Autogenic mesenchymal stem cells for intervertebral disc regeneration View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Filippo Migliorini, Björn Rath, Markus Tingart, Alice Baroncini, Valentin Quack, Jörg Eschweiler

ABSTRACT

PURPOSE: A systematic review of the literature was conducted to clarify the outcomes of autologous mesenchymal stem cells (MSC) injections for the regeneration of the intervertebral disc (IVD). METHODS: The following databases were accessed: PubMed, Medline, CINAHL, Cochrane, Embase and Google Scholar bibliographic databases. Articles including previous or planned surgical interventions were excluded. Only articles reporting percutaneous autologous MSC injection to regenerate IVD in humans were included. We referred to the Coleman Methodology Score for the methodological quality assessment. The statistical analysis was performed using Review Manager Software 5.3. RESULTS: After the databases search and cross-references of the bibliographies, seven studies were included in the present work. The funnel plot detected low risk of publication bias. The Coleman Methodology Score reported a good result, scoring 61.07 points. A total of 98 patients were enrolled, with 122 treated levels. All the patients underwent conservative therapies prior to injection. A remarkable improvement in the quality of life were reported after the treatment. The average Oswestry Disability Index (ODI) improved from "severe disability" to "minimal disability" at one year follow-up. The visual analogue scale (VAS) showed an improvement of ca. 30% at one year follow-up. Only one case of herniated nucleus pulposus was reported. No other adverse events at the aspiration or injection site were observed. CONCLUSIONS: This systematic review of the literature proved MSC injection to be a safe and feasible option for intervertebral disc regeneration in the early-degeneration stage patients. Irrespective of the source of the MSCs, an overall clinical and radiological improvement of the patients has been evidenced, as indeed a very low complication rate during the follow-up. More... »

PAGES

1027-1036

References to SciGraph publications

  • 2016-12. Mesenchymal Stem/Stromal Cells seeded on cartilaginous endplates promote Intervertebral Disc Regeneration through Extracellular Matrix Remodeling in SCIENTIFIC REPORTS
  • 2014-02. High mechanical strain of primary intervertebral disc cells promotes secretion of inflammatory factors associated with disc degeneration and pain in ARTHRITIS RESEARCH & THERAPY
  • 2012. Molecular Basis of Intervertebral Disc Degeneration in REGENERATIVE BIOLOGY OF THE SPINE AND SPINAL CORD
  • 2017-12. Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study in STEM CELL RESEARCH & THERAPY
  • 2014-02. Pluripotent stem cells in regenerative medicine: challenges and recent progress in NATURE REVIEWS GENETICS
  • 2015-11. The presence of stem cells in potential stem cell niches of the intervertebral disc region: an in vitro study on rats in EUROPEAN SPINE JOURNAL
  • 2017-07. Distal biceps brachii tendon repair: a systematic review of patient outcome determination using modified Coleman methodology score criteria in KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
  • 2007-12. Biological aspects of bone, cartilage and tendon regeneration in INTERNATIONAL ORTHOPAEDICS
  • 2017-12. Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2005-08. Orthopaedic applications of gene therapy in INTERNATIONAL ORTHOPAEDICS
  • 2014-06. Disc degeneration-related clinical phenotypes in EUROPEAN SPINE JOURNAL
  • 2016-12. Intra-discal injection of autologous, hypoxic cultured bone marrow-derived mesenchymal stem cells in five patients with chronic lower back pain: a long-term safety and feasibility study in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2004-03. Intervertebral Disc Cell Therapy for Regeneration: Mesenchymal Stem Cell Implantation in Rat Intervertebral Discs in ANNALS OF BIOMEDICAL ENGINEERING
  • 2001-03. Gene therapy and spinal disorders in INTERNATIONAL ORTHOPAEDICS
  • 2007-04. Biological treatment strategies for disc degeneration: potentials and shortcomings in EUROPEAN SPINE JOURNAL
  • 2014-09. Vertebral endplate change as a feature of intervertebral disc degeneration: a heritability study in EUROPEAN SPINE JOURNAL
  • 2014-09. Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study in INTERNATIONAL ORTHOPAEDICS
  • 2016-08. A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions in INTERNATIONAL ORTHOPAEDICS
  • 2017-10. Autologous bone marrow concentrate intradiscal injection for the treatment of degenerative disc disease with three-year follow-up in INTERNATIONAL ORTHOPAEDICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00264-018-4218-y

    DOI

    http://dx.doi.org/10.1007/s00264-018-4218-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1109808812

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30415465


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    81 schema:description PURPOSE: A systematic review of the literature was conducted to clarify the outcomes of autologous mesenchymal stem cells (MSC) injections for the regeneration of the intervertebral disc (IVD). METHODS: The following databases were accessed: PubMed, Medline, CINAHL, Cochrane, Embase and Google Scholar bibliographic databases. Articles including previous or planned surgical interventions were excluded. Only articles reporting percutaneous autologous MSC injection to regenerate IVD in humans were included. We referred to the Coleman Methodology Score for the methodological quality assessment. The statistical analysis was performed using Review Manager Software 5.3. RESULTS: After the databases search and cross-references of the bibliographies, seven studies were included in the present work. The funnel plot detected low risk of publication bias. The Coleman Methodology Score reported a good result, scoring 61.07 points. A total of 98 patients were enrolled, with 122 treated levels. All the patients underwent conservative therapies prior to injection. A remarkable improvement in the quality of life were reported after the treatment. The average Oswestry Disability Index (ODI) improved from "severe disability" to "minimal disability" at one year follow-up. The visual analogue scale (VAS) showed an improvement of ca. 30% at one year follow-up. Only one case of herniated nucleus pulposus was reported. No other adverse events at the aspiration or injection site were observed. CONCLUSIONS: This systematic review of the literature proved MSC injection to be a safe and feasible option for intervertebral disc regeneration in the early-degeneration stage patients. Irrespective of the source of the MSCs, an overall clinical and radiological improvement of the patients has been evidenced, as indeed a very low complication rate during the follow-up.
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