Pancreas Transplantation for Treatment of Diabetes Mellitus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-04

AUTHORS

David E.R. Sutherland, Rainer W.G. Gruessner, Angelika C. Gruessner

ABSTRACT

Pancreas transplantation is the only treatment for type I diabetes mellitus that can induce an insulin-independent normoglycemic state. Because of the need for immunosuppression, it has been most widely applied in uremic diabetic recipients of kidney transplant with a high success rate, particularly when done as a simultaneous (SPK) procedure (insulin independence > 80% at 1 year) with patient and kidney graft survival rates equivalent to or higher than in those who receive a kidney transplant alone. The results of solitary pancreas transplants (PAK in nephropathic diabetic recipients or PTA in nonuremic recipients) have also dramatically improved; 1-year graft survival rates are more than 80% and 70%, respectively, with the new immunosuppressants tacrolimus and mycophenolate mofetil. Multiple factors are important for successful application of pancreas transplantation, as summarized in this review. More... »

PAGES

487-496

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002680020342

DOI

http://dx.doi.org/10.1007/s002680020342

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023272365

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11344403


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