Outcome of Various Treatments for Posttransplant Hepatitis B Virus Recurrence View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-04

AUTHORS

Nam-Joon Yi, Kwang-Woong Lee, Sun-Young Kong, Kyoung-Un Park, Kyoung-Bun Lee, Geun Hong, Sung-Sik Han, Sang-Jae Park, Kyung-Suk Suh

ABSTRACT

BACKGROUND: Currently, no treatment guidelines are available for posttransplant hepatitis B virus (HBV) recurrence. We retrospectively evaluated the rate of clearance of hepatitis B surface antigen (HBsAg) from serum according to various treatment regimens in two large Korean liver transplantation centers. METHODS: Between 1996 and 2008, HBV recurred in 59 patients among 933 HBV liver recipients (6.3 %). Patients with HBV recurrence were divided into four groups according to their treatment: group L (lamivudine-based therapy n = 21) and group N [new nucleos(t)ide analogue (NA)-based therapy, n = 38]. Intravenous hepatitis B immunoglobulin (ivHBIG) had been simultaneously administered to 10 patients in group L and 26 patients in group N. The mean posttransplant follow-up duration and time to HBV recurrence were 69 (14-152) months and 37 (3-120) months. RESULTS: Overall, 22 patients (37.3 %) showed seronegative conversion of HBsAg for a median 8 months after treatment (range 1-15 months). The seroclearance rate was significantly higher in group N (n = 20, 52.6 %) than in group L (n = 2, 9.5 %) (p < 0.000). The time to seroconversion did not differ between group L (7 months, range 5-16) and group N (7 months, range 1-15) (p = 0.428). Subgroup analysis showed that the HBsAg seroconversion rate was much higher for patients given combined ivHBIG and new NAs (15/26 patients, 58.0 %) than the others (p = 0.006). CONCLUSIONS: Seroclearance of HBsAg could be achieved using new NAs in half of the patients after posttransplant HBV recurrence. Combined ivHBIG may add a synergistic effect to new NAs for clearing HBsAg. More... »

PAGES

812-819

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00268-013-1914-z

DOI

http://dx.doi.org/10.1007/s00268-013-1914-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005742248

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23344522


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Download the RDF metadata as:  json-ld nt turtle xml License info

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RDF/XML is a standard XML format for linked data.

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314 Department of Surgery, Seoul National University College of Medicine, 101 Daehak-ro, Chongro-gu, 110-744, Seoul, South Korea
315 rdf:type schema:Organization
316 https://www.grid.ac/institutes/grid.410914.9 schema:alternateName National Cancer Center
317 schema:name Center for Liver Cancer, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea
318 Department of Surgery, Seoul National University College of Medicine, 101 Daehak-ro, Chongro-gu, 110-744, Seoul, South Korea
319 Laboratory Medicine, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea
320 rdf:type schema:Organization
321 https://www.grid.ac/institutes/grid.412480.b schema:alternateName Seoul National University Bundang Hospital
322 schema:name Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea
323 rdf:type schema:Organization
 




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