Escherichia coli-derived BMP-2-absorbed β-TCP granules induce bone regeneration in rabbit critical-sized femoral segmental defects View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-08-10

AUTHORS

Yu Kuroiwa, Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Takashi Iwakura, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda

ABSTRACT

PurposeThis study investigated whether Escherichia coli-derived bone morphogenetic protein (BMP)-2 (E-BMP-2) adsorbed onto β-tricalcium phosphate (β-TCP) granules can induce bone regeneration in critical-size femoral segmental defects in rabbits.MethodsBone defects 20 mm in size and stabilized with an external fixator were created in the femur of New Zealand white rabbits, which were divided into BMP-2 and control groups. E-BMP-2-loaded β-TCP granules were implanted into defects of the BMP-2 group, whereas defects in the controls were implanted with β-TCP granules alone. At 12 and 24 weeks after surgery, radiographs were obtained of the femurs and histological and biomechanical assessments of the defect area were performed. Bone regeneration was quantified using micro-computed tomography at 24 weeks.ResultsRadiographic and histologic analyses revealed bone regeneration in the BMP-2 group but not the control group; no fracturing of newly formed bone occurred when the external fixator was removed at 12 weeks. At 24 weeks, tissue mineral density, the ratio of bone volume to total volume, and volumetric bone mineral density of the callus were higher in the BMP-2 group than in control animals. In the former, ultimate stress, extrinsic stiffness, and failure energy measurements for the femurs were higher at 24 weeks than at 12 weeks.ConclusionE-BMP-2-loaded β-TCP granules can effectively promote bone regeneration in long bone defects. More... »

PAGES

1247-1253

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00264-018-4079-4

DOI

http://dx.doi.org/10.1007/s00264-018-4079-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106097605

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30097727


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adsorption", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Density", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Morphogenetic Protein 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Regeneration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Substitutes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium Phosphates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coated Materials, Biocompatible", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Escherichia coli Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Femur", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prosthesis Implantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rabbits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "X-Ray Microtomography", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuroiwa", 
        "givenName": "Yu", 
        "id": "sg:person.016715020624.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016715020624.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niikura", 
        "givenName": "Takahiro", 
        "id": "sg:person.016327606050.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016327606050.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Sang Yang", 
        "id": "sg:person.016222713747.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016222713747.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oe", 
        "givenName": "Keisuke", 
        "id": "sg:person.01004763715.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004763715.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iwakura", 
        "givenName": "Takashi", 
        "id": "sg:person.016612240054.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016612240054.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukui", 
        "givenName": "Tomoaki", 
        "id": "sg:person.0715234724.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715234724.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumoto", 
        "givenName": "Tomoyuki", 
        "id": "sg:person.0673774654.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673774654.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsushita", 
        "givenName": "Takehiko", 
        "id": "sg:person.01056105637.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056105637.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishida", 
        "givenName": "Kotaro", 
        "id": "sg:person.01260713234.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260713234.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuroda", 
        "givenName": "Ryosuke", 
        "id": "sg:person.01025022257.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025022257.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00586-011-2130-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004451586", 
          "https://doi.org/10.1007/s00586-011-2130-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00774-011-0329-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014332046", 
          "https://doi.org/10.1007/s00774-011-0329-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12917-016-0829-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027636759", 
          "https://doi.org/10.1186/s12917-016-0829-y"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-08-10", 
    "datePublishedReg": "2018-08-10", 
    "description": "PurposeThis study investigated whether Escherichia coli-derived bone morphogenetic protein (BMP)-2 (E-BMP-2) adsorbed onto \u03b2-tricalcium phosphate (\u03b2-TCP) granules can induce bone regeneration in critical-size femoral segmental defects in rabbits.MethodsBone defects 20\u00a0mm in size and stabilized with an external fixator were created in the femur of New Zealand white rabbits, which were divided into BMP-2 and control groups. E-BMP-2-loaded \u03b2-TCP granules were implanted into defects of the BMP-2 group, whereas defects in the controls were implanted with \u03b2-TCP granules alone. At 12 and 24\u00a0weeks after surgery, radiographs were obtained of the femurs and histological and biomechanical assessments of the defect area were performed. Bone regeneration was quantified using micro-computed tomography at 24\u00a0weeks.ResultsRadiographic and histologic analyses revealed bone regeneration in the BMP-2 group but not the control group; no fracturing of newly formed bone occurred when the external fixator was removed at 12\u00a0weeks. At 24\u00a0weeks, tissue mineral density, the ratio of bone volume to total volume, and volumetric bone mineral density of the callus were higher in the BMP-2 group than in control animals. In the former, ultimate stress, extrinsic stiffness, and failure energy measurements for the femurs were higher at 24\u00a0weeks than at 12\u00a0weeks.ConclusionE-BMP-2-loaded \u03b2-TCP granules can effectively promote bone regeneration in long bone defects.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00264-018-4079-4", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1086603", 
        "issn": [
          "0341-2695", 
          "1432-5195"
        ], 
        "name": "International Orthopaedics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "43"
      }
    ], 
    "keywords": [
      "\u03b2-TCP granules", 
      "bone regeneration", 
      "femoral segmental defects", 
      "critical-sized femoral segmental defect", 
      "BMP-2 group", 
      "ultimate stress", 
      "\u03b2-tricalcium phosphate granules", 
      "micro-computed tomography", 
      "segmental defects", 
      "long bone defects", 
      "energy measurements", 
      "phosphate granules", 
      "bone defects", 
      "biomechanical assessment", 
      "tissue mineral density", 
      "defect area", 
      "extrinsic stiffness", 
      "fracturing", 
      "density", 
      "stiffness", 
      "total volume", 
      "external fixator", 
      "defects", 
      "regeneration", 
      "bone volume", 
      "measurements", 
      "volume", 
      "stress", 
      "granules", 
      "fixator", 
      "ratio", 
      "BMP-2", 
      "size", 
      "femur", 
      "control", 
      "area", 
      "bone", 
      "analysis", 
      "E-BMP", 
      "New Zealand white rabbits", 
      "Zealand white rabbits", 
      "white rabbits", 
      "histologic analysis", 
      "assessment", 
      "study", 
      "volumetric bone mineral density", 
      "MethodsBone", 
      "tomography", 
      "bone morphogenetic protein", 
      "morphogenetic proteins", 
      "mineral density", 
      "bone mineral density", 
      "group", 
      "protein", 
      "rabbits", 
      "callus", 
      "PurposeThis study", 
      "animals", 
      "weeks", 
      "radiographs", 
      "control animals", 
      "surgery", 
      "control group"
    ], 
    "name": "Escherichia coli-derived BMP-2-absorbed \u03b2-TCP granules induce bone regeneration in rabbit critical-sized femoral segmental defects", 
    "pagination": "1247-1253", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1106097605"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00264-018-4079-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30097727"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00264-018-4079-4", 
      "https://app.dimensions.ai/details/publication/pub.1106097605"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_779.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00264-018-4079-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00264-018-4079-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00264-018-4079-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00264-018-4079-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00264-018-4079-4'


 

This table displays all metadata directly associated to this object as RDF triples.

259 TRIPLES      21 PREDICATES      106 URIs      95 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00264-018-4079-4 schema:about N028f521aa13a49ce9ea39a4cb6ca9ab0
2 N10ca8c5b51024b7599bbe4c9daacf062
3 N15733c807fac4a6280838deb64614ddb
4 N1886b5ca8b6d49dca075822f89546453
5 N1bce071b7c7346ce947289f2cf188428
6 N32646d28804d455c9f80b744db2f4d7d
7 N3b355b076171430c938e3f595de2dc6a
8 N495590449a6a4865a3b5057ccf550f1b
9 N513e3e93720e4afda3a44bf35d553c96
10 N71bd5db6569346f2b1af807cdf9ea1c9
11 N81815973057e4501b1927a03cbfc0bc2
12 Nb1588bb913eb40838c6902fecba85d7b
13 Nb6c5ab25460f46978213f5cc48b7db11
14 Nda6f622b46044da9afbf8dde6eecfca5
15 Nfe616fd6d1ad4a69bdababdeef72dcc2
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N871c1440388e44e2980450eec8658c3f
19 schema:citation sg:pub.10.1007/s00586-011-2130-x
20 sg:pub.10.1007/s00774-011-0329-x
21 sg:pub.10.1186/s12917-016-0829-y
22 schema:datePublished 2018-08-10
23 schema:datePublishedReg 2018-08-10
24 schema:description PurposeThis study investigated whether Escherichia coli-derived bone morphogenetic protein (BMP)-2 (E-BMP-2) adsorbed onto β-tricalcium phosphate (β-TCP) granules can induce bone regeneration in critical-size femoral segmental defects in rabbits.MethodsBone defects 20 mm in size and stabilized with an external fixator were created in the femur of New Zealand white rabbits, which were divided into BMP-2 and control groups. E-BMP-2-loaded β-TCP granules were implanted into defects of the BMP-2 group, whereas defects in the controls were implanted with β-TCP granules alone. At 12 and 24 weeks after surgery, radiographs were obtained of the femurs and histological and biomechanical assessments of the defect area were performed. Bone regeneration was quantified using micro-computed tomography at 24 weeks.ResultsRadiographic and histologic analyses revealed bone regeneration in the BMP-2 group but not the control group; no fracturing of newly formed bone occurred when the external fixator was removed at 12 weeks. At 24 weeks, tissue mineral density, the ratio of bone volume to total volume, and volumetric bone mineral density of the callus were higher in the BMP-2 group than in control animals. In the former, ultimate stress, extrinsic stiffness, and failure energy measurements for the femurs were higher at 24 weeks than at 12 weeks.ConclusionE-BMP-2-loaded β-TCP granules can effectively promote bone regeneration in long bone defects.
25 schema:genre article
26 schema:isAccessibleForFree true
27 schema:isPartOf N67108fd7aa2e4e81ab2ff2ab336486de
28 Nca004835c6574d2289b7be4cd49d1bae
29 sg:journal.1086603
30 schema:keywords BMP-2
31 BMP-2 group
32 E-BMP
33 MethodsBone
34 New Zealand white rabbits
35 PurposeThis study
36 Zealand white rabbits
37 analysis
38 animals
39 area
40 assessment
41 biomechanical assessment
42 bone
43 bone defects
44 bone mineral density
45 bone morphogenetic protein
46 bone regeneration
47 bone volume
48 callus
49 control
50 control animals
51 control group
52 critical-sized femoral segmental defect
53 defect area
54 defects
55 density
56 energy measurements
57 external fixator
58 extrinsic stiffness
59 femoral segmental defects
60 femur
61 fixator
62 fracturing
63 granules
64 group
65 histologic analysis
66 long bone defects
67 measurements
68 micro-computed tomography
69 mineral density
70 morphogenetic proteins
71 phosphate granules
72 protein
73 rabbits
74 radiographs
75 ratio
76 regeneration
77 segmental defects
78 size
79 stiffness
80 stress
81 study
82 surgery
83 tissue mineral density
84 tomography
85 total volume
86 ultimate stress
87 volume
88 volumetric bone mineral density
89 weeks
90 white rabbits
91 β-TCP granules
92 β-tricalcium phosphate granules
93 schema:name Escherichia coli-derived BMP-2-absorbed β-TCP granules induce bone regeneration in rabbit critical-sized femoral segmental defects
94 schema:pagination 1247-1253
95 schema:productId N6d6b23b01f164108ba1fa6ba996e5951
96 Na339702b0cff4c559e907e314b2de041
97 Nf10c41825529493cb85457f1e97f6f50
98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106097605
99 https://doi.org/10.1007/s00264-018-4079-4
100 schema:sdDatePublished 2022-09-02T16:03
101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
102 schema:sdPublisher N8852af34251b4ebeaacae68a92ba1ccd
103 schema:url https://doi.org/10.1007/s00264-018-4079-4
104 sgo:license sg:explorer/license/
105 sgo:sdDataset articles
106 rdf:type schema:ScholarlyArticle
107 N028f521aa13a49ce9ea39a4cb6ca9ab0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Rabbits
109 rdf:type schema:DefinedTerm
110 N10ca8c5b51024b7599bbe4c9daacf062 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Coated Materials, Biocompatible
112 rdf:type schema:DefinedTerm
113 N15733c807fac4a6280838deb64614ddb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Prosthesis Implantation
115 rdf:type schema:DefinedTerm
116 N1886b5ca8b6d49dca075822f89546453 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Adsorption
118 rdf:type schema:DefinedTerm
119 N1bce071b7c7346ce947289f2cf188428 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Female
121 rdf:type schema:DefinedTerm
122 N235c85451cd44a989792ecd16a08263d rdf:first sg:person.01056105637.26
123 rdf:rest N69e58cd73e5a44b5bdb8c64a3f9d40ef
124 N32646d28804d455c9f80b744db2f4d7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Animals
126 rdf:type schema:DefinedTerm
127 N37302febd9d24c2d86d5f776daabab66 rdf:first sg:person.016222713747.67
128 rdf:rest N48f26e26d42241c594022b4e3aba0de7
129 N3b355b076171430c938e3f595de2dc6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Escherichia coli Proteins
131 rdf:type schema:DefinedTerm
132 N48f26e26d42241c594022b4e3aba0de7 rdf:first sg:person.01004763715.25
133 rdf:rest Ne624879a45c348419a57b2005793a993
134 N495590449a6a4865a3b5057ccf550f1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Bone Substitutes
136 rdf:type schema:DefinedTerm
137 N513e3e93720e4afda3a44bf35d553c96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name X-Ray Microtomography
139 rdf:type schema:DefinedTerm
140 N60896a5b85e047f9b63b254c4e59d126 rdf:first sg:person.0715234724.14
141 rdf:rest N6e755631d19246699993a1fe2707ddfc
142 N67108fd7aa2e4e81ab2ff2ab336486de schema:issueNumber 5
143 rdf:type schema:PublicationIssue
144 N69e58cd73e5a44b5bdb8c64a3f9d40ef rdf:first sg:person.01260713234.87
145 rdf:rest Nc4a8e594f129451994af8dfef5bffa73
146 N6d6b23b01f164108ba1fa6ba996e5951 schema:name dimensions_id
147 schema:value pub.1106097605
148 rdf:type schema:PropertyValue
149 N6e755631d19246699993a1fe2707ddfc rdf:first sg:person.0673774654.56
150 rdf:rest N235c85451cd44a989792ecd16a08263d
151 N71bd5db6569346f2b1af807cdf9ea1c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Calcium Phosphates
153 rdf:type schema:DefinedTerm
154 N81815973057e4501b1927a03cbfc0bc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Bone Regeneration
156 rdf:type schema:DefinedTerm
157 N871c1440388e44e2980450eec8658c3f rdf:first sg:person.016715020624.40
158 rdf:rest Na83c4f224d774a39870ac632a1ecdb4e
159 N8852af34251b4ebeaacae68a92ba1ccd schema:name Springer Nature - SN SciGraph project
160 rdf:type schema:Organization
161 Na339702b0cff4c559e907e314b2de041 schema:name doi
162 schema:value 10.1007/s00264-018-4079-4
163 rdf:type schema:PropertyValue
164 Na83c4f224d774a39870ac632a1ecdb4e rdf:first sg:person.016327606050.40
165 rdf:rest N37302febd9d24c2d86d5f776daabab66
166 Nb1588bb913eb40838c6902fecba85d7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Femur
168 rdf:type schema:DefinedTerm
169 Nb6c5ab25460f46978213f5cc48b7db11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Bone Density
171 rdf:type schema:DefinedTerm
172 Nc4a8e594f129451994af8dfef5bffa73 rdf:first sg:person.01025022257.04
173 rdf:rest rdf:nil
174 Nca004835c6574d2289b7be4cd49d1bae schema:volumeNumber 43
175 rdf:type schema:PublicationVolume
176 Nda6f622b46044da9afbf8dde6eecfca5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Disease Models, Animal
178 rdf:type schema:DefinedTerm
179 Ne624879a45c348419a57b2005793a993 rdf:first sg:person.016612240054.36
180 rdf:rest N60896a5b85e047f9b63b254c4e59d126
181 Nf10c41825529493cb85457f1e97f6f50 schema:name pubmed_id
182 schema:value 30097727
183 rdf:type schema:PropertyValue
184 Nfe616fd6d1ad4a69bdababdeef72dcc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Bone Morphogenetic Protein 2
186 rdf:type schema:DefinedTerm
187 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
188 schema:name Medical and Health Sciences
189 rdf:type schema:DefinedTerm
190 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
191 schema:name Clinical Sciences
192 rdf:type schema:DefinedTerm
193 sg:journal.1086603 schema:issn 0341-2695
194 1432-5195
195 schema:name International Orthopaedics
196 schema:publisher Springer Nature
197 rdf:type schema:Periodical
198 sg:person.01004763715.25 schema:affiliation grid-institutes:grid.31432.37
199 schema:familyName Oe
200 schema:givenName Keisuke
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004763715.25
202 rdf:type schema:Person
203 sg:person.01025022257.04 schema:affiliation grid-institutes:grid.31432.37
204 schema:familyName Kuroda
205 schema:givenName Ryosuke
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025022257.04
207 rdf:type schema:Person
208 sg:person.01056105637.26 schema:affiliation grid-institutes:grid.31432.37
209 schema:familyName Matsushita
210 schema:givenName Takehiko
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056105637.26
212 rdf:type schema:Person
213 sg:person.01260713234.87 schema:affiliation grid-institutes:grid.31432.37
214 schema:familyName Nishida
215 schema:givenName Kotaro
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260713234.87
217 rdf:type schema:Person
218 sg:person.016222713747.67 schema:affiliation grid-institutes:grid.31432.37
219 schema:familyName Lee
220 schema:givenName Sang Yang
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016222713747.67
222 rdf:type schema:Person
223 sg:person.016327606050.40 schema:affiliation grid-institutes:grid.31432.37
224 schema:familyName Niikura
225 schema:givenName Takahiro
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016327606050.40
227 rdf:type schema:Person
228 sg:person.016612240054.36 schema:affiliation grid-institutes:grid.31432.37
229 schema:familyName Iwakura
230 schema:givenName Takashi
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016612240054.36
232 rdf:type schema:Person
233 sg:person.016715020624.40 schema:affiliation grid-institutes:grid.31432.37
234 schema:familyName Kuroiwa
235 schema:givenName Yu
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016715020624.40
237 rdf:type schema:Person
238 sg:person.0673774654.56 schema:affiliation grid-institutes:grid.31432.37
239 schema:familyName Matsumoto
240 schema:givenName Tomoyuki
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673774654.56
242 rdf:type schema:Person
243 sg:person.0715234724.14 schema:affiliation grid-institutes:grid.31432.37
244 schema:familyName Fukui
245 schema:givenName Tomoaki
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715234724.14
247 rdf:type schema:Person
248 sg:pub.10.1007/s00586-011-2130-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004451586
249 https://doi.org/10.1007/s00586-011-2130-x
250 rdf:type schema:CreativeWork
251 sg:pub.10.1007/s00774-011-0329-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014332046
252 https://doi.org/10.1007/s00774-011-0329-x
253 rdf:type schema:CreativeWork
254 sg:pub.10.1186/s12917-016-0829-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1027636759
255 https://doi.org/10.1186/s12917-016-0829-y
256 rdf:type schema:CreativeWork
257 grid-institutes:grid.31432.37 schema:alternateName Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan
258 schema:name Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan
259 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...