Ontology type: schema:ScholarlyArticle
2019-04-02
AUTHORSCristina E. Firanescu, Jolanda de Vries, Paul Lodder, Marinus C. Schoemaker, Albert J. Smeets, Esther Donga, Job R. Juttmann, Caroline A. H. Klazen, Otto E. H. Elgersma, Frits H. Jansen, Irene van der Horst, Marion Blonk, Alexander Venmans, Paul N. M. Lohle
ABSTRACTBACKGROUND: Percutaneous vertebroplasty (PV) is an alternative option to treat pain after an osteoporotic vertebral compression fracture (OVCF). Controversy exists as to whether PV increases the risk of new OVCFs or prevents further vertebral height loss in treated levels. We assessed both during 1-year follow-up in patients with acute OVCF randomised to PV or a sham procedure. METHODS: VERTOS IV is a prospective, multicentre, randomised controlled trial comparing PV with sham therapy in 180 patients. New OVCFs and further vertebral height loss were assessed at 3, 6, and 12 months. RESULTS: After a median follow-up of 12 months (interquartile range (IQR) = 12-12) 31 new fractures were reported in 15 patients from the PV group and 28 new fractures in 19 patients from the sham group. The occurrence of new vertebral fractures did not significantly differ between the groups (χ2(1) = 0.83, p = 0.36, OR = .71, 95%CI = 0.33-1.50). There was no higher fracture risk of adjacent versus distant vertebrae. After sham procedure, further height loss of treated vertebrae occurred more frequently (7 patients (8%) in the PV group and 39 (45%) in the sham group (χ2(1) = 28.85, p < 0.001, OR = 9.84, 95%CI = 4.08-23.73)) and was more severe (p < .001) than after PV. CONCLUSIONS: The risk of further vertebral height loss is significantly lower after PV compared to a sham intervention, i.e. PV protects against progressive vertebral height loss. In addition, PV does not increase the risk of new adjacent and distant OVCFs. LEVEL OF EVIDENCE: Level 1a, therapeutic study. ClinicalTrials.gov number, NCT01200277. More... »
PAGES1-10
http://scigraph.springernature.com/pub.10.1007/s00270-019-02205-w
DOIhttp://dx.doi.org/10.1007/s00270-019-02205-w
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30941490
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"description": "BACKGROUND: Percutaneous vertebroplasty (PV) is an alternative option to treat pain after an osteoporotic vertebral compression fracture (OVCF). Controversy exists as to whether PV increases the risk of new OVCFs or prevents further vertebral height loss in treated levels. We assessed both during 1-year follow-up in patients with acute OVCF randomised to PV or a sham procedure.\nMETHODS: VERTOS IV is a prospective, multicentre, randomised controlled trial comparing PV with sham therapy in 180 patients. New OVCFs and further vertebral height loss were assessed at 3, 6, and 12\u00a0months.\nRESULTS: After a median follow-up of 12\u00a0months (interquartile range (IQR)\u2009=\u200912-12) 31 new fractures were reported in 15 patients from the PV group and 28 new fractures in 19 patients from the sham group. The occurrence of new vertebral fractures did not significantly differ between the groups (\u03c72(1)\u2009=\u20090.83, p\u2009=\u20090.36, OR\u2009=\u2009.71, 95%CI\u2009=\u20090.33-1.50). There was no higher fracture risk of adjacent versus distant vertebrae. After sham procedure, further height loss of treated vertebrae occurred more frequently (7 patients (8%) in the PV group and 39 (45%) in the sham group (\u03c72(1)\u2009=\u200928.85, p\u2009<\u20090.001, OR\u2009=\u20099.84, 95%CI\u2009=\u20094.08-23.73)) and was more severe (p\u2009<\u2009.001) than after PV.\nCONCLUSIONS: The risk of further vertebral height loss is significantly lower after PV compared to a sham intervention, i.e. PV protects against progressive vertebral height loss. In addition, PV does not increase the risk of new adjacent and distant OVCFs.\nLEVEL OF EVIDENCE: Level 1a, therapeutic study. ClinicalTrials.gov number, NCT01200277.",
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"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8003538"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30941490"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00270-019-02205-w",
"https://app.dimensions.ai/details/publication/pub.1113179841"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-15T09:20",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56179_00000006.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs00270-019-02205-w"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00270-019-02205-w'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00270-019-02205-w'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00270-019-02205-w'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00270-019-02205-w'
This table displays all metadata directly associated to this object as RDF triples.
270 TRIPLES
21 PREDICATES
60 URIs
18 LITERALS
7 BLANK NODES