Yttrium-90 Portal Vein Radioembolization in Sprague–Dawley Rats: Dose-Dependent Imaging and Pathological Changes in Normal Liver View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-08-16

AUTHORS

Andrew C. Gordon, Sarah B. White, Vanessa L. Gates, Weiguo Li, Daniel Procissi, Zhuoli Zhang, Kathleen R. Harris, Dong-Hyun Kim, Samdeep K. Mouli, Reed A. Omary, Riad Salem, Andrew C. Larson, Robert J. Lewandowski

ABSTRACT

PurposePortal vein embolization (PVE) is an established neoadjuvant method to induce future liver remnant hypertrophy prior to surgical resection of hepatic tumors. The purpose of our study was to examine the feasibility of PVE with glass 90Y microspheres (Y90 PVE) in Sprague–Dawley rats. We tested the hypothesis that increased doses of Y90 PVE would increase target lobe fibrosis and atrophy. MethodsTwenty-two rats were assigned to four groups for Y90 PVE to the right median lobe: very high- (273.8 MBq; n = 2), high- (99.9 MBq; n = 10), medium- (48.1 MBq; n = 5), and low-dose (14.8 MBq; n = 5). An untreated control group included seven rats. 90Y PET/CT of 90Y distributions confirmed lobar targeting. MRI volumes were measured at baseline, 2-, 4-, 8- and 12-weeks. Explanted hepatic lobes were weighed, sectioned, and stained for H&E and immunohistochemistry. Digitized slides allowed quantitative measurements of fibrosis (20 foci/slide).ResultsEx vivo measurements confirmed 91–97% activity was localized to the target lobe (n = 4). The percent growth of the target lobe relative to baseline was − 5.0% (95% CI − 17.0–6.9%) for high-, medium dose rats compared to + 18.6% (95% CI + 7.6–29.7%) in the low-dose group at 12-weeks (p = 0.0043). Radiation fibrosis increased in a dose-dependent fashion. Fibrotic area/microsphere was 22,893.5, 14,946.2 ± 2253.3, 15,304.5 ± 4716.6, and 5268.8 ± 2297.2 μm2 for very high- (n = 1), high- (n = 4), medium- (n = 3), and low-dose groups (n = 5), respectively.ConclusionY90 PVE was feasible in the rat model, resulted in target lobe atrophy, and dose-dependent increases in hepatic fibrosis at 12 weeks. The onset of imaging-based volumetric changes was 8–12 weeks. More... »

PAGES

1925-1935

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00270-020-02614-2

DOI

http://dx.doi.org/10.1007/s00270-020-02614-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1130149174

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32803285


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemoembolization, Therapeutic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microspheres", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron Emission Tomography Computed Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Yttrium Radioisotopes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA", 
            "Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gordon", 
        "givenName": "Andrew C.", 
        "id": "sg:person.0604321166.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604321166.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Vascular and Interventional Radiology, Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, USA", 
          "id": "http://www.grid.ac/institutes/grid.30760.32", 
          "name": [
            "Division of Vascular and Interventional Radiology, Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "White", 
        "givenName": "Sarah B.", 
        "id": "sg:person.01141713636.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141713636.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gates", 
        "givenName": "Vanessa L.", 
        "id": "sg:person.0761527154.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761527154.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Weiguo", 
        "id": "sg:person.01345706140.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345706140.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Procissi", 
        "givenName": "Daniel", 
        "id": "sg:person.015426352627.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015426352627.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Zhuoli", 
        "id": "sg:person.013232656557.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013232656557.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harris", 
        "givenName": "Kathleen R.", 
        "id": "sg:person.012033135452.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012033135452.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Dong-Hyun", 
        "id": "sg:person.07522463225.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07522463225.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mouli", 
        "givenName": "Samdeep K.", 
        "id": "sg:person.01057551425.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057551425.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA", 
          "id": "http://www.grid.ac/institutes/grid.152326.1", 
          "name": [
            "Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Omary", 
        "givenName": "Reed A.", 
        "id": "sg:person.0727442633.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727442633.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA", 
            "Department of Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA", 
            "Department of Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salem", 
        "givenName": "Riad", 
        "id": "sg:person.01014223541.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223541.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA", 
          "id": "http://www.grid.ac/institutes/grid.152326.1", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA", 
            "Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA", 
            "Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larson", 
        "givenName": "Andrew C.", 
        "id": "sg:person.0677775141.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677775141.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA", 
            "Department of Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA", 
            "Department of Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lewandowski", 
        "givenName": "Robert J.", 
        "id": "sg:person.01147023653.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147023653.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s41747-017-0011-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090257280", 
          "https://doi.org/10.1186/s41747-017-0011-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-007-0148-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031105602", 
          "https://doi.org/10.1007/s10620-007-0148-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-010-1423-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013349737", 
          "https://doi.org/10.1245/s10434-010-1423-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00330-017-4744-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014130524", 
          "https://doi.org/10.1007/s00330-017-4744-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0454-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039859518", 
          "https://doi.org/10.1245/s10434-009-0454-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02553141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006080819", 
          "https://doi.org/10.1007/bf02553141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00270-014-1021-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024224082", 
          "https://doi.org/10.1007/s00270-014-1021-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00330-016-4291-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019620995", 
          "https://doi.org/10.1007/s00330-016-4291-9"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-08-16", 
    "datePublishedReg": "2020-08-16", 
    "description": "PurposePortal vein embolization (PVE) is an established neoadjuvant method to induce future liver remnant hypertrophy prior to surgical resection of hepatic tumors. The purpose of our study was to examine the feasibility of PVE with glass 90Y microspheres (Y90 PVE) in Sprague\u2013Dawley rats. We tested the hypothesis that increased doses of Y90 PVE would increase target lobe fibrosis and atrophy.\nMethodsTwenty-two rats were assigned to four groups for Y90 PVE to the right median lobe: very high- (273.8\u00a0MBq; n\u2009=\u20092), high- (99.9\u00a0MBq; n\u2009=\u200910), medium- (48.1\u00a0MBq; n\u2009=\u20095), and low-dose (14.8\u00a0MBq; n\u2009=\u20095). An untreated control group included seven rats. 90Y PET/CT of 90Y distributions confirmed lobar targeting. MRI volumes were measured at baseline, 2-, 4-, 8- and 12-weeks. Explanted hepatic lobes were weighed, sectioned, and stained for H&E and immunohistochemistry. Digitized slides allowed quantitative measurements of fibrosis (20 foci/slide).ResultsEx vivo measurements confirmed 91\u201397% activity was localized to the target lobe (n\u2009=\u20094). The percent growth of the target lobe relative to baseline was \u2212\u00a05.0% (95% CI \u2212\u00a017.0\u20136.9%) for high-, medium dose rats compared to\u2009+\u200918.6% (95% CI +\u20097.6\u201329.7%) in the low-dose group at 12-weeks (p\u2009=\u20090.0043). Radiation fibrosis increased in a dose-dependent fashion. Fibrotic area/microsphere was 22,893.5, 14,946.2\u2009\u00b1\u20092253.3, 15,304.5\u2009\u00b1\u20094716.6, and 5268.8\u2009\u00b1\u20092297.2\u00a0\u03bcm2 for very high- (n\u2009=\u20091), high- (n\u2009=\u20094), medium- (n\u2009=\u20093), and low-dose groups (n\u2009=\u20095), respectively.ConclusionY90 PVE was feasible in the rat model, resulted in target lobe atrophy, and dose-dependent increases in hepatic fibrosis at 12\u00a0weeks. The onset of imaging-based volumetric changes was 8\u201312\u00a0weeks.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00270-020-02614-2", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2622696", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2683856", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2479215", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438861", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1091062", 
        "issn": [
          "0174-1551", 
          "1432-086X"
        ], 
        "name": "CardioVascular and Interventional Radiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "43"
      }
    ], 
    "keywords": [
      "low-dose group", 
      "Sprague-Dawley rats", 
      "target lobe", 
      "future liver remnant hypertrophy", 
      "dose-dependent increase", 
      "PET/CT", 
      "dose-dependent fashion", 
      "right median lobe", 
      "untreated control group", 
      "dose rats", 
      "vein embolization", 
      "surgical resection", 
      "radiation fibrosis", 
      "lobe atrophy", 
      "hepatic lobe", 
      "hepatic fibrosis", 
      "hepatic tumors", 
      "rat model", 
      "pathological changes", 
      "control group", 
      "normal liver", 
      "fibrosis", 
      "rats", 
      "atrophy", 
      "lobe", 
      "median lobe", 
      "baseline", 
      "weeks", 
      "group", 
      "MRI volumes", 
      "embolization", 
      "resection", 
      "radioembolization", 
      "hypertrophy", 
      "immunohistochemistry", 
      "tumors", 
      "liver", 
      "doses", 
      "volumetric changes", 
      "CT", 
      "ResultsEx", 
      "onset", 
      "imaging", 
      "quantitative measurements", 
      "targeting", 
      "changes", 
      "activity", 
      "study", 
      "slides", 
      "increase", 
      "percent growth", 
      "volume", 
      "hypothesis", 
      "microspheres", 
      "fashion", 
      "purpose", 
      "feasibility", 
      "measurements", 
      "medium", 
      "growth", 
      "method", 
      "model", 
      "distribution", 
      "\u03bcm2"
    ], 
    "name": "Yttrium-90 Portal Vein Radioembolization in Sprague\u2013Dawley Rats: Dose-Dependent Imaging and Pathological Changes in Normal Liver", 
    "pagination": "1925-1935", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1130149174"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00270-020-02614-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "32803285"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00270-020-02614-2", 
      "https://app.dimensions.ai/details/publication/pub.1130149174"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_859.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00270-020-02614-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00270-020-02614-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00270-020-02614-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00270-020-02614-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00270-020-02614-2'


 

This table displays all metadata directly associated to this object as RDF triples.

314 TRIPLES      21 PREDICATES      110 URIs      94 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00270-020-02614-2 schema:about N034f0a6bc2784f8cb1fae989aede11d2
2 N03dfc7aef7704798a15bbe87a710cd1e
3 N043dcac3d41d4b318dd9122e0303ce8a
4 N32c035f8f54341b4866e0ff0b600edf6
5 N4155f79675d24e4e979b46d5e781c1af
6 N756fc89b25824bd6838e66466a926e86
7 N850a23f3adaa40809aff2ec1007f29b4
8 N8637ee6220fb4c77bfd4516b8f43cfa4
9 Na953ed07d2dd4776bbb6998200642a98
10 Nbc5f14bfb57041238614799b3003bf46
11 Ne12f7bc47afc483fb209bdc905c149f0
12 Ne157acd870474e6bb7c4eac40e6e2486
13 Nff77fbfb562146b8902463f1becbcc4e
14 anzsrc-for:11
15 anzsrc-for:1103
16 schema:author Ne65432cc25c44f0985b740cfcc85f3aa
17 schema:citation sg:pub.10.1007/bf02553141
18 sg:pub.10.1007/s00270-014-1021-z
19 sg:pub.10.1007/s00330-016-4291-9
20 sg:pub.10.1007/s00330-017-4744-9
21 sg:pub.10.1007/s10620-007-0148-z
22 sg:pub.10.1186/s41747-017-0011-8
23 sg:pub.10.1245/s10434-009-0454-0
24 sg:pub.10.1245/s10434-010-1423-3
25 schema:datePublished 2020-08-16
26 schema:datePublishedReg 2020-08-16
27 schema:description PurposePortal vein embolization (PVE) is an established neoadjuvant method to induce future liver remnant hypertrophy prior to surgical resection of hepatic tumors. The purpose of our study was to examine the feasibility of PVE with glass 90Y microspheres (Y90 PVE) in Sprague–Dawley rats. We tested the hypothesis that increased doses of Y90 PVE would increase target lobe fibrosis and atrophy. MethodsTwenty-two rats were assigned to four groups for Y90 PVE to the right median lobe: very high- (273.8 MBq; n = 2), high- (99.9 MBq; n = 10), medium- (48.1 MBq; n = 5), and low-dose (14.8 MBq; n = 5). An untreated control group included seven rats. 90Y PET/CT of 90Y distributions confirmed lobar targeting. MRI volumes were measured at baseline, 2-, 4-, 8- and 12-weeks. Explanted hepatic lobes were weighed, sectioned, and stained for H&E and immunohistochemistry. Digitized slides allowed quantitative measurements of fibrosis (20 foci/slide).ResultsEx vivo measurements confirmed 91–97% activity was localized to the target lobe (n = 4). The percent growth of the target lobe relative to baseline was − 5.0% (95% CI − 17.0–6.9%) for high-, medium dose rats compared to + 18.6% (95% CI + 7.6–29.7%) in the low-dose group at 12-weeks (p = 0.0043). Radiation fibrosis increased in a dose-dependent fashion. Fibrotic area/microsphere was 22,893.5, 14,946.2 ± 2253.3, 15,304.5 ± 4716.6, and 5268.8 ± 2297.2 μm2 for very high- (n = 1), high- (n = 4), medium- (n = 3), and low-dose groups (n = 5), respectively.ConclusionY90 PVE was feasible in the rat model, resulted in target lobe atrophy, and dose-dependent increases in hepatic fibrosis at 12 weeks. The onset of imaging-based volumetric changes was 8–12 weeks.
28 schema:genre article
29 schema:isAccessibleForFree true
30 schema:isPartOf N389e891ccee2402e8f8691bba1c076a8
31 N56a6b64995a4498aac6fcc24fa86ed87
32 sg:journal.1091062
33 schema:keywords CT
34 MRI volumes
35 PET/CT
36 ResultsEx
37 Sprague-Dawley rats
38 activity
39 atrophy
40 baseline
41 changes
42 control group
43 distribution
44 dose rats
45 dose-dependent fashion
46 dose-dependent increase
47 doses
48 embolization
49 fashion
50 feasibility
51 fibrosis
52 future liver remnant hypertrophy
53 group
54 growth
55 hepatic fibrosis
56 hepatic lobe
57 hepatic tumors
58 hypertrophy
59 hypothesis
60 imaging
61 immunohistochemistry
62 increase
63 liver
64 lobe
65 lobe atrophy
66 low-dose group
67 measurements
68 median lobe
69 medium
70 method
71 microspheres
72 model
73 normal liver
74 onset
75 pathological changes
76 percent growth
77 purpose
78 quantitative measurements
79 radiation fibrosis
80 radioembolization
81 rat model
82 rats
83 resection
84 right median lobe
85 slides
86 study
87 surgical resection
88 target lobe
89 targeting
90 tumors
91 untreated control group
92 vein embolization
93 volume
94 volumetric changes
95 weeks
96 μm2
97 schema:name Yttrium-90 Portal Vein Radioembolization in Sprague–Dawley Rats: Dose-Dependent Imaging and Pathological Changes in Normal Liver
98 schema:pagination 1925-1935
99 schema:productId N3f3e1e5b87834fa196e23e43a84af114
100 N529a3db629d74ed78df7797b1f24f9fb
101 Nb692050de6854a2ca4fae0c4718ad690
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1130149174
103 https://doi.org/10.1007/s00270-020-02614-2
104 schema:sdDatePublished 2022-09-02T16:04
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N5d270e3775a64b99a1e05c3309a13b79
107 schema:url https://doi.org/10.1007/s00270-020-02614-2
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N034f0a6bc2784f8cb1fae989aede11d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Liver
113 rdf:type schema:DefinedTerm
114 N03dfc7aef7704798a15bbe87a710cd1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Microspheres
116 rdf:type schema:DefinedTerm
117 N043dcac3d41d4b318dd9122e0303ce8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Rats
119 rdf:type schema:DefinedTerm
120 N06500060d6ac45dd90094a4d0360d412 rdf:first sg:person.0677775141.14
121 rdf:rest Nf367670beadb47a5b7eb18012bcf7379
122 N2401ee80f48a4889aca62babbe38ffa4 rdf:first sg:person.015426352627.53
123 rdf:rest Nc4d9d91ba9cc4021b25d03b6b6fd70b6
124 N31f93a0f3c1145599dccd7cae26fb604 rdf:first sg:person.07522463225.08
125 rdf:rest Nf7296afe976741778b75a5780ed5dcc7
126 N32c035f8f54341b4866e0ff0b600edf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Male
128 rdf:type schema:DefinedTerm
129 N389e891ccee2402e8f8691bba1c076a8 schema:issueNumber 12
130 rdf:type schema:PublicationIssue
131 N3f3e1e5b87834fa196e23e43a84af114 schema:name pubmed_id
132 schema:value 32803285
133 rdf:type schema:PropertyValue
134 N4155f79675d24e4e979b46d5e781c1af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Liver Neoplasms
136 rdf:type schema:DefinedTerm
137 N529a3db629d74ed78df7797b1f24f9fb schema:name doi
138 schema:value 10.1007/s00270-020-02614-2
139 rdf:type schema:PropertyValue
140 N56a6b64995a4498aac6fcc24fa86ed87 schema:volumeNumber 43
141 rdf:type schema:PublicationVolume
142 N5a2a670cbe39483fa1b481bd29381973 rdf:first sg:person.01141713636.24
143 rdf:rest N6d23e68c106b4d369c135a0cb21edfa6
144 N5d270e3775a64b99a1e05c3309a13b79 schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 N6d23e68c106b4d369c135a0cb21edfa6 rdf:first sg:person.0761527154.53
147 rdf:rest Nfd9d20eb07e3440f81c2a64c6c170ac9
148 N756fc89b25824bd6838e66466a926e86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Rats, Sprague-Dawley
150 rdf:type schema:DefinedTerm
151 N84e68090b9d24d288fe8c8bb8b51779a rdf:first sg:person.01014223541.41
152 rdf:rest N06500060d6ac45dd90094a4d0360d412
153 N850a23f3adaa40809aff2ec1007f29b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Chemoembolization, Therapeutic
155 rdf:type schema:DefinedTerm
156 N8637ee6220fb4c77bfd4516b8f43cfa4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Animals
158 rdf:type schema:DefinedTerm
159 Na953ed07d2dd4776bbb6998200642a98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Yttrium Radioisotopes
161 rdf:type schema:DefinedTerm
162 Nb692050de6854a2ca4fae0c4718ad690 schema:name dimensions_id
163 schema:value pub.1130149174
164 rdf:type schema:PropertyValue
165 Nbc5f14bfb57041238614799b3003bf46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Positron Emission Tomography Computed Tomography
167 rdf:type schema:DefinedTerm
168 Nc4d9d91ba9cc4021b25d03b6b6fd70b6 rdf:first sg:person.013232656557.16
169 rdf:rest Ne8636730f5544e82a740a5f658f4300f
170 Ne12f7bc47afc483fb209bdc905c149f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Neoplasm Staging
172 rdf:type schema:DefinedTerm
173 Ne157acd870474e6bb7c4eac40e6e2486 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Liver Neoplasms, Experimental
175 rdf:type schema:DefinedTerm
176 Ne65432cc25c44f0985b740cfcc85f3aa rdf:first sg:person.0604321166.95
177 rdf:rest N5a2a670cbe39483fa1b481bd29381973
178 Ne8636730f5544e82a740a5f658f4300f rdf:first sg:person.012033135452.42
179 rdf:rest N31f93a0f3c1145599dccd7cae26fb604
180 Nf367670beadb47a5b7eb18012bcf7379 rdf:first sg:person.01147023653.18
181 rdf:rest rdf:nil
182 Nf453f752c77d49898ffd41cc931b52f6 rdf:first sg:person.0727442633.54
183 rdf:rest N84e68090b9d24d288fe8c8bb8b51779a
184 Nf7296afe976741778b75a5780ed5dcc7 rdf:first sg:person.01057551425.44
185 rdf:rest Nf453f752c77d49898ffd41cc931b52f6
186 Nfd9d20eb07e3440f81c2a64c6c170ac9 rdf:first sg:person.01345706140.26
187 rdf:rest N2401ee80f48a4889aca62babbe38ffa4
188 Nff77fbfb562146b8902463f1becbcc4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Magnetic Resonance Imaging
190 rdf:type schema:DefinedTerm
191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
192 schema:name Medical and Health Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
195 schema:name Clinical Sciences
196 rdf:type schema:DefinedTerm
197 sg:grant.2438861 http://pending.schema.org/fundedItem sg:pub.10.1007/s00270-020-02614-2
198 rdf:type schema:MonetaryGrant
199 sg:grant.2479215 http://pending.schema.org/fundedItem sg:pub.10.1007/s00270-020-02614-2
200 rdf:type schema:MonetaryGrant
201 sg:grant.2622696 http://pending.schema.org/fundedItem sg:pub.10.1007/s00270-020-02614-2
202 rdf:type schema:MonetaryGrant
203 sg:grant.2683856 http://pending.schema.org/fundedItem sg:pub.10.1007/s00270-020-02614-2
204 rdf:type schema:MonetaryGrant
205 sg:journal.1091062 schema:issn 0174-1551
206 1432-086X
207 schema:name CardioVascular and Interventional Radiology
208 schema:publisher Springer Nature
209 rdf:type schema:Periodical
210 sg:person.01014223541.41 schema:affiliation grid-institutes:grid.16753.36
211 schema:familyName Salem
212 schema:givenName Riad
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223541.41
214 rdf:type schema:Person
215 sg:person.01057551425.44 schema:affiliation grid-institutes:grid.16753.36
216 schema:familyName Mouli
217 schema:givenName Samdeep K.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057551425.44
219 rdf:type schema:Person
220 sg:person.01141713636.24 schema:affiliation grid-institutes:grid.30760.32
221 schema:familyName White
222 schema:givenName Sarah B.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141713636.24
224 rdf:type schema:Person
225 sg:person.01147023653.18 schema:affiliation grid-institutes:grid.16753.36
226 schema:familyName Lewandowski
227 schema:givenName Robert J.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147023653.18
229 rdf:type schema:Person
230 sg:person.012033135452.42 schema:affiliation grid-institutes:grid.16753.36
231 schema:familyName Harris
232 schema:givenName Kathleen R.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012033135452.42
234 rdf:type schema:Person
235 sg:person.013232656557.16 schema:affiliation grid-institutes:grid.16753.36
236 schema:familyName Zhang
237 schema:givenName Zhuoli
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013232656557.16
239 rdf:type schema:Person
240 sg:person.01345706140.26 schema:affiliation grid-institutes:grid.16753.36
241 schema:familyName Li
242 schema:givenName Weiguo
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345706140.26
244 rdf:type schema:Person
245 sg:person.015426352627.53 schema:affiliation grid-institutes:grid.16753.36
246 schema:familyName Procissi
247 schema:givenName Daniel
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015426352627.53
249 rdf:type schema:Person
250 sg:person.0604321166.95 schema:affiliation grid-institutes:grid.16753.36
251 schema:familyName Gordon
252 schema:givenName Andrew C.
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604321166.95
254 rdf:type schema:Person
255 sg:person.0677775141.14 schema:affiliation grid-institutes:grid.152326.1
256 schema:familyName Larson
257 schema:givenName Andrew C.
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677775141.14
259 rdf:type schema:Person
260 sg:person.0727442633.54 schema:affiliation grid-institutes:grid.152326.1
261 schema:familyName Omary
262 schema:givenName Reed A.
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727442633.54
264 rdf:type schema:Person
265 sg:person.07522463225.08 schema:affiliation grid-institutes:grid.16753.36
266 schema:familyName Kim
267 schema:givenName Dong-Hyun
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07522463225.08
269 rdf:type schema:Person
270 sg:person.0761527154.53 schema:affiliation grid-institutes:grid.16753.36
271 schema:familyName Gates
272 schema:givenName Vanessa L.
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761527154.53
274 rdf:type schema:Person
275 sg:pub.10.1007/bf02553141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006080819
276 https://doi.org/10.1007/bf02553141
277 rdf:type schema:CreativeWork
278 sg:pub.10.1007/s00270-014-1021-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1024224082
279 https://doi.org/10.1007/s00270-014-1021-z
280 rdf:type schema:CreativeWork
281 sg:pub.10.1007/s00330-016-4291-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019620995
282 https://doi.org/10.1007/s00330-016-4291-9
283 rdf:type schema:CreativeWork
284 sg:pub.10.1007/s00330-017-4744-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014130524
285 https://doi.org/10.1007/s00330-017-4744-9
286 rdf:type schema:CreativeWork
287 sg:pub.10.1007/s10620-007-0148-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1031105602
288 https://doi.org/10.1007/s10620-007-0148-z
289 rdf:type schema:CreativeWork
290 sg:pub.10.1186/s41747-017-0011-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090257280
291 https://doi.org/10.1186/s41747-017-0011-8
292 rdf:type schema:CreativeWork
293 sg:pub.10.1245/s10434-009-0454-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039859518
294 https://doi.org/10.1245/s10434-009-0454-0
295 rdf:type schema:CreativeWork
296 sg:pub.10.1245/s10434-010-1423-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013349737
297 https://doi.org/10.1245/s10434-010-1423-3
298 rdf:type schema:CreativeWork
299 grid-institutes:grid.152326.1 schema:alternateName Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA
300 schema:name Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA
301 Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA
302 Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA
303 rdf:type schema:Organization
304 grid-institutes:grid.16753.36 schema:alternateName Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA
305 Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA
306 Department of Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
307 schema:name Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA
308 Department of Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
309 Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N. St. Clair, Suite 800, 60611, Chicago, IL, USA
310 Department of Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
311 rdf:type schema:Organization
312 grid-institutes:grid.30760.32 schema:alternateName Division of Vascular and Interventional Radiology, Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, USA
313 schema:name Division of Vascular and Interventional Radiology, Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, USA
314 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...