Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-01-21

AUTHORS

Kazunari Ishida, Nobuhiro Tsumura, Atsushi Kitagawa, Sayaka Hamamura, Koji Fukuda, Yoshihiro Dogaki, Seiji Kubo, Tomoyuki Matsumoto, Takehiko Matsushita, Takaaki Chin, Tetsuhiro Iguchi, Masahiro Kurosaka, Ryosuke Kuroda

ABSTRACT

PurposeThis is a randomised controlled trial to examine whether intra-articular injection of tranexamic acid (TXA) decreases blood loss, as well as reducing leg swelling after total knee arthroplasty (TKA).MethodsWe performed 100 TKA in osteoarthritis patients. At closure, a total of 2,000 mg/20 ml TXA was injected into the knee joint through a closed suction drain (TXA group). For the control group, the same volume of physiological saline was injected. The pre-operative condition of the patients, post-operative haemoglobin (Hb) levels, discharge volumes from drain, D-dimer and needs for transfusion were compared between these two groups. Furthermore, leg diameters (thigh, suprapatellar portion and calf girth) were measured pre- and post-operatively to investigate whether TXA has an influence on leg swelling after surgery.ResultsThe results revealed that post-operative decrease in Hb level was significantly reduced in the TXA group. Furthermore, knee joint swelling after operation was significantly suppressed in the TXA group compared to the control group.ConclusionsThe results revealed intra-articular administration of TXA decreased not only blood loss, but also knee joint swelling after TKA. More... »

PAGES

1639-1645

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00264-010-1205-3

DOI

http://dx.doi.org/10.1007/s00264-010-1205-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016464680

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21253725


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27 schema:description PurposeThis is a randomised controlled trial to examine whether intra-articular injection of tranexamic acid (TXA) decreases blood loss, as well as reducing leg swelling after total knee arthroplasty (TKA).MethodsWe performed 100 TKA in osteoarthritis patients. At closure, a total of 2,000 mg/20 ml TXA was injected into the knee joint through a closed suction drain (TXA group). For the control group, the same volume of physiological saline was injected. The pre-operative condition of the patients, post-operative haemoglobin (Hb) levels, discharge volumes from drain, D-dimer and needs for transfusion were compared between these two groups. Furthermore, leg diameters (thigh, suprapatellar portion and calf girth) were measured pre- and post-operatively to investigate whether TXA has an influence on leg swelling after surgery.ResultsThe results revealed that post-operative decrease in Hb level was significantly reduced in the TXA group. Furthermore, knee joint swelling after operation was significantly suppressed in the TXA group compared to the control group.ConclusionsThe results revealed intra-articular administration of TXA decreased not only blood loss, but also knee joint swelling after TKA.
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35 Hb levels
36 MethodsWe
37 PurposeThis
38 ResultsThe results
39 TXA group
40 acid
41 administration
42 arthroplasty
43 blood loss
44 closed suction drain
45 closure
46 conditions
47 control group
48 decrease
49 diameter
50 dimer
51 discharge volume
52 drain
53 group
54 hemoglobin levels
55 influence
56 injection
57 intra-articular administration
58 intra-articular injection
59 joint swelling
60 joints
61 knee arthroplasty
62 knee joint
63 leg
64 leg diameter
65 levels
66 loss
67 mg/20
68 need
69 operation
70 osteoarthritis patients
71 patients
72 physiological saline
73 post-operative decrease
74 post-operative haemoglobin levels
75 pre-operative condition
76 results
77 saline
78 same volume
79 suction drain
80 surgery
81 swelling
82 total
83 total knee arthroplasty
84 tranexamic acid
85 transfusion
86 trials
87 volume
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