Pain management of patients with unresectable peripancreatic carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-06

AUTHORS

Rutger C. I. van Geenen, Claudia M. G. Keyzer-Dekker, Geertjan van Tienhoven, Huug Obertop, Dirk J. Gouma

ABSTRACT

In patients with unresectable peripancreatic carcinoma, pain is generally treated with pain medication or with a celiac plexus blockade. Radiotherapy has also been reported to reduce pain. The efficacy of these treatment modalities is still under discussion. The aim of this study was to analyze the effects of the various types of pain management on patients who underwent palliative bypass surgery for unresectable peripancreatic carcinoma. During the period January 1995 to December 1998 a series of 98 patients underwent palliative bypass surgery, mostly for unresectable disease found during exploration. Patients were divided into three groups: palliative bypass surgery (BP), palliative bypass surgery with an intraoperative celiac plexus blockade (CPB), and palliative bypass surgery with or without celiac plexus blockade followed by high-dose conformal radiotherapy (RT). Radiotherapy was performed only in selected patients with locally advanced disease and without metastases, implying a better prognosis of the last group. The pain medication consumption, pain medication-free survival, hospital-free survival, and overall survival were analyzed. The preoperative consumption of pain medication was significantly higher in the CPB group than in the BP or RT group. The postoperative consumption of pain medication in the CPB, BP, and RT groups increased during follow-up from 15%, 17%, and 13% before surgery to 52%, 57%, and 46%, respectively, at three-fourths of the survival time (NS). This increase in consumption of pain medication was not different in the three groups. In the RT group the median pain medication-free survival was significantly longer than in the BP or CPB group (9.3 vs. 3.1 and 3.3 months; p = 0.02). The median hospital-free survival and median overall survival were significantly longer in the RT group than in the CPB group (10.3 vs. 6.8 months, p = 0.01; and 7.1 vs. 10.8 months, p = 0.01). Celiac plexus blockade as pain management did not result in an increase of the pain medication-free survival or overall survival. Therefore a positive effect of a celiac plexus blockade on pain could not be confirmed in the present study. Radiotherapy resulted in increased pain-medication survival, hospital-free survival, and overall survival compared to celiac plexus blockade. These effects are probably partly related to patient selection. More... »

PAGES

715-720

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00268-002-6210-2

DOI

http://dx.doi.org/10.1007/s00268-002-6210-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014078711

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12053225


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autonomic Nerve Block", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Celiac Plexus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Common Bile Duct Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Duodenal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pain Management", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Palliative Care", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiotherapy, Conformal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Academic Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.5650.6", 
          "name": [
            "Department of Surgery, Academic Medical Center, Meibergdreef 9, PO Box 22660, 1100 DD, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Geenen", 
        "givenName": "Rutger C. I.", 
        "id": "sg:person.011606051007.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011606051007.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academic Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.5650.6", 
          "name": [
            "Department of Surgery, Academic Medical Center, Meibergdreef 9, PO Box 22660, 1100 DD, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keyzer-Dekker", 
        "givenName": "Claudia M. G.", 
        "id": "sg:person.01321122625.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321122625.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academic Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.5650.6", 
          "name": [
            "Department of Radiotherapy, Academic Medical Center, Meibergdreef 9, PO Box 22660, 1100 DD, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Tienhoven", 
        "givenName": "Geertjan", 
        "id": "sg:person.01063151610.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063151610.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academic Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.5650.6", 
          "name": [
            "Department of Surgery, Academic Medical Center, Meibergdreef 9, PO Box 22660, 1100 DD, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Obertop", 
        "givenName": "Huug", 
        "id": "sg:person.015472670014.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015472670014.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academic Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.5650.6", 
          "name": [
            "Department of Surgery, Academic Medical Center, Meibergdreef 9, PO Box 22660, 1100 DD, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gouma", 
        "givenName": "Dirk J.", 
        "id": "sg:person.0650623704.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650623704.27"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1365-2168.1997.02799.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000780013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1997.104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003070296", 
          "https://doi.org/10.1038/bjc.1997.104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1997.104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003070296", 
          "https://doi.org/10.1038/bjc.1997.104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(92)90648-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003085983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3959(95)00189-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004216040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3959(95)00189-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004216040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(91)90146-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009099019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199305010-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015251569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199305010-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015251569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1072-7515(99)00049-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017865150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19851201)56:11<2563::aid-cncr2820561104>3.0.co;2-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018642573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0950-3528(90)90030-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018746030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0039-6060(97)90264-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019038679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19960801)78:3<639::aid-cncr45>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030755596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0885-3924(88)90031-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030898952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(96)05523-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031500206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198409000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031623577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-198409000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031623577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/10.suppl_4.s265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032487599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9610(05)80669-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033814248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000201100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035168778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19830901)52:5<808::aid-cncr2820520510>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039970302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800790105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040514329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3959(93)90130-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043801614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3959(93)90130-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043801614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199401000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048153947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199401000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048153947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2168.1998.00563.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049993214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(90)90486-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052052816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800841018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054296491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.annonc.a059031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082403161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082466580", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082883163", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083334556", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-06", 
    "datePublishedReg": "2002-06-01", 
    "description": "In patients with unresectable peripancreatic carcinoma, pain is generally treated with pain medication or with a celiac plexus blockade. Radiotherapy has also been reported to reduce pain. The efficacy of these treatment modalities is still under discussion. The aim of this study was to analyze the effects of the various types of pain management on patients who underwent palliative bypass surgery for unresectable peripancreatic carcinoma. During the period January 1995 to December 1998 a series of 98 patients underwent palliative bypass surgery, mostly for unresectable disease found during exploration. Patients were divided into three groups: palliative bypass surgery (BP), palliative bypass surgery with an intraoperative celiac plexus blockade (CPB), and palliative bypass surgery with or without celiac plexus blockade followed by high-dose conformal radiotherapy (RT). Radiotherapy was performed only in selected patients with locally advanced disease and without metastases, implying a better prognosis of the last group. The pain medication consumption, pain medication-free survival, hospital-free survival, and overall survival were analyzed. The preoperative consumption of pain medication was significantly higher in the CPB group than in the BP or RT group. The postoperative consumption of pain medication in the CPB, BP, and RT groups increased during follow-up from 15%, 17%, and 13% before surgery to 52%, 57%, and 46%, respectively, at three-fourths of the survival time (NS). This increase in consumption of pain medication was not different in the three groups. In the RT group the median pain medication-free survival was significantly longer than in the BP or CPB group (9.3 vs. 3.1 and 3.3 months; p = 0.02). The median hospital-free survival and median overall survival were significantly longer in the RT group than in the CPB group (10.3 vs. 6.8 months, p = 0.01; and 7.1 vs. 10.8 months, p = 0.01). Celiac plexus blockade as pain management did not result in an increase of the pain medication-free survival or overall survival. Therefore a positive effect of a celiac plexus blockade on pain could not be confirmed in the present study. Radiotherapy resulted in increased pain-medication survival, hospital-free survival, and overall survival compared to celiac plexus blockade. These effects are probably partly related to patient selection.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00268-002-6210-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1086446", 
        "issn": [
          "0364-2313", 
          "1432-2323"
        ], 
        "name": "World Journal of Surgery", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "26"
      }
    ], 
    "name": "Pain management of patients with unresectable peripancreatic carcinoma", 
    "pagination": "715-720", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4311ca20d4ca595874d798291309106c1c89b64d9df197059e9efb841fc3d644"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12053225"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7704052"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00268-002-6210-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014078711"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00268-002-6210-2", 
      "https://app.dimensions.ai/details/publication/pub.1014078711"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000511.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00268-002-6210-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00268-002-6210-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00268-002-6210-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00268-002-6210-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00268-002-6210-2'


 

This table displays all metadata directly associated to this object as RDF triples.

256 TRIPLES      21 PREDICATES      76 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00268-002-6210-2 schema:about N06104d08c6a94c6cb2b825a00a489779
2 N09aedac16d6b4450b12516a43c37dd8d
3 N1653264a3b8c429c972890d0ab33521b
4 N21ecbe3e63a142a79a2c2998b7022fcd
5 N283e759aa4374f7399547b50855cce7f
6 N620d5cddf42d4fc1aff50927b324f3d8
7 N6b27f9567d814cf190ba6eeff0cb3ad5
8 N74859661a1d04934aa28ddf672d763cb
9 N7634db6b79944549a3cb42e569d63f11
10 N84cf4780b40f41b19cc441bd9df9e607
11 N946ec690b081404ab02369ac66de23d8
12 Na098b50e02364a5d9b77aabe89bdaf08
13 Nb64637792ee54698b2912fb4633c6671
14 Nbaa561a438f842c99a9f11cb2f1216ce
15 Nbba0419461674d9a9c89aff350cb5af4
16 Nbc279ff7f8dd4a1e8e0afc98b063e4e4
17 Neb48a61bfbe4430f8c202efef2f0bffd
18 Nf99ceb35dfe0470b84ae3891ff9b540b
19 Nffbe7b986583435db9ca00af429ccead
20 anzsrc-for:11
21 anzsrc-for:1103
22 schema:author N25af609a76af4d8ab724d052a8f0c270
23 schema:citation sg:pub.10.1038/bjc.1997.104
24 https://app.dimensions.ai/details/publication/pub.1082466580
25 https://app.dimensions.ai/details/publication/pub.1082883163
26 https://app.dimensions.ai/details/publication/pub.1083334556
27 https://doi.org/10.1002/(sici)1097-0142(19960801)78:3<639::aid-cncr45>3.0.co;2-x
28 https://doi.org/10.1002/1097-0142(19830901)52:5<808::aid-cncr2820520510>3.0.co;2-u
29 https://doi.org/10.1002/1097-0142(19851201)56:11<2563::aid-cncr2820561104>3.0.co;2-0
30 https://doi.org/10.1002/bjs.1800790105
31 https://doi.org/10.1002/bjs.1800841018
32 https://doi.org/10.1016/0304-3959(93)90130-h
33 https://doi.org/10.1016/0304-3959(95)00189-1
34 https://doi.org/10.1016/0360-3016(90)90486-4
35 https://doi.org/10.1016/0360-3016(91)90146-u
36 https://doi.org/10.1016/0360-3016(92)90648-2
37 https://doi.org/10.1016/0885-3924(88)90031-0
38 https://doi.org/10.1016/0950-3528(90)90030-k
39 https://doi.org/10.1016/s0002-9610(05)80669-5
40 https://doi.org/10.1016/s0039-6060(97)90264-6
41 https://doi.org/10.1016/s0140-6736(96)05523-7
42 https://doi.org/10.1016/s1072-7515(99)00049-6
43 https://doi.org/10.1046/j.1365-2168.1998.00563.x
44 https://doi.org/10.1093/annonc/10.suppl_4.s265
45 https://doi.org/10.1093/oxfordjournals.annonc.a059031
46 https://doi.org/10.1097/00000658-198409000-00006
47 https://doi.org/10.1097/00000658-199305010-00004
48 https://doi.org/10.1097/00000658-199401000-00004
49 https://doi.org/10.1111/j.1365-2168.1997.02799.x
50 https://doi.org/10.1159/000201100
51 schema:datePublished 2002-06
52 schema:datePublishedReg 2002-06-01
53 schema:description In patients with unresectable peripancreatic carcinoma, pain is generally treated with pain medication or with a celiac plexus blockade. Radiotherapy has also been reported to reduce pain. The efficacy of these treatment modalities is still under discussion. The aim of this study was to analyze the effects of the various types of pain management on patients who underwent palliative bypass surgery for unresectable peripancreatic carcinoma. During the period January 1995 to December 1998 a series of 98 patients underwent palliative bypass surgery, mostly for unresectable disease found during exploration. Patients were divided into three groups: palliative bypass surgery (BP), palliative bypass surgery with an intraoperative celiac plexus blockade (CPB), and palliative bypass surgery with or without celiac plexus blockade followed by high-dose conformal radiotherapy (RT). Radiotherapy was performed only in selected patients with locally advanced disease and without metastases, implying a better prognosis of the last group. The pain medication consumption, pain medication-free survival, hospital-free survival, and overall survival were analyzed. The preoperative consumption of pain medication was significantly higher in the CPB group than in the BP or RT group. The postoperative consumption of pain medication in the CPB, BP, and RT groups increased during follow-up from 15%, 17%, and 13% before surgery to 52%, 57%, and 46%, respectively, at three-fourths of the survival time (NS). This increase in consumption of pain medication was not different in the three groups. In the RT group the median pain medication-free survival was significantly longer than in the BP or CPB group (9.3 vs. 3.1 and 3.3 months; p = 0.02). The median hospital-free survival and median overall survival were significantly longer in the RT group than in the CPB group (10.3 vs. 6.8 months, p = 0.01; and 7.1 vs. 10.8 months, p = 0.01). Celiac plexus blockade as pain management did not result in an increase of the pain medication-free survival or overall survival. Therefore a positive effect of a celiac plexus blockade on pain could not be confirmed in the present study. Radiotherapy resulted in increased pain-medication survival, hospital-free survival, and overall survival compared to celiac plexus blockade. These effects are probably partly related to patient selection.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree false
57 schema:isPartOf N11e49fdd7baa4cf287123e0468409f00
58 Nc7d3fcbdc6c84292b736cb21d4d46c88
59 sg:journal.1086446
60 schema:name Pain management of patients with unresectable peripancreatic carcinoma
61 schema:pagination 715-720
62 schema:productId N05038da1bd374c1dbc9d4ff307aab2e2
63 N2729473945e2450e9fdd6ccd428b137a
64 N7c442c1ffe904a12a3a3c73e21d95ac8
65 N8749d7413bab4e4083b670e8ae3f1b37
66 Na233cd94c8db4ac6950c825e7737c001
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014078711
68 https://doi.org/10.1007/s00268-002-6210-2
69 schema:sdDatePublished 2019-04-10T13:16
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher Nbe5a816921534fda897f8ea16bcf8431
72 schema:url http://link.springer.com/10.1007%2Fs00268-002-6210-2
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N05038da1bd374c1dbc9d4ff307aab2e2 schema:name doi
77 schema:value 10.1007/s00268-002-6210-2
78 rdf:type schema:PropertyValue
79 N06104d08c6a94c6cb2b825a00a489779 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Autonomic Nerve Block
81 rdf:type schema:DefinedTerm
82 N09aedac16d6b4450b12516a43c37dd8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Duodenal Neoplasms
84 rdf:type schema:DefinedTerm
85 N11e49fdd7baa4cf287123e0468409f00 schema:issueNumber 6
86 rdf:type schema:PublicationIssue
87 N1653264a3b8c429c972890d0ab33521b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Aged
89 rdf:type schema:DefinedTerm
90 N21ecbe3e63a142a79a2c2998b7022fcd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Celiac Plexus
92 rdf:type schema:DefinedTerm
93 N25af609a76af4d8ab724d052a8f0c270 rdf:first sg:person.011606051007.40
94 rdf:rest Nd532b430b5464fd397db0aa27c817a1f
95 N2729473945e2450e9fdd6ccd428b137a schema:name pubmed_id
96 schema:value 12053225
97 rdf:type schema:PropertyValue
98 N283e759aa4374f7399547b50855cce7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Palliative Care
100 rdf:type schema:DefinedTerm
101 N411e8ac10a7549de89af49df70ad4af7 rdf:first sg:person.0650623704.27
102 rdf:rest rdf:nil
103 N620d5cddf42d4fc1aff50927b324f3d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Radiotherapy, Conformal
105 rdf:type schema:DefinedTerm
106 N6b27f9567d814cf190ba6eeff0cb3ad5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Male
108 rdf:type schema:DefinedTerm
109 N74859661a1d04934aa28ddf672d763cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Middle Aged
111 rdf:type schema:DefinedTerm
112 N7634db6b79944549a3cb42e569d63f11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Adult
114 rdf:type schema:DefinedTerm
115 N7c442c1ffe904a12a3a3c73e21d95ac8 schema:name dimensions_id
116 schema:value pub.1014078711
117 rdf:type schema:PropertyValue
118 N80712a0c5361485c9f2a2805455ecf68 rdf:first sg:person.01063151610.64
119 rdf:rest N85369b55d5054ac3afaefb3787939291
120 N84cf4780b40f41b19cc441bd9df9e607 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Retrospective Studies
122 rdf:type schema:DefinedTerm
123 N85369b55d5054ac3afaefb3787939291 rdf:first sg:person.015472670014.82
124 rdf:rest N411e8ac10a7549de89af49df70ad4af7
125 N8749d7413bab4e4083b670e8ae3f1b37 schema:name readcube_id
126 schema:value 4311ca20d4ca595874d798291309106c1c89b64d9df197059e9efb841fc3d644
127 rdf:type schema:PropertyValue
128 N946ec690b081404ab02369ac66de23d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Aged, 80 and over
130 rdf:type schema:DefinedTerm
131 Na098b50e02364a5d9b77aabe89bdaf08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Humans
133 rdf:type schema:DefinedTerm
134 Na233cd94c8db4ac6950c825e7737c001 schema:name nlm_unique_id
135 schema:value 7704052
136 rdf:type schema:PropertyValue
137 Nb64637792ee54698b2912fb4633c6671 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Cohort Studies
139 rdf:type schema:DefinedTerm
140 Nbaa561a438f842c99a9f11cb2f1216ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Pain
142 rdf:type schema:DefinedTerm
143 Nbba0419461674d9a9c89aff350cb5af4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Female
145 rdf:type schema:DefinedTerm
146 Nbc279ff7f8dd4a1e8e0afc98b063e4e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Pancreatic Neoplasms
148 rdf:type schema:DefinedTerm
149 Nbe5a816921534fda897f8ea16bcf8431 schema:name Springer Nature - SN SciGraph project
150 rdf:type schema:Organization
151 Nc7d3fcbdc6c84292b736cb21d4d46c88 schema:volumeNumber 26
152 rdf:type schema:PublicationVolume
153 Nd532b430b5464fd397db0aa27c817a1f rdf:first sg:person.01321122625.54
154 rdf:rest N80712a0c5361485c9f2a2805455ecf68
155 Neb48a61bfbe4430f8c202efef2f0bffd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Treatment Outcome
157 rdf:type schema:DefinedTerm
158 Nf99ceb35dfe0470b84ae3891ff9b540b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Common Bile Duct Neoplasms
160 rdf:type schema:DefinedTerm
161 Nffbe7b986583435db9ca00af429ccead schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Pain Management
163 rdf:type schema:DefinedTerm
164 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
165 schema:name Medical and Health Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
168 schema:name Clinical Sciences
169 rdf:type schema:DefinedTerm
170 sg:journal.1086446 schema:issn 0364-2313
171 1432-2323
172 schema:name World Journal of Surgery
173 rdf:type schema:Periodical
174 sg:person.01063151610.64 schema:affiliation https://www.grid.ac/institutes/grid.5650.6
175 schema:familyName van Tienhoven
176 schema:givenName Geertjan
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063151610.64
178 rdf:type schema:Person
179 sg:person.011606051007.40 schema:affiliation https://www.grid.ac/institutes/grid.5650.6
180 schema:familyName van Geenen
181 schema:givenName Rutger C. I.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011606051007.40
183 rdf:type schema:Person
184 sg:person.01321122625.54 schema:affiliation https://www.grid.ac/institutes/grid.5650.6
185 schema:familyName Keyzer-Dekker
186 schema:givenName Claudia M. G.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321122625.54
188 rdf:type schema:Person
189 sg:person.015472670014.82 schema:affiliation https://www.grid.ac/institutes/grid.5650.6
190 schema:familyName Obertop
191 schema:givenName Huug
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015472670014.82
193 rdf:type schema:Person
194 sg:person.0650623704.27 schema:affiliation https://www.grid.ac/institutes/grid.5650.6
195 schema:familyName Gouma
196 schema:givenName Dirk J.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650623704.27
198 rdf:type schema:Person
199 sg:pub.10.1038/bjc.1997.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003070296
200 https://doi.org/10.1038/bjc.1997.104
201 rdf:type schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1082466580 schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1082883163 schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1083334556 schema:CreativeWork
205 https://doi.org/10.1002/(sici)1097-0142(19960801)78:3<639::aid-cncr45>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030755596
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1002/1097-0142(19830901)52:5<808::aid-cncr2820520510>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1039970302
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1002/1097-0142(19851201)56:11<2563::aid-cncr2820561104>3.0.co;2-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018642573
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1002/bjs.1800790105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040514329
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1002/bjs.1800841018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054296491
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/0304-3959(93)90130-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1043801614
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/0304-3959(95)00189-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004216040
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/0360-3016(90)90486-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052052816
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/0360-3016(91)90146-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1009099019
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/0360-3016(92)90648-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003085983
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/0885-3924(88)90031-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030898952
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/0950-3528(90)90030-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1018746030
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0002-9610(05)80669-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033814248
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s0039-6060(97)90264-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019038679
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s0140-6736(96)05523-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031500206
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/s1072-7515(99)00049-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017865150
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1046/j.1365-2168.1998.00563.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049993214
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1093/annonc/10.suppl_4.s265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032487599
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1093/oxfordjournals.annonc.a059031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082403161
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1097/00000658-198409000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031623577
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1097/00000658-199305010-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015251569
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1097/00000658-199401000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048153947
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1111/j.1365-2168.1997.02799.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000780013
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1159/000201100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035168778
252 rdf:type schema:CreativeWork
253 https://www.grid.ac/institutes/grid.5650.6 schema:alternateName Academic Medical Center
254 schema:name Department of Radiotherapy, Academic Medical Center, Meibergdreef 9, PO Box 22660, 1100 DD, Amsterdam, The Netherlands
255 Department of Surgery, Academic Medical Center, Meibergdreef 9, PO Box 22660, 1100 DD, Amsterdam, The Netherlands
256 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...