Treatment Outcomes of Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma that Invades Hepatic Vein or Inferior Vena Cava View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-01-25

AUTHORS

Seong Min Chung, Chang Jin Yoon, Sang Soo Lee, Sukho Hong, Jung Wha Chung, Sung Wook Yang, Nak Jong Seong, Eun Sun Jang, Jin-Wook Kim, Sook-Hyang Jeong

ABSTRACT

PurposeWe aimed to elucidate the treatment outcomes of transcatheter arterial chemoembolization (TACE) and survival-associated factors in hepatocellular carcinoma (HCC) patients with hepatic vein (HV) and/or inferior vena cava (IVC) invasion.MethodsThe subjects were consecutively enrolled, newly diagnosed HCC patients with HV/IVC invasion who underwent TACE (n = 62) at the Seoul National University Bundang Hospital from May 2003 to October 2012. Clinical characteristics, treatment responses, overall survival, and survival-related factors were analyzed.ResultsThe mean subject age was 56.6 years, 82.3 % were hepatitis B surface antigen-positive, and 76.2 % were classified as Child-Pugh class A. The tumor volume was ≥50 % of the liver in 64.5 % of patients, and 79, 41.9, and 9.7 % of patients had accompanying portal vein, IVC, and right atrial invasion, respectively. TACE response rates for primary tumors and tumor thrombi in HV or IVC were 55.6 and 13 %, respectively. Median overall survival was 10.9 months (range 0.1–23.0 months). Multivariate analysis showed that Child-Pugh class A (hazard ratio [HR] = 0.31; 95 % confidence interval [CI] 0.14–0.72; p = 0.007), tumor volume <50 % of liver (HR = 0.31; 95 % CI 0.11–0.83; p = 0.019), alpha-fetoprotein (AFP) response (HR = 0.28; 95 % CI 0.11–0.69; p = 0.006), and tumor thrombi treatment response (HR = 0.09; 95 % CI 0.01–0.77; p = 0.027) were independent survival-related factors.ConclusionsTACE seems effective for HCC with HV/IVC invasion, especially in patients with preserved hepatic function, a treatment response for tumor thrombi, and an AFP response. More... »

PAGES

1507-1515

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00270-014-0841-1

DOI

http://dx.doi.org/10.1007/s00270-014-0841-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007328047

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24464259


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31 AFP response
32 B surface
33 Bundang Hospital
34 Child-Pugh class A
35 Child-Pugh class A.
36 ConclusionsTACE
37 HCC
38 HCC patients
39 HV/IVC invasion
40 IVC
41 IVC invasion
42 MethodsThe subjects
43 National University Bundang Hospital
44 PurposeWe
45 Seoul National University Bundang Hospital
46 TACE response rates
47 University Bundang Hospital
48 age
49 alpha-fetoprotein response
50 analysis
51 arterial chemoembolization
52 atrial invasion
53 carcinoma
54 carcinoma patients
55 cava (IVC) invasion
56 characteristics
57 chemoembolization
58 class A
59 class A.
60 clinical characteristics
61 factors
62 function
63 hepatic function
64 hepatic vein
65 hepatitis B surface
66 hepatocellular carcinoma
67 hepatocellular carcinoma patients
68 hospital
69 independent survival-related factors
70 inferior vena
71 inferior vena cava invasion
72 invasion
73 liver
74 median overall survival
75 months
76 multivariate analysis
77 outcomes
78 overall survival
79 patients
80 portal vein
81 primary tumor
82 rate
83 response
84 response rate
85 right atrial invasion
86 subject age
87 subjects
88 surface
89 survival
90 survival-associated factors
91 survival-related factors
92 thrombi treatment response
93 thrombus
94 transcatheter arterial chemoembolization
95 treatment outcomes
96 treatment response
97 tumor thrombi treatment response
98 tumor thrombus
99 tumor volume
100 tumors
101 vein
102 vena
103 vena cava invasion
104 volume
105 years
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