A New Bleaching Protocol for Hyperpigmented Skin Lesions with a High Concentration of All-trans Retinoic Acid Aqueous Gel View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-07

AUTHORS

Kotaro Yoshimura, Kiyonori Harii, Takao Aoyama, Fuminori Shibuya, Tatsuji Iga

ABSTRACT

. A new bleaching protocol for skin hyperpigmentation with a higher concentration of all-trans retinoic acid (atRA) aqueous gel than those commercially available is introduced. AtRA aqueous gel (0.1%) was applied topically twice a day along with 4% hydroquinone, 7% lactic acid ointment to oriental patients with hyperpigmented lesions such as senile lentigines, melasma, and postinflammatory hyperpigmentation. The clinical results of 39 patients treated with 0.1% atRA aqueous gel were compared to those of 22 patients treated with 0.1% atRA hydrophilic ointment. Better clinical results and subjective satisfaction were obtained through a significantly shorter period of treatment with 0.1% atRA aqueous gel than with 0.1% atRA hydrophilic ointment, although side effects such as erythema and irritation were seen at a higher frequency. It is suggested that our bleaching protocol with a high concentration of atRA aqueous gel in combination with hydroquinone and lactic acid has a strong bleaching ability and a potential as a standard therapy for various kinds of skin lesions with hyperpigmentation. More... »

PAGES

285-291

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002669900285

DOI

http://dx.doi.org/10.1007/s002669900285

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033686393

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10441721


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Topical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroquinones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyperpigmentation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lactic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tretinoin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tokyo, Japan, JP", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Tokyo, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshimura", 
        "givenName": "Kotaro", 
        "id": "sg:person.01242345470.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242345470.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo, Japan, JP", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Tokyo, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harii", 
        "givenName": "Kiyonori", 
        "id": "sg:person.01210715322.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210715322.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo, Japan, JP", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Tokyo, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoyama", 
        "givenName": "Takao", 
        "id": "sg:person.011206573461.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011206573461.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo, Japan, JP", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Tokyo, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shibuya", 
        "givenName": "Fuminori", 
        "id": "sg:person.01111476757.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111476757.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo, Japan, JP", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Tokyo, Japan, JP"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iga", 
        "givenName": "Tatsuji", 
        "id": "sg:person.01242657317.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242657317.59"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1999-07", 
    "datePublishedReg": "1999-07-01", 
    "description": "Abstract. A new bleaching protocol for skin hyperpigmentation with a higher concentration of all-trans retinoic acid (atRA) aqueous gel than those commercially available is introduced. AtRA aqueous gel (0.1%) was applied topically twice a day along with 4% hydroquinone, 7% lactic acid ointment to oriental patients with hyperpigmented lesions such as senile lentigines, melasma, and postinflammatory hyperpigmentation. The clinical results of 39 patients treated with 0.1% atRA aqueous gel were compared to those of 22 patients treated with 0.1% atRA hydrophilic ointment. Better clinical results and subjective satisfaction were obtained through a significantly shorter period of treatment with 0.1% atRA aqueous gel than with 0.1% atRA hydrophilic ointment, although side effects such as erythema and irritation were seen at a higher frequency. It is suggested that our bleaching protocol with a high concentration of atRA aqueous gel in combination with hydroquinone and lactic acid has a strong bleaching ability and a potential as a standard therapy for various kinds of skin lesions with hyperpigmentation.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s002669900285", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1086134", 
        "issn": [
          "0364-216X", 
          "1432-5241"
        ], 
        "name": "Aesthetic Plastic Surgery", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "23"
      }
    ], 
    "keywords": [
      "clinical results", 
      "skin lesions", 
      "bleaching protocol", 
      "lactic acid ointment", 
      "hyperpigmented skin lesions", 
      "hydrophilic ointment", 
      "standard therapy", 
      "Oriental patients", 
      "acid ointment", 
      "side effects", 
      "skin hyperpigmentation", 
      "hyperpigmented lesions", 
      "postinflammatory hyperpigmentation", 
      "senile lentigo", 
      "patients", 
      "lesions", 
      "hyperpigmentation", 
      "ointment", 
      "subjective satisfaction", 
      "high concentrations", 
      "high frequency", 
      "erythema", 
      "therapy", 
      "melasma", 
      "irritation", 
      "lentigines", 
      "protocol", 
      "short period", 
      "treatment", 
      "aqueous gel", 
      "days", 
      "concentration", 
      "lactic acid", 
      "period", 
      "satisfaction", 
      "effect", 
      "results", 
      "frequency", 
      "combination", 
      "gel", 
      "acid", 
      "ability", 
      "potential", 
      "hydroquinone", 
      "bleaching ability", 
      "kind", 
      "new bleaching protocol", 
      "trans retinoic acid (atRA) aqueous gel", 
      "retinoic acid (atRA) aqueous gel", 
      "acid (atRA) aqueous gel", 
      "atRA aqueous gel", 
      "atRA hydrophilic ointment", 
      "strong bleaching ability"
    ], 
    "name": "A New Bleaching Protocol for Hyperpigmented Skin Lesions with a High Concentration of All-trans Retinoic Acid Aqueous Gel", 
    "pagination": "285-291", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033686393"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s002669900285"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10441721"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s002669900285", 
      "https://app.dimensions.ai/details/publication/pub.1033686393"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_318.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s002669900285"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s002669900285'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s002669900285'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s002669900285'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s002669900285'


 

This table displays all metadata directly associated to this object as RDF triples.

187 TRIPLES      21 PREDICATES      91 URIs      83 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s002669900285 schema:about N29b439637dc34f53916274a9f6331974
2 N6894c48978c54d60a5246921056dd37f
3 N7ea95e6eef974a92aebc3f20ab1cfa0c
4 N92a8f84aa61d454baf8c7dbfc4597284
5 Nb601b793eeda491284a65e82de423e8f
6 Nc2ffc3cf7913412190b3debbbba1c74c
7 Nce936596d0a9425a92cfd1a0aeb1403b
8 Nd10852bd1f9d4c39b97ff396c985b97f
9 Nd37141f4ac2d4c5cb32bf99c51ee14d7
10 Ne2a539fbd64545a6a1734a21a6012afa
11 Nee2ead96bc8b4860a591a36f51eb5fba
12 anzsrc-for:11
13 anzsrc-for:1103
14 schema:author N634d16eea70843d3b2d8fccf491044a5
15 schema:datePublished 1999-07
16 schema:datePublishedReg 1999-07-01
17 schema:description Abstract. A new bleaching protocol for skin hyperpigmentation with a higher concentration of all-trans retinoic acid (atRA) aqueous gel than those commercially available is introduced. AtRA aqueous gel (0.1%) was applied topically twice a day along with 4% hydroquinone, 7% lactic acid ointment to oriental patients with hyperpigmented lesions such as senile lentigines, melasma, and postinflammatory hyperpigmentation. The clinical results of 39 patients treated with 0.1% atRA aqueous gel were compared to those of 22 patients treated with 0.1% atRA hydrophilic ointment. Better clinical results and subjective satisfaction were obtained through a significantly shorter period of treatment with 0.1% atRA aqueous gel than with 0.1% atRA hydrophilic ointment, although side effects such as erythema and irritation were seen at a higher frequency. It is suggested that our bleaching protocol with a high concentration of atRA aqueous gel in combination with hydroquinone and lactic acid has a strong bleaching ability and a potential as a standard therapy for various kinds of skin lesions with hyperpigmentation.
18 schema:genre article
19 schema:inLanguage en
20 schema:isAccessibleForFree true
21 schema:isPartOf N7b585af78c78495090c2f55f5e773481
22 Nd360de2ede2946278b1116769b3d49cc
23 sg:journal.1086134
24 schema:keywords Oriental patients
25 ability
26 acid
27 acid (atRA) aqueous gel
28 acid ointment
29 aqueous gel
30 atRA aqueous gel
31 atRA hydrophilic ointment
32 bleaching ability
33 bleaching protocol
34 clinical results
35 combination
36 concentration
37 days
38 effect
39 erythema
40 frequency
41 gel
42 high concentrations
43 high frequency
44 hydrophilic ointment
45 hydroquinone
46 hyperpigmentation
47 hyperpigmented lesions
48 hyperpigmented skin lesions
49 irritation
50 kind
51 lactic acid
52 lactic acid ointment
53 lentigines
54 lesions
55 melasma
56 new bleaching protocol
57 ointment
58 patients
59 period
60 postinflammatory hyperpigmentation
61 potential
62 protocol
63 results
64 retinoic acid (atRA) aqueous gel
65 satisfaction
66 senile lentigo
67 short period
68 side effects
69 skin hyperpigmentation
70 skin lesions
71 standard therapy
72 strong bleaching ability
73 subjective satisfaction
74 therapy
75 trans retinoic acid (atRA) aqueous gel
76 treatment
77 schema:name A New Bleaching Protocol for Hyperpigmented Skin Lesions with a High Concentration of All-trans Retinoic Acid Aqueous Gel
78 schema:pagination 285-291
79 schema:productId N75aa795c2cf84c70aea86c7e16aa64f4
80 Nd9e33f7cc4af4e9bb1aca915e463d348
81 Necad87c2248742bc904f397c958eca79
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033686393
83 https://doi.org/10.1007/s002669900285
84 schema:sdDatePublished 2021-11-01T18:04
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher N6420e36340cf4969b08391fd09101934
87 schema:url https://doi.org/10.1007/s002669900285
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N1c01f618559e4ae6ac896afdd9c6e86e rdf:first sg:person.011206573461.15
92 rdf:rest N5e343ac246c44d8698cd0b85e8b38400
93 N29b439637dc34f53916274a9f6331974 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Administration, Topical
95 rdf:type schema:DefinedTerm
96 N5d191635177b4dd48c9a91dce03ab0d2 rdf:first sg:person.01242657317.59
97 rdf:rest rdf:nil
98 N5e343ac246c44d8698cd0b85e8b38400 rdf:first sg:person.01111476757.52
99 rdf:rest N5d191635177b4dd48c9a91dce03ab0d2
100 N634d16eea70843d3b2d8fccf491044a5 rdf:first sg:person.01242345470.74
101 rdf:rest N8735723ae40c49ebad4f8dbde5b59dd9
102 N6420e36340cf4969b08391fd09101934 schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 N6894c48978c54d60a5246921056dd37f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Female
106 rdf:type schema:DefinedTerm
107 N75aa795c2cf84c70aea86c7e16aa64f4 schema:name pubmed_id
108 schema:value 10441721
109 rdf:type schema:PropertyValue
110 N7b585af78c78495090c2f55f5e773481 schema:volumeNumber 23
111 rdf:type schema:PublicationVolume
112 N7ea95e6eef974a92aebc3f20ab1cfa0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Hyperpigmentation
114 rdf:type schema:DefinedTerm
115 N8735723ae40c49ebad4f8dbde5b59dd9 rdf:first sg:person.01210715322.48
116 rdf:rest N1c01f618559e4ae6ac896afdd9c6e86e
117 N92a8f84aa61d454baf8c7dbfc4597284 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Tretinoin
119 rdf:type schema:DefinedTerm
120 Nb601b793eeda491284a65e82de423e8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Middle Aged
122 rdf:type schema:DefinedTerm
123 Nc2ffc3cf7913412190b3debbbba1c74c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Male
125 rdf:type schema:DefinedTerm
126 Nce936596d0a9425a92cfd1a0aeb1403b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Lactic Acid
128 rdf:type schema:DefinedTerm
129 Nd10852bd1f9d4c39b97ff396c985b97f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Adult
131 rdf:type schema:DefinedTerm
132 Nd360de2ede2946278b1116769b3d49cc schema:issueNumber 4
133 rdf:type schema:PublicationIssue
134 Nd37141f4ac2d4c5cb32bf99c51ee14d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Hydroquinones
136 rdf:type schema:DefinedTerm
137 Nd9e33f7cc4af4e9bb1aca915e463d348 schema:name dimensions_id
138 schema:value pub.1033686393
139 rdf:type schema:PropertyValue
140 Ne2a539fbd64545a6a1734a21a6012afa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Gels
142 rdf:type schema:DefinedTerm
143 Necad87c2248742bc904f397c958eca79 schema:name doi
144 schema:value 10.1007/s002669900285
145 rdf:type schema:PropertyValue
146 Nee2ead96bc8b4860a591a36f51eb5fba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Humans
148 rdf:type schema:DefinedTerm
149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
150 schema:name Medical and Health Sciences
151 rdf:type schema:DefinedTerm
152 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
153 schema:name Clinical Sciences
154 rdf:type schema:DefinedTerm
155 sg:journal.1086134 schema:issn 0364-216X
156 1432-5241
157 schema:name Aesthetic Plastic Surgery
158 schema:publisher Springer Nature
159 rdf:type schema:Periodical
160 sg:person.01111476757.52 schema:affiliation grid-institutes:None
161 schema:familyName Shibuya
162 schema:givenName Fuminori
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111476757.52
164 rdf:type schema:Person
165 sg:person.011206573461.15 schema:affiliation grid-institutes:None
166 schema:familyName Aoyama
167 schema:givenName Takao
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011206573461.15
169 rdf:type schema:Person
170 sg:person.01210715322.48 schema:affiliation grid-institutes:None
171 schema:familyName Harii
172 schema:givenName Kiyonori
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210715322.48
174 rdf:type schema:Person
175 sg:person.01242345470.74 schema:affiliation grid-institutes:None
176 schema:familyName Yoshimura
177 schema:givenName Kotaro
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242345470.74
179 rdf:type schema:Person
180 sg:person.01242657317.59 schema:affiliation grid-institutes:None
181 schema:familyName Iga
182 schema:givenName Tatsuji
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242657317.59
184 rdf:type schema:Person
185 grid-institutes:None schema:alternateName Tokyo, Japan, JP
186 schema:name Tokyo, Japan, JP
187 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...