Electrochemotherapy in the Treatment of Bone Metastases: A Phase II Trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-07-21

AUTHORS

Giuseppe Bianchi, Laura Campanacci, Mattia Ronchetti, Davide Donati

ABSTRACT

IntroductionBone metastatic disease is a major cause of pain and decreased quality of life in patients with cancer. In addition to systemic therapy and pain control with narcotic analgesics, standard local treatments include palliation with radiation therapy and surgery. However, 20–30 % of patients do not respond to conventional treatments, increasing the interest in alternative therapies. We present the results of a new minimally invasive technique in the treatment of bone metastases.MethodsTwenty-nine patients affected by painful bone metastases were treated with electrochemotherapy (ECT) from July 2009 to July 2011; the mean age was 60 years (range 37–87); 21 patients received a previous ineffective local treatment; the appendicular skeleton was affected in 15 patients while in 14 patients other sites were involved. ECT was performed using the Cliniporator Vitae under fluoroscopy or CT guidance depending on the site of the lesion. Clinical response was assessed using VAS scale and objective tumour response was evaluated according to the MD Anderson criteria for bone metastases.ResultsAll patients well tolerated the procedure and no intraoperative or postoperative complications were observed. At a mean follow-up of 7 months, 24 patients were available for evaluation. 84 % of the patients (20 out of 24) referred improvement of pain ≥50 % with reduction of narcotics consumption. Radiographic evaluation after 3 months in 20 evaluable patients, showed “partial response” in 1 patient, “stable disease” in 17 and “progression” in two cases.DiscussionResults reported in this study demonstrated ECT to be safe and feasible in the treatment of painful bone metastases even when other previous treatments were ineffective. Pain and disease progression control was achieved in the majority of the patients with consequent improvement of quality of life.ConclusionECT should be considered a new feasible tool in the treatment of bone metastases in place or in combination with standard treatments; further developments are required to extend the use of this technique to spine metastases. More... »

PAGES

3088-3094

References to SciGraph publications

  • 2013-07-07. Electrochemotherapy is effective in the treatment of rat bone metastases in CLINICAL & EXPERIMENTAL METASTASIS
  • 2008-05-23. Electrochemotherapy with Intravenous Bleomycin in the Local Treatment of Skin Melanoma Metastases in ANNALS OF SURGICAL ONCOLOGY
  • 2006. Cancer in ENCYCLOPEDIC REFERENCE OF GENOMICS AND PROTEOMICS IN MOLECULAR MEDICINE
  • 2012-03-19. Embolisation of bone metastases from renal cancer in LA RADIOLOGIA MEDICA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00268-016-3627-6

    DOI

    http://dx.doi.org/10.1007/s00268-016-3627-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006304316

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27443372


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cancer Pain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Electrochemotherapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pain Management", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pain Measurement", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Quality of Life", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Radiology, Interventional", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Clinica Ortoepdica III, Istituto Ortopedico Rizzoli, Bologna, Italy", 
              "id": "http://www.grid.ac/institutes/grid.419038.7", 
              "name": [
                "Clinica Ortoepdica III, Istituto Ortopedico Rizzoli, Bologna, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bianchi", 
            "givenName": "Giuseppe", 
            "id": "sg:person.016345573425.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016345573425.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinica Ortoepdica III, Istituto Ortopedico Rizzoli, Bologna, Italy", 
              "id": "http://www.grid.ac/institutes/grid.419038.7", 
              "name": [
                "Clinica Ortoepdica III, Istituto Ortopedico Rizzoli, Bologna, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Campanacci", 
            "givenName": "Laura", 
            "id": "sg:person.01122000652.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122000652.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Oncology Clinical, Research & Development, IGEA S.p.A., via Parmenide 10/a, 41012, Carpi, Modena, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Oncology Clinical, Research & Development, IGEA S.p.A., via Parmenide 10/a, 41012, Carpi, Modena, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ronchetti", 
            "givenName": "Mattia", 
            "id": "sg:person.01075231475.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075231475.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinica Ortoepdica III, Istituto Ortopedico Rizzoli, Bologna, Italy", 
              "id": "http://www.grid.ac/institutes/grid.419038.7", 
              "name": [
                "Clinica Ortoepdica III, Istituto Ortopedico Rizzoli, Bologna, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Donati", 
            "givenName": "Davide", 
            "id": "sg:person.01202643430.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202643430.41"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/3-540-29623-9_6378", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040743911", 
              "https://doi.org/10.1007/3-540-29623-9_6378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-013-9601-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027353313", 
              "https://doi.org/10.1007/s10585-013-9601-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-008-9976-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019823425", 
              "https://doi.org/10.1245/s10434-008-9976-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11547-012-0802-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007884362", 
              "https://doi.org/10.1007/s11547-012-0802-4"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-07-21", 
        "datePublishedReg": "2016-07-21", 
        "description": "IntroductionBone metastatic disease is a major cause of pain and decreased quality of life in patients with cancer. In addition to systemic therapy and pain control with narcotic analgesics, standard local treatments include palliation with radiation therapy and surgery. However, 20\u201330\u00a0% of patients do not respond to conventional treatments, increasing the interest in alternative therapies. We present the results of a new minimally invasive technique in the treatment of bone metastases.MethodsTwenty-nine patients affected by painful bone metastases were treated with electrochemotherapy (ECT) from July 2009 to July 2011; the mean age was 60 years (range 37\u201387); 21 patients received a previous ineffective local treatment; the appendicular skeleton was affected in 15 patients while in 14 patients other sites were involved. ECT was performed using the Cliniporator Vitae under fluoroscopy or CT guidance depending on the site of the lesion. Clinical response was assessed using VAS scale and objective tumour response was evaluated according to the MD Anderson criteria for bone metastases.ResultsAll patients well tolerated the procedure and no intraoperative or postoperative complications were observed. At a mean follow-up of 7\u00a0months, 24 patients were available for evaluation. 84\u00a0% of the patients (20 out of 24) referred improvement of pain \u226550\u00a0% with reduction of narcotics consumption. Radiographic evaluation after 3\u00a0months in 20 evaluable patients, showed \u201cpartial response\u201d in 1 patient, \u201cstable disease\u201d in 17 and \u201cprogression\u201d in two cases.DiscussionResults reported in this study demonstrated ECT to be safe and feasible in the treatment of painful bone metastases even when other previous treatments were ineffective. Pain and disease progression control was achieved in the majority of the patients with consequent improvement of quality of life.ConclusionECT should be considered a new feasible tool in the treatment of bone metastases in place or in combination with standard treatments; further developments are required to extend the use of this technique to spine metastases.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00268-016-3627-6", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1086446", 
            "issn": [
              "0364-2313", 
              "1432-2323"
            ], 
            "name": "World Journal of Surgery", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "12", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "40"
          }
        ], 
        "keywords": [
          "painful bone metastases", 
          "bone metastases", 
          "local treatment", 
          "standard local treatment", 
          "MD Anderson criteria", 
          "disease progression control", 
          "objective tumor response", 
          "improvement of pain", 
          "MethodsTwenty-nine patients", 
          "phase II trial", 
          "quality of life", 
          "ResultsAll patients", 
          "evaluable patients", 
          "stable disease", 
          "pain control", 
          "postoperative complications", 
          "II trial", 
          "metastatic disease", 
          "systemic therapy", 
          "clinical response", 
          "narcotic consumption", 
          "partial response", 
          "spine metastases", 
          "VAS scale", 
          "mean age", 
          "radiographic evaluation", 
          "standard treatment", 
          "narcotic analgesics", 
          "tumor response", 
          "alternative therapies", 
          "CT guidance", 
          "radiation therapy", 
          "invasive techniques", 
          "patients", 
          "metastasis", 
          "conventional treatment", 
          "pain", 
          "progression control", 
          "major cause", 
          "previous treatment", 
          "therapy", 
          "new feasible tool", 
          "electrochemotherapy", 
          "appendicular skeleton", 
          "treatment", 
          "disease", 
          "Anderson criteria", 
          "months", 
          "feasible tool", 
          "palliation", 
          "analgesics", 
          "response", 
          "complications", 
          "surgery", 
          "lesions", 
          "consequent improvement", 
          "cancer", 
          "fluoroscopy", 
          "progression", 
          "trials", 
          "age", 
          "control", 
          "evaluation", 
          "cause", 
          "life", 
          "improvement", 
          "majority", 
          "years", 
          "quality", 
          "criteria", 
          "cases", 
          "sites", 
          "study", 
          "further development", 
          "procedure", 
          "reduction", 
          "guidance", 
          "use", 
          "combination", 
          "addition", 
          "development", 
          "consumption", 
          "technique", 
          "scale", 
          "results", 
          "skeleton", 
          "tool", 
          "interest", 
          "place", 
          "discussionResults", 
          "vitae"
        ], 
        "name": "Electrochemotherapy in the Treatment of Bone Metastases: A Phase II Trial", 
        "pagination": "3088-3094", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1006304316"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00268-016-3627-6"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27443372"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00268-016-3627-6", 
          "https://app.dimensions.ai/details/publication/pub.1006304316"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T15:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_714.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00268-016-3627-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00268-016-3627-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00268-016-3627-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00268-016-3627-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00268-016-3627-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    264 TRIPLES      21 PREDICATES      138 URIs      125 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00268-016-3627-6 schema:about N034001bdfbbb43b0b69d85aaffddeabf
    2 N0ec60f516ad74a31bcc5d856ffdc35d3
    3 N1faea3ee283e407ba7315fefda30557a
    4 N39f3285216b94610ba3f143e2447cd50
    5 N41e19ed7b37c43888e5a5aba5b86b90c
    6 N463ad56d41f24030afd72ca4c5e22465
    7 N5adbb8e9c902470bb0d5b851f5db7879
    8 N63afc40eb2ae461ab6aa58ca4eb83e4f
    9 N6b10a97cff9e43188ad024f9a9e73a34
    10 N6b15390a0c0b475391267ed859765b1b
    11 N738a29864669427d918d61fbdbece951
    12 N7870ff59cd9f4f879fed185b77eee9c0
    13 N90e2da0151cb490b90e08d12668b2f13
    14 N949a41d1dc6f49afbea221ad611328d9
    15 Ne1ebf6e2bee04d6cac1205b7a8bdb54e
    16 Ne88f5cada9cf418ebb2a0d943db757c7
    17 Nef2e424ac8754c75be3c5427f8808679
    18 anzsrc-for:11
    19 anzsrc-for:1103
    20 anzsrc-for:1112
    21 schema:author N4d956bd8c1c44db3a731f9c7b6c3010f
    22 schema:citation sg:pub.10.1007/3-540-29623-9_6378
    23 sg:pub.10.1007/s10585-013-9601-x
    24 sg:pub.10.1007/s11547-012-0802-4
    25 sg:pub.10.1245/s10434-008-9976-0
    26 schema:datePublished 2016-07-21
    27 schema:datePublishedReg 2016-07-21
    28 schema:description IntroductionBone metastatic disease is a major cause of pain and decreased quality of life in patients with cancer. In addition to systemic therapy and pain control with narcotic analgesics, standard local treatments include palliation with radiation therapy and surgery. However, 20–30 % of patients do not respond to conventional treatments, increasing the interest in alternative therapies. We present the results of a new minimally invasive technique in the treatment of bone metastases.MethodsTwenty-nine patients affected by painful bone metastases were treated with electrochemotherapy (ECT) from July 2009 to July 2011; the mean age was 60 years (range 37–87); 21 patients received a previous ineffective local treatment; the appendicular skeleton was affected in 15 patients while in 14 patients other sites were involved. ECT was performed using the Cliniporator Vitae under fluoroscopy or CT guidance depending on the site of the lesion. Clinical response was assessed using VAS scale and objective tumour response was evaluated according to the MD Anderson criteria for bone metastases.ResultsAll patients well tolerated the procedure and no intraoperative or postoperative complications were observed. At a mean follow-up of 7 months, 24 patients were available for evaluation. 84 % of the patients (20 out of 24) referred improvement of pain ≥50 % with reduction of narcotics consumption. Radiographic evaluation after 3 months in 20 evaluable patients, showed “partial response” in 1 patient, “stable disease” in 17 and “progression” in two cases.DiscussionResults reported in this study demonstrated ECT to be safe and feasible in the treatment of painful bone metastases even when other previous treatments were ineffective. Pain and disease progression control was achieved in the majority of the patients with consequent improvement of quality of life.ConclusionECT should be considered a new feasible tool in the treatment of bone metastases in place or in combination with standard treatments; further developments are required to extend the use of this technique to spine metastases.
    29 schema:genre article
    30 schema:isAccessibleForFree true
    31 schema:isPartOf N13c923dafd34400c919ca7f03ee8b142
    32 Ndbbbad60d03f4f12bdc7f642d5069d54
    33 sg:journal.1086446
    34 schema:keywords Anderson criteria
    35 CT guidance
    36 II trial
    37 MD Anderson criteria
    38 MethodsTwenty-nine patients
    39 ResultsAll patients
    40 VAS scale
    41 addition
    42 age
    43 alternative therapies
    44 analgesics
    45 appendicular skeleton
    46 bone metastases
    47 cancer
    48 cases
    49 cause
    50 clinical response
    51 combination
    52 complications
    53 consequent improvement
    54 consumption
    55 control
    56 conventional treatment
    57 criteria
    58 development
    59 discussionResults
    60 disease
    61 disease progression control
    62 electrochemotherapy
    63 evaluable patients
    64 evaluation
    65 feasible tool
    66 fluoroscopy
    67 further development
    68 guidance
    69 improvement
    70 improvement of pain
    71 interest
    72 invasive techniques
    73 lesions
    74 life
    75 local treatment
    76 major cause
    77 majority
    78 mean age
    79 metastasis
    80 metastatic disease
    81 months
    82 narcotic analgesics
    83 narcotic consumption
    84 new feasible tool
    85 objective tumor response
    86 pain
    87 pain control
    88 painful bone metastases
    89 palliation
    90 partial response
    91 patients
    92 phase II trial
    93 place
    94 postoperative complications
    95 previous treatment
    96 procedure
    97 progression
    98 progression control
    99 quality
    100 quality of life
    101 radiation therapy
    102 radiographic evaluation
    103 reduction
    104 response
    105 results
    106 scale
    107 sites
    108 skeleton
    109 spine metastases
    110 stable disease
    111 standard local treatment
    112 standard treatment
    113 study
    114 surgery
    115 systemic therapy
    116 technique
    117 therapy
    118 tool
    119 treatment
    120 trials
    121 tumor response
    122 use
    123 vitae
    124 years
    125 schema:name Electrochemotherapy in the Treatment of Bone Metastases: A Phase II Trial
    126 schema:pagination 3088-3094
    127 schema:productId N0a06d6f8cda54da5bcc79d76190e263e
    128 N497dda55a0434faea5a7a108d00c8b2d
    129 Ndd6e2627dc484541a221d36e69d966ad
    130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006304316
    131 https://doi.org/10.1007/s00268-016-3627-6
    132 schema:sdDatePublished 2022-09-02T15:59
    133 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    134 schema:sdPublisher Nf9180dc7e482434cb6516974edeb9999
    135 schema:url https://doi.org/10.1007/s00268-016-3627-6
    136 sgo:license sg:explorer/license/
    137 sgo:sdDataset articles
    138 rdf:type schema:ScholarlyArticle
    139 N034001bdfbbb43b0b69d85aaffddeabf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Aged, 80 and over
    141 rdf:type schema:DefinedTerm
    142 N0a06d6f8cda54da5bcc79d76190e263e schema:name dimensions_id
    143 schema:value pub.1006304316
    144 rdf:type schema:PropertyValue
    145 N0ec60f516ad74a31bcc5d856ffdc35d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Adult
    147 rdf:type schema:DefinedTerm
    148 N11a707efa56646dcb531779c8189c05d rdf:first sg:person.01075231475.10
    149 rdf:rest N930ea5c09beb4d2abb77140fad091d82
    150 N13c923dafd34400c919ca7f03ee8b142 schema:volumeNumber 40
    151 rdf:type schema:PublicationVolume
    152 N1faea3ee283e407ba7315fefda30557a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Quality of Life
    154 rdf:type schema:DefinedTerm
    155 N2d2a4a899fbd40c2992b99b27da78ae5 rdf:first sg:person.01122000652.34
    156 rdf:rest N11a707efa56646dcb531779c8189c05d
    157 N39f3285216b94610ba3f143e2447cd50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Treatment Outcome
    159 rdf:type schema:DefinedTerm
    160 N41e19ed7b37c43888e5a5aba5b86b90c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Male
    162 rdf:type schema:DefinedTerm
    163 N463ad56d41f24030afd72ca4c5e22465 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Bone Neoplasms
    165 rdf:type schema:DefinedTerm
    166 N497dda55a0434faea5a7a108d00c8b2d schema:name pubmed_id
    167 schema:value 27443372
    168 rdf:type schema:PropertyValue
    169 N4d956bd8c1c44db3a731f9c7b6c3010f rdf:first sg:person.016345573425.18
    170 rdf:rest N2d2a4a899fbd40c2992b99b27da78ae5
    171 N5adbb8e9c902470bb0d5b851f5db7879 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Pain Measurement
    173 rdf:type schema:DefinedTerm
    174 N63afc40eb2ae461ab6aa58ca4eb83e4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Prospective Studies
    176 rdf:type schema:DefinedTerm
    177 N6b10a97cff9e43188ad024f9a9e73a34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Aged
    179 rdf:type schema:DefinedTerm
    180 N6b15390a0c0b475391267ed859765b1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Pain Management
    182 rdf:type schema:DefinedTerm
    183 N738a29864669427d918d61fbdbece951 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Electrochemotherapy
    185 rdf:type schema:DefinedTerm
    186 N7870ff59cd9f4f879fed185b77eee9c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Female
    188 rdf:type schema:DefinedTerm
    189 N90e2da0151cb490b90e08d12668b2f13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Middle Aged
    191 rdf:type schema:DefinedTerm
    192 N930ea5c09beb4d2abb77140fad091d82 rdf:first sg:person.01202643430.41
    193 rdf:rest rdf:nil
    194 N949a41d1dc6f49afbea221ad611328d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Antineoplastic Agents
    196 rdf:type schema:DefinedTerm
    197 Ndbbbad60d03f4f12bdc7f642d5069d54 schema:issueNumber 12
    198 rdf:type schema:PublicationIssue
    199 Ndd6e2627dc484541a221d36e69d966ad schema:name doi
    200 schema:value 10.1007/s00268-016-3627-6
    201 rdf:type schema:PropertyValue
    202 Ne1ebf6e2bee04d6cac1205b7a8bdb54e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Cancer Pain
    204 rdf:type schema:DefinedTerm
    205 Ne88f5cada9cf418ebb2a0d943db757c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Humans
    207 rdf:type schema:DefinedTerm
    208 Nef2e424ac8754c75be3c5427f8808679 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Radiology, Interventional
    210 rdf:type schema:DefinedTerm
    211 Nf9180dc7e482434cb6516974edeb9999 schema:name Springer Nature - SN SciGraph project
    212 rdf:type schema:Organization
    213 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    214 schema:name Medical and Health Sciences
    215 rdf:type schema:DefinedTerm
    216 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    217 schema:name Clinical Sciences
    218 rdf:type schema:DefinedTerm
    219 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    220 schema:name Oncology and Carcinogenesis
    221 rdf:type schema:DefinedTerm
    222 sg:journal.1086446 schema:issn 0364-2313
    223 1432-2323
    224 schema:name World Journal of Surgery
    225 schema:publisher Springer Nature
    226 rdf:type schema:Periodical
    227 sg:person.01075231475.10 schema:affiliation grid-institutes:None
    228 schema:familyName Ronchetti
    229 schema:givenName Mattia
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075231475.10
    231 rdf:type schema:Person
    232 sg:person.01122000652.34 schema:affiliation grid-institutes:grid.419038.7
    233 schema:familyName Campanacci
    234 schema:givenName Laura
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122000652.34
    236 rdf:type schema:Person
    237 sg:person.01202643430.41 schema:affiliation grid-institutes:grid.419038.7
    238 schema:familyName Donati
    239 schema:givenName Davide
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202643430.41
    241 rdf:type schema:Person
    242 sg:person.016345573425.18 schema:affiliation grid-institutes:grid.419038.7
    243 schema:familyName Bianchi
    244 schema:givenName Giuseppe
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016345573425.18
    246 rdf:type schema:Person
    247 sg:pub.10.1007/3-540-29623-9_6378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040743911
    248 https://doi.org/10.1007/3-540-29623-9_6378
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1007/s10585-013-9601-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027353313
    251 https://doi.org/10.1007/s10585-013-9601-x
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1007/s11547-012-0802-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007884362
    254 https://doi.org/10.1007/s11547-012-0802-4
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1245/s10434-008-9976-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019823425
    257 https://doi.org/10.1245/s10434-008-9976-0
    258 rdf:type schema:CreativeWork
    259 grid-institutes:None schema:alternateName Oncology Clinical, Research & Development, IGEA S.p.A., via Parmenide 10/a, 41012, Carpi, Modena, Italy
    260 schema:name Oncology Clinical, Research & Development, IGEA S.p.A., via Parmenide 10/a, 41012, Carpi, Modena, Italy
    261 rdf:type schema:Organization
    262 grid-institutes:grid.419038.7 schema:alternateName Clinica Ortoepdica III, Istituto Ortopedico Rizzoli, Bologna, Italy
    263 schema:name Clinica Ortoepdica III, Istituto Ortopedico Rizzoli, Bologna, Italy
    264 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...