Two-Year Clinical Outcomes of the CONSEQUENT Trial: Can Femoropopliteal Lesions be Treated with Sustainable Clinical Results that are Economically Sound? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07

AUTHORS

Thomas Albrecht, Matthias Waliszewski, Catherine Roca, Ulf Redlich, Jörg Tautenhahn, Maciej Pech, Zuhir Halloul, Özlem Gögebakan, Dirk-Roelfs Meyer, Ines Gemeinhardt, Thomas Zeller, Stefan Müller-Hülsbeck, Ilka Ott, Gunnar Tepe

ABSTRACT

PURPOSE: The previously reported 6-month angiographic and 12-month clinical outcomes of the CONSEQUENT trial demonstrated the safety and efficacy of a novel paclitaxel-resveratrol-coated balloon for the treatment of lesions in the femoropopliteal segment. The purpose of this report is to present the 2-year results including a cost-benefit analysis for Germany. MATERIALS AND METHODS: Patients with symptomatic peripheral artery occlusive disease in femoropopliteal lesions were randomized either to drug-coated balloon (DCB, n = 78) or plain old balloon angioplasty (POBA, n = 75). As secondary endpoints, the 2-year clinical results consisting of target lesion revascularization (TLR), patency and increase in walking distance were recorded. Based on the Kaplan-Meier analyses for TLR and other adverse events, a cost-benefit analysis was conducted for the German DRG system. RESULTS: There were no additional TLRs in both groups between 14 and 24 months so that the corresponding rates remained significantly different between the treatment groups (DCB: 19.1 vs. POBA 40.6%, p = 0.007). At 2 years, the patency rate was significantly higher in the DCB group (72.3 vs. 48.4%, p = 0.006). The walking distance increase was also significantly higher after DCB angioplasty (172 ± 103 vs. 52 ± 136 m, p = 0.001). We estimated 2-year cost savings of € 1111.97 per patient treated with DCB instead of POBA. CONCLUSIONS: The use of paclitaxel-resveratrol matrix-coated peripheral balloons compared to POBA was associated with a significantly reduced TLR rate, superior patency and substantial cost savings at 2 years. ClinicalTrials.gov Identifier NCT01970579. More... »

PAGES

1008-1014

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00270-018-1940-1

DOI

http://dx.doi.org/10.1007/s00270-018-1940-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101785740

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29589098


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angioplasty, Balloon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coated Materials, Biocompatible", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Femoral Artery", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Germany", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peripheral Arterial Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Popliteal Artery", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Radiology and Interventional Therapy, Vivantes Hospital Berlin Neuk\u00f6lln, Rudower Str. 48, 12351, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Albrecht", 
        "givenName": "Thomas", 
        "id": "sg:person.01015575110.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015575110.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Medical Scientific Affairs, B.Braun Melsungen AG, Berlin, Germany", 
            "Department of Internal Medicine and Cardiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Virchow, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Waliszewski", 
        "givenName": "Matthias", 
        "id": "sg:person.01232617525.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232617525.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fresenius University of Applied Sciences", 
          "id": "https://www.grid.ac/institutes/grid.440934.e", 
          "name": [
            "Welsh School of Pharmacy, Cardiff University, Cardiff, UK", 
            "Hochschule Fresenius, Idstein, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roca", 
        "givenName": "Catherine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinikum Magdeburg", 
          "id": "https://www.grid.ac/institutes/grid.473621.5", 
          "name": [
            "Departments of Radiology and Vascular Surgery, Klinikum Magdeburg, Magdeburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Redlich", 
        "givenName": "Ulf", 
        "id": "sg:person.0726022212.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726022212.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinikum Magdeburg", 
          "id": "https://www.grid.ac/institutes/grid.473621.5", 
          "name": [
            "Departments of Radiology and Vascular Surgery, Klinikum Magdeburg, Magdeburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tautenhahn", 
        "givenName": "J\u00f6rg", 
        "id": "sg:person.014633116164.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014633116164.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsaugenklinik Magdeburg", 
          "id": "https://www.grid.ac/institutes/grid.488575.3", 
          "name": [
            "Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pech", 
        "givenName": "Maciej", 
        "id": "sg:person.01002436022.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002436022.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsaugenklinik Magdeburg", 
          "id": "https://www.grid.ac/institutes/grid.488575.3", 
          "name": [
            "Departments of Vascular Surgery, University Hospital Magdeburg, Magdeburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Halloul", 
        "givenName": "Zuhir", 
        "id": "sg:person.01364554764.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364554764.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Radiology and Interventional Therapy, Vivantes Hospital Berlin Neuk\u00f6lln, Rudower Str. 48, 12351, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00f6gebakan", 
        "givenName": "\u00d6zlem", 
        "id": "sg:person.01141372641.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141372641.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Diagnostic and Interventional Radiology, Hubertus Hospital, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meyer", 
        "givenName": "Dirk-Roelfs", 
        "id": "sg:person.01366154431.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366154431.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Charit\u00e9 Universit\u00e4tsmedizin, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gemeinhardt", 
        "givenName": "Ines", 
        "id": "sg:person.01232201114.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232201114.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4ts-Herzzentrum Freiburg-Bad Krozingen", 
          "id": "https://www.grid.ac/institutes/grid.418466.9", 
          "name": [
            "University Heart Center Bad Krozingen, Bad Krozingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zeller", 
        "givenName": "Thomas", 
        "id": "sg:person.01306206724.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306206724.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Diagnostic and Interventional Radiology and Neuroradiology, Diakonissenanstalt zu Flensburg, Flensburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00fcller-H\u00fclsbeck", 
        "givenName": "Stefan", 
        "id": "sg:person.0775352560.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775352560.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Heart Center Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ott", 
        "givenName": "Ilka", 
        "id": "sg:person.01254410443.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254410443.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "RoMed Kliniken", 
          "id": "https://www.grid.ac/institutes/grid.477776.2", 
          "name": [
            "Department of Radiology, RoMed Klinikum Rosenheim, Rosenheim, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tepe", 
        "givenName": "Gunnar", 
        "id": "sg:person.01235146031.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235146031.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1177/1526602815626557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005656130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1526602815626557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005656130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ccd.25536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010346822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrcardio.2013.165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024099524", 
          "https://doi.org/10.1038/nrcardio.2013.165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circinterventions.112.971630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027060586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circinterventions.112.971630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027060586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ccd.25900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027893590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1406235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032511404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcin.2013.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032730434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00015458.2008.11680246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038107762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2015.09.063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042007604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1526602814564383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042735794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1526602814564383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042735794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcin.2016.08.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043146872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/vhrm.s81122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044847471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0706356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045759254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.107.735985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048136217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcin.2016.06.055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048458625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.116.026493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085231933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.116.026493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085231933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00270-017-1713-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090282013", 
          "https://doi.org/10.1007/s00270-017-1713-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00270-017-1713-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090282013", 
          "https://doi.org/10.1007/s00270-017-1713-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.117.028893", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090838777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.117.028893", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090838777"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-07", 
    "datePublishedReg": "2018-07-01", 
    "description": "PURPOSE: The previously reported 6-month angiographic and 12-month clinical outcomes of the CONSEQUENT trial demonstrated the safety and efficacy of a novel paclitaxel-resveratrol-coated balloon for the treatment of lesions in the femoropopliteal segment. The purpose of this report is to present the 2-year results including a cost-benefit analysis for Germany.\nMATERIALS AND METHODS: Patients with symptomatic peripheral artery occlusive disease in femoropopliteal lesions were randomized either to drug-coated balloon (DCB, n\u2009=\u200978) or plain old balloon angioplasty (POBA, n\u2009=\u200975). As secondary endpoints, the 2-year clinical results consisting of target lesion revascularization (TLR), patency and increase in walking distance were recorded. Based on the Kaplan-Meier analyses for TLR and other adverse events, a cost-benefit analysis was conducted for the German DRG system.\nRESULTS: There were no additional TLRs in both groups between 14 and 24\u00a0months so that the corresponding rates remained significantly different between the treatment groups (DCB: 19.1 vs. POBA 40.6%, p\u2009=\u20090.007). At 2\u00a0years, the patency rate was significantly higher in the DCB group (72.3 vs. 48.4%, p\u2009=\u20090.006). The walking distance increase was also significantly higher after DCB angioplasty (172\u2009\u00b1\u2009103 vs. 52\u2009\u00b1\u2009136\u00a0m, p\u2009=\u20090.001). We estimated 2-year cost savings of \u20ac 1111.97 per patient treated with DCB instead of POBA.\nCONCLUSIONS: The use of paclitaxel-resveratrol matrix-coated peripheral balloons compared to POBA was associated with a significantly reduced TLR rate, superior patency and substantial cost savings at 2\u00a0years. ClinicalTrials.gov Identifier NCT01970579.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00270-018-1940-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1091062", 
        "issn": [
          "0174-1551", 
          "1432-086X"
        ], 
        "name": "CardioVascular and Interventional Radiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "41"
      }
    ], 
    "name": "Two-Year Clinical Outcomes of the CONSEQUENT Trial: Can Femoropopliteal Lesions be Treated with Sustainable Clinical Results that are Economically Sound?", 
    "pagination": "1008-1014", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c13a38655b1bea3b689740c6f160449e6f83ef28ad8058299145f556e9691f96"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29589098"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8003538"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00270-018-1940-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101785740"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00270-018-1940-1", 
      "https://app.dimensions.ai/details/publication/pub.1101785740"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88251_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00270-018-1940-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00270-018-1940-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00270-018-1940-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00270-018-1940-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00270-018-1940-1'


 

This table displays all metadata directly associated to this object as RDF triples.

304 TRIPLES      21 PREDICATES      62 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00270-018-1940-1 schema:about N003fd32eb5624aaeb5b7c0b6a282dfc3
2 N14f15a64d978456ab31b1830f3f7b5d4
3 N26d3b37f1bee417eb88841a8e3b54d9d
4 N4ac2600594134199af39d3e24106bd3c
5 N4be3c0305e5848d79afe048db1b1b482
6 N61395c6eb0f64f58a6840e62bf41d5b0
7 N8872b831a1f44b99bdfafbecc7ac91ac
8 N98e40e4e92614ea1bd6521e7610b4076
9 Naa6281cafa754243ae64fe6255ccbea8
10 Nae4f0dca2ad940658e9730d201c98e94
11 Nb2bb59f39cff41968bf38f6fdc80501a
12 Nc638419952da49f1b0479b0d29006292
13 Nc79a77da398c4cf09fa3b8dd5f964657
14 Nf77bfce1cecc4009bd6d2760dcc51ffd
15 Nfcda40d0041749499795633101eef128
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N812b6818061f466ca0d1f7260b28d7a9
19 schema:citation sg:pub.10.1007/s00270-017-1713-2
20 sg:pub.10.1038/nrcardio.2013.165
21 https://doi.org/10.1002/ccd.25536
22 https://doi.org/10.1002/ccd.25900
23 https://doi.org/10.1016/j.jacc.2015.09.063
24 https://doi.org/10.1016/j.jcin.2013.05.022
25 https://doi.org/10.1016/j.jcin.2016.06.055
26 https://doi.org/10.1016/j.jcin.2016.08.036
27 https://doi.org/10.1056/nejmoa0706356
28 https://doi.org/10.1056/nejmoa1406235
29 https://doi.org/10.1080/00015458.2008.11680246
30 https://doi.org/10.1161/circinterventions.112.971630
31 https://doi.org/10.1161/circulationaha.107.735985
32 https://doi.org/10.1161/circulationaha.116.026493
33 https://doi.org/10.1161/circulationaha.117.028893
34 https://doi.org/10.1177/1526602814564383
35 https://doi.org/10.1177/1526602815626557
36 https://doi.org/10.2147/vhrm.s81122
37 schema:datePublished 2018-07
38 schema:datePublishedReg 2018-07-01
39 schema:description PURPOSE: The previously reported 6-month angiographic and 12-month clinical outcomes of the CONSEQUENT trial demonstrated the safety and efficacy of a novel paclitaxel-resveratrol-coated balloon for the treatment of lesions in the femoropopliteal segment. The purpose of this report is to present the 2-year results including a cost-benefit analysis for Germany. MATERIALS AND METHODS: Patients with symptomatic peripheral artery occlusive disease in femoropopliteal lesions were randomized either to drug-coated balloon (DCB, n = 78) or plain old balloon angioplasty (POBA, n = 75). As secondary endpoints, the 2-year clinical results consisting of target lesion revascularization (TLR), patency and increase in walking distance were recorded. Based on the Kaplan-Meier analyses for TLR and other adverse events, a cost-benefit analysis was conducted for the German DRG system. RESULTS: There were no additional TLRs in both groups between 14 and 24 months so that the corresponding rates remained significantly different between the treatment groups (DCB: 19.1 vs. POBA 40.6%, p = 0.007). At 2 years, the patency rate was significantly higher in the DCB group (72.3 vs. 48.4%, p = 0.006). The walking distance increase was also significantly higher after DCB angioplasty (172 ± 103 vs. 52 ± 136 m, p = 0.001). We estimated 2-year cost savings of € 1111.97 per patient treated with DCB instead of POBA. CONCLUSIONS: The use of paclitaxel-resveratrol matrix-coated peripheral balloons compared to POBA was associated with a significantly reduced TLR rate, superior patency and substantial cost savings at 2 years. ClinicalTrials.gov Identifier NCT01970579.
40 schema:genre research_article
41 schema:inLanguage en
42 schema:isAccessibleForFree false
43 schema:isPartOf N8d662f41b7c64616a621ca9295798979
44 Ne9b96c0a68c8448cb1914d52dfab21be
45 sg:journal.1091062
46 schema:name Two-Year Clinical Outcomes of the CONSEQUENT Trial: Can Femoropopliteal Lesions be Treated with Sustainable Clinical Results that are Economically Sound?
47 schema:pagination 1008-1014
48 schema:productId N08119af6c6ba424098161d6059f96f4c
49 N4435552007854fda9f3ad2c78301f671
50 N771259a5c4604bdb8b6ddb7a690bb2fe
51 Nbc1b132da4ad43909c395aa682f6cdce
52 Nf10730b019944290aeac8876036f7997
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101785740
54 https://doi.org/10.1007/s00270-018-1940-1
55 schema:sdDatePublished 2019-04-11T13:11
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher N15e5709c1a504ba1becceea3c9c97e7c
58 schema:url https://link.springer.com/10.1007%2Fs00270-018-1940-1
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N003fd32eb5624aaeb5b7c0b6a282dfc3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Male
64 rdf:type schema:DefinedTerm
65 N03d6dc23f0954631a60519e52805d6b1 rdf:first sg:person.0775352560.93
66 rdf:rest N881c2fc864bb4e9d820377a2385e4ee6
67 N08119af6c6ba424098161d6059f96f4c schema:name doi
68 schema:value 10.1007/s00270-018-1940-1
69 rdf:type schema:PropertyValue
70 N14f15a64d978456ab31b1830f3f7b5d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Angiography
72 rdf:type schema:DefinedTerm
73 N15e5709c1a504ba1becceea3c9c97e7c schema:name Springer Nature - SN SciGraph project
74 rdf:type schema:Organization
75 N215965ea8aa743a782a4bdd5530b33bf rdf:first sg:person.01366154431.47
76 rdf:rest Nc0acdba2dc9441b18b64754d15884ead
77 N21bb754d4281484299dcefa05aa9c1b2 rdf:first sg:person.01364554764.75
78 rdf:rest N5d4a4bf624b14e0ba058540c82fc1070
79 N26d3b37f1bee417eb88841a8e3b54d9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Female
81 rdf:type schema:DefinedTerm
82 N30d0062cf90c426fbc0f23a1d6d6998d rdf:first sg:person.01235146031.45
83 rdf:rest rdf:nil
84 N4435552007854fda9f3ad2c78301f671 schema:name pubmed_id
85 schema:value 29589098
86 rdf:type schema:PropertyValue
87 N4ac2600594134199af39d3e24106bd3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Treatment Outcome
89 rdf:type schema:DefinedTerm
90 N4be3c0305e5848d79afe048db1b1b482 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Coated Materials, Biocompatible
92 rdf:type schema:DefinedTerm
93 N5931f6b445364eafa10ec56e5accb5ee schema:name Department of Diagnostic and Interventional Radiology, Hubertus Hospital, Berlin, Germany
94 rdf:type schema:Organization
95 N5d4a4bf624b14e0ba058540c82fc1070 rdf:first sg:person.01141372641.97
96 rdf:rest N215965ea8aa743a782a4bdd5530b33bf
97 N61395c6eb0f64f58a6840e62bf41d5b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Angioplasty, Balloon
99 rdf:type schema:DefinedTerm
100 N63a679bcf50f41a7b68b0d67ad169c4b rdf:first sg:person.014633116164.36
101 rdf:rest Nf72c4502e6254a7c9ca171ec326b7cd7
102 N771259a5c4604bdb8b6ddb7a690bb2fe schema:name nlm_unique_id
103 schema:value 8003538
104 rdf:type schema:PropertyValue
105 N7dafef8e4285492fadf12027896bea93 rdf:first sg:person.01306206724.74
106 rdf:rest N03d6dc23f0954631a60519e52805d6b1
107 N812b6818061f466ca0d1f7260b28d7a9 rdf:first sg:person.01015575110.70
108 rdf:rest Naf32189001764e2eb1629ea353bdfd8e
109 N881c2fc864bb4e9d820377a2385e4ee6 rdf:first sg:person.01254410443.35
110 rdf:rest N30d0062cf90c426fbc0f23a1d6d6998d
111 N8872b831a1f44b99bdfafbecc7ac91ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Aged
113 rdf:type schema:DefinedTerm
114 N8d662f41b7c64616a621ca9295798979 schema:volumeNumber 41
115 rdf:type schema:PublicationVolume
116 N98e40e4e92614ea1bd6521e7610b4076 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Peripheral Arterial Disease
118 rdf:type schema:DefinedTerm
119 Na1a7192398e542efa946dadbab1ab762 schema:name Radiology and Interventional Therapy, Vivantes Hospital Berlin Neukölln, Rudower Str. 48, 12351, Berlin, Germany
120 rdf:type schema:Organization
121 Na7843dedac4f4c7ea879d98fed5a47b2 schema:name Heart Center Munich, Munich, Germany
122 rdf:type schema:Organization
123 Na8002d33f87f4977ac8adb1e5207816c rdf:first Nacadb8a2de0141abb45ae77a8370f120
124 rdf:rest Nac69eb17f2e24659868400d6dbfd46ba
125 Naa6281cafa754243ae64fe6255ccbea8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Germany
127 rdf:type schema:DefinedTerm
128 Nac69eb17f2e24659868400d6dbfd46ba rdf:first sg:person.0726022212.86
129 rdf:rest N63a679bcf50f41a7b68b0d67ad169c4b
130 Nacadb8a2de0141abb45ae77a8370f120 schema:affiliation https://www.grid.ac/institutes/grid.440934.e
131 schema:familyName Roca
132 schema:givenName Catherine
133 rdf:type schema:Person
134 Nae4f0dca2ad940658e9730d201c98e94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Prospective Studies
136 rdf:type schema:DefinedTerm
137 Naf32189001764e2eb1629ea353bdfd8e rdf:first sg:person.01232617525.60
138 rdf:rest Na8002d33f87f4977ac8adb1e5207816c
139 Nb2bb59f39cff41968bf38f6fdc80501a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Femoral Artery
141 rdf:type schema:DefinedTerm
142 Nbc1b132da4ad43909c395aa682f6cdce schema:name dimensions_id
143 schema:value pub.1101785740
144 rdf:type schema:PropertyValue
145 Nc0acdba2dc9441b18b64754d15884ead rdf:first sg:person.01232201114.88
146 rdf:rest N7dafef8e4285492fadf12027896bea93
147 Nc638419952da49f1b0479b0d29006292 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Popliteal Artery
149 rdf:type schema:DefinedTerm
150 Nc79a77da398c4cf09fa3b8dd5f964657 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Humans
152 rdf:type schema:DefinedTerm
153 Ne6123c4782a34f809d4cecbfe82db1fc schema:name Department of Diagnostic and Interventional Radiology and Neuroradiology, Diakonissenanstalt zu Flensburg, Flensburg, Germany
154 rdf:type schema:Organization
155 Ne9842c62af6f49f185f4fb7c6d5e60c3 schema:name Radiology and Interventional Therapy, Vivantes Hospital Berlin Neukölln, Rudower Str. 48, 12351, Berlin, Germany
156 rdf:type schema:Organization
157 Ne9b96c0a68c8448cb1914d52dfab21be schema:issueNumber 7
158 rdf:type schema:PublicationIssue
159 Nf10730b019944290aeac8876036f7997 schema:name readcube_id
160 schema:value c13a38655b1bea3b689740c6f160449e6f83ef28ad8058299145f556e9691f96
161 rdf:type schema:PropertyValue
162 Nf72c4502e6254a7c9ca171ec326b7cd7 rdf:first sg:person.01002436022.97
163 rdf:rest N21bb754d4281484299dcefa05aa9c1b2
164 Nf77bfce1cecc4009bd6d2760dcc51ffd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Kaplan-Meier Estimate
166 rdf:type schema:DefinedTerm
167 Nfcda40d0041749499795633101eef128 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Time Factors
169 rdf:type schema:DefinedTerm
170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
171 schema:name Medical and Health Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
174 schema:name Clinical Sciences
175 rdf:type schema:DefinedTerm
176 sg:journal.1091062 schema:issn 0174-1551
177 1432-086X
178 schema:name CardioVascular and Interventional Radiology
179 rdf:type schema:Periodical
180 sg:person.01002436022.97 schema:affiliation https://www.grid.ac/institutes/grid.488575.3
181 schema:familyName Pech
182 schema:givenName Maciej
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002436022.97
184 rdf:type schema:Person
185 sg:person.01015575110.70 schema:affiliation Ne9842c62af6f49f185f4fb7c6d5e60c3
186 schema:familyName Albrecht
187 schema:givenName Thomas
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015575110.70
189 rdf:type schema:Person
190 sg:person.01141372641.97 schema:affiliation Na1a7192398e542efa946dadbab1ab762
191 schema:familyName Gögebakan
192 schema:givenName Özlem
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141372641.97
194 rdf:type schema:Person
195 sg:person.01232201114.88 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
196 schema:familyName Gemeinhardt
197 schema:givenName Ines
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232201114.88
199 rdf:type schema:Person
200 sg:person.01232617525.60 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
201 schema:familyName Waliszewski
202 schema:givenName Matthias
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232617525.60
204 rdf:type schema:Person
205 sg:person.01235146031.45 schema:affiliation https://www.grid.ac/institutes/grid.477776.2
206 schema:familyName Tepe
207 schema:givenName Gunnar
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235146031.45
209 rdf:type schema:Person
210 sg:person.01254410443.35 schema:affiliation Na7843dedac4f4c7ea879d98fed5a47b2
211 schema:familyName Ott
212 schema:givenName Ilka
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254410443.35
214 rdf:type schema:Person
215 sg:person.01306206724.74 schema:affiliation https://www.grid.ac/institutes/grid.418466.9
216 schema:familyName Zeller
217 schema:givenName Thomas
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306206724.74
219 rdf:type schema:Person
220 sg:person.01364554764.75 schema:affiliation https://www.grid.ac/institutes/grid.488575.3
221 schema:familyName Halloul
222 schema:givenName Zuhir
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364554764.75
224 rdf:type schema:Person
225 sg:person.01366154431.47 schema:affiliation N5931f6b445364eafa10ec56e5accb5ee
226 schema:familyName Meyer
227 schema:givenName Dirk-Roelfs
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366154431.47
229 rdf:type schema:Person
230 sg:person.014633116164.36 schema:affiliation https://www.grid.ac/institutes/grid.473621.5
231 schema:familyName Tautenhahn
232 schema:givenName Jörg
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014633116164.36
234 rdf:type schema:Person
235 sg:person.0726022212.86 schema:affiliation https://www.grid.ac/institutes/grid.473621.5
236 schema:familyName Redlich
237 schema:givenName Ulf
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726022212.86
239 rdf:type schema:Person
240 sg:person.0775352560.93 schema:affiliation Ne6123c4782a34f809d4cecbfe82db1fc
241 schema:familyName Müller-Hülsbeck
242 schema:givenName Stefan
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775352560.93
244 rdf:type schema:Person
245 sg:pub.10.1007/s00270-017-1713-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090282013
246 https://doi.org/10.1007/s00270-017-1713-2
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nrcardio.2013.165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024099524
249 https://doi.org/10.1038/nrcardio.2013.165
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/ccd.25536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010346822
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/ccd.25900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027893590
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.jacc.2015.09.063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042007604
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.jcin.2013.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032730434
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.jcin.2016.06.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048458625
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.jcin.2016.08.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043146872
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1056/nejmoa0706356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045759254
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1056/nejmoa1406235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032511404
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1080/00015458.2008.11680246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038107762
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1161/circinterventions.112.971630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027060586
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1161/circulationaha.107.735985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048136217
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1161/circulationaha.116.026493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085231933
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1161/circulationaha.117.028893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090838777
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1177/1526602814564383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042735794
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1177/1526602815626557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005656130
280 rdf:type schema:CreativeWork
281 https://doi.org/10.2147/vhrm.s81122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044847471
282 rdf:type schema:CreativeWork
283 https://www.grid.ac/institutes/grid.418466.9 schema:alternateName Universitäts-Herzzentrum Freiburg-Bad Krozingen
284 schema:name University Heart Center Bad Krozingen, Bad Krozingen, Germany
285 rdf:type schema:Organization
286 https://www.grid.ac/institutes/grid.440934.e schema:alternateName Fresenius University of Applied Sciences
287 schema:name Hochschule Fresenius, Idstein, Germany
288 Welsh School of Pharmacy, Cardiff University, Cardiff, UK
289 rdf:type schema:Organization
290 https://www.grid.ac/institutes/grid.473621.5 schema:alternateName Klinikum Magdeburg
291 schema:name Departments of Radiology and Vascular Surgery, Klinikum Magdeburg, Magdeburg, Germany
292 rdf:type schema:Organization
293 https://www.grid.ac/institutes/grid.477776.2 schema:alternateName RoMed Kliniken
294 schema:name Department of Radiology, RoMed Klinikum Rosenheim, Rosenheim, Germany
295 rdf:type schema:Organization
296 https://www.grid.ac/institutes/grid.488575.3 schema:alternateName Universitätsaugenklinik Magdeburg
297 schema:name Department of Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany
298 Departments of Vascular Surgery, University Hospital Magdeburg, Magdeburg, Germany
299 rdf:type schema:Organization
300 https://www.grid.ac/institutes/grid.6363.0 schema:alternateName Charité
301 schema:name Charité Universitätsmedizin, Berlin, Germany
302 Department of Internal Medicine and Cardiology, Charité – Universitätsmedizin Berlin, Campus Virchow, Berlin, Germany
303 Medical Scientific Affairs, B.Braun Melsungen AG, Berlin, Germany
304 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...