Feasibility of Combination Intra-arterial Yttrium-90 and Irinotecan Microspheres in the VX2 Rabbit Model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-06-12

AUTHORS

Andrew C. Gordon, Sarah B. White, Yihe Yang, Vanessa L. Gates, Daniel Procissi, Kathleen R. Harris, Zhuoli Zhang, Tianchu Lyu, Xiaoke Huang, Matthew R. Dreher, Reed A. Omary, Riad Salem, Robert J. Lewandowski, Andrew C. Larson

ABSTRACT

PurposeTo evaluate the combination of 90Y radioembolization (Y90) and drug-eluting bead irinotecan (DEBIRI) microspheres in the VX2 rabbit model.Materials and MethodsAn initial dose finding study was performed in 6 White New Zealand rabbits to identify a therapeutic but subcurative dose of Y90. In total, 29 rabbits were used in four groups: Y90 treatment (n = 8), DEBIRI treatment (n = 6), Y90 + DEBIRI treatment (n = 7), and an untreated control group (n = 8). Hepatic toxicity was evaluated at baseline, 24 h, 72 h, 1 week, and 2 weeks. MRI tumor volume (TV) and enhancing tumor volume were assessed baseline and 2 weeks. Tumor area and necrosis were evaluated on H&E for pathology.ResultsInfused activities of 84.0–94.4 MBq (corresponding to 55.1–72.7 Gy) were selected based on the initial dose finding study. Infusion of DEBIRI after Y90 was technically feasible in all cases (7/7). Overall, 21/29 animals survived to 2 weeks, and the remaining animals had extrahepatic disease on necropsy. Liver transaminases were elevated with Y90, DEBIRI, and Y90 + DEBIRI compared to control at 24 h, 72 h, and 1 week post-treatment and returned to baseline by 2 weeks. By TV, Y90 + DEBIRI was the only treatment to show statistically significant reduction at 2 weeks compared to the control group (p = 0.012). The change in tumor volume (week 2—baseline) for both Y90 + DEBIRI versus control (p = 0.002) and Y90 versus control (p = 0.014) was significantly decreased. There were no statistically significant differences among groups on pathology.ConclusionIntra-arterial Y90 + DEBIRI was safe and demonstrated enhanced antitumor activity in rabbit VX2 tumors. This combined approach warrants further investigation. More... »

PAGES

1528-1537

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00270-020-02538-x

DOI

http://dx.doi.org/10.1007/s00270-020-02538-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1128447495

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32533312


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemoembolization, Therapeutic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feasibility Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Irinotecan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microspheres", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Necrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rabbits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Yttrium Radioisotopes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA", 
            "Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gordon", 
        "givenName": "Andrew C.", 
        "id": "sg:person.0604321166.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604321166.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, Milwaukee, WI, USA", 
          "id": "http://www.grid.ac/institutes/grid.30760.32", 
          "name": [
            "Department of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, Milwaukee, WI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "White", 
        "givenName": "Sarah B.", 
        "id": "sg:person.01141713636.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141713636.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Yihe", 
        "id": "sg:person.014630700367.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014630700367.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gates", 
        "givenName": "Vanessa L.", 
        "id": "sg:person.0761527154.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761527154.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Procissi", 
        "givenName": "Daniel", 
        "id": "sg:person.015426352627.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015426352627.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harris", 
        "givenName": "Kathleen R.", 
        "id": "sg:person.012033135452.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012033135452.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Zhuoli", 
        "id": "sg:person.013232656557.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013232656557.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lyu", 
        "givenName": "Tianchu", 
        "id": "sg:person.014101535653.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014101535653.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Xiaoke", 
        "id": "sg:person.01152017266.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152017266.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BTG International Inc, West Conshohocken, PA, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BTG International Inc, West Conshohocken, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dreher", 
        "givenName": "Matthew R.", 
        "id": "sg:person.010656500177.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010656500177.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA", 
          "id": "http://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Omary", 
        "givenName": "Reed A.", 
        "id": "sg:person.0727442633.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727442633.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA", 
            "Department of Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA", 
            "Department of Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salem", 
        "givenName": "Riad", 
        "id": "sg:person.01014223541.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223541.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA", 
            "Department of Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA", 
            "Department of Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lewandowski", 
        "givenName": "Robert J.", 
        "id": "sg:person.01147023653.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147023653.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA", 
          "id": "http://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA", 
            "Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Larson", 
        "givenName": "Andrew C.", 
        "id": "sg:person.0677775141.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677775141.14"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1245/s10434-010-1288-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012691102", 
          "https://doi.org/10.1245/s10434-010-1288-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038476683", 
          "https://doi.org/10.1038/sj.bjc.6690233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00270-012-0343-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020579386", 
          "https://doi.org/10.1007/s00270-012-0343-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00270-010-9937-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028019140", 
          "https://doi.org/10.1007/s00270-010-9937-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40336-016-0172-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013246699", 
          "https://doi.org/10.1007/s40336-016-0172-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-012-9404-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051629482", 
          "https://doi.org/10.1007/s10555-012-9404-6"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-06-12", 
    "datePublishedReg": "2020-06-12", 
    "description": "PurposeTo evaluate the combination of 90Y radioembolization (Y90) and drug-eluting bead irinotecan (DEBIRI) microspheres in the VX2 rabbit model.Materials and MethodsAn initial dose finding study was performed in 6 White New Zealand rabbits to identify a therapeutic but subcurative dose of Y90. In total, 29 rabbits were used in four groups: Y90 treatment (n\u2009=\u20098), DEBIRI treatment (n\u2009=\u20096), Y90\u2009+\u2009DEBIRI treatment (n\u2009=\u20097), and an untreated control group (n\u2009=\u20098). Hepatic toxicity was evaluated at baseline, 24\u00a0h, 72\u00a0h, 1\u00a0week, and 2\u00a0weeks. MRI tumor volume (TV) and enhancing tumor volume were assessed baseline and 2\u00a0weeks. Tumor area and necrosis were evaluated on H&E for pathology.ResultsInfused activities of 84.0\u201394.4\u00a0MBq (corresponding to 55.1\u201372.7\u00a0Gy) were selected based on the initial dose finding study. Infusion of DEBIRI after Y90 was technically feasible in all cases (7/7). Overall, 21/29 animals survived to 2\u00a0weeks, and the remaining animals had extrahepatic disease on necropsy. Liver transaminases were elevated with Y90, DEBIRI, and Y90\u2009+\u2009DEBIRI compared to control at 24\u00a0h, 72\u00a0h, and 1\u00a0week post-treatment and returned to baseline by 2\u00a0weeks. By TV, Y90\u2009+\u2009DEBIRI was the only treatment to show statistically significant reduction at 2\u00a0weeks compared to the control group (p\u2009=\u20090.012). The change in tumor volume (week 2\u2014baseline) for both Y90\u2009+\u2009DEBIRI versus control (p\u2009=\u20090.002) and Y90 versus control (p\u2009=\u20090.014) was significantly decreased. There were no statistically significant differences among groups on pathology.ConclusionIntra-arterial Y90\u2009+\u2009DEBIRI was safe and demonstrated enhanced antitumor activity in rabbit VX2 tumors. This combined approach warrants further investigation.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00270-020-02538-x", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2683856", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2479215", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2622696", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438861", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1091062", 
        "issn": [
          "0174-1551", 
          "1432-086X"
        ], 
        "name": "CardioVascular and Interventional Radiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "43"
      }
    ], 
    "keywords": [
      "tumor volume", 
      "VX2 rabbit model", 
      "DEBIRI treatments", 
      "initial dose", 
      "control group", 
      "rabbit model", 
      "MRI tumor volume", 
      "white New Zealand rabbits", 
      "untreated control group", 
      "rabbit VX2 tumor", 
      "New Zealand rabbits", 
      "enhanced antitumor activity", 
      "warrants further investigation", 
      "subcurative dose", 
      "Y90 treatment", 
      "extrahepatic disease", 
      "liver transaminases", 
      "hepatic toxicity", 
      "DEBIRI", 
      "yttrium-90", 
      "VX2 tumors", 
      "Zealand rabbits", 
      "only treatment", 
      "tumor area", 
      "weeks", 
      "antitumor activity", 
      "dose", 
      "baseline", 
      "significant differences", 
      "treatment", 
      "significant reduction", 
      "pathology", 
      "further investigation", 
      "rabbits", 
      "Y90", 
      "group", 
      "animals", 
      "radioembolization", 
      "PurposeTo", 
      "infusion", 
      "tumors", 
      "necrosis", 
      "necropsy", 
      "transaminase", 
      "disease", 
      "MBq", 
      "control", 
      "activity", 
      "study", 
      "volume", 
      "toxicity", 
      "differences", 
      "cases", 
      "reduction", 
      "changes", 
      "microspheres", 
      "combination", 
      "feasibility", 
      "investigation", 
      "area", 
      "model", 
      "materials"
    ], 
    "name": "Feasibility of Combination Intra-arterial Yttrium-90 and Irinotecan Microspheres in the VX2 Rabbit Model", 
    "pagination": "1528-1537", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1128447495"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00270-020-02538-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "32533312"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00270-020-02538-x", 
      "https://app.dimensions.ai/details/publication/pub.1128447495"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_851.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00270-020-02538-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00270-020-02538-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00270-020-02538-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00270-020-02538-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00270-020-02538-x'


 

This table displays all metadata directly associated to this object as RDF triples.

312 TRIPLES      21 PREDICATES      106 URIs      92 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00270-020-02538-x schema:about N020f323777cc44f2853fb9d96d2e3d2f
2 N0a6a9f2f481d48dea889d0aab565e2d0
3 N1728f0c887ac4840bce54d95469f19ef
4 N260f95910bfe45ef83a69b2aad8877a9
5 N35e3eacfe9ff49c3b3725e75e03927a9
6 N378029bea8df400a872590b01fb758cf
7 N3bd753b1cd474022afbcfb718314191e
8 N48905febed304a5289c81bd2c928ea0b
9 N4a9892fe5fae40a284817b3148c237e2
10 N78f38c6b6e814b14a86683b846d05575
11 N84fd79a50c7d4fd1a1f6df779d3fa1c2
12 Na5b5835154424949b79ccbe170e1c66f
13 Ne0529455e7d44e58a81afe8189074e39
14 anzsrc-for:11
15 anzsrc-for:1103
16 schema:author Ne4a63a0bc1744ff0a1be056349df61b8
17 schema:citation sg:pub.10.1007/s00270-010-9937-4
18 sg:pub.10.1007/s00270-012-0343-y
19 sg:pub.10.1007/s10555-012-9404-6
20 sg:pub.10.1007/s40336-016-0172-0
21 sg:pub.10.1038/sj.bjc.6690233
22 sg:pub.10.1245/s10434-010-1288-5
23 schema:datePublished 2020-06-12
24 schema:datePublishedReg 2020-06-12
25 schema:description PurposeTo evaluate the combination of 90Y radioembolization (Y90) and drug-eluting bead irinotecan (DEBIRI) microspheres in the VX2 rabbit model.Materials and MethodsAn initial dose finding study was performed in 6 White New Zealand rabbits to identify a therapeutic but subcurative dose of Y90. In total, 29 rabbits were used in four groups: Y90 treatment (n = 8), DEBIRI treatment (n = 6), Y90 + DEBIRI treatment (n = 7), and an untreated control group (n = 8). Hepatic toxicity was evaluated at baseline, 24 h, 72 h, 1 week, and 2 weeks. MRI tumor volume (TV) and enhancing tumor volume were assessed baseline and 2 weeks. Tumor area and necrosis were evaluated on H&E for pathology.ResultsInfused activities of 84.0–94.4 MBq (corresponding to 55.1–72.7 Gy) were selected based on the initial dose finding study. Infusion of DEBIRI after Y90 was technically feasible in all cases (7/7). Overall, 21/29 animals survived to 2 weeks, and the remaining animals had extrahepatic disease on necropsy. Liver transaminases were elevated with Y90, DEBIRI, and Y90 + DEBIRI compared to control at 24 h, 72 h, and 1 week post-treatment and returned to baseline by 2 weeks. By TV, Y90 + DEBIRI was the only treatment to show statistically significant reduction at 2 weeks compared to the control group (p = 0.012). The change in tumor volume (week 2—baseline) for both Y90 + DEBIRI versus control (p = 0.002) and Y90 versus control (p = 0.014) was significantly decreased. There were no statistically significant differences among groups on pathology.ConclusionIntra-arterial Y90 + DEBIRI was safe and demonstrated enhanced antitumor activity in rabbit VX2 tumors. This combined approach warrants further investigation.
26 schema:genre article
27 schema:isAccessibleForFree true
28 schema:isPartOf N9ac0670def1045d1b994fcd1330894ea
29 Nab7361623205421d9335de3b1eb54af5
30 sg:journal.1091062
31 schema:keywords DEBIRI
32 DEBIRI treatments
33 MBq
34 MRI tumor volume
35 New Zealand rabbits
36 PurposeTo
37 VX2 rabbit model
38 VX2 tumors
39 Y90
40 Y90 treatment
41 Zealand rabbits
42 activity
43 animals
44 antitumor activity
45 area
46 baseline
47 cases
48 changes
49 combination
50 control
51 control group
52 differences
53 disease
54 dose
55 enhanced antitumor activity
56 extrahepatic disease
57 feasibility
58 further investigation
59 group
60 hepatic toxicity
61 infusion
62 initial dose
63 investigation
64 liver transaminases
65 materials
66 microspheres
67 model
68 necropsy
69 necrosis
70 only treatment
71 pathology
72 rabbit VX2 tumor
73 rabbit model
74 rabbits
75 radioembolization
76 reduction
77 significant differences
78 significant reduction
79 study
80 subcurative dose
81 toxicity
82 transaminase
83 treatment
84 tumor area
85 tumor volume
86 tumors
87 untreated control group
88 volume
89 warrants further investigation
90 weeks
91 white New Zealand rabbits
92 yttrium-90
93 schema:name Feasibility of Combination Intra-arterial Yttrium-90 and Irinotecan Microspheres in the VX2 Rabbit Model
94 schema:pagination 1528-1537
95 schema:productId N436f14359e534741a7bd0062a00047bc
96 Nc573b83b98c9435ca9c79ccb967dc4d1
97 Ne2cf9ff350d84cb2a446e128a3f74a28
98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1128447495
99 https://doi.org/10.1007/s00270-020-02538-x
100 schema:sdDatePublished 2022-09-02T16:04
101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
102 schema:sdPublisher N626514b19dd7413c85868cd7a231ea8c
103 schema:url https://doi.org/10.1007/s00270-020-02538-x
104 sgo:license sg:explorer/license/
105 sgo:sdDataset articles
106 rdf:type schema:ScholarlyArticle
107 N020f323777cc44f2853fb9d96d2e3d2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Rabbits
109 rdf:type schema:DefinedTerm
110 N09c81f9c8cf0440a8f40e23f0ff80605 rdf:first sg:person.01152017266.03
111 rdf:rest N7ea713367fd843029d01cce9954f4b85
112 N0a6a9f2f481d48dea889d0aab565e2d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Necrosis
114 rdf:type schema:DefinedTerm
115 N1728f0c887ac4840bce54d95469f19ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Chemoembolization, Therapeutic
117 rdf:type schema:DefinedTerm
118 N1d3192edafe94a8594895c8722be22a8 rdf:first sg:person.013232656557.16
119 rdf:rest N8bd108018b054733badaccd6c20efafd
120 N20d0e20e25534f769fa198734b133d48 rdf:first sg:person.014630700367.53
121 rdf:rest N95071ea53d154a58b3472e62338de040
122 N246233f6501040e6872d5839d2897ac6 rdf:first sg:person.015426352627.53
123 rdf:rest N55e6df3cf94744d1801bf90d5afebc64
124 N260f95910bfe45ef83a69b2aad8877a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Disease Models, Animal
126 rdf:type schema:DefinedTerm
127 N29bf49814c82437dad78f6d31a5f948e rdf:first sg:person.0677775141.14
128 rdf:rest rdf:nil
129 N35e3eacfe9ff49c3b3725e75e03927a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Antineoplastic Agents
131 rdf:type schema:DefinedTerm
132 N378029bea8df400a872590b01fb758cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Liver Neoplasms, Experimental
134 rdf:type schema:DefinedTerm
135 N3bd753b1cd474022afbcfb718314191e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Dose-Response Relationship, Drug
137 rdf:type schema:DefinedTerm
138 N436f14359e534741a7bd0062a00047bc schema:name dimensions_id
139 schema:value pub.1128447495
140 rdf:type schema:PropertyValue
141 N48905febed304a5289c81bd2c928ea0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Microspheres
143 rdf:type schema:DefinedTerm
144 N4a9892fe5fae40a284817b3148c237e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Animals
146 rdf:type schema:DefinedTerm
147 N55e6df3cf94744d1801bf90d5afebc64 rdf:first sg:person.012033135452.42
148 rdf:rest N1d3192edafe94a8594895c8722be22a8
149 N626514b19dd7413c85868cd7a231ea8c schema:name Springer Nature - SN SciGraph project
150 rdf:type schema:Organization
151 N65c8d23e367d49bdaf53d02affb26d10 rdf:first sg:person.0727442633.54
152 rdf:rest N9e41a29043a740a7b64386f9a186f079
153 N78f38c6b6e814b14a86683b846d05575 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Feasibility Studies
155 rdf:type schema:DefinedTerm
156 N7ea713367fd843029d01cce9954f4b85 rdf:first sg:person.010656500177.05
157 rdf:rest N65c8d23e367d49bdaf53d02affb26d10
158 N84fd79a50c7d4fd1a1f6df779d3fa1c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Irinotecan
160 rdf:type schema:DefinedTerm
161 N8bd108018b054733badaccd6c20efafd rdf:first sg:person.014101535653.42
162 rdf:rest N09c81f9c8cf0440a8f40e23f0ff80605
163 N95071ea53d154a58b3472e62338de040 rdf:first sg:person.0761527154.53
164 rdf:rest N246233f6501040e6872d5839d2897ac6
165 N9ac0670def1045d1b994fcd1330894ea schema:volumeNumber 43
166 rdf:type schema:PublicationVolume
167 N9e41a29043a740a7b64386f9a186f079 rdf:first sg:person.01014223541.41
168 rdf:rest Na4706ba449654eb6ac956c6e31439588
169 Na4706ba449654eb6ac956c6e31439588 rdf:first sg:person.01147023653.18
170 rdf:rest N29bf49814c82437dad78f6d31a5f948e
171 Na5b5835154424949b79ccbe170e1c66f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Yttrium Radioisotopes
173 rdf:type schema:DefinedTerm
174 Nab7361623205421d9335de3b1eb54af5 schema:issueNumber 10
175 rdf:type schema:PublicationIssue
176 Nbb3db1ca36da40bda647dd9ad6c5d9bf rdf:first sg:person.01141713636.24
177 rdf:rest N20d0e20e25534f769fa198734b133d48
178 Nc573b83b98c9435ca9c79ccb967dc4d1 schema:name pubmed_id
179 schema:value 32533312
180 rdf:type schema:PropertyValue
181 Ne0529455e7d44e58a81afe8189074e39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Magnetic Resonance Imaging
183 rdf:type schema:DefinedTerm
184 Ne2cf9ff350d84cb2a446e128a3f74a28 schema:name doi
185 schema:value 10.1007/s00270-020-02538-x
186 rdf:type schema:PropertyValue
187 Ne4a63a0bc1744ff0a1be056349df61b8 rdf:first sg:person.0604321166.95
188 rdf:rest Nbb3db1ca36da40bda647dd9ad6c5d9bf
189 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
190 schema:name Medical and Health Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
193 schema:name Clinical Sciences
194 rdf:type schema:DefinedTerm
195 sg:grant.2438861 http://pending.schema.org/fundedItem sg:pub.10.1007/s00270-020-02538-x
196 rdf:type schema:MonetaryGrant
197 sg:grant.2479215 http://pending.schema.org/fundedItem sg:pub.10.1007/s00270-020-02538-x
198 rdf:type schema:MonetaryGrant
199 sg:grant.2622696 http://pending.schema.org/fundedItem sg:pub.10.1007/s00270-020-02538-x
200 rdf:type schema:MonetaryGrant
201 sg:grant.2683856 http://pending.schema.org/fundedItem sg:pub.10.1007/s00270-020-02538-x
202 rdf:type schema:MonetaryGrant
203 sg:journal.1091062 schema:issn 0174-1551
204 1432-086X
205 schema:name CardioVascular and Interventional Radiology
206 schema:publisher Springer Nature
207 rdf:type schema:Periodical
208 sg:person.01014223541.41 schema:affiliation grid-institutes:grid.16753.36
209 schema:familyName Salem
210 schema:givenName Riad
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014223541.41
212 rdf:type schema:Person
213 sg:person.010656500177.05 schema:affiliation grid-institutes:None
214 schema:familyName Dreher
215 schema:givenName Matthew R.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010656500177.05
217 rdf:type schema:Person
218 sg:person.01141713636.24 schema:affiliation grid-institutes:grid.30760.32
219 schema:familyName White
220 schema:givenName Sarah B.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141713636.24
222 rdf:type schema:Person
223 sg:person.01147023653.18 schema:affiliation grid-institutes:grid.16753.36
224 schema:familyName Lewandowski
225 schema:givenName Robert J.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147023653.18
227 rdf:type schema:Person
228 sg:person.01152017266.03 schema:affiliation grid-institutes:grid.16753.36
229 schema:familyName Huang
230 schema:givenName Xiaoke
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152017266.03
232 rdf:type schema:Person
233 sg:person.012033135452.42 schema:affiliation grid-institutes:grid.16753.36
234 schema:familyName Harris
235 schema:givenName Kathleen R.
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012033135452.42
237 rdf:type schema:Person
238 sg:person.013232656557.16 schema:affiliation grid-institutes:grid.16753.36
239 schema:familyName Zhang
240 schema:givenName Zhuoli
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013232656557.16
242 rdf:type schema:Person
243 sg:person.014101535653.42 schema:affiliation grid-institutes:grid.16753.36
244 schema:familyName Lyu
245 schema:givenName Tianchu
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014101535653.42
247 rdf:type schema:Person
248 sg:person.014630700367.53 schema:affiliation grid-institutes:grid.16753.36
249 schema:familyName Yang
250 schema:givenName Yihe
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014630700367.53
252 rdf:type schema:Person
253 sg:person.015426352627.53 schema:affiliation grid-institutes:grid.16753.36
254 schema:familyName Procissi
255 schema:givenName Daniel
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015426352627.53
257 rdf:type schema:Person
258 sg:person.0604321166.95 schema:affiliation grid-institutes:grid.16753.36
259 schema:familyName Gordon
260 schema:givenName Andrew C.
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604321166.95
262 rdf:type schema:Person
263 sg:person.0677775141.14 schema:affiliation grid-institutes:grid.16753.36
264 schema:familyName Larson
265 schema:givenName Andrew C.
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677775141.14
267 rdf:type schema:Person
268 sg:person.0727442633.54 schema:affiliation grid-institutes:grid.412807.8
269 schema:familyName Omary
270 schema:givenName Reed A.
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727442633.54
272 rdf:type schema:Person
273 sg:person.0761527154.53 schema:affiliation grid-institutes:grid.16753.36
274 schema:familyName Gates
275 schema:givenName Vanessa L.
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761527154.53
277 rdf:type schema:Person
278 sg:pub.10.1007/s00270-010-9937-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028019140
279 https://doi.org/10.1007/s00270-010-9937-4
280 rdf:type schema:CreativeWork
281 sg:pub.10.1007/s00270-012-0343-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1020579386
282 https://doi.org/10.1007/s00270-012-0343-y
283 rdf:type schema:CreativeWork
284 sg:pub.10.1007/s10555-012-9404-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051629482
285 https://doi.org/10.1007/s10555-012-9404-6
286 rdf:type schema:CreativeWork
287 sg:pub.10.1007/s40336-016-0172-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013246699
288 https://doi.org/10.1007/s40336-016-0172-0
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/sj.bjc.6690233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038476683
291 https://doi.org/10.1038/sj.bjc.6690233
292 rdf:type schema:CreativeWork
293 sg:pub.10.1245/s10434-010-1288-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012691102
294 https://doi.org/10.1245/s10434-010-1288-5
295 rdf:type schema:CreativeWork
296 grid-institutes:None schema:alternateName BTG International Inc, West Conshohocken, PA, USA
297 schema:name BTG International Inc, West Conshohocken, PA, USA
298 rdf:type schema:Organization
299 grid-institutes:grid.16753.36 schema:alternateName Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA
300 Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA
301 Department of Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
302 schema:name Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA
303 Department of Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
304 Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N. Michigan Ave, 16th Floor, 60611, Chicago, IL, USA
305 Department of Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
306 rdf:type schema:Organization
307 grid-institutes:grid.30760.32 schema:alternateName Department of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, Milwaukee, WI, USA
308 schema:name Department of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, Milwaukee, WI, USA
309 rdf:type schema:Organization
310 grid-institutes:grid.412807.8 schema:alternateName Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
311 schema:name Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
312 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...