Chemoembolic Hepatopulmonary Shunt Reduction to Allow Safe Yttrium-90 Radioembolization Lobectomy of Hepatocellular Carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-12

AUTHORS

Ron C. Gaba, Kyle A. VanMiddlesworth

ABSTRACT

Yttrium-90 ((90)Y) radioembolization represents an emerging transcatheter treatment option for the management of hepatocellular carcinoma (HCC). Elevation of the hepatopulmonary shunt fraction risks nontarget radiation to the lungs and may limit the use of (90)Y therapy in patients with locally advanced disease with vascular invasion, who often demonstrate increased shunting. We present two cases in which patients with HCC and portal vein invasion resulting in elevated hepatopulmonary shunt fractions underwent chemoembolic shunt closure to allow safe (90)Y radioembolization. Both patients demonstrated excellent tumor response and patient survival. On this basis, we propose a role for chemoembolic reduction of the lung shunt fraction before (90)Y radioembolization in patients with extensive tumor-related hepatopulmonary shunting. More... »

PAGES

1505-1511

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00270-012-0371-7

DOI

http://dx.doi.org/10.1007/s00270-012-0371-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034659542

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22526098


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