Correlation between synovial fluid and serum IL-1β levels after ACL surgery–preliminary report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-04

AUTHORS

Nikica Darabos, Zeljka Hundric-Haspl, Miroslav Haspl, Alemka Markotic, Anela Darabos, Carsten Moser

ABSTRACT

The possibility of controlling the harmful intra-articular influence of elevated interleukin (IL)-1beta synovial fluid concentration after anterior cruciate ligament (ACL) surgery could be useful. We investigated the correlation between serum and synovial fluid IL-1beta levels following ACL reconstruction. We measured IL-1beta concentration periodically in three synovial fluid and four serum samples in each of 20 patients receiving either autologous conditioned serum (ACS) containing endogenous anti-inflammatory cytokines including IL-1Ra and several growth factors (group A) or placebo (group B). A decrease in IL-1beta synovial fluid concentration appeared to be more pronounced in absolute terms in group A. In eight patients serum IL-1beta was detected on the 6th postoperative day. In four of them whose synovial fluid levels were over 10 pg/ml on the 6th postoperative day, serum IL-1beta was detected on the 10th postoperative day. The results were different in group B. Correlation between serum and synovial fluid IL-1beta appearance persists in patients after ACL surgery and ACS application. This study is an example of ACS influence on the ACL healing process controlling the IL-1beta levels on the basis of the serum IL-1beta detection. More... »

PAGES

413-418

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00264-008-0649-1

DOI

http://dx.doi.org/10.1007/s00264-008-0649-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009366092

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18751702


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