376

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002709900170

DOI

http://dx.doi.org/10.1007/s002709900170

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013531544

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9271648


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