Transcutaneous carbon dioxide application accelerates muscle injury repair in rat models View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-02-16

AUTHORS

Shiho Akahane, Yoshitada Sakai, Takeshi Ueha, Hanako Nishimoto, Miho Inoue, Takahiro Niikura, Ryosuke Kuroda

ABSTRACT

PurposeSkeletal muscle injuries are commonly observed in sports and traumatology medicine. Previously, we demonstrated that transcutaneous application of carbon dioxide (CO2) to lower limbs increased the number of muscle mitochondria and promoted muscle endurance. Therefore, we aimed to investigate whether transcutaneous CO2 application could enhance recovery from muscle injury.MethodsTibialis anterior muscle damage was induced in 27 Sprague Dawley rats via intramuscular injection of bupivacaine. After muscle injury, rats were randomly assigned to transcutaneous CO2-treated or -untreated groups. From each group, three rats were sacrificed at weeks one, two, four and six. At each time point, histology and immunofluorescence analyses were performed, and changes in muscle weight, muscle weight/body weight ratio, muscle fibre circumference, gene expression levels and capillary density were measured.ResultsInjured muscle fibres were completely repaired at week six in the CO2-treated group but only partially repaired in the untreated group. The repair of basement and plasma membranes did not differ significantly between groups. However, expression levels of genes and proteins related to muscle protein synthesis were significantly higher in the CO2−treated group and significantly more capillaries four weeks after injury.ConclusionTranscutaneous CO2 application can accelerate recovery after muscle injury in rats. More... »

PAGES

1007-1015

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00264-017-3417-2

DOI

http://dx.doi.org/10.1007/s00264-017-3417-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083845600

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28210805


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