Clinicopathological prognostic factors and impact of surgical treatment of mass-forming intrahepatic cholangiocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-06

AUTHORS

Shohachi Suzuki, Takanori Sakaguchi, Yoshihiro Yokoi, Kazuya Okamoto, Kiyotaka Kurachi, Yasuo Tsuchiya, Takuya Okumura, Hiroyuki Konno, Satoshi Baba, Satoshi Nakamura

ABSTRACT

The clinicopathological characteristics relevant to prognosis after surgical treatment of intrahepatic cholangiocarcinoma (ICC) remain unclear. In this study, the clinicopathological features of 19 patients with mass-forming ICC, the most common form of the disease, were reviewed to analyze prognostic determinants. Two or more segmentectomies of the liver with systematic lymphadenectomy were performed in 18 patients. Resection of the extrahepatic bile duct was performed in 14 patients, and reconstruction of the portal vein was accomplished in 5 patients. Stage IVA or IVB tumors were seen in 13 patients, and lymph node (LN) metastasis was present in 14 patients. The estimated 5-year survival rate after surgery for mass-forming ICC was 28%, with median survival time of 18 months. In univariate analysis, five variables were determined to be significantly correlated with poor survival of patients with mass-forming ICC after surgery. These variables include mass-forming ICC with periductal infiltration, perineural invasion, portal vein invasion, presence of intrahepatic metastasis, and two or more LN metastases. Survival rates of 5 patients without LN metastasis and 6 patients with a single LN metastasis were 80% and 33% at 5 years, respectively, while 8 patients with two or more LN metastasis failed to survive beyond 2 years. Multivariate analysis revealed the presence of intrahepatic metastasis to be an independent prognostic factor of poor survival. Hepatectomy with resection of the extrahepatic bile duct and systematic lymphadenectomy yields a good chance for prolonged survival for patients with mass-forming ICC when the lesion is singular and LN metastasis is limited to a regional LN. Because the presence of intrahepatic metastasis was closely related to a poor prognosis in patients with mass-forming ICC, efficacious chemotherapy would be needed to control development of the lesion. More... »

PAGES

687-693

References to SciGraph publications

  • 1999-07. Clinicopathological features and outcome of hepatic resection for intrahepatic cholangiocarcinoma in Japan in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 1995-01. Surgical treatment of cholangiocellular carcinoma in WORLD JOURNAL OF SURGERY
  • 1998-04. Surgical management of intrahepatic cholangiocarcinoma: A 31-year experience in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 1999-07. Intrahepatic cholangiocarcinoma in Korea in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 1999-07. Resection of intrahepatic cholangiocarcinoma: a Western experience in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00268-001-0291-1

    DOI

    http://dx.doi.org/10.1007/s00268-001-0291-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004801848

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12053220


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