Cytoreductive Surgery Combined with Intraperitoneal Chemohyperthermia for the Treatment of Advanced Colon Cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-10-06

AUTHORS

Claudio Zanon, Massimiliano Bortolini, Isabella Chiappino, Paolo Simone, Francesco Bruno, Piero Gaglia, Mario Airoldi, Leonorda DeRiu, Alon Mashiah

ABSTRACT

BackgroundChemohyperthermic peritoneal perfusion (CHPP) after extensive cytoreductive surgery is a possible choice as a regional treatment for peritoneal carcinomatosis (PC). The multicentric France EVOCAPE 1 study demonstrated that the median overall survival of patients with colon peritoneal carcinomatosis subjected to conventional surgical and/or chemotherapeutic treatment was 5.2 months. Historically, mitomycin C is the drug of choice in the treatment of intraperitoneal carcinomatosis from colon cancer.MethodsTwenty-five patients affected by stage IV colon cancer with only peritoneal involvement and a prior completion of at least a partial first cycle of systemic chemotherapeutic and/or surgical treatment (24 patients) were enrolled. Immediately following extensive cytoreductive surgery, early postoperative closed abdomen CHPP was performed.ResultsComplete surgical cytoreduction (CC0–CC1) was obtained in 22 patients. Postoperative mortality was 1 out of 25 (4%). Major postoperative morbidity was 6 out of 25 (24%). Median overall survival estimated by Kaplan–Meier curve was 30.3 months. Locoregional progression-free survival was 17.3 months. Of all the patients 64% and 40% were alive after 1 and 2 years respectively.ConclusionsIn referral centers CHPP after optimal surgical debulking is a safe procedure for peritoneal carcinomatosis from colonic cancer. Locoregional control was obtained in the majority of the pretreated patients and 1-year survival was statistically improved. A closed abdomen CHPP procedure lasting 1 hour and standard mitomycin C at a dosage of 15 mg/m2 is probably as efficacious as other hyperthermic procedures, using higher mitomycin C dosages, with a comparable or lower number of cases of side effects. These results, as in other published phase II studies, justify future randomized trials to assess definitively the role of CHPP in the treatment of locally advanced colon neoplasms in western countries. More... »

PAGES

2025-2032

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00268-005-0486-y

DOI

http://dx.doi.org/10.1007/s00268-005-0486-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030264283

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17058031


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