A new bioabsorbable cotton-textured synthetic polymer scaffold for osteochondral repair View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-01-03

AUTHORS

Ryosuke Sakata, Takeshi Kokubu, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Hiroyuki Fujioka, Ryosuke Kuroda, Masahiro Kurosaka

ABSTRACT

PurposeWe have previously reported that a cylindrical bioabsorbable synthetic polymer scaffold made of poly (DL-lactide-co-glycolide) (PLG) can be used to repair osteochondral defects without using cultured cells in a rabbit model. This cylindrical scaffold has a solid and pre-formed design, which limits its widespread application. Therefore, we created a cotton-textured PLG scaffold, which would be superior to other scaffolds in terms of plastic property and operability. The purpose of the present study was to examine the efficacy of the cotton-textured PLG scaffold in the repair of osteochondral defects.MethodsCotton-textured PLG scaffolds were prepared using the electrospinning method and used to repair osteochondral defects produced on the right femoral condyle in 36 rabbits. As a control, the defect was left untreated. The outcomes of repair were examined histologically at postoperative weeks four, eight, and 12.ResultsIn the untreated control group, the surface of the defect remained concave and the regenerated cartilaginous tissue partially covered the articular surface even at postoperative week 12. In the scaffold group, cartilaginous tissue covered the surface of the defect at postoperative week four, and the surface was smooth and the cartilaginous tissue was well regenerated and integrated with the native cartilage at postoperative week 12.ConclusionsThe cotton-textured PLG scaffold could repair the osteochondral defect with good outcomes similar to those previously reported for the cylindrical scaffold, with its characteristic advantages of better plasticity and operability. We conclude that the cotton-textured PLG scaffold has potential for clinical application in comminuted osteochondral injury. More... »

PAGES

2413-2420

References to SciGraph publications

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  • 2012-01-20. Dermatan sulphate in methoxy polyethylene glycol-polylactide-co-glycolic acid scaffolds upregulates fibronectin gene expression but has no effect on in vivo osteochondral repair in INTERNATIONAL ORTHOPAEDICS
  • 2008-07-01. Bone marrow mesenchymal stem cells in a hyaluronan scaffold for treatment of an osteochondral defect in a rabbit model in KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
  • 2008-04-16. The effect of porosity and mechanical property of a synthetic polymer scaffold on repair of osteochondral defects in INTERNATIONAL ORTHOPAEDICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00264-013-2253-2

    DOI

    http://dx.doi.org/10.1007/s00264-013-2253-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046452007

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24384940


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    47 concave
    48 condyle
    49 control
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    51 cotton-textured PLG scaffold
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    80 postoperative week four
    81 pre-form design
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    88 repair
    89 right femoral condyle
    90 scaffold group
    91 scaffolds
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    93 surface
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