Effects of Irradiation Combined with Cis-diamminedichloroplatinum (CDDP) Suppository in Rabbit VX2 Rectal Tumors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-03

AUTHORS

Kazuo Wakatsuki, Kenji Oda, Keiji Koda, Kazuhiro Seike, Nobuhiro Takiguchi, Norio Saito, Masaru Miyazaki

ABSTRACT

To decrease local recurrence and increase disease free survival, various preoperative therapies for patients with advanced rectal cancer have been studied. Cis-diamminedichloroplatinum (II) (CDDP) has become one of the most widely used cancer chemotherapeutic drugs. It has also been found to have radiosensitizing properties. In this experimental study, the efficacy of chemoradiotherapy using a novel CDDP suppository, and one with mixed micelles, was examined in a rabbit VX2 rectal tumor model. Rabbits were divided into four groups: control group, irradiation (R) group, CDDP suppository plus irradiation (CR) group, and mixed micelles plus CDDP suppository plus irradiation (CMR) group. Tumor growth ratios were reduced significantly in the CR and CMR groups as compared with the ratio in the control group. Microscopically, response rates of main tumors were 0%, 33.3%, 70.0%, and 91. 7%, respectively. The number of metastatic lymph nodes in the CR and CMR groups decreased significantly compared to the control group and the R group. The microscopic response rates of metastatic lymph nodes were 0%, 11.1%, 40.0%, and 41.7%, respectively. Lung metastases were observed in three rabbits in the R group, and in one rabbit in the CMR group. Tissue platinum concentrations both in tumors and in regional lymph nodes increased significantly when mixed micelles were used. Chemoradiotherapy using the CDDP suppository and mixed micelles was effective for local control in the rabbit VX2 rectal tumor model. More... »

PAGES

388-395

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00268-004-7625-8

DOI

http://dx.doi.org/10.1007/s00268-004-7625-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035169193

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15706445


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Micelles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rabbits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Suppositories", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba City, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wakatsuki", 
        "givenName": "Kazuo", 
        "id": "sg:person.01023031013.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023031013.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba City, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oda", 
        "givenName": "Kenji", 
        "id": "sg:person.016221460254.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016221460254.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba City, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koda", 
        "givenName": "Keiji", 
        "id": "sg:person.0647155176.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647155176.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba City, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seike", 
        "givenName": "Kazuhiro", 
        "id": "sg:person.01143710571.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143710571.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.418490.0", 
          "name": [
            "Department of General Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, 260-8777 Chiba City, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takiguchi", 
        "givenName": "Nobuhiro", 
        "id": "sg:person.0616257621.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616257621.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Department of Pelvic Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577 Kashiwa City, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saito", 
        "givenName": "Norio", 
        "id": "sg:person.01100314172.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100314172.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba City, Chiba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyazaki", 
        "givenName": "Masaru", 
        "id": "sg:person.0773025611.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773025611.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.5649/jjphcs1975.16.269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001758955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(94)90398-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003587781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19930601)71:11<3690::aid-cncr2820711136>3.0.co;2-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007565672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(89)90299-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008823116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(91)90103-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010268218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.39.1518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011230571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10350-004-6325-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014747462", 
          "https://doi.org/10.1007/s10350-004-6325-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s10350-004-6325-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014747462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002689900625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019361479", 
          "https://doi.org/10.1007/s002689900625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-565050-2.50012-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022384219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-3084(81)90013-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022687529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-3084(81)90013-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022687529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(87)90015-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027078984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02234632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028070268", 
          "https://doi.org/10.1007/bf02234632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf02234632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028070268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf02234632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028070268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19840501)53:9<1811::aid-cncr2820530902>3.0.co;2-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030469547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9610(98)00018-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032275691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5173(80)90003-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037910085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5173(80)90003-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037910085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039748815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02234821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041478881", 
          "https://doi.org/10.1007/bf02234821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf02234821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041478881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf02234821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041478881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199506000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049723087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199506000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049723087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1072-7515(03)00115-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051351350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1072-7515(03)00115-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051351350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/02656739409022442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053417600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.10.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075062215", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1992.10.1.79", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077366757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081722630", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-03", 
    "datePublishedReg": "2005-03-01", 
    "description": "To decrease local recurrence and increase disease free survival, various preoperative therapies for patients with advanced rectal cancer have been studied. Cis-diamminedichloroplatinum (II) (CDDP) has become one of the most widely used cancer chemotherapeutic drugs. It has also been found to have radiosensitizing properties. In this experimental study, the efficacy of chemoradiotherapy using a novel CDDP suppository, and one with mixed micelles, was examined in a rabbit VX2 rectal tumor model. Rabbits were divided into four groups: control group, irradiation (R) group, CDDP suppository plus irradiation (CR) group, and mixed micelles plus CDDP suppository plus irradiation (CMR) group. Tumor growth ratios were reduced significantly in the CR and CMR groups as compared with the ratio in the control group. Microscopically, response rates of main tumors were 0%, 33.3%, 70.0%, and 91. 7%, respectively. The number of metastatic lymph nodes in the CR and CMR groups decreased significantly compared to the control group and the R group. The microscopic response rates of metastatic lymph nodes were 0%, 11.1%, 40.0%, and 41.7%, respectively. Lung metastases were observed in three rabbits in the R group, and in one rabbit in the CMR group. Tissue platinum concentrations both in tumors and in regional lymph nodes increased significantly when mixed micelles were used. Chemoradiotherapy using the CDDP suppository and mixed micelles was effective for local control in the rabbit VX2 rectal tumor model.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00268-004-7625-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1086446", 
        "issn": [
          "0364-2313", 
          "1432-2323"
        ], 
        "name": "World Journal of Surgery", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "29"
      }
    ], 
    "name": "Effects of Irradiation Combined with Cis-diamminedichloroplatinum (CDDP) Suppository in Rabbit VX2 Rectal Tumors", 
    "pagination": "388-395", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a7884b19527fe1d4012df2b4255dae731f6753cf1cb7880953c02a4d44cdace4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15706445"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7704052"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00268-004-7625-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035169193"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00268-004-7625-8", 
      "https://app.dimensions.ai/details/publication/pub.1035169193"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13109_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00268-004-7625-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00268-004-7625-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00268-004-7625-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00268-004-7625-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00268-004-7625-8'


 

This table displays all metadata directly associated to this object as RDF triples.

244 TRIPLES      21 PREDICATES      67 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00268-004-7625-8 schema:about N08721f285ca34433a5ab5396ec46c82e
2 N29d0f0c053a04249a6a5ea0b8ec514c7
3 N30e851a835f04ef9ac5289aa7180c955
4 N6996dd7678214e5eb3fa1ed45c61074c
5 N7fdd81460c5943089fa428dddd468acb
6 N8a868a7b7a3c4920905f7308c2bd8cec
7 N9499021b2bc245289b309394241f1ac3
8 Nc7bab1bfb0a6406e961f611510e0c55a
9 Ncc0602ac959f4f9d867550ef7ca0aaa9
10 Ndc01b37840914cabb5f85199509dacf8
11 Ne2a4e2b4027f4b95af71840d869676fd
12 anzsrc-for:11
13 anzsrc-for:1112
14 schema:author N32f80e9dbc104a6d8c890104d6ade1f1
15 schema:citation sg:pub.10.1007/bf02234632
16 sg:pub.10.1007/bf02234821
17 sg:pub.10.1007/s002689900625
18 sg:pub.10.1007/s10350-004-6325-7
19 https://app.dimensions.ai/details/publication/pub.1075062215
20 https://app.dimensions.ai/details/publication/pub.1081722630
21 https://doi.org/10.1002/1097-0142(19840501)53:9<1811::aid-cncr2820530902>3.0.co;2-h
22 https://doi.org/10.1002/1097-0142(19930601)71:11<3690::aid-cncr2820711136>3.0.co;2-h
23 https://doi.org/10.1002/ijc.10997
24 https://doi.org/10.1007/bf02234632
25 https://doi.org/10.1007/bf02234821
26 https://doi.org/10.1007/s10350-004-6325-7
27 https://doi.org/10.1016/0009-3084(81)90013-x
28 https://doi.org/10.1016/0360-3016(87)90015-0
29 https://doi.org/10.1016/0360-3016(89)90299-x
30 https://doi.org/10.1016/0360-3016(91)90103-b
31 https://doi.org/10.1016/0360-3016(94)90398-0
32 https://doi.org/10.1016/0378-5173(80)90003-4
33 https://doi.org/10.1016/b978-0-12-565050-2.50012-7
34 https://doi.org/10.1016/s0002-9610(98)00018-x
35 https://doi.org/10.1016/s1072-7515(03)00115-7
36 https://doi.org/10.1097/00000658-199506000-00016
37 https://doi.org/10.1200/jco.1992.10.1.79
38 https://doi.org/10.1200/jco.2003.10.045
39 https://doi.org/10.1248/cpb.39.1518
40 https://doi.org/10.3109/02656739409022442
41 https://doi.org/10.5649/jjphcs1975.16.269
42 schema:datePublished 2005-03
43 schema:datePublishedReg 2005-03-01
44 schema:description To decrease local recurrence and increase disease free survival, various preoperative therapies for patients with advanced rectal cancer have been studied. Cis-diamminedichloroplatinum (II) (CDDP) has become one of the most widely used cancer chemotherapeutic drugs. It has also been found to have radiosensitizing properties. In this experimental study, the efficacy of chemoradiotherapy using a novel CDDP suppository, and one with mixed micelles, was examined in a rabbit VX2 rectal tumor model. Rabbits were divided into four groups: control group, irradiation (R) group, CDDP suppository plus irradiation (CR) group, and mixed micelles plus CDDP suppository plus irradiation (CMR) group. Tumor growth ratios were reduced significantly in the CR and CMR groups as compared with the ratio in the control group. Microscopically, response rates of main tumors were 0%, 33.3%, 70.0%, and 91. 7%, respectively. The number of metastatic lymph nodes in the CR and CMR groups decreased significantly compared to the control group and the R group. The microscopic response rates of metastatic lymph nodes were 0%, 11.1%, 40.0%, and 41.7%, respectively. Lung metastases were observed in three rabbits in the R group, and in one rabbit in the CMR group. Tissue platinum concentrations both in tumors and in regional lymph nodes increased significantly when mixed micelles were used. Chemoradiotherapy using the CDDP suppository and mixed micelles was effective for local control in the rabbit VX2 rectal tumor model.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf Nb297c63f7dcd409d8cf11c7d2a922bc9
49 Nd753c9bab44f4255addd8f01f52860c0
50 sg:journal.1086446
51 schema:name Effects of Irradiation Combined with Cis-diamminedichloroplatinum (CDDP) Suppository in Rabbit VX2 Rectal Tumors
52 schema:pagination 388-395
53 schema:productId N05ad166f1e314338b3939128e3353fea
54 N2f3c71d5755c453fb3b9666792acc285
55 N821912ea240244d0a955424f7aac5b92
56 N92f05cf7f8c4468b823674cd6535c004
57 Na20dda657d7f4d7a8e376d320f4422f2
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035169193
59 https://doi.org/10.1007/s00268-004-7625-8
60 schema:sdDatePublished 2019-04-11T14:34
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N86fa16959e4d466b9683e7b00ad2a71d
63 schema:url http://link.springer.com/10.1007%2Fs00268-004-7625-8
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N05ad166f1e314338b3939128e3353fea schema:name readcube_id
68 schema:value a7884b19527fe1d4012df2b4255dae731f6753cf1cb7880953c02a4d44cdace4
69 rdf:type schema:PropertyValue
70 N08721f285ca34433a5ab5396ec46c82e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Rectal Neoplasms
72 rdf:type schema:DefinedTerm
73 N29d0f0c053a04249a6a5ea0b8ec514c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Lymphatic Metastasis
75 rdf:type schema:DefinedTerm
76 N2f3c71d5755c453fb3b9666792acc285 schema:name doi
77 schema:value 10.1007/s00268-004-7625-8
78 rdf:type schema:PropertyValue
79 N30e851a835f04ef9ac5289aa7180c955 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Suppositories
81 rdf:type schema:DefinedTerm
82 N31b69a817eba485cb7a3cf9bc1c09e1f rdf:first sg:person.0616257621.35
83 rdf:rest N9cb925d313f245299558d0d70bfe333b
84 N32f80e9dbc104a6d8c890104d6ade1f1 rdf:first sg:person.01023031013.63
85 rdf:rest Nf8468d8a7d2a49e197f09b551bbd5d63
86 N42a2fcad8885430c8d03044db0f9a760 rdf:first sg:person.0647155176.80
87 rdf:rest N66438cad5f6b4d40b349713a87b00496
88 N66438cad5f6b4d40b349713a87b00496 rdf:first sg:person.01143710571.13
89 rdf:rest N31b69a817eba485cb7a3cf9bc1c09e1f
90 N6996dd7678214e5eb3fa1ed45c61074c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Antineoplastic Agents
92 rdf:type schema:DefinedTerm
93 N7cc1c03b359d4590ac8d149dfd4aeea7 rdf:first sg:person.0773025611.35
94 rdf:rest rdf:nil
95 N7fdd81460c5943089fa428dddd468acb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Animals
97 rdf:type schema:DefinedTerm
98 N821912ea240244d0a955424f7aac5b92 schema:name dimensions_id
99 schema:value pub.1035169193
100 rdf:type schema:PropertyValue
101 N86fa16959e4d466b9683e7b00ad2a71d schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 N8a868a7b7a3c4920905f7308c2bd8cec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Cisplatin
105 rdf:type schema:DefinedTerm
106 N92f05cf7f8c4468b823674cd6535c004 schema:name nlm_unique_id
107 schema:value 7704052
108 rdf:type schema:PropertyValue
109 N9499021b2bc245289b309394241f1ac3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Rabbits
111 rdf:type schema:DefinedTerm
112 N9cb925d313f245299558d0d70bfe333b rdf:first sg:person.01100314172.30
113 rdf:rest N7cc1c03b359d4590ac8d149dfd4aeea7
114 Na20dda657d7f4d7a8e376d320f4422f2 schema:name pubmed_id
115 schema:value 15706445
116 rdf:type schema:PropertyValue
117 Nb297c63f7dcd409d8cf11c7d2a922bc9 schema:volumeNumber 29
118 rdf:type schema:PublicationVolume
119 Nc7bab1bfb0a6406e961f611510e0c55a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Micelles
121 rdf:type schema:DefinedTerm
122 Ncc0602ac959f4f9d867550ef7ca0aaa9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Disease Models, Animal
124 rdf:type schema:DefinedTerm
125 Nd753c9bab44f4255addd8f01f52860c0 schema:issueNumber 3
126 rdf:type schema:PublicationIssue
127 Ndc01b37840914cabb5f85199509dacf8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Combined Modality Therapy
129 rdf:type schema:DefinedTerm
130 Ne2a4e2b4027f4b95af71840d869676fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Female
132 rdf:type schema:DefinedTerm
133 Nf8468d8a7d2a49e197f09b551bbd5d63 rdf:first sg:person.016221460254.53
134 rdf:rest N42a2fcad8885430c8d03044db0f9a760
135 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
136 schema:name Medical and Health Sciences
137 rdf:type schema:DefinedTerm
138 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
139 schema:name Oncology and Carcinogenesis
140 rdf:type schema:DefinedTerm
141 sg:journal.1086446 schema:issn 0364-2313
142 1432-2323
143 schema:name World Journal of Surgery
144 rdf:type schema:Periodical
145 sg:person.01023031013.63 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
146 schema:familyName Wakatsuki
147 schema:givenName Kazuo
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023031013.63
149 rdf:type schema:Person
150 sg:person.01100314172.30 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
151 schema:familyName Saito
152 schema:givenName Norio
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100314172.30
154 rdf:type schema:Person
155 sg:person.01143710571.13 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
156 schema:familyName Seike
157 schema:givenName Kazuhiro
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143710571.13
159 rdf:type schema:Person
160 sg:person.016221460254.53 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
161 schema:familyName Oda
162 schema:givenName Kenji
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016221460254.53
164 rdf:type schema:Person
165 sg:person.0616257621.35 schema:affiliation https://www.grid.ac/institutes/grid.418490.0
166 schema:familyName Takiguchi
167 schema:givenName Nobuhiro
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616257621.35
169 rdf:type schema:Person
170 sg:person.0647155176.80 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
171 schema:familyName Koda
172 schema:givenName Keiji
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647155176.80
174 rdf:type schema:Person
175 sg:person.0773025611.35 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
176 schema:familyName Miyazaki
177 schema:givenName Masaru
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773025611.35
179 rdf:type schema:Person
180 sg:pub.10.1007/bf02234632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028070268
181 https://doi.org/10.1007/bf02234632
182 rdf:type schema:CreativeWork
183 sg:pub.10.1007/bf02234821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041478881
184 https://doi.org/10.1007/bf02234821
185 rdf:type schema:CreativeWork
186 sg:pub.10.1007/s002689900625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019361479
187 https://doi.org/10.1007/s002689900625
188 rdf:type schema:CreativeWork
189 sg:pub.10.1007/s10350-004-6325-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014747462
190 https://doi.org/10.1007/s10350-004-6325-7
191 rdf:type schema:CreativeWork
192 https://app.dimensions.ai/details/publication/pub.1075062215 schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1081722630 schema:CreativeWork
194 https://doi.org/10.1002/1097-0142(19840501)53:9<1811::aid-cncr2820530902>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1030469547
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1002/1097-0142(19930601)71:11<3690::aid-cncr2820711136>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1007565672
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1002/ijc.10997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039748815
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1007/bf02234632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028070268
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1007/bf02234821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041478881
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1007/s10350-004-6325-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014747462
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/0009-3084(81)90013-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022687529
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/0360-3016(87)90015-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027078984
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/0360-3016(89)90299-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008823116
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/0360-3016(91)90103-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1010268218
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/0360-3016(94)90398-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003587781
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/0378-5173(80)90003-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037910085
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/b978-0-12-565050-2.50012-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022384219
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/s0002-9610(98)00018-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032275691
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/s1072-7515(03)00115-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051351350
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1097/00000658-199506000-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049723087
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1200/jco.1992.10.1.79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077366757
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1200/jco.2003.10.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203894
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1248/cpb.39.1518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011230571
231 rdf:type schema:CreativeWork
232 https://doi.org/10.3109/02656739409022442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053417600
233 rdf:type schema:CreativeWork
234 https://doi.org/10.5649/jjphcs1975.16.269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001758955
235 rdf:type schema:CreativeWork
236 https://www.grid.ac/institutes/grid.136304.3 schema:alternateName Chiba University
237 schema:name Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba City, Chiba, Japan
238 rdf:type schema:Organization
239 https://www.grid.ac/institutes/grid.272242.3 schema:alternateName National Cancer Centre
240 schema:name Department of Pelvic Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, 277-8577 Kashiwa City, Chiba, Japan
241 rdf:type schema:Organization
242 https://www.grid.ac/institutes/grid.418490.0 schema:alternateName Chiba Cancer Center
243 schema:name Department of General Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, 260-8777 Chiba City, Chiba, Japan
244 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...