Establishment of a new methicillin resistant staphylococcus aureus animal model of osteomyelitis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-10-30

AUTHORS

Lars Helbig, Hans Georg Simank, Helga Lorenz, Cornelia Putz, Christoph Wölfl, Arnold J. Suda, Arash Moghaddam, Gerhard Schmidmaier, Thorsten Guehring

ABSTRACT

PurposeThe increase in methicillin-resistant Staphylococcus aureus (MRSA) infections is currently a major health care problem. Vancomycin is still often the first-line anti-microbiological agent for treating such infections; however, a recent decline in efficacy of vancomycin in MRSA infections has raised concerns and accelerated the search for new antibiotics. The aim of this study was to establish a MRSA peri-implant osteomyelitis animal model for future testing of new anti-microbiological agents under typical MRSA infection conditions.MethodsEighteen randomised NZW-rabbits underwent a standardised surgical procedure with the insertion of a femoral bone implant. Animals were then divided into group 1 (MRSA inoculation, no antibiotics; M/N), group 2 (MRSA inoculation, Vancomyin; M/V), and group 3 (no MRSA inoculation, no antibiotics; N/N). The primary study outcome parameters were animal leucocyte count, animal weight, and animal body temperature at one, seven, and 42 days after surgery. Additionally, a histo-morphometrical score was established and adjusted to a modified histological Smeltzer score.ResultsMacroscopic and histo-morphometrical findings showed a peri-implant osteomyelitis in group 1 with both increased acute and chronic infection parameters in M/N, as compared to M/V and N/N, indicating that vancomycin treatment prevented typical morphological changes of MRSA peri-implant osteomyelitis. Similarly, there was a reduction in animal weight and increase in leucocyte count and body temperature in group 1 (each p < 0.005). Vancomycin treatment again resulted in significantly reduced leucocyte count and body temperature, and increased animal body weight.ConclusionsHere we have established a peri-implant MRSA osteomyelitis model that successfully combined clinical and laboratory outcome parameters of infection with histo-morphometrical results; this model appears to be valuable for future experimental use and therapeutic monitoring of new anti-microbiological MRSA drugs. More... »

PAGES

891-897

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00264-013-2149-1

DOI

http://dx.doi.org/10.1007/s00264-013-2149-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029127981

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24170130


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