Hemorrhage after Duodenopancreatectomy: Impact of Neoadjuvant Radiochemotherapy and Experience with Sentinel Bleeding View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-02

AUTHORS

Olivier Turrini, Vincent Moutardier, Jerome Guiramand, Bernard Lelong, Erwan Bories, Antoine Sannini, Valerie Magnin, Frederic Viret, Jean-Louis Blache, Marc Giovannini, Jean-Robert Delpero

ABSTRACT

Postoperative hemorrhage (PH) after duodenopancreatectomy (DP) is frequently lethal. The aim of this study was to delineate guidelines of management. Between August 1994 and July 2003, 172 patients underwent DP for cancer. Altogether, 26 patients were subjected to an institutional protocol (IP) with standard-dose chemoradiation (CRT) and 4 patients to an extrainstitutional protocol (EIP) with high-dose CRT. Sixteen patients (9.3%) were reoperated for PH. Hemorrhage occurred in 23% of irradiated patients (4 EIP, 3 IP) and in 6% of nonirradiated patients [confidence interval (CI) 1.8-6.5]. Pancreatic leak occurred in nine patients with PH (56%). Sentinel bleeding (SB) was noted in eight patients (50%) with a mean delay of 10 days after DP. Overall mortality after hemorrhage was 56%. Morality rates of patients with EIP or IP were, respectively, 100% and 0%. Mortality rates of patients with or without SB were similar. Mortality rates of axial bleeding (hepatic artery, mesenteric vessels) or lateral bleeding (pancreas remnant, splenic vessels) were, respectively, 88% and 25% (CI 1.6-8.6). Completion of pancreatectomy was achieved in 75% without rebleeding. Preoperative high-dose CRT increased the risk of fatal PH. Because SB occurs before massive hemorrhage, prompt reoperation could reduce mortality. Completion of pancreatectomy was essential during reintervention. Axial bleeding supports high mortality. Moving to the left, the pancreatojejunostomy could avoid contact of pancreatic juice with axial vessels in the case of pancreatic leakage. Ligating the gastroduodenal artery during DP had to leave a stump of around 1 cm to facilitate hemorrhage control without ligating the common hepatic artery. More... »

PAGES

212-216

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00268-004-7557-3

DOI

http://dx.doi.org/10.1007/s00268-004-7557-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031683410

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15654661


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Neuroendocrine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ligation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoadjuvant Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreaticoduodenectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Postoperative Hemorrhage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reoperation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Surgical Oncology, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turrini", 
        "givenName": "Olivier", 
        "id": "sg:person.0640310146.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640310146.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgical Oncology, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moutardier", 
        "givenName": "Vincent", 
        "id": "sg:person.0601253364.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601253364.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgical Oncology, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guiramand", 
        "givenName": "Jerome", 
        "id": "sg:person.01230366154.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230366154.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgical Oncology, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lelong", 
        "givenName": "Bernard", 
        "id": "sg:person.0715501764.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715501764.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology-Endoscopy, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bories", 
        "givenName": "Erwan", 
        "id": "sg:person.0640775145.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640775145.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Intensive Care, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sannini", 
        "givenName": "Antoine", 
        "id": "sg:person.01247464005.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247464005.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Radiotherapy, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Magnin", 
        "givenName": "Valerie", 
        "id": "sg:person.01227407426.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227407426.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Medical Oncology, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Viret", 
        "givenName": "Frederic", 
        "id": "sg:person.01075141322.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075141322.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Intensive Care, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blache", 
        "givenName": "Jean-Louis", 
        "id": "sg:person.01027457225.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027457225.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Gastroenterology-Endoscopy, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giovannini", 
        "givenName": "Marc", 
        "id": "sg:person.01071452145.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071452145.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgical Oncology, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delpero", 
        "givenName": "Jean-Robert", 
        "id": "sg:person.01005527046.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005527046.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1001/archsurg.1991.01410310095014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003255909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.133.10.1099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004819139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200110000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010781875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200110000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010781875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200110000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010781875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200009000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016453257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200009000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016453257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.7-1-34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018408588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9610(05)80151-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023416749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(02)04157-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030402740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(02)04157-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030402740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s1091-255x(00)80105-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048529586", 
          "https://doi.org/10.1016/s1091-255x(00)80105-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1991.01410320127019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051728431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200107000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052290064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200107000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052290064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199709000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199709000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199709000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199802000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199802000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199802000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199802000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199810000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199810000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199810000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074841372", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078778817", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082907048", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083361199", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-02", 
    "datePublishedReg": "2005-02-01", 
    "description": "Postoperative hemorrhage (PH) after duodenopancreatectomy (DP) is frequently lethal. The aim of this study was to delineate guidelines of management. Between August 1994 and July 2003, 172 patients underwent DP for cancer. Altogether, 26 patients were subjected to an institutional protocol (IP) with standard-dose chemoradiation (CRT) and 4 patients to an extrainstitutional protocol (EIP) with high-dose CRT. Sixteen patients (9.3%) were reoperated for PH. Hemorrhage occurred in 23% of irradiated patients (4 EIP, 3 IP) and in 6% of nonirradiated patients [confidence interval (CI) 1.8-6.5]. Pancreatic leak occurred in nine patients with PH (56%). Sentinel bleeding (SB) was noted in eight patients (50%) with a mean delay of 10 days after DP. Overall mortality after hemorrhage was 56%. Morality rates of patients with EIP or IP were, respectively, 100% and 0%. Mortality rates of patients with or without SB were similar. Mortality rates of axial bleeding (hepatic artery, mesenteric vessels) or lateral bleeding (pancreas remnant, splenic vessels) were, respectively, 88% and 25% (CI 1.6-8.6). Completion of pancreatectomy was achieved in 75% without rebleeding. Preoperative high-dose CRT increased the risk of fatal PH. Because SB occurs before massive hemorrhage, prompt reoperation could reduce mortality. Completion of pancreatectomy was essential during reintervention. Axial bleeding supports high mortality. Moving to the left, the pancreatojejunostomy could avoid contact of pancreatic juice with axial vessels in the case of pancreatic leakage. Ligating the gastroduodenal artery during DP had to leave a stump of around 1 cm to facilitate hemorrhage control without ligating the common hepatic artery.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00268-004-7557-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1086446", 
        "issn": [
          "0364-2313", 
          "1432-2323"
        ], 
        "name": "World Journal of Surgery", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "29"
      }
    ], 
    "name": "Hemorrhage after Duodenopancreatectomy: Impact of Neoadjuvant Radiochemotherapy and Experience with Sentinel Bleeding", 
    "pagination": "212-216", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "96ef3f8f557e0442b391e617538328703d8c700ca6a9d008d7a68801c0caa2d8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15654661"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7704052"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00268-004-7557-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031683410"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00268-004-7557-3", 
      "https://app.dimensions.ai/details/publication/pub.1031683410"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000489.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00268-004-7557-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00268-004-7557-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00268-004-7557-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00268-004-7557-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00268-004-7557-3'


 

This table displays all metadata directly associated to this object as RDF triples.

278 TRIPLES      21 PREDICATES      64 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00268-004-7557-3 schema:about N0aed9a65a3794fed9827145bd6abbe42
2 N0c6a04f4092b40b49477b1c8b2eb5e87
3 N2433660a7feb40518864fef81c67aaee
4 N4679101a7005413b8c61515ce34c683c
5 N5e67d11f2b2047c6abb4cf897849e4fe
6 N64a42afb630641a49505c37f80ee38f6
7 N6623ab164924464ca3b536f21135a026
8 N69174be9e2004cd7967a00158bf26030
9 N6b5a83d346d84d33b2e236a48794ec0b
10 N78e1ac7da1124aa4b40b084ef39426c8
11 N80e2e9e4a26f4f1cb4ea1cc0f92c9d34
12 N9fc93c5d26e54d37a5afba4ff8fac4fc
13 Na9d465b6c05349b8bdcf732fe13f561b
14 Nb224066f707d4baf9c4d848851482bde
15 Nbe2d3c1179f04112bea2f9541a71436b
16 Nc3c306dbbb044c2b869ccb786b3586fa
17 Nc9b78acb11ac436caca146b81a3e524c
18 Nfd02010bdd0e41188c50870ce47a51ff
19 anzsrc-for:11
20 anzsrc-for:1103
21 schema:author Na7dd39831c174d7ba2e02228ab7e9d83
22 schema:citation sg:pub.10.1016/s1091-255x(00)80105-5
23 https://app.dimensions.ai/details/publication/pub.1074841372
24 https://app.dimensions.ai/details/publication/pub.1078778817
25 https://app.dimensions.ai/details/publication/pub.1082907048
26 https://app.dimensions.ai/details/publication/pub.1083361199
27 https://doi.org/10.1001/archsurg.133.10.1099
28 https://doi.org/10.1001/archsurg.1991.01410310095014
29 https://doi.org/10.1001/archsurg.1991.01410320127019
30 https://doi.org/10.1016/s0002-9610(05)80151-5
31 https://doi.org/10.1016/s0360-3016(02)04157-3
32 https://doi.org/10.1097/00000658-199709000-00004
33 https://doi.org/10.1097/00000658-199802000-00013
34 https://doi.org/10.1097/00000658-199810000-00007
35 https://doi.org/10.1097/00000658-200009000-00014
36 https://doi.org/10.1097/00000658-200107000-00008
37 https://doi.org/10.1097/00000658-200110000-00008
38 https://doi.org/10.1634/theoncologist.7-1-34
39 schema:datePublished 2005-02
40 schema:datePublishedReg 2005-02-01
41 schema:description Postoperative hemorrhage (PH) after duodenopancreatectomy (DP) is frequently lethal. The aim of this study was to delineate guidelines of management. Between August 1994 and July 2003, 172 patients underwent DP for cancer. Altogether, 26 patients were subjected to an institutional protocol (IP) with standard-dose chemoradiation (CRT) and 4 patients to an extrainstitutional protocol (EIP) with high-dose CRT. Sixteen patients (9.3%) were reoperated for PH. Hemorrhage occurred in 23% of irradiated patients (4 EIP, 3 IP) and in 6% of nonirradiated patients [confidence interval (CI) 1.8-6.5]. Pancreatic leak occurred in nine patients with PH (56%). Sentinel bleeding (SB) was noted in eight patients (50%) with a mean delay of 10 days after DP. Overall mortality after hemorrhage was 56%. Morality rates of patients with EIP or IP were, respectively, 100% and 0%. Mortality rates of patients with or without SB were similar. Mortality rates of axial bleeding (hepatic artery, mesenteric vessels) or lateral bleeding (pancreas remnant, splenic vessels) were, respectively, 88% and 25% (CI 1.6-8.6). Completion of pancreatectomy was achieved in 75% without rebleeding. Preoperative high-dose CRT increased the risk of fatal PH. Because SB occurs before massive hemorrhage, prompt reoperation could reduce mortality. Completion of pancreatectomy was essential during reintervention. Axial bleeding supports high mortality. Moving to the left, the pancreatojejunostomy could avoid contact of pancreatic juice with axial vessels in the case of pancreatic leakage. Ligating the gastroduodenal artery during DP had to leave a stump of around 1 cm to facilitate hemorrhage control without ligating the common hepatic artery.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree false
45 schema:isPartOf N4e2557fbb16f4a4e9373dd494efd9523
46 Nde3be64a733946679f067a53d3444809
47 sg:journal.1086446
48 schema:name Hemorrhage after Duodenopancreatectomy: Impact of Neoadjuvant Radiochemotherapy and Experience with Sentinel Bleeding
49 schema:pagination 212-216
50 schema:productId N0c3664a0054c45b6880155e35434d518
51 N37b927604ceb4a65a1a573dd366b2d36
52 Nbd098b97fe5648f58b6dec8f5c1e1c22
53 Ncacb71194e274e0da2ed0164463de6a4
54 Neb3f56341ac3491db77e7b455072ac6f
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031683410
56 https://doi.org/10.1007/s00268-004-7557-3
57 schema:sdDatePublished 2019-04-10T22:26
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher N428c2041cadb43dea0259ba84719281e
60 schema:url http://link.springer.com/10.1007/s00268-004-7557-3
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N07c34dee54734ae5893fc65794943def schema:name Department of Medical Oncology, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France
65 rdf:type schema:Organization
66 N0aed9a65a3794fed9827145bd6abbe42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Ligation
68 rdf:type schema:DefinedTerm
69 N0c3664a0054c45b6880155e35434d518 schema:name pubmed_id
70 schema:value 15654661
71 rdf:type schema:PropertyValue
72 N0c6a04f4092b40b49477b1c8b2eb5e87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Chemotherapy, Adjuvant
74 rdf:type schema:DefinedTerm
75 N1cf74d7eb4704cb38420b0234376f513 rdf:first sg:person.01075141322.65
76 rdf:rest Ne79c2fd226a64be89e7ca12c4dd0fcef
77 N2433660a7feb40518864fef81c67aaee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Neoadjuvant Therapy
79 rdf:type schema:DefinedTerm
80 N37b927604ceb4a65a1a573dd366b2d36 schema:name dimensions_id
81 schema:value pub.1031683410
82 rdf:type schema:PropertyValue
83 N428c2041cadb43dea0259ba84719281e schema:name Springer Nature - SN SciGraph project
84 rdf:type schema:Organization
85 N4679101a7005413b8c61515ce34c683c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Middle Aged
87 rdf:type schema:DefinedTerm
88 N4d392abd32ed439bb8832f8c5c64e256 rdf:first sg:person.01227407426.05
89 rdf:rest N1cf74d7eb4704cb38420b0234376f513
90 N4e2557fbb16f4a4e9373dd494efd9523 schema:issueNumber 2
91 rdf:type schema:PublicationIssue
92 N5d96325aec374dc1bfcdefe55f52bdf8 schema:name Department of Intensive Care, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France
93 rdf:type schema:Organization
94 N5e67d11f2b2047c6abb4cf897849e4fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Retrospective Studies
96 rdf:type schema:DefinedTerm
97 N60f1c83a9677406083de87add3d7546b schema:name Department of Surgical Oncology, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France
98 rdf:type schema:Organization
99 N64a42afb630641a49505c37f80ee38f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Reoperation
101 rdf:type schema:DefinedTerm
102 N6623ab164924464ca3b536f21135a026 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Pancreatic Neoplasms
104 rdf:type schema:DefinedTerm
105 N69174be9e2004cd7967a00158bf26030 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Aged, 80 and over
107 rdf:type schema:DefinedTerm
108 N6b5a83d346d84d33b2e236a48794ec0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Adenocarcinoma
110 rdf:type schema:DefinedTerm
111 N70ef9ae7b6fb456eb9706cf8bad96a7e rdf:first sg:person.0640775145.87
112 rdf:rest Ncbaff023e29d44a8a98fc55958ca4eff
113 N7211271174fb4bd0b727210c4146563c rdf:first sg:person.0715501764.33
114 rdf:rest N70ef9ae7b6fb456eb9706cf8bad96a7e
115 N78e1ac7da1124aa4b40b084ef39426c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Carcinoma, Neuroendocrine
117 rdf:type schema:DefinedTerm
118 N7a5bd048eac2405cb1d11518196772fe schema:name Department of Surgical Oncology, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France
119 rdf:type schema:Organization
120 N80e2e9e4a26f4f1cb4ea1cc0f92c9d34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Adult
122 rdf:type schema:DefinedTerm
123 N82c32dbecadf45d7a484ea30c95d4f43 schema:name Department of Surgical Oncology, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France
124 rdf:type schema:Organization
125 N840167f60c734604b36be4d54702176c schema:name Department of Radiotherapy, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France
126 rdf:type schema:Organization
127 N8b7c513c7d2e43efab8896db2db67244 schema:name Department of Intensive Care, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France
128 rdf:type schema:Organization
129 N933e1d9c25584c50822bc00938a48743 rdf:first sg:person.0601253364.64
130 rdf:rest Nf85f088e33d84ce6837884090f3bbe21
131 N9fc93c5d26e54d37a5afba4ff8fac4fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Radiotherapy, Adjuvant
133 rdf:type schema:DefinedTerm
134 Na2e1fc523884401288c1131087c49a86 schema:name Department of Gastroenterology-Endoscopy, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France
135 rdf:type schema:Organization
136 Na7dd39831c174d7ba2e02228ab7e9d83 rdf:first sg:person.0640310146.73
137 rdf:rest N933e1d9c25584c50822bc00938a48743
138 Na9d465b6c05349b8bdcf732fe13f561b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Male
140 rdf:type schema:DefinedTerm
141 Naa65b79d22844a9c829c12e9ecb4ac80 rdf:first sg:person.01005527046.96
142 rdf:rest rdf:nil
143 Nb224066f707d4baf9c4d848851482bde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Humans
145 rdf:type schema:DefinedTerm
146 Nbd098b97fe5648f58b6dec8f5c1e1c22 schema:name readcube_id
147 schema:value 96ef3f8f557e0442b391e617538328703d8c700ca6a9d008d7a68801c0caa2d8
148 rdf:type schema:PropertyValue
149 Nbe2d3c1179f04112bea2f9541a71436b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Aged
151 rdf:type schema:DefinedTerm
152 Nc3c306dbbb044c2b869ccb786b3586fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Postoperative Hemorrhage
154 rdf:type schema:DefinedTerm
155 Nc9b78acb11ac436caca146b81a3e524c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Female
157 rdf:type schema:DefinedTerm
158 Ncacb71194e274e0da2ed0164463de6a4 schema:name nlm_unique_id
159 schema:value 7704052
160 rdf:type schema:PropertyValue
161 Ncbaff023e29d44a8a98fc55958ca4eff rdf:first sg:person.01247464005.49
162 rdf:rest N4d392abd32ed439bb8832f8c5c64e256
163 Ncc69e42c05f246b3acbb0d91f3127ae3 schema:name Department of Surgical Oncology, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France
164 rdf:type schema:Organization
165 Nd6097693839c44a4919d4aac93f18928 schema:name Department of Gastroenterology-Endoscopy, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France
166 rdf:type schema:Organization
167 Nde3be64a733946679f067a53d3444809 schema:volumeNumber 29
168 rdf:type schema:PublicationVolume
169 Ne646b24ca7ce433eb8ea25512f2ada09 schema:name Department of Surgical Oncology, Institute Paoli-Calmettes, Universite de la Mediterranee, 232 Boulevard Sainte Marguerite, 13009, Marseille, France
170 rdf:type schema:Organization
171 Ne79c2fd226a64be89e7ca12c4dd0fcef rdf:first sg:person.01027457225.55
172 rdf:rest Nfd573215a9dc4c95a288fb730f91ef87
173 Neb3f56341ac3491db77e7b455072ac6f schema:name doi
174 schema:value 10.1007/s00268-004-7557-3
175 rdf:type schema:PropertyValue
176 Nf85f088e33d84ce6837884090f3bbe21 rdf:first sg:person.01230366154.70
177 rdf:rest N7211271174fb4bd0b727210c4146563c
178 Nfd02010bdd0e41188c50870ce47a51ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Pancreaticoduodenectomy
180 rdf:type schema:DefinedTerm
181 Nfd573215a9dc4c95a288fb730f91ef87 rdf:first sg:person.01071452145.89
182 rdf:rest Naa65b79d22844a9c829c12e9ecb4ac80
183 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
184 schema:name Medical and Health Sciences
185 rdf:type schema:DefinedTerm
186 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
187 schema:name Clinical Sciences
188 rdf:type schema:DefinedTerm
189 sg:journal.1086446 schema:issn 0364-2313
190 1432-2323
191 schema:name World Journal of Surgery
192 rdf:type schema:Periodical
193 sg:person.01005527046.96 schema:affiliation Ne646b24ca7ce433eb8ea25512f2ada09
194 schema:familyName Delpero
195 schema:givenName Jean-Robert
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005527046.96
197 rdf:type schema:Person
198 sg:person.01027457225.55 schema:affiliation N8b7c513c7d2e43efab8896db2db67244
199 schema:familyName Blache
200 schema:givenName Jean-Louis
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027457225.55
202 rdf:type schema:Person
203 sg:person.01071452145.89 schema:affiliation Nd6097693839c44a4919d4aac93f18928
204 schema:familyName Giovannini
205 schema:givenName Marc
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071452145.89
207 rdf:type schema:Person
208 sg:person.01075141322.65 schema:affiliation N07c34dee54734ae5893fc65794943def
209 schema:familyName Viret
210 schema:givenName Frederic
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075141322.65
212 rdf:type schema:Person
213 sg:person.01227407426.05 schema:affiliation N840167f60c734604b36be4d54702176c
214 schema:familyName Magnin
215 schema:givenName Valerie
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227407426.05
217 rdf:type schema:Person
218 sg:person.01230366154.70 schema:affiliation Ncc69e42c05f246b3acbb0d91f3127ae3
219 schema:familyName Guiramand
220 schema:givenName Jerome
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230366154.70
222 rdf:type schema:Person
223 sg:person.01247464005.49 schema:affiliation N5d96325aec374dc1bfcdefe55f52bdf8
224 schema:familyName Sannini
225 schema:givenName Antoine
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247464005.49
227 rdf:type schema:Person
228 sg:person.0601253364.64 schema:affiliation N82c32dbecadf45d7a484ea30c95d4f43
229 schema:familyName Moutardier
230 schema:givenName Vincent
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601253364.64
232 rdf:type schema:Person
233 sg:person.0640310146.73 schema:affiliation N7a5bd048eac2405cb1d11518196772fe
234 schema:familyName Turrini
235 schema:givenName Olivier
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640310146.73
237 rdf:type schema:Person
238 sg:person.0640775145.87 schema:affiliation Na2e1fc523884401288c1131087c49a86
239 schema:familyName Bories
240 schema:givenName Erwan
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640775145.87
242 rdf:type schema:Person
243 sg:person.0715501764.33 schema:affiliation N60f1c83a9677406083de87add3d7546b
244 schema:familyName Lelong
245 schema:givenName Bernard
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715501764.33
247 rdf:type schema:Person
248 sg:pub.10.1016/s1091-255x(00)80105-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048529586
249 https://doi.org/10.1016/s1091-255x(00)80105-5
250 rdf:type schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1074841372 schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1078778817 schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1082907048 schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1083361199 schema:CreativeWork
255 https://doi.org/10.1001/archsurg.133.10.1099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004819139
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1001/archsurg.1991.01410310095014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003255909
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1001/archsurg.1991.01410320127019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051728431
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/s0002-9610(05)80151-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023416749
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/s0360-3016(02)04157-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030402740
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1097/00000658-199709000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060134615
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1097/00000658-199802000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060134702
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1097/00000658-199810000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060134874
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1097/00000658-200009000-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016453257
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1097/00000658-200107000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052290064
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1097/00000658-200110000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010781875
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1634/theoncologist.7-1-34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018408588
278 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...