Above 5 cm, Size Does Not Matter Anymore in Patients with Hepatocellular Carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-08-07

AUTHORS

Chetana Lim, Yoshihiro Mise, Yoshihiro Sakamoto, Satoshi Yamamoto, Junichi Shindoh, Takeaki Ishizawa, Taku Aoki, Kiyoshi Hasegawa, Yasuhiko Sugawara, Masatoshi Makuuchi, Norihiro Kokudo

ABSTRACT

BackgroundSolitary hepatocellular carcinoma (HCC) is a good candidate for surgical resection. However, the significance of the size of the tumor in solitary HCC remains unclear.ObjectiveThe aim of this study was to evaluate the impact of tumor size on overall and recurrence-free survival of patients with solitary HCC.MaterialsWe retrospectively reviewed 616 patients with histologically confirmed solitary HCC who underwent curative surgical resection between 1994 and 2010. The characteristics and prognosis of patients with HCC were analyzed stratified by tumor size.ResultsA total of 403 patients (65 %) had tumors <5 cm, 172 (28 %) had tumors between 5 and 10 cm, and 41 (7 %) had tumors >10 cm. The incidence of microvascular invasion, satellite nodules, and advanced tumor grade significantly increased with tumor size. The 5-year overall and recurrence-free survival rates of HCC <5 cm were 69.6 % and 32 %, respectively, which were significantly better than those of HCC between 5 and 10 cm (58 % and 26 %, respectively) and HCC >10 cm (53 % and 24 %, respectively). On multivariate analysis, cirrhosis (p = 0.0307), Child–Pugh B (p = 0.0159), indocyanine green retention rate at 15 min >10 % (p = 0.0071), microvascular invasion (p < 0.0001), and satellite nodules (p = 0.0009) were independent predictors of poor survival, whereas tumor size >5 cm was not.ConclusionAlthough recurrence rates are high, surgical resection for solitary HCC offers good overall survival. Tumor size was not a prognostic factor. Solitary large HCC >10 cm would be a good candidate for hepatectomy as well as solitary HCC between 5 and 10 cm. More... »

PAGES

2910-2918

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00268-014-2704-y

DOI

http://dx.doi.org/10.1007/s00268-014-2704-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032891161

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25099682


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30 schema:description BackgroundSolitary hepatocellular carcinoma (HCC) is a good candidate for surgical resection. However, the significance of the size of the tumor in solitary HCC remains unclear.ObjectiveThe aim of this study was to evaluate the impact of tumor size on overall and recurrence-free survival of patients with solitary HCC.MaterialsWe retrospectively reviewed 616 patients with histologically confirmed solitary HCC who underwent curative surgical resection between 1994 and 2010. The characteristics and prognosis of patients with HCC were analyzed stratified by tumor size.ResultsA total of 403 patients (65 %) had tumors <5 cm, 172 (28 %) had tumors between 5 and 10 cm, and 41 (7 %) had tumors >10 cm. The incidence of microvascular invasion, satellite nodules, and advanced tumor grade significantly increased with tumor size. The 5-year overall and recurrence-free survival rates of HCC <5 cm were 69.6 % and 32 %, respectively, which were significantly better than those of HCC between 5 and 10 cm (58 % and 26 %, respectively) and HCC >10 cm (53 % and 24 %, respectively). On multivariate analysis, cirrhosis (p = 0.0307), Child–Pugh B (p = 0.0159), indocyanine green retention rate at 15 min >10 % (p = 0.0071), microvascular invasion (p < 0.0001), and satellite nodules (p = 0.0009) were independent predictors of poor survival, whereas tumor size >5 cm was not.ConclusionAlthough recurrence rates are high, surgical resection for solitary HCC offers good overall survival. Tumor size was not a prognostic factor. Solitary large HCC >10 cm would be a good candidate for hepatectomy as well as solitary HCC between 5 and 10 cm.
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37 MaterialsWe
38 Overall
39 ResultsA total
40 advanced tumor grade
41 aim
42 analysis
43 better overall survival
44 candidates
45 carcinoma
46 characteristics
47 cirrhosis
48 curative surgical resection
49 factors
50 good candidate
51 grade
52 hepatectomy
53 hepatocellular carcinoma
54 impact
55 incidence
56 independent predictors
57 indocyanine green retention rate
58 invasion
59 large hepatocellular carcinoma
60 microvascular invasion
61 min
62 multivariate analysis
63 nodules
64 overall survival
65 patients
66 poor survival
67 predictors
68 prognosis
69 prognosis of patients
70 prognostic factors
71 rate
72 recurrence rate
73 recurrence-free survival
74 recurrence-free survival rates
75 resection
76 retention rate
77 satellite nodules
78 significance
79 size
80 solitary hepatocellular carcinoma
81 solitary large hepatocellular carcinoma
82 study
83 surgical resection
84 survival
85 survival rate
86 total
87 tumor grade
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