Treatment of medullary thyroid carcinoma by combined expression of suicide and interleukin-2 genes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-06

AUTHORS

M. N. Soler, G. Milhaud, F. Lekmine, F. Treilhou-Lahille, D. Klatzmann, S. Lausson

ABSTRACT

Inherited medullary thyroid carcinomas (MTC) are aggressive and resistant to conventional chemo- and radiotherapies. We evaluated a novel strategy for treatment of MTC, combining "suicide" and interleukin-2 (IL-2) gene therapies. Tumors were produced in Wag/Rij rats by orthotopic injection of the rMTC 6-23 cell line, and/or derivatives expressing the herpes simplex virus 1 thymidine kinase (HSV1-TK) gene (rMTC-TK). Ganciclovir, a nucleoside analog selectively transformed to a toxic metabolite by HSV1-TK, totally eradicated rMTC-TK tumors in 60% of the animals. 1:1 rMTC and rMTC-TK mixed tumors were also strongly inhibited by ganciclovir (P < 0.05), indicating the occurrence of an efficient "bystander" effect in vivo. Double labelling of rMTC cell membranes and apoptotic nuclei revealed that, as with the TK+ cells, some TK- cells died by apoptosis. A 1:1 mixture of rMTC and rMTC-TK cells was administered to produce established tumors and then rMTC cells, transfected to express the IL-2 gene (rMTC-IL2), were inoculated. Combined ganciclovir and IL-2 treatment improved the inhibition of tumor growth compared to that following ganciclovir alone (86% compared to 54%, P < 0.05). This treatment also significantly enhanced macrophage activation and tumor infiltration by CD8+ and CD4+ T lymphocytes. These results open an avenue for combining suicide and immunoregulatory gene therapies for MTC management in man. More... »

PAGES

91-99

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s002620050552

DOI

http://dx.doi.org/10.1007/s002620050552

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031191903

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10414462


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiviral Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Medullary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ganciclovir", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Herpesvirus 1, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thymidine Kinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroid Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Paris-Sud", 
          "id": "https://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "Laboratoire d'Endocrinologie Cellulaire et Evolution, B\u00e2t. 440, Universit\u00e9 Paris-Sud, 91405 Orsay C\u00e9dex, France, FR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soler", 
        "givenName": "M. N.", 
        "id": "sg:person.0750150376.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750150376.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Saint-Antoine", 
          "id": "https://www.grid.ac/institutes/grid.412370.3", 
          "name": [
            "Service de Biophysique, H\u00f4pital Saint Antoine, 75012 Paris, France, FR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milhaud", 
        "givenName": "G.", 
        "id": "sg:person.01164415374.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164415374.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Paris-Sud", 
          "id": "https://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "Laboratoire d'Endocrinologie Cellulaire et Evolution, B\u00e2t. 440, Universit\u00e9 Paris-Sud, 91405 Orsay C\u00e9dex, France, FR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lekmine", 
        "givenName": "F.", 
        "id": "sg:person.0616516652.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616516652.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Paris-Sud", 
          "id": "https://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "Laboratoire d'Endocrinologie Cellulaire et Evolution, B\u00e2t. 440, Universit\u00e9 Paris-Sud, 91405 Orsay C\u00e9dex, France, FR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Treilhou-Lahille", 
        "givenName": "F.", 
        "id": "sg:person.077446054.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.077446054.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Laboratoire de biologie et th\u00e9rapeutique des pathologies immunitaires, CNRS ESA 7087, B\u00e2t. Servi, H\u00f4pital La Piti\u00e9-Salpetri\u00e8re, 75651 Paris C\u00e9dex 13, France, FR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klatzmann", 
        "givenName": "D.", 
        "id": "sg:person.0774460013.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774460013.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Paris-Sud", 
          "id": "https://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "Laboratoire d'Endocrinologie Cellulaire et Evolution, B\u00e2t. 440, Universit\u00e9 Paris-Sud, 91405 Orsay C\u00e9dex, France, FR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lausson", 
        "givenName": "S.", 
        "id": "sg:person.0644305627.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644305627.27"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19970117)70:2<183::aid-ijc8>3.0.co;2-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001849566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.172.4.1217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006730953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.177.4.1127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006938858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003072-198803000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015716062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003072-198803000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015716062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-198607000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016671453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-198607000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016671453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19970410)71:2<267::aid-ijc23>3.0.co;2-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019604977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-2478(90)90074-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019669586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-2478(90)90074-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019669586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.10.4348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020769259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0042-6822(95)80065-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020900646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(90)90591-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021299438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.24.11071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023396733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.15.7024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026395098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.149.1.273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027027853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005792-198411000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029111881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005792-198411000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029111881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00192117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031035035", 
          "https://doi.org/10.1007/bf00192117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01517231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032189175", 
          "https://doi.org/10.1007/bf01517231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.5.1831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038739974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002620050311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041951177", 
          "https://doi.org/10.1007/s002620050311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.7.2577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043529031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.1995.6.12-1525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059271510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.1997.8.15-1807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059271936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.1997.8.5-563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059272027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/4.12.1429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059711686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1317968", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062474541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.139.2.5764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064282180"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-06", 
    "datePublishedReg": "1999-06-01", 
    "description": "Inherited medullary thyroid carcinomas (MTC) are aggressive and resistant to conventional chemo- and radiotherapies. We evaluated a novel strategy for treatment of MTC, combining \"suicide\" and interleukin-2 (IL-2) gene therapies. Tumors were produced in Wag/Rij rats by orthotopic injection of the rMTC 6-23 cell line, and/or derivatives expressing the herpes simplex virus 1 thymidine kinase (HSV1-TK) gene (rMTC-TK). Ganciclovir, a nucleoside analog selectively transformed to a toxic metabolite by HSV1-TK, totally eradicated rMTC-TK tumors in 60% of the animals. 1:1 rMTC and rMTC-TK mixed tumors were also strongly inhibited by ganciclovir (P < 0.05), indicating the occurrence of an efficient \"bystander\" effect in vivo. Double labelling of rMTC cell membranes and apoptotic nuclei revealed that, as with the TK+ cells, some TK- cells died by apoptosis. A 1:1 mixture of rMTC and rMTC-TK cells was administered to produce established tumors and then rMTC cells, transfected to express the IL-2 gene (rMTC-IL2), were inoculated. Combined ganciclovir and IL-2 treatment improved the inhibition of tumor growth compared to that following ganciclovir alone (86% compared to 54%, P < 0.05). This treatment also significantly enhanced macrophage activation and tumor infiltration by CD8+ and CD4+ T lymphocytes. These results open an avenue for combining suicide and immunoregulatory gene therapies for MTC management in man.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s002620050552", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096240", 
        "issn": [
          "0340-7004", 
          "1432-0851"
        ], 
        "name": "Cancer Immunology, Immunotherapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2-3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "48"
      }
    ], 
    "name": "Treatment of medullary thyroid carcinoma by combined expression of suicide and interleukin-2 genes", 
    "pagination": "91-99", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "94987b87f54a456e3d71f9739313eeba9d909508f71173416d7320fb2baed63e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10414462"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8605732"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s002620050552"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031191903"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s002620050552", 
      "https://app.dimensions.ai/details/publication/pub.1031191903"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000532.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs002620050552"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s002620050552'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s002620050552'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s002620050552'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s002620050552'


 

This table displays all metadata directly associated to this object as RDF triples.

236 TRIPLES      21 PREDICATES      66 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s002620050552 schema:about N039ec40d1dbe4b61881a6b35276e0d11
2 N0cf0a69b0ab146b8a1afec8ed7da7861
3 N1791df8e9c8642af8d0a7313976896f0
4 N17baf6c27099424fb59f3ede07537b0b
5 N45a42ad92b6b4c5d8cbc5b01f7db0fcb
6 N4877b6ce670b4d40a677070a005952a9
7 N4ed202fe115449b9b14d4ccc7814be56
8 N8704af6ee81b4239af392b3ac0e07f6d
9 Ncce563e5401f4e1e96f65ce98173711c
10 Nd05766f485b644138764f88f459d77c1
11 Nd6c74bfd0a5349f980b8e03dbc0073ef
12 Nfdd42c19a1744de9be9b6375b56176e4
13 anzsrc-for:11
14 anzsrc-for:1107
15 schema:author Nacdbbcdd791f4615a50ac1c498608d68
16 schema:citation sg:pub.10.1007/bf00192117
17 sg:pub.10.1007/bf01517231
18 sg:pub.10.1007/s002620050311
19 https://doi.org/10.1002/(sici)1097-0215(19970117)70:2<183::aid-ijc8>3.0.co;2-t
20 https://doi.org/10.1002/(sici)1097-0215(19970410)71:2<267::aid-ijc23>3.0.co;2-d
21 https://doi.org/10.1016/0092-8674(90)90591-2
22 https://doi.org/10.1016/0165-2478(90)90074-z
23 https://doi.org/10.1016/s0042-6822(95)80065-4
24 https://doi.org/10.1073/pnas.90.15.7024
25 https://doi.org/10.1073/pnas.91.10.4348
26 https://doi.org/10.1073/pnas.92.24.11071
27 https://doi.org/10.1073/pnas.92.7.2577
28 https://doi.org/10.1073/pnas.93.5.1831
29 https://doi.org/10.1084/jem.149.1.273
30 https://doi.org/10.1084/jem.172.4.1217
31 https://doi.org/10.1084/jem.177.4.1127
32 https://doi.org/10.1089/hum.1995.6.12-1525
33 https://doi.org/10.1089/hum.1997.8.15-1807
34 https://doi.org/10.1089/hum.1997.8.5-563
35 https://doi.org/10.1093/intimm/4.12.1429
36 https://doi.org/10.1097/00000478-198607000-00009
37 https://doi.org/10.1097/00003072-198803000-00003
38 https://doi.org/10.1097/00005792-198411000-00001
39 https://doi.org/10.1126/science.1317968
40 https://doi.org/10.1210/endo.139.2.5764
41 schema:datePublished 1999-06
42 schema:datePublishedReg 1999-06-01
43 schema:description Inherited medullary thyroid carcinomas (MTC) are aggressive and resistant to conventional chemo- and radiotherapies. We evaluated a novel strategy for treatment of MTC, combining "suicide" and interleukin-2 (IL-2) gene therapies. Tumors were produced in Wag/Rij rats by orthotopic injection of the rMTC 6-23 cell line, and/or derivatives expressing the herpes simplex virus 1 thymidine kinase (HSV1-TK) gene (rMTC-TK). Ganciclovir, a nucleoside analog selectively transformed to a toxic metabolite by HSV1-TK, totally eradicated rMTC-TK tumors in 60% of the animals. 1:1 rMTC and rMTC-TK mixed tumors were also strongly inhibited by ganciclovir (P < 0.05), indicating the occurrence of an efficient "bystander" effect in vivo. Double labelling of rMTC cell membranes and apoptotic nuclei revealed that, as with the TK+ cells, some TK- cells died by apoptosis. A 1:1 mixture of rMTC and rMTC-TK cells was administered to produce established tumors and then rMTC cells, transfected to express the IL-2 gene (rMTC-IL2), were inoculated. Combined ganciclovir and IL-2 treatment improved the inhibition of tumor growth compared to that following ganciclovir alone (86% compared to 54%, P < 0.05). This treatment also significantly enhanced macrophage activation and tumor infiltration by CD8+ and CD4+ T lymphocytes. These results open an avenue for combining suicide and immunoregulatory gene therapies for MTC management in man.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree false
47 schema:isPartOf N52da9d1940d44a2ba50bbc9c36d0733c
48 N9ab3e360de0c46c7800126f478f6404c
49 sg:journal.1096240
50 schema:name Treatment of medullary thyroid carcinoma by combined expression of suicide and interleukin-2 genes
51 schema:pagination 91-99
52 schema:productId N3b4ce5a020104ecab6dad6fdf61bc1d4
53 N950bbc7816344b47989f147318dd05db
54 Nb13b7e11286b470389d755d279a2257a
55 Nb8fa942a4dfc48ae8d9a8bf76b1cd4b0
56 Nd1a216ee5a8a4b49ab39149bbe56578b
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031191903
58 https://doi.org/10.1007/s002620050552
59 schema:sdDatePublished 2019-04-10T15:55
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N782c8a9612cc40c3bdb3d6ed0633b1e0
62 schema:url http://link.springer.com/10.1007%2Fs002620050552
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N039ec40d1dbe4b61881a6b35276e0d11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Rats
68 rdf:type schema:DefinedTerm
69 N0cf0a69b0ab146b8a1afec8ed7da7861 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Herpesvirus 1, Human
71 rdf:type schema:DefinedTerm
72 N1791df8e9c8642af8d0a7313976896f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name T-Lymphocytes
74 rdf:type schema:DefinedTerm
75 N17baf6c27099424fb59f3ede07537b0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Carcinoma, Medullary
77 rdf:type schema:DefinedTerm
78 N3b4ce5a020104ecab6dad6fdf61bc1d4 schema:name readcube_id
79 schema:value 94987b87f54a456e3d71f9739313eeba9d909508f71173416d7320fb2baed63e
80 rdf:type schema:PropertyValue
81 N45a42ad92b6b4c5d8cbc5b01f7db0fcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Genetic Therapy
83 rdf:type schema:DefinedTerm
84 N4877b6ce670b4d40a677070a005952a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Interleukin-2
86 rdf:type schema:DefinedTerm
87 N4ed202fe115449b9b14d4ccc7814be56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Rats, Inbred Strains
89 rdf:type schema:DefinedTerm
90 N52c6db4c0ec147659d1c7be8c666a216 rdf:first sg:person.0616516652.05
91 rdf:rest N9d6ee58368084989bc4b027efe25da7e
92 N52da9d1940d44a2ba50bbc9c36d0733c schema:volumeNumber 48
93 rdf:type schema:PublicationVolume
94 N539d8ae69a1d4aa383ddf124782559fb rdf:first sg:person.01164415374.69
95 rdf:rest N52c6db4c0ec147659d1c7be8c666a216
96 N6c990f3deb9d43fc9ceff4a95d1fd4d5 rdf:first sg:person.0774460013.91
97 rdf:rest Ncfc98fd72b7d40eaa712ea3fa1ed399f
98 N782c8a9612cc40c3bdb3d6ed0633b1e0 schema:name Springer Nature - SN SciGraph project
99 rdf:type schema:Organization
100 N8704af6ee81b4239af392b3ac0e07f6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Thymidine Kinase
102 rdf:type schema:DefinedTerm
103 N950bbc7816344b47989f147318dd05db schema:name pubmed_id
104 schema:value 10414462
105 rdf:type schema:PropertyValue
106 N9ab3e360de0c46c7800126f478f6404c schema:issueNumber 2-3
107 rdf:type schema:PublicationIssue
108 N9d6ee58368084989bc4b027efe25da7e rdf:first sg:person.077446054.18
109 rdf:rest N6c990f3deb9d43fc9ceff4a95d1fd4d5
110 Nacdbbcdd791f4615a50ac1c498608d68 rdf:first sg:person.0750150376.30
111 rdf:rest N539d8ae69a1d4aa383ddf124782559fb
112 Nb13b7e11286b470389d755d279a2257a schema:name nlm_unique_id
113 schema:value 8605732
114 rdf:type schema:PropertyValue
115 Nb8fa942a4dfc48ae8d9a8bf76b1cd4b0 schema:name dimensions_id
116 schema:value pub.1031191903
117 rdf:type schema:PropertyValue
118 Ncce563e5401f4e1e96f65ce98173711c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Antiviral Agents
120 rdf:type schema:DefinedTerm
121 Ncfc98fd72b7d40eaa712ea3fa1ed399f rdf:first sg:person.0644305627.27
122 rdf:rest rdf:nil
123 Nd05766f485b644138764f88f459d77c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Ganciclovir
125 rdf:type schema:DefinedTerm
126 Nd1a216ee5a8a4b49ab39149bbe56578b schema:name doi
127 schema:value 10.1007/s002620050552
128 rdf:type schema:PropertyValue
129 Nd6c74bfd0a5349f980b8e03dbc0073ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Thyroid Neoplasms
131 rdf:type schema:DefinedTerm
132 Nfdd42c19a1744de9be9b6375b56176e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Animals
134 rdf:type schema:DefinedTerm
135 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
136 schema:name Medical and Health Sciences
137 rdf:type schema:DefinedTerm
138 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
139 schema:name Immunology
140 rdf:type schema:DefinedTerm
141 sg:journal.1096240 schema:issn 0340-7004
142 1432-0851
143 schema:name Cancer Immunology, Immunotherapy
144 rdf:type schema:Periodical
145 sg:person.01164415374.69 schema:affiliation https://www.grid.ac/institutes/grid.412370.3
146 schema:familyName Milhaud
147 schema:givenName G.
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164415374.69
149 rdf:type schema:Person
150 sg:person.0616516652.05 schema:affiliation https://www.grid.ac/institutes/grid.5842.b
151 schema:familyName Lekmine
152 schema:givenName F.
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616516652.05
154 rdf:type schema:Person
155 sg:person.0644305627.27 schema:affiliation https://www.grid.ac/institutes/grid.5842.b
156 schema:familyName Lausson
157 schema:givenName S.
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644305627.27
159 rdf:type schema:Person
160 sg:person.0750150376.30 schema:affiliation https://www.grid.ac/institutes/grid.5842.b
161 schema:familyName Soler
162 schema:givenName M. N.
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750150376.30
164 rdf:type schema:Person
165 sg:person.0774460013.91 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
166 schema:familyName Klatzmann
167 schema:givenName D.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774460013.91
169 rdf:type schema:Person
170 sg:person.077446054.18 schema:affiliation https://www.grid.ac/institutes/grid.5842.b
171 schema:familyName Treilhou-Lahille
172 schema:givenName F.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.077446054.18
174 rdf:type schema:Person
175 sg:pub.10.1007/bf00192117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031035035
176 https://doi.org/10.1007/bf00192117
177 rdf:type schema:CreativeWork
178 sg:pub.10.1007/bf01517231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032189175
179 https://doi.org/10.1007/bf01517231
180 rdf:type schema:CreativeWork
181 sg:pub.10.1007/s002620050311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041951177
182 https://doi.org/10.1007/s002620050311
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1002/(sici)1097-0215(19970117)70:2<183::aid-ijc8>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1001849566
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1002/(sici)1097-0215(19970410)71:2<267::aid-ijc23>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1019604977
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/0092-8674(90)90591-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021299438
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/0165-2478(90)90074-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1019669586
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s0042-6822(95)80065-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020900646
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1073/pnas.90.15.7024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026395098
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1073/pnas.91.10.4348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020769259
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1073/pnas.92.24.11071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023396733
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1073/pnas.92.7.2577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043529031
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1073/pnas.93.5.1831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038739974
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1084/jem.149.1.273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027027853
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1084/jem.172.4.1217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006730953
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1084/jem.177.4.1127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006938858
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1089/hum.1995.6.12-1525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059271510
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1089/hum.1997.8.15-1807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059271936
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1089/hum.1997.8.5-563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059272027
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1093/intimm/4.12.1429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059711686
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1097/00000478-198607000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016671453
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1097/00003072-198803000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015716062
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1097/00005792-198411000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029111881
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1126/science.1317968 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062474541
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1210/endo.139.2.5764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064282180
227 rdf:type schema:CreativeWork
228 https://www.grid.ac/institutes/grid.411439.a schema:alternateName Pitié-Salpêtrière Hospital
229 schema:name Laboratoire de biologie et thérapeutique des pathologies immunitaires, CNRS ESA 7087, Bât. Servi, Hôpital La Pitié-Salpetrière, 75651 Paris Cédex 13, France, FR
230 rdf:type schema:Organization
231 https://www.grid.ac/institutes/grid.412370.3 schema:alternateName Hôpital Saint-Antoine
232 schema:name Service de Biophysique, Hôpital Saint Antoine, 75012 Paris, France, FR
233 rdf:type schema:Organization
234 https://www.grid.ac/institutes/grid.5842.b schema:alternateName University of Paris-Sud
235 schema:name Laboratoire d'Endocrinologie Cellulaire et Evolution, Bât. 440, Université Paris-Sud, 91405 Orsay Cédex, France, FR
236 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...