Randomized Controlled Trial of Tamsulosin for Prevention of Acute Voiding Difficulty After Rectal Cancer Surgery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-07-18

AUTHORS

Je-Ho Jang, Sung-Bum Kang, Sung-Min Lee, Jun-Seok Park, Duck-Woo Kim, Soyeon Ahn

ABSTRACT

BackgroundWe conducted a randomized clinical trial to investigate the efficacy of the selective α1A-adrenoceptor antagonist tamsulosin in preventing acute voiding difficulty after rectal cancer surgery.MethodsA total of 94 rectal cancer patients with an International Prostate Symptom Score (IPSS) of ≤7 were randomly assigned (1:1) to the tamsulosin group (0.2 mg/day orally for 7 days) (n = 47) or the control group (n = 47). The primary endpoint was the reinsertion rate of the urinary catheter after its removal on postoperative day (POD) 3. The secondary endpoints included the maximum (Qmax) and average (Qavg) urinary flow rates on POD 3, and the voided volume (VV), residual urine volume (RU), and IPSS on POD 7. Analyses were based on an intention-to-treat population.ResultsThe reinsertion rate of the urinary catheter in the tamsulosin group was similar to that in the control group (23.4 vs. 21.3 %, respectively; p = 0.804). The postoperative voiding parameters and IPSS were not better in the tamsulosin group than in the control group after adjustments were made for the baseline measurements with analysis of covariance (Qmax, p = 0.537; Qavg, p = 0.399; VV, p = 0.645; RU, p = 0.703; IPSS, p = 0.761). Multivariate analysis revealed that being male was the only independent risk factor for reinsertion of the urinary catheter (odds ratio 0.239; 95 % confidence interval 0.069–0.823; p = 0.023).ConclusionsThis controlled trial showed that tamsulosin at 0.2 mg/day does not prevent acute voiding difficulty after rectal cancer surgery. More... »

PAGES

2730-2737

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00268-012-1712-z

DOI

http://dx.doi.org/10.1007/s00268-012-1712-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002879264

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22806208


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