Clinicopathologic Features and Results of Transcatheter Arterial Chemoembolization for Osteosarcoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-01-02

AUTHORS

Jian-ping Chu, Wei Chen, Jia-ping Li, Wen-quan Zhuang, Yong-hui Huang, Zhao-min Huang, Jian-yong Yang

ABSTRACT

PurposeTo evaluate the effect of transcatheter arterial chemoembolization (TACE) for osteosarcoma and to describe the clinicopathologic features produced by TACE as well as the effect of different embolic materials.MethodsFrom January 1998 to December 2003, preoperative TACE was carried out in 32 patients. The preoperative and postoperative clinical response, levels of alkaline phosphatase (AKP), leukocyte count, and clinicopathologic features were recorded. We also compared the effect of different embolic materials: adriblastine gelatin microspheres, anhydrous alcohol, common bletilla tuber, and gelatin sponge particles.ResultsThe levels of AKP were significantly decreased after treatment (p < 0.05), but there was no significant difference in the leukocyte count. Large areas of necrosis were found histologically within 85.5% tumors after TACE. Embolic agents such as adriblastine microspheres, anhydrous alcohol, and common bletilla tuber have better clinical effects than gelatin sponge particles, but there was no significant difference among the first three embolic materials. After treatment, no serious complications were noted. During successful follow-up for 86 months, the survival rate after TACE at 1, 2, and 5 years was 95.5%, 72%, and 42% respectively.ConclusionTACE accelerated tumor necrosis and shrank the tumor volume, thus making adequate tumor resection possible. The optimal time to operate is 10–14 days after TACE. TACE in combination with limb salvage surgery and postoperative periodical chemotherapy may be beneficial for increasing local control rates. More... »

PAGES

201-206

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00270-005-0302-y

DOI

http://dx.doi.org/10.1007/s00270-005-0302-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025742530

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17200904


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91 response
92 results
93 salvage surgery
94 serious complications
95 significant differences
96 sponge particles
97 surgery
98 survival rate
99 time
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101 treatment
102 tubers
103 tumor necrosis
104 tumor resection
105 tumor volume
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