The Use of Prophylactic Somatostatin Therapy Following Pancreaticoduodenectomy: A Meta-analysis of Randomised Controlled Trials View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-23

AUTHORS

A. Adiamah, Z. Arif, F. Berti, S. Singh, N. Laskar, D. Gomez

ABSTRACT

BACKGROUND: Prophylactic administration of somatostatin analogues (SA) to reduce the incidence of post-operative pancreatic fistula (POPF) remains contentious. This meta-analysis evaluated its impact on outcomes following pancreaticoduodenectomy (PD). METHODS: The EMBASE, MEDLINE and Cochrane databases were searched for randomised controlled trials (RCTs) investigating prophylactic SA following PD. Comparative effects were summarised as odds ratio and weighted mean difference based on an intention to treat. Quantitative pooling of the effect sizes was derived using the random-effects model. MAIN RESULTS: Twelve RCTs were included involving 1615 patients [SA-treated group (n = 820) and control group (n = 795)]. The SA used included somatostatin-14, pasireotide, vapreotide and octreotide. Pooling of the data showed no significant benefit of its use for the primary outcome measure of all grades of POPF, odds ratio (OR) 0.73 [95% confidence interval (CI), 0.51-1.05, p = 0.09] and clinically relevant POPF, OR 0.48 [95% CI, 0.22-1.06, p = 0.07]. There were no benefits in the secondary outcome measures of delayed gastric emptying, OR 0.98 [95% CI, 0.57-1.69, p = 0.94]; infected abdominal collections, OR 0.80 [95% CI, 0.44-1.43, p = 0.80]; reoperation rates, OR 1.24 [95% CI, 0.73-2.13, p = 0.42]; duration of hospital stay, - 0.23 [95% CI - .59 to 1.13, p = 0.74]; and mortality, 1.78 [95% CI, 0.94-3.39, p = 0.08]. CONCLUSION: SA did not improve the post-operative outcomes following PD, including reducing the incidence of POPF. The routine administration of SA cannot be recommended following PD. More... »

PAGES

1-14

References to SciGraph publications

Journal

TITLE

World Journal of Surgery

ISSUE

N/A

VOLUME

N/A

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00268-019-04956-6

DOI

http://dx.doi.org/10.1007/s00268-019-04956-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112361245

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30798417


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Queen's Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.415598.4", 
          "name": [
            "Department of Hepatobiliary and Pancreatic Surgery, Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen\u2019s Medical Centre, E Floor, West Block, Derby Road, NG7 2UH, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adiamah", 
        "givenName": "A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen's Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.415598.4", 
          "name": [
            "Department of Hepatobiliary and Pancreatic Surgery, Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen\u2019s Medical Centre, E Floor, West Block, Derby Road, NG7 2UH, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arif", 
        "givenName": "Z.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen's Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.415598.4", 
          "name": [
            "Department of Hepatobiliary and Pancreatic Surgery, Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen\u2019s Medical Centre, E Floor, West Block, Derby Road, NG7 2UH, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berti", 
        "givenName": "F.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen's Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.415598.4", 
          "name": [
            "Department of Hepatobiliary and Pancreatic Surgery, Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen\u2019s Medical Centre, E Floor, West Block, Derby Road, NG7 2UH, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Singh", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen's Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.415598.4", 
          "name": [
            "Department of Hepatobiliary and Pancreatic Surgery, Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen\u2019s Medical Centre, E Floor, West Block, Derby Road, NG7 2UH, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laskar", 
        "givenName": "N.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Queen's Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.415598.4", 
          "name": [
            "Department of Hepatobiliary and Pancreatic Surgery, Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen\u2019s Medical Centre, E Floor, West Block, Derby Road, NG7 2UH, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gomez", 
        "givenName": "D.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1159/000050193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001083554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e3181343f5d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004503619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mpa.0b013e3181343f5d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004503619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-005-7546-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008009168", 
          "https://doi.org/10.1007/s00268-005-7546-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-005-7546-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008009168", 
          "https://doi.org/10.1007/s00268-005-7546-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000381032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008766195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0039-6060(99)70234-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010025894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2008.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013294722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2016.11.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014347476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200009000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016453257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200009000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016453257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.2001.25536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018571387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd008370.pub3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019404827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000217673.04165.ea", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019489294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000217673.04165.ea", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019489294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2036.1999.00583.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021153350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-005-7943-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021979085", 
          "https://doi.org/10.1007/s00268-005-7943-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-005-7943-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021979085", 
          "https://doi.org/10.1007/s00268-005-7943-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s1091-255x(99)80064-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023992272", 
          "https://doi.org/10.1016/s1091-255x(99)80064-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9610(01)00829-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030006311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hpb.12314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030011029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11102-015-0677-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031145264", 
          "https://doi.org/10.1007/s11102-015-0677-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11102-015-0677-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031145264", 
          "https://doi.org/10.1007/s11102-015-0677-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajodo.2015.03.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033815552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11605-015-2925-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035279796", 
          "https://doi.org/10.1007/s11605-015-2925-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.0007-1323.2001.01906.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036732127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1000097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037575666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ceg.s13984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037688982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2005.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041588260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2005.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041588260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.d5928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041893471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jamcollsurg.2008.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042131852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200012000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043366541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200012000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043366541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0039-6060(05)80225-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046547878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00534-007-1301-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048498440", 
          "https://doi.org/10.1007/s00534-007-1301-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00534-007-1301-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048498440", 
          "https://doi.org/10.1007/s00534-007-1301-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1313688", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048687600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0000000000001975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048963895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0000000000001975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048963895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1072-7515(03)00104-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049493120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1072-7515(03)00104-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049493120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1477-2574.2012.00608.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050756851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.139.3.288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054119951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.179.4068.77", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062506310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v21.i1.262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071372243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-152-11-201006010-00232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073711230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078652441", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080583279", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081571276", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0188928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099612858"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02-23", 
    "datePublishedReg": "2019-02-23", 
    "description": "BACKGROUND: Prophylactic administration of somatostatin analogues (SA) to reduce the incidence of post-operative pancreatic fistula (POPF) remains contentious. This meta-analysis evaluated its impact on outcomes following pancreaticoduodenectomy (PD).\nMETHODS: The EMBASE, MEDLINE and Cochrane databases were searched for randomised controlled trials (RCTs) investigating prophylactic SA following PD. Comparative effects were summarised as odds ratio and weighted mean difference based on an intention to treat. Quantitative pooling of the effect sizes was derived using the random-effects model.\nMAIN RESULTS: Twelve RCTs were included involving 1615 patients [SA-treated group (n\u2009=\u2009820) and control group (n\u2009=\u2009795)]. The SA used included somatostatin-14, pasireotide, vapreotide and octreotide. Pooling of the data showed no significant benefit of its use for the primary outcome measure of all grades of POPF, odds ratio (OR) 0.73 [95% confidence interval (CI), 0.51-1.05, p\u2009=\u20090.09] and clinically relevant POPF, OR 0.48 [95% CI, 0.22-1.06, p\u2009=\u20090.07]. There were no benefits in the secondary outcome measures of delayed gastric emptying, OR 0.98 [95% CI, 0.57-1.69, p\u2009=\u20090.94]; infected abdominal collections, OR 0.80 [95% CI, 0.44-1.43, p\u2009=\u20090.80]; reoperation rates, OR 1.24 [95% CI, 0.73-2.13, p\u2009=\u20090.42]; duration of hospital stay, -\u20090.23 [95% CI -\u2009.59 to 1.13, p\u2009=\u20090.74]; and mortality, 1.78 [95% CI, 0.94-3.39, p\u2009=\u20090.08].\nCONCLUSION: SA did not improve the post-operative outcomes following PD, including reducing the incidence of POPF. The routine administration of SA cannot be recommended following PD.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00268-019-04956-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1086446", 
        "issn": [
          "0364-2313", 
          "1432-2323"
        ], 
        "name": "World Journal of Surgery", 
        "type": "Periodical"
      }
    ], 
    "name": "The Use of Prophylactic Somatostatin Therapy Following Pancreaticoduodenectomy: A Meta-analysis of Randomised Controlled Trials", 
    "pagination": "1-14", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8242fb9157275b083b9306c19670db9f541f2c9278f9340d33d0c2b479842e78"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30798417"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7704052"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00268-019-04956-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112361245"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00268-019-04956-6", 
      "https://app.dimensions.ai/details/publication/pub.1112361245"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99836_00000005.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00268-019-04956-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00268-019-04956-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00268-019-04956-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00268-019-04956-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00268-019-04956-6'


 

This table displays all metadata directly associated to this object as RDF triples.

215 TRIPLES      21 PREDICATES      66 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00268-019-04956-6 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Ne4d8ee778c9c411f88cff6ca1c3b592d
4 schema:citation sg:pub.10.1007/s00268-005-7546-1
5 sg:pub.10.1007/s00268-005-7943-5
6 sg:pub.10.1007/s00534-007-1301-y
7 sg:pub.10.1007/s11102-015-0677-y
8 sg:pub.10.1007/s11605-015-2925-x
9 sg:pub.10.1016/s1091-255x(99)80064-x
10 https://app.dimensions.ai/details/publication/pub.1078652441
11 https://app.dimensions.ai/details/publication/pub.1080583279
12 https://app.dimensions.ai/details/publication/pub.1081571276
13 https://doi.org/10.1001/archsurg.139.3.288
14 https://doi.org/10.1002/14651858.cd008370.pub3
15 https://doi.org/10.1016/j.ajodo.2015.03.014
16 https://doi.org/10.1016/j.ejso.2008.01.014
17 https://doi.org/10.1016/j.jamcollsurg.2008.05.003
18 https://doi.org/10.1016/j.surg.2005.05.001
19 https://doi.org/10.1016/j.surg.2016.11.014
20 https://doi.org/10.1016/s0002-9610(01)00829-7
21 https://doi.org/10.1016/s0039-6060(05)80225-9
22 https://doi.org/10.1016/s0039-6060(99)70234-5
23 https://doi.org/10.1016/s1072-7515(03)00104-2
24 https://doi.org/10.1046/j.0007-1323.2001.01906.x
25 https://doi.org/10.1046/j.1365-2036.1999.00583.x
26 https://doi.org/10.1053/gast.2001.25536
27 https://doi.org/10.1056/nejmoa1313688
28 https://doi.org/10.1097/00000658-200009000-00014
29 https://doi.org/10.1097/00000658-200012000-00007
30 https://doi.org/10.1097/01.sla.0000217673.04165.ea
31 https://doi.org/10.1097/mpa.0b013e3181343f5d
32 https://doi.org/10.1097/sla.0000000000001975
33 https://doi.org/10.1111/hpb.12314
34 https://doi.org/10.1111/j.1477-2574.2012.00608.x
35 https://doi.org/10.1126/science.179.4068.77
36 https://doi.org/10.1136/bmj.d5928
37 https://doi.org/10.1159/000050193
38 https://doi.org/10.1159/000381032
39 https://doi.org/10.1371/journal.pmed.1000097
40 https://doi.org/10.1371/journal.pone.0188928
41 https://doi.org/10.2147/ceg.s13984
42 https://doi.org/10.3748/wjg.v21.i1.262
43 https://doi.org/10.7326/0003-4819-152-11-201006010-00232
44 schema:datePublished 2019-02-23
45 schema:datePublishedReg 2019-02-23
46 schema:description BACKGROUND: Prophylactic administration of somatostatin analogues (SA) to reduce the incidence of post-operative pancreatic fistula (POPF) remains contentious. This meta-analysis evaluated its impact on outcomes following pancreaticoduodenectomy (PD). METHODS: The EMBASE, MEDLINE and Cochrane databases were searched for randomised controlled trials (RCTs) investigating prophylactic SA following PD. Comparative effects were summarised as odds ratio and weighted mean difference based on an intention to treat. Quantitative pooling of the effect sizes was derived using the random-effects model. MAIN RESULTS: Twelve RCTs were included involving 1615 patients [SA-treated group (n = 820) and control group (n = 795)]. The SA used included somatostatin-14, pasireotide, vapreotide and octreotide. Pooling of the data showed no significant benefit of its use for the primary outcome measure of all grades of POPF, odds ratio (OR) 0.73 [95% confidence interval (CI), 0.51-1.05, p = 0.09] and clinically relevant POPF, OR 0.48 [95% CI, 0.22-1.06, p = 0.07]. There were no benefits in the secondary outcome measures of delayed gastric emptying, OR 0.98 [95% CI, 0.57-1.69, p = 0.94]; infected abdominal collections, OR 0.80 [95% CI, 0.44-1.43, p = 0.80]; reoperation rates, OR 1.24 [95% CI, 0.73-2.13, p = 0.42]; duration of hospital stay, - 0.23 [95% CI - .59 to 1.13, p = 0.74]; and mortality, 1.78 [95% CI, 0.94-3.39, p = 0.08]. CONCLUSION: SA did not improve the post-operative outcomes following PD, including reducing the incidence of POPF. The routine administration of SA cannot be recommended following PD.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree false
50 schema:isPartOf sg:journal.1086446
51 schema:name The Use of Prophylactic Somatostatin Therapy Following Pancreaticoduodenectomy: A Meta-analysis of Randomised Controlled Trials
52 schema:pagination 1-14
53 schema:productId N0a3a2a96db074d41b71c9a55d38ed05a
54 N518606c3a3f14b56b8a16c028b8068d1
55 N52088b3160ce4c93aa11e2c829e406c1
56 N9a437922fdf6436ba59367ea76f98272
57 Ncf803c66760745c99c22afa571ba7d32
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112361245
59 https://doi.org/10.1007/s00268-019-04956-6
60 schema:sdDatePublished 2019-04-11T09:40
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher Nd93f91377ae949cbacd07e8632807281
63 schema:url https://link.springer.com/10.1007%2Fs00268-019-04956-6
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N0a3a2a96db074d41b71c9a55d38ed05a schema:name readcube_id
68 schema:value 8242fb9157275b083b9306c19670db9f541f2c9278f9340d33d0c2b479842e78
69 rdf:type schema:PropertyValue
70 N2903931da35e492295d52d818158a3ae schema:affiliation https://www.grid.ac/institutes/grid.415598.4
71 schema:familyName Gomez
72 schema:givenName D.
73 rdf:type schema:Person
74 N2cac8ac8f2cb48bdbb3844cbddbfbb7c rdf:first N5cf1d92854264ccebe19c2d0a3203db4
75 rdf:rest N8a7dbd2facc34600918331f9de34fb74
76 N46de24e2725549a1b364093ed02a63a9 schema:affiliation https://www.grid.ac/institutes/grid.415598.4
77 schema:familyName Berti
78 schema:givenName F.
79 rdf:type schema:Person
80 N518606c3a3f14b56b8a16c028b8068d1 schema:name pubmed_id
81 schema:value 30798417
82 rdf:type schema:PropertyValue
83 N52088b3160ce4c93aa11e2c829e406c1 schema:name doi
84 schema:value 10.1007/s00268-019-04956-6
85 rdf:type schema:PropertyValue
86 N5cf1d92854264ccebe19c2d0a3203db4 schema:affiliation https://www.grid.ac/institutes/grid.415598.4
87 schema:familyName Laskar
88 schema:givenName N.
89 rdf:type schema:Person
90 N8a7dbd2facc34600918331f9de34fb74 rdf:first N2903931da35e492295d52d818158a3ae
91 rdf:rest rdf:nil
92 N928f76589c474ef3aee64941a40b23b4 schema:affiliation https://www.grid.ac/institutes/grid.415598.4
93 schema:familyName Adiamah
94 schema:givenName A.
95 rdf:type schema:Person
96 N9a437922fdf6436ba59367ea76f98272 schema:name dimensions_id
97 schema:value pub.1112361245
98 rdf:type schema:PropertyValue
99 Na3b04fe31e15438db58581cd568a1150 schema:affiliation https://www.grid.ac/institutes/grid.415598.4
100 schema:familyName Arif
101 schema:givenName Z.
102 rdf:type schema:Person
103 Nad4822dcad774c7995d274f796e0f725 rdf:first Na3b04fe31e15438db58581cd568a1150
104 rdf:rest Nbe4bd9080bad419d916e5d9339461f11
105 Nbe4bd9080bad419d916e5d9339461f11 rdf:first N46de24e2725549a1b364093ed02a63a9
106 rdf:rest Nd23c1ff7cf324e168bddfffba876ae55
107 Ncab9af8042ab4cbb9b04ded5551b1d1d schema:affiliation https://www.grid.ac/institutes/grid.415598.4
108 schema:familyName Singh
109 schema:givenName S.
110 rdf:type schema:Person
111 Ncf803c66760745c99c22afa571ba7d32 schema:name nlm_unique_id
112 schema:value 7704052
113 rdf:type schema:PropertyValue
114 Nd23c1ff7cf324e168bddfffba876ae55 rdf:first Ncab9af8042ab4cbb9b04ded5551b1d1d
115 rdf:rest N2cac8ac8f2cb48bdbb3844cbddbfbb7c
116 Nd93f91377ae949cbacd07e8632807281 schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 Ne4d8ee778c9c411f88cff6ca1c3b592d rdf:first N928f76589c474ef3aee64941a40b23b4
119 rdf:rest Nad4822dcad774c7995d274f796e0f725
120 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
121 schema:name Medical and Health Sciences
122 rdf:type schema:DefinedTerm
123 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
124 schema:name Clinical Sciences
125 rdf:type schema:DefinedTerm
126 sg:journal.1086446 schema:issn 0364-2313
127 1432-2323
128 schema:name World Journal of Surgery
129 rdf:type schema:Periodical
130 sg:pub.10.1007/s00268-005-7546-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008009168
131 https://doi.org/10.1007/s00268-005-7546-1
132 rdf:type schema:CreativeWork
133 sg:pub.10.1007/s00268-005-7943-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021979085
134 https://doi.org/10.1007/s00268-005-7943-5
135 rdf:type schema:CreativeWork
136 sg:pub.10.1007/s00534-007-1301-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1048498440
137 https://doi.org/10.1007/s00534-007-1301-y
138 rdf:type schema:CreativeWork
139 sg:pub.10.1007/s11102-015-0677-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1031145264
140 https://doi.org/10.1007/s11102-015-0677-y
141 rdf:type schema:CreativeWork
142 sg:pub.10.1007/s11605-015-2925-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035279796
143 https://doi.org/10.1007/s11605-015-2925-x
144 rdf:type schema:CreativeWork
145 sg:pub.10.1016/s1091-255x(99)80064-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023992272
146 https://doi.org/10.1016/s1091-255x(99)80064-x
147 rdf:type schema:CreativeWork
148 https://app.dimensions.ai/details/publication/pub.1078652441 schema:CreativeWork
149 https://app.dimensions.ai/details/publication/pub.1080583279 schema:CreativeWork
150 https://app.dimensions.ai/details/publication/pub.1081571276 schema:CreativeWork
151 https://doi.org/10.1001/archsurg.139.3.288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054119951
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1002/14651858.cd008370.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019404827
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1016/j.ajodo.2015.03.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033815552
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/j.ejso.2008.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013294722
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/j.jamcollsurg.2008.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042131852
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1016/j.surg.2005.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041588260
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1016/j.surg.2016.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014347476
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/s0002-9610(01)00829-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030006311
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/s0039-6060(05)80225-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046547878
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1016/s0039-6060(99)70234-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010025894
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/s1072-7515(03)00104-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049493120
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1046/j.0007-1323.2001.01906.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036732127
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1046/j.1365-2036.1999.00583.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021153350
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1053/gast.2001.25536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018571387
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1056/nejmoa1313688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048687600
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1097/00000658-200009000-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016453257
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1097/00000658-200012000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043366541
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1097/01.sla.0000217673.04165.ea schema:sameAs https://app.dimensions.ai/details/publication/pub.1019489294
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1097/mpa.0b013e3181343f5d schema:sameAs https://app.dimensions.ai/details/publication/pub.1004503619
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1097/sla.0000000000001975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048963895
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1111/hpb.12314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030011029
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1111/j.1477-2574.2012.00608.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050756851
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1126/science.179.4068.77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062506310
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1136/bmj.d5928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041893471
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1159/000050193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001083554
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1159/000381032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008766195
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1371/journal.pmed.1000097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037575666
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1371/journal.pone.0188928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099612858
206 rdf:type schema:CreativeWork
207 https://doi.org/10.2147/ceg.s13984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037688982
208 rdf:type schema:CreativeWork
209 https://doi.org/10.3748/wjg.v21.i1.262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071372243
210 rdf:type schema:CreativeWork
211 https://doi.org/10.7326/0003-4819-152-11-201006010-00232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073711230
212 rdf:type schema:CreativeWork
213 https://www.grid.ac/institutes/grid.415598.4 schema:alternateName Queen's Medical Centre
214 schema:name Department of Hepatobiliary and Pancreatic Surgery, Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen’s Medical Centre, E Floor, West Block, Derby Road, NG7 2UH, Nottingham, UK
215 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...