Patterns and Treatment of Recurrence Following Pulmonary Resection for Colorectal Metastases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-07

AUTHORS

Mitsuru Yokota, Akihiro Kobayashi, Shogo Nomura, Yuji Nishizawa, Masaaki Ito, Kanji Nagai, Norio Saito

ABSTRACT

BACKGROUND: Pulmonary resection is the best therapeutic option for lung metastases from colorectal cancer (CRC) today. However, recurrences are frequent following pulmonary resection. We aimed to evaluate the recurrence pattern and treatment of initial pulmonary resection for metastases from CRC. METHODS: Data from 76 patients with recurrence after curative resection of primary CRC and lung metastases were reviewed. The primary outcome measure was overall survival (OS), defined as the interval between the date of recurrence after pulmonary resection and the date of death or last follow-up. Cox regression analyses were performed to identify the factors associated with OS. RESULTS: Recurrence sites after initial pulmonary resection were lung (n = 37), liver (n = 12), others (n = 11), and multiple (n = 16). Treatments for recurrence included surgery (n = 35), chemotherapy (n = 37), and palliative care (n = 4). Of 35 patients who underwent surgery, 22 had pulmonary resection, and 11 had hepatic resection, and 2 had other resection. The 3-year OS was 84.1 % for surgery, 38.9 % for chemotherapy, and 0 % for palliative care, respectively (p < 0.001). In the surgery group, there was no difference in survival between surgical treatments for pulmonary and hepatic recurrences (p = 0.503). Cox regression analyses identified three factors: disease-free interval (DFI) (HR 1.99, 95 % CI 1.03-3.83), surgery (HR 0.30, 95 % CI 0.12-0.72), and recurrence site (lung: HR 0.10, 95 % CI 0.04-0.28, liver: HR 0.08, 95 % CI 0.02-0.31). CONCLUSIONS: The most common recurrence site after resection of lung metastases was the lung. Although the relapse rate is high, surgery for isolated recurrences is a promising strategy, especially for patients with long DFI. More... »

PAGES

1758-1766

References to SciGraph publications

  • 2005-03. Repeat Pulmonary Resection for Isolated Recurrent Lung Metastases Yields Results Comparable to Those after First Pulmonary Resection in Colorectal Cancer in WORLD JOURNAL OF SURGERY
  • 2006-11. Surgical Management of Pulmonary Metastases from Colorectal Cancer in 153 Patients in ANNALS OF SURGICAL ONCOLOGY
  • 2010-12. Predicting survival after pulmonary metastasectomy for colorectal cancer: previous liver metastases matter in BMC SURGERY
  • 2012-02. Survival after Lung Metastasectomy in Colorectal Cancer Patients with Previously Resected Liver Metastases in WORLD JOURNAL OF SURGERY
  • 2009-04. Pulmonary Resection for Colorectal Cancer Metastases: Duration Between Cancer Onset and Lung Metastasis as an Important Prognostic Factor in ANNALS OF SURGICAL ONCOLOGY
  • 2007-12. Surgical outcomes for colon and rectal cancer over a decade: results from a consecutive monocentric experience in 902 unselected patients in WORLD JOURNAL OF SURGICAL ONCOLOGY
  • 2013-06. Repeated Resection of Colorectal Cancer Pulmonary Oligometastases: Pooled Analysis and Prognostic Assessment in ANNALS OF SURGICAL ONCOLOGY
  • 2010-10. Repeat Resection of Pulmonary Metastasis Is Beneficial for Patients with Colorectal Carcinoma in WORLD JOURNAL OF SURGERY
  • 2011-02. Role of surgical resection in colorectal lung metastases: analysis of 137 patients in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2013-02. Risk Factors for Survival after Lung Metastasectomy in Colorectal Cancer Patients: A Systematic Review and Meta-Analysis in ANNALS OF SURGICAL ONCOLOGY
  • 2006-04. Surgical resection of hepatic metastases from colorectal cancer: A systematic review of published studies in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00268-015-3006-8

    DOI

    http://dx.doi.org/10.1007/s00268-015-3006-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017442046

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25665680


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colorectal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lung Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Recurrence, Local", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Palliative Care", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pneumonectomy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "National Cancer Center Hospital East", 
              "id": "https://www.grid.ac/institutes/grid.497282.2", 
              "name": [
                "Division of Colorectal Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yokota", 
            "givenName": "Mitsuru", 
            "id": "sg:person.01043463401.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043463401.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Center Hospital East", 
              "id": "https://www.grid.ac/institutes/grid.497282.2", 
              "name": [
                "Division of Colorectal Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kobayashi", 
            "givenName": "Akihiro", 
            "id": "sg:person.0611475774.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611475774.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Center Hospital East", 
              "id": "https://www.grid.ac/institutes/grid.497282.2", 
              "name": [
                "Clinical Trial Section, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nomura", 
            "givenName": "Shogo", 
            "id": "sg:person.01213706300.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213706300.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Center Hospital East", 
              "id": "https://www.grid.ac/institutes/grid.497282.2", 
              "name": [
                "Division of Colorectal Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nishizawa", 
            "givenName": "Yuji", 
            "id": "sg:person.01026265613.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026265613.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Center Hospital East", 
              "id": "https://www.grid.ac/institutes/grid.497282.2", 
              "name": [
                "Division of Colorectal Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ito", 
            "givenName": "Masaaki", 
            "id": "sg:person.011006743562.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011006743562.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Center Hospital East", 
              "id": "https://www.grid.ac/institutes/grid.497282.2", 
              "name": [
                "Division of Thoracic Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagai", 
            "givenName": "Kanji", 
            "id": "sg:person.0602077653.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602077653.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Cancer Center Hospital East", 
              "id": "https://www.grid.ac/institutes/grid.497282.2", 
              "name": [
                "Division of Colorectal Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saito", 
            "givenName": "Norio", 
            "id": "sg:person.01100314172.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100314172.30"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.athoracsur.2009.10.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000982615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jjco/hyl076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001041970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archsurg.142.12.1144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005681964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-012-2860-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007673089", 
              "https://doi.org/10.1245/s10434-012-2860-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.20107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009055747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-012-2726-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009829406", 
              "https://doi.org/10.1245/s10434-012-2726-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2006.06.8353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012458227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-004-7537-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013473653", 
              "https://doi.org/10.1007/s00268-004-7537-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-004-7537-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013473653", 
              "https://doi.org/10.1007/s00268-004-7537-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.17.3781", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015374378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-006-9100-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015606290", 
              "https://doi.org/10.1245/s10434-006-9100-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.20138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020626779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.6682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020897630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bjs.6682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020897630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-011-1381-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021765386", 
              "https://doi.org/10.1007/s00268-011-1381-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31826eda3b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022214905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e31826eda3b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022214905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdp475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022945687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1067/mtc.2002.125165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026035745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1067/mtc.2002.125165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026035745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-200206000-00015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027074204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-200206000-00015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027074204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.20.7050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028000882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejso.2011.05.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031907655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.athoracsur.2012.07.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033265353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejcts.2006.11.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035004385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.athoracsur.2007.03.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036300172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-008-0286-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036739144", 
              "https://doi.org/10.1245/s10434-008-0286-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00384-010-1075-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037878591", 
              "https://doi.org/10.1007/s00384-010-1075-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejso.2006.10.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041210598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1477-7819-5-73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047767922", 
              "https://doi.org/10.1186/1477-7819-5-73"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2482-10-17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049581009", 
              "https://doi.org/10.1186/1471-2482-10-17"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051210499", 
              "https://doi.org/10.1038/sj.bjc.6603033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051210499", 
              "https://doi.org/10.1038/sj.bjc.6603033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejcts.2008.10.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051777264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-010-0695-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053455850", 
              "https://doi.org/10.1007/s00268-010-0695-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-010-0695-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053455850", 
              "https://doi.org/10.1007/s00268-010-0695-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3181b4539b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077952929"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-07", 
        "datePublishedReg": "2015-07-01", 
        "description": "BACKGROUND: Pulmonary resection is the best therapeutic option for lung metastases from colorectal cancer (CRC) today. However, recurrences are frequent following pulmonary resection. We aimed to evaluate the recurrence pattern and treatment of initial pulmonary resection for metastases from CRC.\nMETHODS: Data from 76 patients with recurrence after curative resection of primary CRC and lung metastases were reviewed. The primary outcome measure was overall survival (OS), defined as the interval between the date of recurrence after pulmonary resection and the date of death or last follow-up. Cox regression analyses were performed to identify the factors associated with OS.\nRESULTS: Recurrence sites after initial pulmonary resection were lung (n = 37), liver (n = 12), others (n = 11), and multiple (n = 16). Treatments for recurrence included surgery (n = 35), chemotherapy (n = 37), and palliative care (n = 4). Of 35 patients who underwent surgery, 22 had pulmonary resection, and 11 had hepatic resection, and 2 had other resection. The 3-year OS was 84.1 % for surgery, 38.9 % for chemotherapy, and 0 % for palliative care, respectively (p < 0.001). In the surgery group, there was no difference in survival between surgical treatments for pulmonary and hepatic recurrences (p = 0.503). Cox regression analyses identified three factors: disease-free interval (DFI) (HR 1.99, 95 % CI 1.03-3.83), surgery (HR 0.30, 95 % CI 0.12-0.72), and recurrence site (lung: HR 0.10, 95 % CI 0.04-0.28, liver: HR 0.08, 95 % CI 0.02-0.31).\nCONCLUSIONS: The most common recurrence site after resection of lung metastases was the lung. Although the relapse rate is high, surgery for isolated recurrences is a promising strategy, especially for patients with long DFI.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00268-015-3006-8", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6111884", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1086446", 
            "issn": [
              "0364-2313", 
              "1432-2323"
            ], 
            "name": "World Journal of Surgery", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "39"
          }
        ], 
        "name": "Patterns and Treatment of Recurrence Following Pulmonary Resection for Colorectal Metastases", 
        "pagination": "1758-1766", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "5319a7a72f7068f772a5c89019d1b4f95c456a6adb19762872c8099dee612acc"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25665680"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "7704052"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00268-015-3006-8"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1017442046"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00268-015-3006-8", 
          "https://app.dimensions.ai/details/publication/pub.1017442046"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T20:46", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000511.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs00268-015-3006-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00268-015-3006-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00268-015-3006-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00268-015-3006-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00268-015-3006-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    275 TRIPLES      21 PREDICATES      74 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00268-015-3006-8 schema:about N10db1f549f7b433e965ac1f0915870c2
    2 N33473b9cf8ad498ca15abab00517b9d9
    3 N4fa42a707bd94324b7d2907165014d8d
    4 N5eb2b154d9bb4e0aa8742f2b8f1dddb4
    5 N676a7b78dd424599aba98d6718f1d42f
    6 N70f4707d3c5a4eb4ac2dddf27ed17381
    7 N72e68cff0c29461881b6a57d88eea364
    8 N84b69f690a9948b9bf9bf3bcff5cf5e8
    9 N9b9675af24ee43cda184011654545726
    10 Na209d7e6c605437e909dfd3865b3c6be
    11 Naabf9fc28dc949628bd9c9d4b59b8723
    12 Nc11b8e8d5101485da3fe31a33f87eb50
    13 Nd605b1bfcff14839a00682936d84a932
    14 Ne0f40d4a16484335a251e959191af535
    15 anzsrc-for:11
    16 anzsrc-for:1112
    17 schema:author N56f2b92e2b6243da99e4da08ad1917f2
    18 schema:citation sg:pub.10.1007/s00268-004-7537-7
    19 sg:pub.10.1007/s00268-010-0695-x
    20 sg:pub.10.1007/s00268-011-1381-3
    21 sg:pub.10.1007/s00384-010-1075-6
    22 sg:pub.10.1038/sj.bjc.6603033
    23 sg:pub.10.1186/1471-2482-10-17
    24 sg:pub.10.1186/1477-7819-5-73
    25 sg:pub.10.1245/s10434-006-9100-2
    26 sg:pub.10.1245/s10434-008-0286-3
    27 sg:pub.10.1245/s10434-012-2726-3
    28 sg:pub.10.1245/s10434-012-2860-y
    29 https://doi.org/10.1001/archsurg.142.12.1144
    30 https://doi.org/10.1002/bjs.6682
    31 https://doi.org/10.1016/j.athoracsur.2007.03.028
    32 https://doi.org/10.1016/j.athoracsur.2009.10.005
    33 https://doi.org/10.1016/j.athoracsur.2012.07.014
    34 https://doi.org/10.1016/j.ejcts.2006.11.004
    35 https://doi.org/10.1016/j.ejcts.2008.10.047
    36 https://doi.org/10.1016/j.ejso.2006.10.016
    37 https://doi.org/10.1016/j.ejso.2011.05.014
    38 https://doi.org/10.1067/mtc.2002.125165
    39 https://doi.org/10.1093/annonc/mdp475
    40 https://doi.org/10.1093/jjco/hyl076
    41 https://doi.org/10.1097/00000658-200206000-00015
    42 https://doi.org/10.1097/sla.0b013e3181b4539b
    43 https://doi.org/10.1097/sla.0b013e31826eda3b
    44 https://doi.org/10.1200/jco.2006.06.8353
    45 https://doi.org/10.1200/jco.2008.17.3781
    46 https://doi.org/10.1200/jco.2008.20.7050
    47 https://doi.org/10.3322/caac.20107
    48 https://doi.org/10.3322/caac.20138
    49 schema:datePublished 2015-07
    50 schema:datePublishedReg 2015-07-01
    51 schema:description BACKGROUND: Pulmonary resection is the best therapeutic option for lung metastases from colorectal cancer (CRC) today. However, recurrences are frequent following pulmonary resection. We aimed to evaluate the recurrence pattern and treatment of initial pulmonary resection for metastases from CRC. METHODS: Data from 76 patients with recurrence after curative resection of primary CRC and lung metastases were reviewed. The primary outcome measure was overall survival (OS), defined as the interval between the date of recurrence after pulmonary resection and the date of death or last follow-up. Cox regression analyses were performed to identify the factors associated with OS. RESULTS: Recurrence sites after initial pulmonary resection were lung (n = 37), liver (n = 12), others (n = 11), and multiple (n = 16). Treatments for recurrence included surgery (n = 35), chemotherapy (n = 37), and palliative care (n = 4). Of 35 patients who underwent surgery, 22 had pulmonary resection, and 11 had hepatic resection, and 2 had other resection. The 3-year OS was 84.1 % for surgery, 38.9 % for chemotherapy, and 0 % for palliative care, respectively (p < 0.001). In the surgery group, there was no difference in survival between surgical treatments for pulmonary and hepatic recurrences (p = 0.503). Cox regression analyses identified three factors: disease-free interval (DFI) (HR 1.99, 95 % CI 1.03-3.83), surgery (HR 0.30, 95 % CI 0.12-0.72), and recurrence site (lung: HR 0.10, 95 % CI 0.04-0.28, liver: HR 0.08, 95 % CI 0.02-0.31). CONCLUSIONS: The most common recurrence site after resection of lung metastases was the lung. Although the relapse rate is high, surgery for isolated recurrences is a promising strategy, especially for patients with long DFI.
    52 schema:genre research_article
    53 schema:inLanguage en
    54 schema:isAccessibleForFree false
    55 schema:isPartOf Nbe6a944bdbd24ddea9f8cb098a9ef3a7
    56 Nc99e4c160cf1405fb72c21a047dafa02
    57 sg:journal.1086446
    58 schema:name Patterns and Treatment of Recurrence Following Pulmonary Resection for Colorectal Metastases
    59 schema:pagination 1758-1766
    60 schema:productId N446c4362447f4630807578cb25025b26
    61 N5961c76d3a374be4ba2b30ad3fea9d67
    62 N5c748884b0374cc9a43cc31b811f4a63
    63 Nb34b36160741458598ce5e54f8293852
    64 Ne273f4aaf6f648f497528e59529bde11
    65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017442046
    66 https://doi.org/10.1007/s00268-015-3006-8
    67 schema:sdDatePublished 2019-04-10T20:46
    68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    69 schema:sdPublisher N7deed30316804b37a1e8634aeb2dbef6
    70 schema:url http://link.springer.com/10.1007%2Fs00268-015-3006-8
    71 sgo:license sg:explorer/license/
    72 sgo:sdDataset articles
    73 rdf:type schema:ScholarlyArticle
    74 N039b35c0933146728a18e5fa24a4d35b rdf:first sg:person.01213706300.52
    75 rdf:rest Ndb4723ddc8f24de7bb097d75ee0996d2
    76 N09abd23bfa7f41c3a4f2a17cf8600d6c rdf:first sg:person.0602077653.45
    77 rdf:rest N22134cf78e654b0a8afc844540e0e2ec
    78 N0bd8c958e62b49bb87383de553099cd2 rdf:first sg:person.011006743562.77
    79 rdf:rest N09abd23bfa7f41c3a4f2a17cf8600d6c
    80 N10db1f549f7b433e965ac1f0915870c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    81 schema:name Aged, 80 and over
    82 rdf:type schema:DefinedTerm
    83 N22134cf78e654b0a8afc844540e0e2ec rdf:first sg:person.01100314172.30
    84 rdf:rest rdf:nil
    85 N33473b9cf8ad498ca15abab00517b9d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    86 schema:name Humans
    87 rdf:type schema:DefinedTerm
    88 N446c4362447f4630807578cb25025b26 schema:name doi
    89 schema:value 10.1007/s00268-015-3006-8
    90 rdf:type schema:PropertyValue
    91 N4fa42a707bd94324b7d2907165014d8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Palliative Care
    93 rdf:type schema:DefinedTerm
    94 N56f2b92e2b6243da99e4da08ad1917f2 rdf:first sg:person.01043463401.26
    95 rdf:rest N9189ef9d564a420ab03a28f484d378fe
    96 N5961c76d3a374be4ba2b30ad3fea9d67 schema:name pubmed_id
    97 schema:value 25665680
    98 rdf:type schema:PropertyValue
    99 N5c748884b0374cc9a43cc31b811f4a63 schema:name nlm_unique_id
    100 schema:value 7704052
    101 rdf:type schema:PropertyValue
    102 N5eb2b154d9bb4e0aa8742f2b8f1dddb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Liver Neoplasms
    104 rdf:type schema:DefinedTerm
    105 N676a7b78dd424599aba98d6718f1d42f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Colorectal Neoplasms
    107 rdf:type schema:DefinedTerm
    108 N70f4707d3c5a4eb4ac2dddf27ed17381 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Retrospective Studies
    110 rdf:type schema:DefinedTerm
    111 N72e68cff0c29461881b6a57d88eea364 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Pneumonectomy
    113 rdf:type schema:DefinedTerm
    114 N7deed30316804b37a1e8634aeb2dbef6 schema:name Springer Nature - SN SciGraph project
    115 rdf:type schema:Organization
    116 N84b69f690a9948b9bf9bf3bcff5cf5e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Aged
    118 rdf:type schema:DefinedTerm
    119 N9189ef9d564a420ab03a28f484d378fe rdf:first sg:person.0611475774.31
    120 rdf:rest N039b35c0933146728a18e5fa24a4d35b
    121 N9b9675af24ee43cda184011654545726 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Adult
    123 rdf:type schema:DefinedTerm
    124 Na209d7e6c605437e909dfd3865b3c6be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Lung Neoplasms
    126 rdf:type schema:DefinedTerm
    127 Naabf9fc28dc949628bd9c9d4b59b8723 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Middle Aged
    129 rdf:type schema:DefinedTerm
    130 Nb34b36160741458598ce5e54f8293852 schema:name readcube_id
    131 schema:value 5319a7a72f7068f772a5c89019d1b4f95c456a6adb19762872c8099dee612acc
    132 rdf:type schema:PropertyValue
    133 Nbe6a944bdbd24ddea9f8cb098a9ef3a7 schema:volumeNumber 39
    134 rdf:type schema:PublicationVolume
    135 Nc11b8e8d5101485da3fe31a33f87eb50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Male
    137 rdf:type schema:DefinedTerm
    138 Nc99e4c160cf1405fb72c21a047dafa02 schema:issueNumber 7
    139 rdf:type schema:PublicationIssue
    140 Nd605b1bfcff14839a00682936d84a932 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Neoplasm Recurrence, Local
    142 rdf:type schema:DefinedTerm
    143 Ndb4723ddc8f24de7bb097d75ee0996d2 rdf:first sg:person.01026265613.02
    144 rdf:rest N0bd8c958e62b49bb87383de553099cd2
    145 Ne0f40d4a16484335a251e959191af535 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Female
    147 rdf:type schema:DefinedTerm
    148 Ne273f4aaf6f648f497528e59529bde11 schema:name dimensions_id
    149 schema:value pub.1017442046
    150 rdf:type schema:PropertyValue
    151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    152 schema:name Medical and Health Sciences
    153 rdf:type schema:DefinedTerm
    154 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    155 schema:name Oncology and Carcinogenesis
    156 rdf:type schema:DefinedTerm
    157 sg:grant.6111884 http://pending.schema.org/fundedItem sg:pub.10.1007/s00268-015-3006-8
    158 rdf:type schema:MonetaryGrant
    159 sg:journal.1086446 schema:issn 0364-2313
    160 1432-2323
    161 schema:name World Journal of Surgery
    162 rdf:type schema:Periodical
    163 sg:person.01026265613.02 schema:affiliation https://www.grid.ac/institutes/grid.497282.2
    164 schema:familyName Nishizawa
    165 schema:givenName Yuji
    166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026265613.02
    167 rdf:type schema:Person
    168 sg:person.01043463401.26 schema:affiliation https://www.grid.ac/institutes/grid.497282.2
    169 schema:familyName Yokota
    170 schema:givenName Mitsuru
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043463401.26
    172 rdf:type schema:Person
    173 sg:person.01100314172.30 schema:affiliation https://www.grid.ac/institutes/grid.497282.2
    174 schema:familyName Saito
    175 schema:givenName Norio
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100314172.30
    177 rdf:type schema:Person
    178 sg:person.011006743562.77 schema:affiliation https://www.grid.ac/institutes/grid.497282.2
    179 schema:familyName Ito
    180 schema:givenName Masaaki
    181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011006743562.77
    182 rdf:type schema:Person
    183 sg:person.01213706300.52 schema:affiliation https://www.grid.ac/institutes/grid.497282.2
    184 schema:familyName Nomura
    185 schema:givenName Shogo
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213706300.52
    187 rdf:type schema:Person
    188 sg:person.0602077653.45 schema:affiliation https://www.grid.ac/institutes/grid.497282.2
    189 schema:familyName Nagai
    190 schema:givenName Kanji
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602077653.45
    192 rdf:type schema:Person
    193 sg:person.0611475774.31 schema:affiliation https://www.grid.ac/institutes/grid.497282.2
    194 schema:familyName Kobayashi
    195 schema:givenName Akihiro
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611475774.31
    197 rdf:type schema:Person
    198 sg:pub.10.1007/s00268-004-7537-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013473653
    199 https://doi.org/10.1007/s00268-004-7537-7
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1007/s00268-010-0695-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053455850
    202 https://doi.org/10.1007/s00268-010-0695-x
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1007/s00268-011-1381-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021765386
    205 https://doi.org/10.1007/s00268-011-1381-3
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1007/s00384-010-1075-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037878591
    208 https://doi.org/10.1007/s00384-010-1075-6
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/sj.bjc.6603033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051210499
    211 https://doi.org/10.1038/sj.bjc.6603033
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1186/1471-2482-10-17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049581009
    214 https://doi.org/10.1186/1471-2482-10-17
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1186/1477-7819-5-73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047767922
    217 https://doi.org/10.1186/1477-7819-5-73
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1245/s10434-006-9100-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015606290
    220 https://doi.org/10.1245/s10434-006-9100-2
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1245/s10434-008-0286-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036739144
    223 https://doi.org/10.1245/s10434-008-0286-3
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1245/s10434-012-2726-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009829406
    226 https://doi.org/10.1245/s10434-012-2726-3
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1245/s10434-012-2860-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1007673089
    229 https://doi.org/10.1245/s10434-012-2860-y
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1001/archsurg.142.12.1144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005681964
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1002/bjs.6682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020897630
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1016/j.athoracsur.2007.03.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036300172
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/j.athoracsur.2009.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000982615
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/j.athoracsur.2012.07.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033265353
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1016/j.ejcts.2006.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035004385
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/j.ejcts.2008.10.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051777264
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/j.ejso.2006.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041210598
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.ejso.2011.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031907655
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1067/mtc.2002.125165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026035745
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1093/annonc/mdp475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022945687
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1093/jjco/hyl076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001041970
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1097/00000658-200206000-00015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027074204
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1097/sla.0b013e3181b4539b schema:sameAs https://app.dimensions.ai/details/publication/pub.1077952929
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1097/sla.0b013e31826eda3b schema:sameAs https://app.dimensions.ai/details/publication/pub.1022214905
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1200/jco.2006.06.8353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012458227
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1200/jco.2008.17.3781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015374378
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1200/jco.2008.20.7050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028000882
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.3322/caac.20107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009055747
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.3322/caac.20138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020626779
    270 rdf:type schema:CreativeWork
    271 https://www.grid.ac/institutes/grid.497282.2 schema:alternateName National Cancer Center Hospital East
    272 schema:name Clinical Trial Section, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan
    273 Division of Colorectal Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan
    274 Division of Thoracic Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577, Kashiwa, Chiba, Japan
    275 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...