Phase II Trial of Transarterial Embolization Using an n-Butyl-2-Cyanoacrylate/Lipiodol Mixture (JIVROSG-0802) View Full Text


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Article Info

DATE

2019-04

AUTHORS

Shunsuke Sugawara, Yasuaki Arai, Miyuki Sone, Tsuneo Ishiguchi, Akira Kitagawa, Takeshi Aramaki, Rui Sato, Hiroyuki Morishita, Yoshito Takeuchi, Yoshitaka Inaba

ABSTRACT

PURPOSE: To evaluate the embolic effect and the safety of transarterial embolization (TAE) using n-butyl-2-cyanoacrylate (NBCA) in a prospective multicenter trial. MATERIALS AND METHODS: This study was an open-label, multicenter, phase II trial. The inclusion criteria were (1) active bleeding or pseudoaneurysm, (2) true aneurysm, (3) arteriovenous malformation (except cerebral lesion), (4) arteriovenous fistula, or (5) need for arterial distribution before transarterial treatment. Selective TAE with NBCA diluted 2-10 times was performed. The primary endpoint was the success rate of embolization with a per-patient analysis based on the angiographic findings. Secondary endpoints were safety, evaluated based on Common Terminology Criteria for Adverse Events (CTCAE) version 4, and the success rate of embolization with a per-vessel calculation. RESULTS: Sixty-five patients were initially enrolled, but due to protocol violation in two patients, efficacy was ultimately analyzed in 63 patients (103 vessels) and safety was analyzed in 64 patients. The success rate per patient was 98.4% (62/63; 95% confidence interval (CI), 91.5-100.00), and the success rate per vessel was 99.0% (102/103; 95% CI, 94.7-100.0). Adverse events of grade 3 or above based on CTCAE version 4 occurred in 22/64 patients (34.4%). Twelve intraoperative or postoperative adverse events grade 3 or above, which may have been related to embolization using NBCA, occurred in 11/64 patients (17.2%). Three patients died after embolization using NBCA, but their deaths were unrelated to TAE. CONCLUSION: In this prospective multicenter clinical trial, the efficacy of TAE using NBCA was 98.4% and adverse events were clinically acceptable. LEVEL OF EVIDENCE: Level 3b. More... »

PAGES

534-541

References to SciGraph publications

  • 2012-06. Efficacy and Safety of Two Different n-Butyl-2-Cyanoacrylates for the Embolization of Varicoceles: A Prospective, Randomized, Blinded Study in CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
  • 1995-11. Malignant insulinoma: Permanent hepatic artery embolization of liver metastases—Preliminary results in CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
  • 2003-01. Embolization of visceral pseudoaneurysms with platinum coils and N-butyl cyanoacrylate in ABDOMINAL RADIOLOGY
  • 2007-11. Endovascular Treatment of Lower Limb Penetrating Arterial Traumas in CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
  • 2010-02. Selective arterial embolization of 36 aneurysmal bone cysts of the skeleton with N-2-butyl cyanoacrylate in SKELETAL RADIOLOGY
  • 2009-05. Portal Vein Embolization Using a Nitinol Plug (Amplatzer Vascular Plug) in Combination with Histoacryl Glue and Iodinized Oil: Adequate Hypertrophy with a Reduced Risk of Nontarget Embolization in CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
  • 2010-04. Pancreatitis after transcatheter embolization of a splenic aneurysm in JAPANESE JOURNAL OF RADIOLOGY
  • 2008-12. Transarterial glue embolization in iatrogenic renovascular injuries in GERIATRIC NEPHROLOGY AND UROLOGY
  • 2006-05. Improved distal distribution of n-butyl cyanoacrylate glue by simultaneous injection of dextrose 5% through the guiding catheter: technical note in NEURORADIOLOGY
  • 2008-07. Use of a Balloon and N-Butyl-2-Cyanoacrylate for Treatment of Arteriovenous Fistula in CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
  • 2014-07. Randomised controlled trial of doxorubicin-eluting beads vs conventional chemoembolisation for hepatocellular carcinoma in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00270-018-2141-7

    DOI

    http://dx.doi.org/10.1007/s00270-018-2141-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110421640

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30523386


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    243 https://www.grid.ac/institutes/grid.411234.1 schema:alternateName Aichi Medical University
    244 schema:name Department of Radiology, Aichi Medical University, 1-1 Yazako Karimata, 480-1195, Nagakute, Aichi, Japan
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    246 https://www.grid.ac/institutes/grid.415797.9 schema:alternateName Shizuoka Cancer Center
    247 schema:name Division of Interventional Radiology, Shizuoka Cancer Center, 1007 Shimonagakubo, 411-8777, Nagaizumi-cho, Shizuoka, Japan
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