Trans-Arterial Chemoembolization with Irinotecan-Loaded Drug-Eluting Beads (DEBIRI) and Capecitabine in Refractory Liver Prevalent Colorectal Metastases: A Phase II Single-Center Study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-12

AUTHORS

Roberto Iezzi, Valentina Angela Marsico, Alessandra Guerra, Eleonora Cerchiaro, Alessandra Cassano, Michele Basso, Ersilia Devicienti, Elena Rodolfino, Carlo Barone, Lorenzo Bonomo

ABSTRACT

PURPOSE: The purpose of this study was to evaluate feasibility, safety, tolerance, and efficacy of drug-eluting beads loaded with irinotecan (DEBIRI) in combination with capecitabine in the treatment of mCRC refractory to chemotherapy in patients affected by liver predominant metastatic disease. MATERIALS AND METHODS: Twenty patients affected by CRC hepatic metastasis with liver-dominant disease, who had progression after two or more lines of chemotherapy, were enrolled. TACE with 100 mg of Irinotecan loaded into 2-ml of 70-150 µm drug-eluting beads was administrated every 4 weeks in patients with unilobar disease (2 treatments) and every 2 weeks in patients with bilobar disease (4 treatments). All patients assumed capecitabine 1000 mg/m(2) twice daily on days 1-14 every 3 weeks, until disease progression. Primary endpoints were safety, tolerance and overall disease control (ODC); secondary endpoints were progression free survival (PFS) and overall survival (OS). RESULTS: A total of 54 treatments were performed (54/66, 82%). No intra/peri-procedural death occurred. During the mean follow-up of 11 months, two partial responses (PR) were reported with ODC of 60% (2 PR + 10 stable disease). PFS and OS were 4 and 7.3 months, respectively. Univariate analysis showed that patients presenting with KRAS wild-type, good ECOG performance status and unilobar disease had a better prognosis. Only performance status (ECOG) correlated with OS in multivariate analysis (p = 0.03). CONCLUSION: DEBIRI with capecitabine seem to be a safe, technically feasible and well-tolerated treatment in chemotherapy refractory liver prevalent colorectal metastases. More... »

PAGES

1523-1531

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00270-015-1080-9

DOI

http://dx.doi.org/10.1007/s00270-015-1080-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004898907

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25799948


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antimetabolites, Antineoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Phytogenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Camptothecin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Capecitabine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemoembolization, Therapeutic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Delivery Systems", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feasibility Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Agostino Gemelli University Polyclinic", 
          "id": "https://www.grid.ac/institutes/grid.411075.6", 
          "name": [
            "Department of Bioimaging and Radiological Sciences, Institute of Radiology, \u201cA. Gemelli\u201d Hospital - Catholic University, L.go A Gemelli 8, 00168, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iezzi", 
        "givenName": "Roberto", 
        "id": "sg:person.01023531012.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023531012.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agostino Gemelli University Polyclinic", 
          "id": "https://www.grid.ac/institutes/grid.411075.6", 
          "name": [
            "Department of medical Oncology, \u201cA. Gemelli\u201d Hospital - Catholic University, L.go A Gemelli 8, 00168, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marsico", 
        "givenName": "Valentina Angela", 
        "id": "sg:person.01277133253.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277133253.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agostino Gemelli University Polyclinic", 
          "id": "https://www.grid.ac/institutes/grid.411075.6", 
          "name": [
            "Department of Bioimaging and Radiological Sciences, Institute of Radiology, \u201cA. Gemelli\u201d Hospital - Catholic University, L.go A Gemelli 8, 00168, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guerra", 
        "givenName": "Alessandra", 
        "id": "sg:person.01063072241.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063072241.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agostino Gemelli University Polyclinic", 
          "id": "https://www.grid.ac/institutes/grid.411075.6", 
          "name": [
            "Department of medical Oncology, \u201cA. Gemelli\u201d Hospital - Catholic University, L.go A Gemelli 8, 00168, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cerchiaro", 
        "givenName": "Eleonora", 
        "id": "sg:person.01211205437.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211205437.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agostino Gemelli University Polyclinic", 
          "id": "https://www.grid.ac/institutes/grid.411075.6", 
          "name": [
            "Department of medical Oncology, \u201cA. Gemelli\u201d Hospital - Catholic University, L.go A Gemelli 8, 00168, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cassano", 
        "givenName": "Alessandra", 
        "id": "sg:person.01101214710.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101214710.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agostino Gemelli University Polyclinic", 
          "id": "https://www.grid.ac/institutes/grid.411075.6", 
          "name": [
            "Department of medical Oncology, \u201cA. Gemelli\u201d Hospital - Catholic University, L.go A Gemelli 8, 00168, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Basso", 
        "givenName": "Michele", 
        "id": "sg:person.01040612743.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040612743.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agostino Gemelli University Polyclinic", 
          "id": "https://www.grid.ac/institutes/grid.411075.6", 
          "name": [
            "Department of Bioimaging and Radiological Sciences, Institute of Radiology, \u201cA. Gemelli\u201d Hospital - Catholic University, L.go A Gemelli 8, 00168, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Devicienti", 
        "givenName": "Ersilia", 
        "id": "sg:person.01166345607.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166345607.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agostino Gemelli University Polyclinic", 
          "id": "https://www.grid.ac/institutes/grid.411075.6", 
          "name": [
            "Department of Bioimaging and Radiological Sciences, Institute of Radiology, \u201cA. Gemelli\u201d Hospital - Catholic University, L.go A Gemelli 8, 00168, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodolfino", 
        "givenName": "Elena", 
        "id": "sg:person.01234461007.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234461007.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agostino Gemelli University Polyclinic", 
          "id": "https://www.grid.ac/institutes/grid.411075.6", 
          "name": [
            "Department of medical Oncology, \u201cA. Gemelli\u201d Hospital - Catholic University, L.go A Gemelli 8, 00168, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barone", 
        "givenName": "Carlo", 
        "id": "sg:person.016416311142.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016416311142.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agostino Gemelli University Polyclinic", 
          "id": "https://www.grid.ac/institutes/grid.411075.6", 
          "name": [
            "Department of Bioimaging and Radiological Sciences, Institute of Radiology, \u201cA. Gemelli\u201d Hospital - Catholic University, L.go A Gemelli 8, 00168, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bonomo", 
        "givenName": "Lorenzo", 
        "id": "sg:person.01015413034.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015413034.57"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.2967/jnumed.113.119545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002357665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11605-012-1892-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004291179", 
          "https://doi.org/10.1007/s11605-012-1892-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-010-1288-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012691102", 
          "https://doi.org/10.1245/s10434-010-1288-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa032691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014051315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000348579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015643108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-006-9045-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019448373", 
          "https://doi.org/10.1245/s10434-006-9045-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)61900-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020430219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jvir.2008.11.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022383287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-013-1564-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023106729", 
          "https://doi.org/10.1007/s00432-013-1564-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-013-1564-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023106729", 
          "https://doi.org/10.1007/s00432-013-1564-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.05.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025767346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1743-7563.2010.01363.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026030714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31815aa2c2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026128215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e31815aa2c2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026128215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2012.1572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029015548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2006.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029538220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19910901)68:5<988::aid-cncr2820680513>3.0.co;2-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029925981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa033025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035161767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.11.0833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037561935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200206000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041943148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200206000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041943148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jvir.2013.05.055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045615169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jvir.2013.05.055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045615169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fonc.2014.00120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050463411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)92529-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051430862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)92529-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051430862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075215611", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075537691", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077594319", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078494384", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078546947", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082604065", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "PURPOSE: The purpose of this study was to evaluate feasibility, safety, tolerance, and efficacy of drug-eluting beads loaded with irinotecan (DEBIRI) in combination with capecitabine in the treatment of mCRC refractory to chemotherapy in patients affected by liver predominant metastatic disease.\nMATERIALS AND METHODS: Twenty patients affected by CRC hepatic metastasis with liver-dominant disease, who had progression after two or more lines of chemotherapy, were enrolled. TACE with 100 mg of Irinotecan loaded into 2-ml of 70-150 \u00b5m drug-eluting beads was administrated every 4 weeks in patients with unilobar disease (2 treatments) and every 2 weeks in patients with bilobar disease (4 treatments). All patients assumed capecitabine 1000 mg/m(2) twice daily on days 1-14 every 3 weeks, until disease progression. Primary endpoints were safety, tolerance and overall disease control (ODC); secondary endpoints were progression free survival (PFS) and overall survival (OS).\nRESULTS: A total of 54 treatments were performed (54/66, 82%). No intra/peri-procedural death occurred. During the mean follow-up of 11 months, two partial responses (PR) were reported with ODC of 60% (2 PR + 10 stable disease). PFS and OS were 4 and 7.3 months, respectively. Univariate analysis showed that patients presenting with KRAS wild-type, good ECOG performance status and unilobar disease had a better prognosis. Only performance status (ECOG) correlated with OS in multivariate analysis (p = 0.03).\nCONCLUSION: DEBIRI with capecitabine seem to be a safe, technically feasible and well-tolerated treatment in chemotherapy refractory liver prevalent colorectal metastases.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00270-015-1080-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1091062", 
        "issn": [
          "0174-1551", 
          "1432-086X"
        ], 
        "name": "CardioVascular and Interventional Radiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "38"
      }
    ], 
    "name": "Trans-Arterial Chemoembolization with Irinotecan-Loaded Drug-Eluting Beads (DEBIRI) and Capecitabine in Refractory Liver Prevalent Colorectal Metastases: A Phase II Single-Center Study", 
    "pagination": "1523-1531", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1757f4d3e5e382330a1733ecec663a50cfd152df412a9a6e7a76d5e8e602d815"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25799948"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8003538"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00270-015-1080-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004898907"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00270-015-1080-9", 
      "https://app.dimensions.ai/details/publication/pub.1004898907"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00270-015-1080-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00270-015-1080-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00270-015-1080-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00270-015-1080-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00270-015-1080-9'


 

This table displays all metadata directly associated to this object as RDF triples.

280 TRIPLES      21 PREDICATES      73 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00270-015-1080-9 schema:about N368eb3ad04bc4f88a97aa9cad0cde767
2 N3b041f226c224c01ae4e5b40fb3e5705
3 N3e4e441cc3584bca83f9f00cdedc8b84
4 N568bba6de4ea414794b760be41396fe7
5 N629e385e7d654fab9ac6b5c8ec22f151
6 N6b1e872b70344828986ddede447fdb7a
7 N6c4370e0f3134d3988ddfd531eeeacc2
8 N6f839018097a45d2bb11d405d721f321
9 N8848875bb0d64739a47cec05978a30bc
10 N884aff2b12fb48dcac7d129b655f5c1a
11 N95fb53010b1e48e0b5843ad30b8d01a4
12 Nbb9f0cd3e7d445c88bcfa1f2d3d5b04a
13 Nbcd1e06c0a744ef09b3a0536848a0fd1
14 Nbe4c3f341520410681152538b403af98
15 Nc45250133a544854b7226aa437314959
16 Nd9b371b762984d5dbe4c64dc71d50cca
17 Nd9ca78ffa36c4bbfb2b3eb88f9877ffc
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author N9baab89cec14400fab282180d4e8825d
21 schema:citation sg:pub.10.1007/s00432-013-1564-4
22 sg:pub.10.1007/s11605-012-1892-8
23 sg:pub.10.1245/s10434-006-9045-5
24 sg:pub.10.1245/s10434-010-1288-5
25 https://app.dimensions.ai/details/publication/pub.1075215611
26 https://app.dimensions.ai/details/publication/pub.1075537691
27 https://app.dimensions.ai/details/publication/pub.1077594319
28 https://app.dimensions.ai/details/publication/pub.1078494384
29 https://app.dimensions.ai/details/publication/pub.1078546947
30 https://app.dimensions.ai/details/publication/pub.1082604065
31 https://doi.org/10.1002/1097-0142(19910901)68:5<988::aid-cncr2820680513>3.0.co;2-8
32 https://doi.org/10.1016/j.ejca.2006.04.012
33 https://doi.org/10.1016/j.jvir.2008.11.019
34 https://doi.org/10.1016/j.jvir.2013.05.055
35 https://doi.org/10.1016/s0140-6736(12)61900-x
36 https://doi.org/10.1016/s0140-6736(94)92529-1
37 https://doi.org/10.1056/nejmoa032691
38 https://doi.org/10.1056/nejmoa033025
39 https://doi.org/10.1097/00000658-200206000-00002
40 https://doi.org/10.1097/sla.0b013e31815aa2c2
41 https://doi.org/10.1111/j.1743-7563.2010.01363.x
42 https://doi.org/10.1159/000348579
43 https://doi.org/10.1200/jco.2004.05.113
44 https://doi.org/10.1200/jco.2007.11.0833
45 https://doi.org/10.2967/jnumed.113.119545
46 https://doi.org/10.3389/fonc.2014.00120
47 https://doi.org/10.3892/ijo.2012.1572
48 schema:datePublished 2015-12
49 schema:datePublishedReg 2015-12-01
50 schema:description PURPOSE: The purpose of this study was to evaluate feasibility, safety, tolerance, and efficacy of drug-eluting beads loaded with irinotecan (DEBIRI) in combination with capecitabine in the treatment of mCRC refractory to chemotherapy in patients affected by liver predominant metastatic disease. MATERIALS AND METHODS: Twenty patients affected by CRC hepatic metastasis with liver-dominant disease, who had progression after two or more lines of chemotherapy, were enrolled. TACE with 100 mg of Irinotecan loaded into 2-ml of 70-150 µm drug-eluting beads was administrated every 4 weeks in patients with unilobar disease (2 treatments) and every 2 weeks in patients with bilobar disease (4 treatments). All patients assumed capecitabine 1000 mg/m(2) twice daily on days 1-14 every 3 weeks, until disease progression. Primary endpoints were safety, tolerance and overall disease control (ODC); secondary endpoints were progression free survival (PFS) and overall survival (OS). RESULTS: A total of 54 treatments were performed (54/66, 82%). No intra/peri-procedural death occurred. During the mean follow-up of 11 months, two partial responses (PR) were reported with ODC of 60% (2 PR + 10 stable disease). PFS and OS were 4 and 7.3 months, respectively. Univariate analysis showed that patients presenting with KRAS wild-type, good ECOG performance status and unilobar disease had a better prognosis. Only performance status (ECOG) correlated with OS in multivariate analysis (p = 0.03). CONCLUSION: DEBIRI with capecitabine seem to be a safe, technically feasible and well-tolerated treatment in chemotherapy refractory liver prevalent colorectal metastases.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree false
54 schema:isPartOf N4040856824f746c080358fef50c05627
55 Nde0e1117d9f9435d980e9a235de33b96
56 sg:journal.1091062
57 schema:name Trans-Arterial Chemoembolization with Irinotecan-Loaded Drug-Eluting Beads (DEBIRI) and Capecitabine in Refractory Liver Prevalent Colorectal Metastases: A Phase II Single-Center Study
58 schema:pagination 1523-1531
59 schema:productId N151a29a8fbb643d384b904654615cdbd
60 N450245d9e48b4c8db3c05e16890636e7
61 Nb1c9396f93244f15a0f3575a0740a6c4
62 Nbb0620ee497f48dab6cf9d9ffb655074
63 Ndd4847c52c43466f931d7a3c747b1ce7
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004898907
65 https://doi.org/10.1007/s00270-015-1080-9
66 schema:sdDatePublished 2019-04-10T19:56
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher Nd5c3228812f64848abb4f1288f5d64eb
69 schema:url http://link.springer.com/10.1007%2Fs00270-015-1080-9
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N151a29a8fbb643d384b904654615cdbd schema:name nlm_unique_id
74 schema:value 8003538
75 rdf:type schema:PropertyValue
76 N31d75522fd7341238265c5d84ba7bf37 rdf:first sg:person.01277133253.31
77 rdf:rest N3bcc5165d0994c398930f388309f30ec
78 N368eb3ad04bc4f88a97aa9cad0cde767 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Male
80 rdf:type schema:DefinedTerm
81 N3948b6e4ce9c43cb986cdf6a0f3b9e52 rdf:first sg:person.01166345607.04
82 rdf:rest Nc824b4907bf44da6b6cc64fdc8aef431
83 N3a15d3b49e284566ab050a44b0c6b5b8 rdf:first sg:person.01015413034.57
84 rdf:rest rdf:nil
85 N3b041f226c224c01ae4e5b40fb3e5705 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Humans
87 rdf:type schema:DefinedTerm
88 N3bcc5165d0994c398930f388309f30ec rdf:first sg:person.01063072241.26
89 rdf:rest N98c02cb6b73a48dbb997970ff0a3e991
90 N3e4e441cc3584bca83f9f00cdedc8b84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Chemoembolization, Therapeutic
92 rdf:type schema:DefinedTerm
93 N4040856824f746c080358fef50c05627 schema:volumeNumber 38
94 rdf:type schema:PublicationVolume
95 N450245d9e48b4c8db3c05e16890636e7 schema:name pubmed_id
96 schema:value 25799948
97 rdf:type schema:PropertyValue
98 N568bba6de4ea414794b760be41396fe7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Antimetabolites, Antineoplastic
100 rdf:type schema:DefinedTerm
101 N629e385e7d654fab9ac6b5c8ec22f151 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Treatment Outcome
103 rdf:type schema:DefinedTerm
104 N6b1e872b70344828986ddede447fdb7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Prospective Studies
106 rdf:type schema:DefinedTerm
107 N6c4370e0f3134d3988ddfd531eeeacc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Middle Aged
109 rdf:type schema:DefinedTerm
110 N6f839018097a45d2bb11d405d721f321 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Antineoplastic Agents, Phytogenic
112 rdf:type schema:DefinedTerm
113 N8848875bb0d64739a47cec05978a30bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Camptothecin
115 rdf:type schema:DefinedTerm
116 N884aff2b12fb48dcac7d129b655f5c1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Capecitabine
118 rdf:type schema:DefinedTerm
119 N95fb53010b1e48e0b5843ad30b8d01a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Colorectal Neoplasms
121 rdf:type schema:DefinedTerm
122 N98c02cb6b73a48dbb997970ff0a3e991 rdf:first sg:person.01211205437.18
123 rdf:rest Nc98c5fc10f7f4a458959152f7026043a
124 N9baab89cec14400fab282180d4e8825d rdf:first sg:person.01023531012.24
125 rdf:rest N31d75522fd7341238265c5d84ba7bf37
126 Nb1c9396f93244f15a0f3575a0740a6c4 schema:name readcube_id
127 schema:value 1757f4d3e5e382330a1733ecec663a50cfd152df412a9a6e7a76d5e8e602d815
128 rdf:type schema:PropertyValue
129 Nbb0620ee497f48dab6cf9d9ffb655074 schema:name doi
130 schema:value 10.1007/s00270-015-1080-9
131 rdf:type schema:PropertyValue
132 Nbb9f0cd3e7d445c88bcfa1f2d3d5b04a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Feasibility Studies
134 rdf:type schema:DefinedTerm
135 Nbcd1e06c0a744ef09b3a0536848a0fd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Aged
137 rdf:type schema:DefinedTerm
138 Nbe4c3f341520410681152538b403af98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Liver Neoplasms
140 rdf:type schema:DefinedTerm
141 Nc45250133a544854b7226aa437314959 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Female
143 rdf:type schema:DefinedTerm
144 Nc4a93400c9af4b8788d896be36b2c2aa rdf:first sg:person.01040612743.13
145 rdf:rest N3948b6e4ce9c43cb986cdf6a0f3b9e52
146 Nc824b4907bf44da6b6cc64fdc8aef431 rdf:first sg:person.01234461007.92
147 rdf:rest Ne4a3e7be2a0e43f29f952f00652a6cfc
148 Nc98c5fc10f7f4a458959152f7026043a rdf:first sg:person.01101214710.19
149 rdf:rest Nc4a93400c9af4b8788d896be36b2c2aa
150 Nd5c3228812f64848abb4f1288f5d64eb schema:name Springer Nature - SN SciGraph project
151 rdf:type schema:Organization
152 Nd9b371b762984d5dbe4c64dc71d50cca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Disease-Free Survival
154 rdf:type schema:DefinedTerm
155 Nd9ca78ffa36c4bbfb2b3eb88f9877ffc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Drug Delivery Systems
157 rdf:type schema:DefinedTerm
158 Ndd4847c52c43466f931d7a3c747b1ce7 schema:name dimensions_id
159 schema:value pub.1004898907
160 rdf:type schema:PropertyValue
161 Nde0e1117d9f9435d980e9a235de33b96 schema:issueNumber 6
162 rdf:type schema:PublicationIssue
163 Ne4a3e7be2a0e43f29f952f00652a6cfc rdf:first sg:person.016416311142.14
164 rdf:rest N3a15d3b49e284566ab050a44b0c6b5b8
165 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
166 schema:name Medical and Health Sciences
167 rdf:type schema:DefinedTerm
168 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
169 schema:name Oncology and Carcinogenesis
170 rdf:type schema:DefinedTerm
171 sg:journal.1091062 schema:issn 0174-1551
172 1432-086X
173 schema:name CardioVascular and Interventional Radiology
174 rdf:type schema:Periodical
175 sg:person.01015413034.57 schema:affiliation https://www.grid.ac/institutes/grid.411075.6
176 schema:familyName Bonomo
177 schema:givenName Lorenzo
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015413034.57
179 rdf:type schema:Person
180 sg:person.01023531012.24 schema:affiliation https://www.grid.ac/institutes/grid.411075.6
181 schema:familyName Iezzi
182 schema:givenName Roberto
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023531012.24
184 rdf:type schema:Person
185 sg:person.01040612743.13 schema:affiliation https://www.grid.ac/institutes/grid.411075.6
186 schema:familyName Basso
187 schema:givenName Michele
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040612743.13
189 rdf:type schema:Person
190 sg:person.01063072241.26 schema:affiliation https://www.grid.ac/institutes/grid.411075.6
191 schema:familyName Guerra
192 schema:givenName Alessandra
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063072241.26
194 rdf:type schema:Person
195 sg:person.01101214710.19 schema:affiliation https://www.grid.ac/institutes/grid.411075.6
196 schema:familyName Cassano
197 schema:givenName Alessandra
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101214710.19
199 rdf:type schema:Person
200 sg:person.01166345607.04 schema:affiliation https://www.grid.ac/institutes/grid.411075.6
201 schema:familyName Devicienti
202 schema:givenName Ersilia
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166345607.04
204 rdf:type schema:Person
205 sg:person.01211205437.18 schema:affiliation https://www.grid.ac/institutes/grid.411075.6
206 schema:familyName Cerchiaro
207 schema:givenName Eleonora
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211205437.18
209 rdf:type schema:Person
210 sg:person.01234461007.92 schema:affiliation https://www.grid.ac/institutes/grid.411075.6
211 schema:familyName Rodolfino
212 schema:givenName Elena
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234461007.92
214 rdf:type schema:Person
215 sg:person.01277133253.31 schema:affiliation https://www.grid.ac/institutes/grid.411075.6
216 schema:familyName Marsico
217 schema:givenName Valentina Angela
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277133253.31
219 rdf:type schema:Person
220 sg:person.016416311142.14 schema:affiliation https://www.grid.ac/institutes/grid.411075.6
221 schema:familyName Barone
222 schema:givenName Carlo
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016416311142.14
224 rdf:type schema:Person
225 sg:pub.10.1007/s00432-013-1564-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023106729
226 https://doi.org/10.1007/s00432-013-1564-4
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/s11605-012-1892-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004291179
229 https://doi.org/10.1007/s11605-012-1892-8
230 rdf:type schema:CreativeWork
231 sg:pub.10.1245/s10434-006-9045-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019448373
232 https://doi.org/10.1245/s10434-006-9045-5
233 rdf:type schema:CreativeWork
234 sg:pub.10.1245/s10434-010-1288-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012691102
235 https://doi.org/10.1245/s10434-010-1288-5
236 rdf:type schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1075215611 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1075537691 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1077594319 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1078494384 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1078546947 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1082604065 schema:CreativeWork
243 https://doi.org/10.1002/1097-0142(19910901)68:5<988::aid-cncr2820680513>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029925981
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.ejca.2006.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029538220
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.jvir.2008.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022383287
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.jvir.2013.05.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045615169
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0140-6736(12)61900-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020430219
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0140-6736(94)92529-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051430862
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1056/nejmoa032691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014051315
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1056/nejmoa033025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035161767
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1097/00000658-200206000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041943148
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1097/sla.0b013e31815aa2c2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026128215
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1111/j.1743-7563.2010.01363.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026030714
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1159/000348579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015643108
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1200/jco.2004.05.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025767346
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1200/jco.2007.11.0833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037561935
270 rdf:type schema:CreativeWork
271 https://doi.org/10.2967/jnumed.113.119545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002357665
272 rdf:type schema:CreativeWork
273 https://doi.org/10.3389/fonc.2014.00120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050463411
274 rdf:type schema:CreativeWork
275 https://doi.org/10.3892/ijo.2012.1572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029015548
276 rdf:type schema:CreativeWork
277 https://www.grid.ac/institutes/grid.411075.6 schema:alternateName Agostino Gemelli University Polyclinic
278 schema:name Department of Bioimaging and Radiological Sciences, Institute of Radiology, “A. Gemelli” Hospital - Catholic University, L.go A Gemelli 8, 00168, Rome, Italy
279 Department of medical Oncology, “A. Gemelli” Hospital - Catholic University, L.go A Gemelli 8, 00168, Rome, Italy
280 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...