Activation of Monocytes and Endothelial Cells Depends on the Severity of Surgical Stress View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-01

AUTHORS

Suefumi Aosasa, Satoshi Ono, Hidetaka Mochizuki, Hironori Tsujimoto, Shun-ichi Osada, Eiji Takayama, Shuhji Seki, Hoshio Hiraide

ABSTRACT

Surgical injury not only induces a systemic endocrine-metabolic response but also influences the function of the leukocytes and endothelial cells leading to various systemic responses. These responses appear to depend on the severity of surgical stress, which differs according to the surgical procedures. In this study, we investigated the response of monocytes and endothelial cells, and the development of systemic inflammatory response syndrome (SIRS) in relation to the severity of surgical stress. The postoperative clinical course was evaluated between patients undergoing an esophagectomy (ER group) and a distal gastrectomy (DG group). The tumor necrosis factor α (TNFα) production of monocytes, the serum interleukin 6 (IL-6) levels, the CD11b expression on either monocytes or granulocytes, and the intercellular adhesion molecule-1 (ICAM-1) expression on human umbilical vein endothelial cells (HUVECs) stimulated with culture supernatants of monocytes were compared between the 2 groups. The development of SIRS was observed in all patients in the ER group, whereas no patients demonstrated SIRS in the DG group. The serum IL-6 levels, TNFα production of monocytes, and CD11b intensity on monocytes or granulocytes in the ER group were higher than those in the DG group. In the ER group, the ICAM-1 intensity on HUVECs with monocytes immediately after operation significantly increased compared with before the operation. In conclusion, both the CD11b expression on monocytes and the TNFα production of monocytes are considered to reflect the degree of surgical stress, and the activation of endothelial cells stimulated with these activated leukocytes may therefore lead to both tissue and organ injury. More... »

PAGES

10-16

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002689910003

DOI

http://dx.doi.org/10.1007/s002689910003

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029285473

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10594196


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