Focal Stenting of Complex Femoropopliteal Lesions with the Multi-LOC Multiple Stent Delivery System: 12-Month Results of the Multicenter LOCOMOTIVE Study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10-25

AUTHORS

Martin Sigl, Ulrich Beschorner, Thomas Zeller, Matthias Waliszewski, Ralf Langhoff, Jörg Tautenhahn, Klaus Amendt

ABSTRACT

IntroductionThe purpose of this observational study is to report the 12-month clinical outcomes with the novel Multiple Stent Delivery System (MSDS) to treat complex femoropopliteal lesions. Previously, we reported the 6-month clinical outcomes of the all-comers LOCOMOTIVE study, which demonstrated the safety and efficacy of the MSDS with a favorable target lesion revascularization (TLR) rate of 5.3% and a 90.7% patency rate at 6 months in claudicants and critical limb ischemia patients. The 12-month outcomes of LOCOMOTIVE registry are presented in this report. ClinicalTrials.gov Identifier: NCT02531230.MethodsThe LOCOMOTIVE study (Multi-LOC for flOw liMiting Outcomes after POBA and/or DCB Treatment in the infrainguinal position with the objecIVE to implant multiple stent segments) investigates the efficacy and safety of the MSDS approach in an all-comers population. Clinical follow-ups at 6 and 12 months are scheduled to assess TLR, ABI, and vessel patency based on sonographic imaging.ResultsAt 12 months, the primary unassisted patency was 85.7% and all-cause TLR rate was 9.3% in the overall cohort. Between baseline and 12 months, the target leg ABI increased from 0.62 ± 0.24 to 0.91 ± 0.38 (p < 0.001) and the mean Rutherford class improved from 3.5 to 1.9 (p < 0.001).ConclusionsOver a 12-month post-procedural period, MSDS for focal provisional stenting of complex femoropopliteal lesions demonstrated a promising primary patency and freedom from TLR after 12 months. In addition, significant improvements were observed in symptom classification and hemodynamics. More... »

PAGES

169-175

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00270-018-2095-9

DOI

http://dx.doi.org/10.1007/s00270-018-2095-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107848883

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30361959


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