Ontology type: schema:ScholarlyArticle
2021-04-20
AUTHORSYoshinori Takeda, Yoshihiro Mise, Masaru Matsumura, Kiyoshi Hasegawa, Jiro Yoshimoto, Hiroshi Imamura, Takuji Noro, Junji Yamamoto, Naoki Ishizuka, Yosuke Inoue, Hiromichi Ito, Yu Takahashi, Akio Saiura
ABSTRACTBackgroundA modified Fong clinical score (m-Fong CS) that includes the RAS mutation status has recently been proposed and offered an improved survival stratification of patients who undergo surgery and systemic chemotherapy for colorectal liver metastases (CLM). The aim of this study is to assess whether a CS that includes RAS status is influenced by whether patients receive perioperative chemotherapy.MethodsWe created a new CS using multivariate analysis of data of patients who underwent hepatectomy for CLM for the first time between 2010 and 2016 at a single hospital (n = 341, 79% received perioperative chemotherapy). The resulting CS and m-Fong CS were then validated in the patient cohort at three other hospitals (n = 309). Furthermore, the applicability of the two CS in the total cohort (n = 650) was tested according to whether the patients received perioperative chemotherapy.ResultsThe new CS comprised mutant RAS status, ≥4 CLMs, and a CA19-9 level ≥100 U/mL (1 point per factor). Both the new CS and m-Fong CS failed to stratify the survival of the 309 patients in the validation cohort, including those who did not receive perioperative chemotherapy (29%). Both of the CS accurately stratified the survival of patients who underwent perioperative chemotherapy but not of those who underwent surgery alone.ConclusionA CS that includes the RAS mutation status can stratify the survival of patients who undergo hepatectomy combined with perioperative chemotherapy, but it has limited value for patients who undergo surgery alone. More... »
PAGES2176-2184
http://scigraph.springernature.com/pub.10.1007/s00268-021-05976-x
DOIhttp://dx.doi.org/10.1007/s00268-021-05976-x
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1137341002
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/33880608
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Colorectal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hepatectomy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Liver Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mutation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Risk Factors",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Hongo, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.258269.2",
"name": [
"Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Ariake, 113-8421, Tokyo, Japan",
"Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Hongo, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Takeda",
"givenName": "Yoshinori",
"id": "sg:person.015104775355.77",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015104775355.77"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Hongo, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.258269.2",
"name": [
"Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Ariake, 113-8421, Tokyo, Japan",
"Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Hongo, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Mise",
"givenName": "Yoshihiro",
"id": "sg:person.0626665021.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626665021.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Clinical Research and Medical Development Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Ariake, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.486756.e",
"name": [
"Clinical Research and Medical Development Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Ariake, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Matsumura",
"givenName": "Masaru",
"id": "sg:person.01147204517.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147204517.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Clinical Research and Medical Development Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Ariake, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.486756.e",
"name": [
"Clinical Research and Medical Development Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Ariake, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Hasegawa",
"givenName": "Kiyoshi",
"id": "sg:person.01065410232.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065410232.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Hongo, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.258269.2",
"name": [
"Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Hongo, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Yoshimoto",
"givenName": "Jiro",
"id": "sg:person.0663261015.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663261015.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Hongo, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.258269.2",
"name": [
"Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Hongo, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Imamura",
"givenName": "Hiroshi",
"id": "sg:person.0644576333.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644576333.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan",
"id": "http://www.grid.ac/institutes/grid.416614.0",
"name": [
"Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan"
],
"type": "Organization"
},
"familyName": "Noro",
"givenName": "Takuji",
"id": "sg:person.0751340257.60",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751340257.60"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan",
"id": "http://www.grid.ac/institutes/grid.416614.0",
"name": [
"Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan"
],
"type": "Organization"
},
"familyName": "Yamamoto",
"givenName": "Junji",
"id": "sg:person.0760422621.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760422621.80"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Clinical Research and Medical Development Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.486756.e",
"name": [
"Clinical Research and Medical Development Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Ishizuka",
"givenName": "Naoki",
"id": "sg:person.0641301702.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641301702.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Ariake, 113-8421, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Ariake, 113-8421, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Inoue",
"givenName": "Yosuke",
"id": "sg:person.0770623646.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770623646.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Ariake, 113-8421, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Ariake, 113-8421, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Ito",
"givenName": "Hiromichi",
"id": "sg:person.011406547173.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011406547173.21"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Ariake, 113-8421, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Ariake, 113-8421, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Takahashi",
"givenName": "Yu",
"id": "sg:person.01307772440.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307772440.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Hongo, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.258269.2",
"name": [
"Department of Hepato-Biliary-Pancreatic Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Ariake, 113-8421, Tokyo, Japan",
"Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Hongo, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Saiura",
"givenName": "Akio",
"id": "sg:person.0612301703.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612301703.87"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1245/s10434-013-3421-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050458161",
"https://doi.org/10.1245/s10434-013-3421-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12957-019-1641-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1117139998",
"https://doi.org/10.1186/s12957-019-1641-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-016-5278-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004294834",
"https://doi.org/10.1245/s10434-016-5278-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00534-011-0460-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039831105",
"https://doi.org/10.1007/s00534-011-0460-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-014-4042-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028729249",
"https://doi.org/10.1245/s10434-014-4042-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00384-012-1438-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046464035",
"https://doi.org/10.1007/s00384-012-1438-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-2407-10-309",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028347950",
"https://doi.org/10.1186/1471-2407-10-309"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12032-016-0838-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052669411",
"https://doi.org/10.1007/s12032-016-0838-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-016-5187-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050206513",
"https://doi.org/10.1245/s10434-016-5187-2"
],
"type": "CreativeWork"
}
],
"datePublished": "2021-04-20",
"datePublishedReg": "2021-04-20",
"description": "BackgroundA modified Fong clinical score (m-Fong CS) that includes the RAS mutation status has recently been proposed and offered an improved survival stratification of patients who undergo surgery and systemic chemotherapy for colorectal liver metastases (CLM). The aim of this study is to assess whether a CS that includes RAS status is influenced by whether patients receive perioperative chemotherapy.MethodsWe created a new CS using multivariate analysis of data of patients who underwent hepatectomy for CLM for the first time between 2010 and 2016 at a single hospital (n\u2009=\u2009341, 79% received perioperative chemotherapy). The resulting CS and m-Fong CS were then validated in the patient cohort at three other hospitals (n\u2009=\u2009309). Furthermore, the applicability of the two CS in the total cohort (n\u2009=\u2009650) was tested according to whether the patients received perioperative chemotherapy.ResultsThe new CS comprised mutant RAS status,\u2009\u22654 CLMs, and a CA19-9 level\u2009\u2265100\u00a0U/mL (1 point per factor). Both the new CS and m-Fong CS failed to stratify the survival of the 309 patients in the validation cohort, including those who did not receive perioperative chemotherapy (29%). Both of the CS accurately stratified the survival of patients who underwent perioperative chemotherapy but not of those who underwent surgery alone.ConclusionA CS that includes the RAS mutation status can stratify the survival of patients who undergo hepatectomy combined with perioperative chemotherapy, but it has limited value for patients who undergo surgery alone.",
"genre": "article",
"id": "sg:pub.10.1007/s00268-021-05976-x",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1086446",
"issn": [
"0364-2313",
"1432-2323"
],
"name": "World Journal of Surgery",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "7",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "45"
}
],
"keywords": [
"colorectal liver metastases",
"perioperative chemotherapy",
"survival of patients",
"RAS mutation status",
"RAS status",
"liver metastases",
"mutation status",
"clinical risk score",
"CA19-9 levels",
"systemic chemotherapy",
"total cohort",
"clinical scores",
"validation cohort",
"patient cohort",
"RA status",
"single hospital",
"survival stratification",
"risk score",
"chemotherapy",
"patients",
"multivariate analysis",
"surgery",
"cohort",
"metastasis",
"survival",
"hepatectomy",
"hospital",
"status",
"scores",
"MethodsWe",
"BackgroundA",
"mL",
"aim",
"stratification",
"CS",
"levels",
"study",
"new CS",
"first time",
"data",
"time",
"analysis",
"values",
"accuracy",
"applicability"
],
"name": "Accuracy of Modern Clinical Risk Score Including RAS Status Changes Based on Whether Patients Received Perioperative Chemotherapy for Colorectal Liver Metastases",
"pagination": "2176-2184",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1137341002"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00268-021-05976-x"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"33880608"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00268-021-05976-x",
"https://app.dimensions.ai/details/publication/pub.1137341002"
],
"sdDataset": "articles",
"sdDatePublished": "2022-06-01T22:25",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_923.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00268-021-05976-x"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00268-021-05976-x'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00268-021-05976-x'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00268-021-05976-x'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00268-021-05976-x'
This table displays all metadata directly associated to this object as RDF triples.
263 TRIPLES
22 PREDICATES
86 URIs
69 LITERALS
13 BLANK NODES