High-Dose RAI Therapy Justified by Pathological N1a Disease Revealed by Prophylactic Central Neck Dissection for cN0 Papillary Thyroid Cancer Patients: ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01-25

AUTHORS

Lan Wei, Lin Bai, Lina Zhao, Tianyu Yu, Qingjie Ma, Bin Ji

ABSTRACT

ObjectiveOne of the presumed advantages of prophylactic central neck dissection (pCND) is offering staging basis for more aggressive radioactive iodine (RAI) therapy, which postulates the necessity of high dose for treatment efficacy. The present study aims to compare the effectiveness between low-dose and high-dose RAI in a select cohort of cN0 papillary thyroid cancer (PTC) patients with pathological N1a (pN1a) disease revealed by pCND in terms of ablation rate and response to therapy. The frequency of short-term adverse effects between the two groups was also compared.Patients and MethodsFrom January 2014 to April 2016, cN0 PTC patients with pN1a disease revealed by pCND in our hospital were retrospectively reviewed. Patients with other indications for high-dose RAI, such as the presence of extrathyroidal extension, vascular invasion or suspicions of distant metastasis, were excluded. For the included patients, high dose (3700 MBq) was administered between January 2014 and August 2015 and low dose (1110 MBq) between August 2015 and April 2016. Ablation assessment was performed 6 months after RAI therapy. Response evaluation after RAI therapy was performed after 46.3 ± 9.5 months for high-dose group and 29.1 ± 2.6 months for low-dose group. All patients were also evaluated for short-term adverse effects 24 and 72 hours after RAI administration.ResultsA total of 84 patients were enrolled. Among them, 42 were in the high-dose group and the other 42 in the low-dose group. There was no significant difference in ablation rate (P = 0.7707) and response to RAI therapy (P = 0.6454) between the two groups. Twenty-four hours after RAI administration, neck pain and swelling (33.3% VS. 11.9%; P = 0.0372) and gastrointestinal discomfort (45.2% vs. 21.4%; P = 0.0373) were significantly more frequent in the high-dose group.ConclusionHigh-dose RAI therapy, with higher frequency of short-term adverse effects, appears to be not superior to low-dose RAI therapy for cN0 PTC patients with pN1a disease revealed by pCND to achieve better response to therapy. Further randomized studies with larger series of patients and longer follow-up duration, especially with the low-dose group, are needed to validate our results. More... »

PAGES

1256-1263

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00268-019-04924-0

DOI

http://dx.doi.org/10.1007/s00268-019-04924-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111664560

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30684002


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Iodine Radioisotopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neck Dissection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiation Injuries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiotherapy Dosage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroid Cancer, Papillary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroid Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroidectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China", 
          "id": "http://www.grid.ac/institutes/grid.415954.8", 
          "name": [
            "Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wei", 
        "givenName": "Lan", 
        "id": "sg:person.011031061553.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011031061553.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China", 
          "id": "http://www.grid.ac/institutes/grid.415954.8", 
          "name": [
            "Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bai", 
        "givenName": "Lin", 
        "id": "sg:person.0661346507.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661346507.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China", 
          "id": "http://www.grid.ac/institutes/grid.415954.8", 
          "name": [
            "Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Lina", 
        "id": "sg:person.016434254703.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016434254703.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China", 
          "id": "http://www.grid.ac/institutes/grid.415954.8", 
          "name": [
            "Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Tianyu", 
        "id": "sg:person.015352566231.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015352566231.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China", 
          "id": "http://www.grid.ac/institutes/grid.415954.8", 
          "name": [
            "Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Qingjie", 
        "id": "sg:person.01043710307.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043710307.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China", 
          "id": "http://www.grid.ac/institutes/grid.415954.8", 
          "name": [
            "Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ji", 
        "givenName": "Bin", 
        "id": "sg:person.0755011056.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755011056.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00405-014-3453-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025513689", 
          "https://doi.org/10.1007/s00405-014-3453-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-018-6528-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104137900", 
          "https://doi.org/10.1245/s10434-018-6528-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-013-3258-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022113075", 
          "https://doi.org/10.1245/s10434-013-3258-1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-01-25", 
    "datePublishedReg": "2019-01-25", 
    "description": "ObjectiveOne of the presumed advantages of prophylactic central neck dissection (pCND) is offering staging basis for more aggressive radioactive iodine (RAI) therapy, which postulates the necessity of high dose for treatment efficacy. The present study aims to compare the effectiveness between low-dose and high-dose RAI in a select cohort of cN0 papillary thyroid cancer (PTC) patients with pathological N1a (pN1a) disease revealed by pCND in terms of ablation rate and response to therapy. The frequency of short-term adverse effects between the two groups was also compared.Patients and MethodsFrom January 2014 to April 2016, cN0 PTC patients with pN1a disease revealed by pCND in our hospital were retrospectively reviewed. Patients with other indications for high-dose RAI, such as the presence of extrathyroidal extension, vascular invasion or suspicions of distant metastasis, were excluded. For the included patients, high dose (3700 MBq) was administered between January 2014 and August 2015 and low dose (1110 MBq) between August 2015 and April 2016. Ablation assessment was performed 6 months after RAI therapy. Response evaluation after RAI therapy was performed after 46.3 \u00b1 9.5 months for high-dose group and 29.1 \u00b1 2.6 months for low-dose group. All patients were also evaluated for short-term adverse effects 24 and 72 hours after RAI administration.ResultsA total of 84 patients were enrolled. Among them, 42 were in the high-dose group and the other 42 in the low-dose group. There was no significant difference in ablation rate (P = 0.7707) and response to RAI therapy (P = 0.6454) between the two groups. Twenty-four hours after RAI administration, neck pain and swelling (33.3% VS. 11.9%; P = 0.0372) and gastrointestinal discomfort (45.2% vs. 21.4%; P = 0.0373) were significantly more frequent in the high-dose group.ConclusionHigh-dose RAI therapy, with higher frequency of short-term adverse effects, appears to be not superior to low-dose RAI therapy for cN0 PTC patients with pN1a disease revealed by pCND to achieve better response to therapy. Further randomized studies with larger series of patients and longer follow-up duration, especially with the low-dose group, are needed to validate our results.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00268-019-04924-0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1086446", 
        "issn": [
          "0364-2313", 
          "1432-2323"
        ], 
        "name": "World Journal of Surgery", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "43"
      }
    ], 
    "keywords": [
      "prophylactic central neck dissection", 
      "low-dose group", 
      "high-dose group", 
      "papillary thyroid cancer patients", 
      "short-term adverse effects", 
      "high-dose RAI", 
      "cN0 PTC patients", 
      "RAI therapy", 
      "central neck dissection", 
      "thyroid cancer patients", 
      "RAI administration", 
      "neck dissection", 
      "cancer patients", 
      "PTC patients", 
      "high dose", 
      "adverse effects", 
      "dose RAI therapy", 
      "radioactive iodine therapy", 
      "N1a disease", 
      "iodine therapy", 
      "neck pain", 
      "distant metastasis", 
      "gastrointestinal discomfort", 
      "vascular invasion", 
      "select cohort", 
      "ResultsA total", 
      "low dose", 
      "treatment efficacy", 
      "patients", 
      "large series", 
      "therapy", 
      "disease", 
      "response evaluation", 
      "dose", 
      "months", 
      "good response", 
      "significant differences", 
      "administration", 
      "dissection", 
      "present study", 
      "group", 
      "RAI", 
      "hours", 
      "response", 
      "pain", 
      "metastasis", 
      "high frequency", 
      "hospital", 
      "cohort", 
      "suspicion", 
      "discomfort", 
      "efficacy", 
      "total", 
      "study", 
      "invasion", 
      "duration", 
      "indications", 
      "rate", 
      "swelling", 
      "effect", 
      "Justified", 
      "assessment", 
      "frequency", 
      "differences", 
      "evaluation", 
      "ablation rate", 
      "presence", 
      "effectiveness", 
      "series", 
      "results", 
      "necessity", 
      "basis", 
      "terms", 
      "extension", 
      "advantages", 
      "aggressive radioactive iodine (RAI) therapy", 
      "cN0 papillary thyroid cancer (PTC) patients", 
      "pN1a disease", 
      "Ablation assessment", 
      "short-term adverse effects 24", 
      "adverse effects 24", 
      "effects 24", 
      "ConclusionHigh-dose RAI therapy", 
      "Dose RAI Therapy Justified", 
      "RAI Therapy Justified", 
      "Therapy Justified", 
      "Pathological N1a Disease", 
      "Low-Dose RAI Therapy"
    ], 
    "name": "High-Dose RAI Therapy Justified by Pathological N1a Disease Revealed by Prophylactic Central Neck Dissection for cN0 Papillary Thyroid Cancer Patients: Is it Superior to Low-Dose RAI Therapy?", 
    "pagination": "1256-1263", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111664560"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00268-019-04924-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30684002"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00268-019-04924-0", 
      "https://app.dimensions.ai/details/publication/pub.1111664560"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_817.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00268-019-04924-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00268-019-04924-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00268-019-04924-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00268-019-04924-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00268-019-04924-0'


 

This table displays all metadata directly associated to this object as RDF triples.

279 TRIPLES      22 PREDICATES      137 URIs      126 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00268-019-04924-0 schema:about N03aa039eb2244311a936ceda788e2931
2 N10fee013eebc41ac8d27fb23a9e86d45
3 N1178a8fafccc4bdeb80ac10a7d91be65
4 N376a8df89ea54d98ab1ee3623d075ab1
5 N416bc2baa2f8477a937ac6f19597e0a1
6 N492b56e6d6fb46d089fb8b6fa60a4e81
7 N5f929bd1966647cf942e768fc8cf81b4
8 N6c689cbfc8e24d66a7832f28c9310ac2
9 N79943813579641ecbcec6f13af9cc8e8
10 N8915307cc1e54242aa757873dbf906af
11 N8efe9b9a927d48459d6757204550ac7b
12 Na91e416266e547c99b70bec8c3840cd5
13 Nac60dc2650b244c990b1fef4c02ff3a9
14 Nb20c6053991f4785b9daf3ba6b83ef3f
15 Nbd7d92d6a4564ecfb69dd5bfd010c34c
16 Nca5d23984c0c445fb53bd3cb39d08601
17 Ncceeba57f5f24c1a8b296d54d6bed6ab
18 Ne9beb53207174ee1bfc0674ec48e2381
19 Nef596ed41e23487a9177b37af711af0e
20 Nf282e64da9154c7da5346f953f675a16
21 anzsrc-for:11
22 anzsrc-for:1112
23 schema:author Nbc429ef425a34dc99348fa8754663e20
24 schema:citation sg:pub.10.1007/s00405-014-3453-0
25 sg:pub.10.1245/s10434-013-3258-1
26 sg:pub.10.1245/s10434-018-6528-0
27 schema:datePublished 2019-01-25
28 schema:datePublishedReg 2019-01-25
29 schema:description ObjectiveOne of the presumed advantages of prophylactic central neck dissection (pCND) is offering staging basis for more aggressive radioactive iodine (RAI) therapy, which postulates the necessity of high dose for treatment efficacy. The present study aims to compare the effectiveness between low-dose and high-dose RAI in a select cohort of cN0 papillary thyroid cancer (PTC) patients with pathological N1a (pN1a) disease revealed by pCND in terms of ablation rate and response to therapy. The frequency of short-term adverse effects between the two groups was also compared.Patients and MethodsFrom January 2014 to April 2016, cN0 PTC patients with pN1a disease revealed by pCND in our hospital were retrospectively reviewed. Patients with other indications for high-dose RAI, such as the presence of extrathyroidal extension, vascular invasion or suspicions of distant metastasis, were excluded. For the included patients, high dose (3700 MBq) was administered between January 2014 and August 2015 and low dose (1110 MBq) between August 2015 and April 2016. Ablation assessment was performed 6 months after RAI therapy. Response evaluation after RAI therapy was performed after 46.3 ± 9.5 months for high-dose group and 29.1 ± 2.6 months for low-dose group. All patients were also evaluated for short-term adverse effects 24 and 72 hours after RAI administration.ResultsA total of 84 patients were enrolled. Among them, 42 were in the high-dose group and the other 42 in the low-dose group. There was no significant difference in ablation rate (P = 0.7707) and response to RAI therapy (P = 0.6454) between the two groups. Twenty-four hours after RAI administration, neck pain and swelling (33.3% VS. 11.9%; P = 0.0372) and gastrointestinal discomfort (45.2% vs. 21.4%; P = 0.0373) were significantly more frequent in the high-dose group.ConclusionHigh-dose RAI therapy, with higher frequency of short-term adverse effects, appears to be not superior to low-dose RAI therapy for cN0 PTC patients with pN1a disease revealed by pCND to achieve better response to therapy. Further randomized studies with larger series of patients and longer follow-up duration, especially with the low-dose group, are needed to validate our results.
30 schema:genre article
31 schema:inLanguage en
32 schema:isAccessibleForFree false
33 schema:isPartOf N119f52d24347447aa4ca4cb7e15cf77f
34 Nc7fe7d1662ce45258a1c45951dc7071e
35 sg:journal.1086446
36 schema:keywords Ablation assessment
37 ConclusionHigh-dose RAI therapy
38 Dose RAI Therapy Justified
39 Justified
40 Low-Dose RAI Therapy
41 N1a disease
42 PTC patients
43 Pathological N1a Disease
44 RAI
45 RAI Therapy Justified
46 RAI administration
47 RAI therapy
48 ResultsA total
49 Therapy Justified
50 ablation rate
51 administration
52 advantages
53 adverse effects
54 adverse effects 24
55 aggressive radioactive iodine (RAI) therapy
56 assessment
57 basis
58 cN0 PTC patients
59 cN0 papillary thyroid cancer (PTC) patients
60 cancer patients
61 central neck dissection
62 cohort
63 differences
64 discomfort
65 disease
66 dissection
67 distant metastasis
68 dose
69 dose RAI therapy
70 duration
71 effect
72 effectiveness
73 effects 24
74 efficacy
75 evaluation
76 extension
77 frequency
78 gastrointestinal discomfort
79 good response
80 group
81 high dose
82 high frequency
83 high-dose RAI
84 high-dose group
85 hospital
86 hours
87 indications
88 invasion
89 iodine therapy
90 large series
91 low dose
92 low-dose group
93 metastasis
94 months
95 necessity
96 neck dissection
97 neck pain
98 pN1a disease
99 pain
100 papillary thyroid cancer patients
101 patients
102 presence
103 present study
104 prophylactic central neck dissection
105 radioactive iodine therapy
106 rate
107 response
108 response evaluation
109 results
110 select cohort
111 series
112 short-term adverse effects
113 short-term adverse effects 24
114 significant differences
115 study
116 suspicion
117 swelling
118 terms
119 therapy
120 thyroid cancer patients
121 total
122 treatment efficacy
123 vascular invasion
124 schema:name High-Dose RAI Therapy Justified by Pathological N1a Disease Revealed by Prophylactic Central Neck Dissection for cN0 Papillary Thyroid Cancer Patients: Is it Superior to Low-Dose RAI Therapy?
125 schema:pagination 1256-1263
126 schema:productId N0278ff0000a8480595f29bf6a5e9a04b
127 N50fb5cd0420a40c68e5a9e073b5582bd
128 N7041167875a94714950901b81b190c43
129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111664560
130 https://doi.org/10.1007/s00268-019-04924-0
131 schema:sdDatePublished 2021-12-01T19:45
132 schema:sdLicense https://scigraph.springernature.com/explorer/license/
133 schema:sdPublisher N16c1c71fc252431abc2262c26298904e
134 schema:url https://doi.org/10.1007/s00268-019-04924-0
135 sgo:license sg:explorer/license/
136 sgo:sdDataset articles
137 rdf:type schema:ScholarlyArticle
138 N0278ff0000a8480595f29bf6a5e9a04b schema:name dimensions_id
139 schema:value pub.1111664560
140 rdf:type schema:PropertyValue
141 N03aa039eb2244311a936ceda788e2931 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Adolescent
143 rdf:type schema:DefinedTerm
144 N1027625e834a4961ab714efeea07d268 rdf:first sg:person.0661346507.89
145 rdf:rest N882b86ab0460420088ee15d3d77175ec
146 N10fee013eebc41ac8d27fb23a9e86d45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Female
148 rdf:type schema:DefinedTerm
149 N1178a8fafccc4bdeb80ac10a7d91be65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Radiotherapy, Adjuvant
151 rdf:type schema:DefinedTerm
152 N119f52d24347447aa4ca4cb7e15cf77f schema:issueNumber 5
153 rdf:type schema:PublicationIssue
154 N16c1c71fc252431abc2262c26298904e schema:name Springer Nature - SN SciGraph project
155 rdf:type schema:Organization
156 N376a8df89ea54d98ab1ee3623d075ab1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Aged
158 rdf:type schema:DefinedTerm
159 N416bc2baa2f8477a937ac6f19597e0a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Humans
161 rdf:type schema:DefinedTerm
162 N492b56e6d6fb46d089fb8b6fa60a4e81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Adult
164 rdf:type schema:DefinedTerm
165 N50fb5cd0420a40c68e5a9e073b5582bd schema:name doi
166 schema:value 10.1007/s00268-019-04924-0
167 rdf:type schema:PropertyValue
168 N5f929bd1966647cf942e768fc8cf81b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Young Adult
170 rdf:type schema:DefinedTerm
171 N6c689cbfc8e24d66a7832f28c9310ac2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Retrospective Studies
173 rdf:type schema:DefinedTerm
174 N7041167875a94714950901b81b190c43 schema:name pubmed_id
175 schema:value 30684002
176 rdf:type schema:PropertyValue
177 N79943813579641ecbcec6f13af9cc8e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Thyroidectomy
179 rdf:type schema:DefinedTerm
180 N7d9c57ae0f294eb4816e77dcd1149ad0 rdf:first sg:person.015352566231.04
181 rdf:rest Ncf8c9e2c95724b9cbde4ba7914d1dc3c
182 N882b86ab0460420088ee15d3d77175ec rdf:first sg:person.016434254703.01
183 rdf:rest N7d9c57ae0f294eb4816e77dcd1149ad0
184 N8915307cc1e54242aa757873dbf906af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Middle Aged
186 rdf:type schema:DefinedTerm
187 N8efe9b9a927d48459d6757204550ac7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Radiation Injuries
189 rdf:type schema:DefinedTerm
190 Na91e416266e547c99b70bec8c3840cd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Lymphatic Metastasis
192 rdf:type schema:DefinedTerm
193 Nac60dc2650b244c990b1fef4c02ff3a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Radiotherapy Dosage
195 rdf:type schema:DefinedTerm
196 Nb20c6053991f4785b9daf3ba6b83ef3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Male
198 rdf:type schema:DefinedTerm
199 Nbc429ef425a34dc99348fa8754663e20 rdf:first sg:person.011031061553.14
200 rdf:rest N1027625e834a4961ab714efeea07d268
201 Nbd7d92d6a4564ecfb69dd5bfd010c34c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Neck Dissection
203 rdf:type schema:DefinedTerm
204 Nc7fe7d1662ce45258a1c45951dc7071e schema:volumeNumber 43
205 rdf:type schema:PublicationVolume
206 Nca5d23984c0c445fb53bd3cb39d08601 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Thyroid Neoplasms
208 rdf:type schema:DefinedTerm
209 Ncceeba57f5f24c1a8b296d54d6bed6ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Treatment Outcome
211 rdf:type schema:DefinedTerm
212 Ncf8c9e2c95724b9cbde4ba7914d1dc3c rdf:first sg:person.01043710307.59
213 rdf:rest Nfe786a3f0f9f4e4f89d33281532496cc
214 Ne9beb53207174ee1bfc0674ec48e2381 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Iodine Radioisotopes
216 rdf:type schema:DefinedTerm
217 Nef596ed41e23487a9177b37af711af0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Thyroid Cancer, Papillary
219 rdf:type schema:DefinedTerm
220 Nf282e64da9154c7da5346f953f675a16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
221 schema:name Neoplasm Staging
222 rdf:type schema:DefinedTerm
223 Nfe786a3f0f9f4e4f89d33281532496cc rdf:first sg:person.0755011056.43
224 rdf:rest rdf:nil
225 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
226 schema:name Medical and Health Sciences
227 rdf:type schema:DefinedTerm
228 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
229 schema:name Oncology and Carcinogenesis
230 rdf:type schema:DefinedTerm
231 sg:journal.1086446 schema:issn 0364-2313
232 1432-2323
233 schema:name World Journal of Surgery
234 schema:publisher Springer Nature
235 rdf:type schema:Periodical
236 sg:person.01043710307.59 schema:affiliation grid-institutes:grid.415954.8
237 schema:familyName Ma
238 schema:givenName Qingjie
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043710307.59
240 rdf:type schema:Person
241 sg:person.011031061553.14 schema:affiliation grid-institutes:grid.415954.8
242 schema:familyName Wei
243 schema:givenName Lan
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011031061553.14
245 rdf:type schema:Person
246 sg:person.015352566231.04 schema:affiliation grid-institutes:grid.415954.8
247 schema:familyName Yu
248 schema:givenName Tianyu
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015352566231.04
250 rdf:type schema:Person
251 sg:person.016434254703.01 schema:affiliation grid-institutes:grid.415954.8
252 schema:familyName Zhao
253 schema:givenName Lina
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016434254703.01
255 rdf:type schema:Person
256 sg:person.0661346507.89 schema:affiliation grid-institutes:grid.415954.8
257 schema:familyName Bai
258 schema:givenName Lin
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661346507.89
260 rdf:type schema:Person
261 sg:person.0755011056.43 schema:affiliation grid-institutes:grid.415954.8
262 schema:familyName Ji
263 schema:givenName Bin
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755011056.43
265 rdf:type schema:Person
266 sg:pub.10.1007/s00405-014-3453-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025513689
267 https://doi.org/10.1007/s00405-014-3453-0
268 rdf:type schema:CreativeWork
269 sg:pub.10.1245/s10434-013-3258-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022113075
270 https://doi.org/10.1245/s10434-013-3258-1
271 rdf:type schema:CreativeWork
272 sg:pub.10.1245/s10434-018-6528-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104137900
273 https://doi.org/10.1245/s10434-018-6528-0
274 rdf:type schema:CreativeWork
275 grid-institutes:grid.415954.8 schema:alternateName Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China
276 Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China
277 schema:name Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China
278 Department of Thyroid Surgery, China-Japan Union Hospital of Jilin University, No. 126, Xiantai Street, Changchun, Jilin Province, China
279 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...