Effect of Sirolimus in the Prevention of Adhesions Around Intraabdominal Prosthetic Graft View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-09

AUTHORS

Muhip Kanko, Ersan Ozbudak, Ali Ozerdem, Ahmet Aksoy, Metehan Kilic, K. Turan Berki

ABSTRACT

BACKGROUND: Adhesions due to the reactions caused by the grafts used in primary vascular operations can lead to various problems when a secondary operation is necessary. These problems include bleeding, injuries to neighboring organs, and complications occurring due to a prolonged operation. We investigated the effects of sirolimus, which has antiproliferative features, on vascular adhesions. METHODS: The abdominal aorta of rats was explored and abrasions applied. Following the fixation of a polytetrafluoroethylene (PTFE) graft on the abdominal aorta, sirolimus (rapamycin) is applied (in powdered form) onto the grafts of the study group. Eight weeks later a laparotomy was repeated and any adhesions were evaluated. RESULTS: In the study group the adhesions were determined to be fewer in number and milder in severity. Severe cases of adhesion were determined in the control group. CONCLUSIONS: Therefore, sirolimus applied around the prosthesis in vascular operations was determined to be effective at preventing possible adhesions. More... »

PAGES

1648-1652

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00268-005-0750-1

DOI

http://dx.doi.org/10.1007/s00268-005-0750-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000246480

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16847710


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