Sirtuin2 enhances the tumoricidal function of liver natural killer cells in a mouse hepatocellular carcinoma model. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-06

AUTHORS

Ming Chen, Min Xu, Chengliang Zhu, Hongling Wang, Qiu Zhao, Feng Zhou

ABSTRACT

Hepatocellular carcinoma (HCC) is the third most lethal cancer in the world. Natural killer (NK) cell-mediated immunity is crucial for tumor surveillance and therapy. Characterization of the regulatory mechanisms of NK cell function is important for developing novel immunotherapies against HCC. In this study, we used a chemical-induced mouse HCC model to identify the upregulation of Sirtuin2 (SIRT2) in liver NK cells. In particular, SIRT2 was predominantly expressed in liver CD94+ NK cells. The HCC liver microenvironment induced SIRT2 expression in NK cells. In addition, overexpression of exogenous SIRT2 significantly upregulated the production of cytokines and cytotoxic mediators in activated NK cells. Consistently, SIRT2-overexpressing NK cells showed a stronger tumoricidal effect on hepatoma cells. Moreover, SIRT2 remarkably promoted the phosphorylation of Extracellular-signal-regulated kinase 1/2 (Erk1/2) and p38 Mitogen-activated protein kinases (MAPK) in activated NK cells. SIRT2 knockdown in liver CD94+ NK cells impaired their cytotoxic effect on hepatoma cells. Our study indicates that SIRT2 enhances the tumoricidal activity of liver NK cells in HCC. More... »

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-019-02337-5

DOI

http://dx.doi.org/10.1007/s00262-019-02337-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113283274

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30955067


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Zhongnan Hospital of Wuhan University", 
          "id": "https://www.grid.ac/institutes/grid.413247.7", 
          "name": [
            "Department of Blood Transfusion, Zhongnan Hospital of Wuhan University, Wuhan, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Ming", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Huazhong University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.33199.31", 
          "name": [
            "Department of Hematology and Oncology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Min", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Renmin Hospital of Wuhan University", 
          "id": "https://www.grid.ac/institutes/grid.412632.0", 
          "name": [
            "Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Chengliang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Zhongnan Hospital of Wuhan University", 
          "id": "https://www.grid.ac/institutes/grid.413247.7", 
          "name": [
            "Hubei Clinical Center and Key Laboratory for Intestinal and Colorectal Disease, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, 169 East Lake Road, Wuchang District, Wuhan City, Hubei Province, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Hongling", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Zhongnan Hospital of Wuhan University", 
          "id": "https://www.grid.ac/institutes/grid.413247.7", 
          "name": [
            "Hubei Clinical Center and Key Laboratory for Intestinal and Colorectal Disease, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, 169 East Lake Road, Wuchang District, Wuhan City, Hubei Province, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Qiu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Zhongnan Hospital of Wuhan University", 
          "id": "https://www.grid.ac/institutes/grid.413247.7", 
          "name": [
            "Hubei Clinical Center and Key Laboratory for Intestinal and Colorectal Disease, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, 169 East Lake Road, Wuchang District, Wuhan City, Hubei Province, China. fengzhou@whu.edu.cn."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Feng", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1371/journal.pone.0075139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001978085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15384101.2016.1189041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006239774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1100903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006463271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2014030226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009638921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1681/asn.2014030226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009638921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/abbs/gmt151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009797816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/imm.12224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010100326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012096644", 
          "https://doi.org/10.1038/onc.2013.344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012096644", 
          "https://doi.org/10.1038/onc.2013.344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2009.09.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012815377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnagi.2014.00333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013756149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci38902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031678995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci38902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031678995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2015.00578", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041465049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cmi.2016.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043364562", 
          "https://doi.org/10.1038/cmi.2016.28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0611655104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046757744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0019047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048316550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01206-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049815904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.201600410rr", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052135531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2015.3275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071514139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2015.3275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071514139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.165.4.1782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074678970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.180.6.3739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077616239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0900907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077966315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2017.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083906181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymthe.2017.06.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090283765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1600789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090695075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymthe.2017.12.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099712744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.201747281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100394339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.201747281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100394339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.201747281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100394339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41590-018-0044-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100671496", 
          "https://doi.org/10.1038/s41590-018-0044-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2018.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101837116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2018.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101837116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2018.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101837116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2018.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101837116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2018.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101837116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12035-018-1058-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103248527", 
          "https://doi.org/10.1007/s12035-018-1058-0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04-06", 
    "datePublishedReg": "2019-04-06", 
    "description": "Hepatocellular carcinoma (HCC) is the third most lethal cancer in the world. Natural killer (NK) cell-mediated immunity is crucial for tumor surveillance and therapy. Characterization of the regulatory mechanisms of NK cell function is important for developing novel immunotherapies against HCC. In this study, we used a chemical-induced mouse HCC model to identify the upregulation of Sirtuin2 (SIRT2) in liver NK cells. In particular, SIRT2 was predominantly expressed in liver CD94+ NK cells. The HCC liver microenvironment induced SIRT2 expression in NK cells. In addition, overexpression of exogenous SIRT2 significantly upregulated the production of cytokines and cytotoxic mediators in activated NK cells. Consistently, SIRT2-overexpressing NK cells showed a stronger tumoricidal effect on hepatoma cells. Moreover, SIRT2 remarkably promoted the phosphorylation of Extracellular-signal-regulated kinase 1/2 (Erk1/2) and p38 Mitogen-activated protein kinases (MAPK) in activated NK cells. SIRT2 knockdown in liver CD94+ NK cells impaired their cytotoxic effect on hepatoma cells. Our study indicates that SIRT2 enhances the tumoricidal activity of liver NK cells in HCC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00262-019-02337-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096240", 
        "issn": [
          "0340-7004", 
          "1432-0851"
        ], 
        "name": "Cancer Immunology, Immunotherapy", 
        "type": "Periodical"
      }
    ], 
    "name": "Sirtuin2 enhances the tumoricidal function of liver natural killer cells in a mouse hepatocellular carcinoma model.", 
    "productId": [
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30955067"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8605732"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00262-019-02337-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113283274"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00262-019-02337-5", 
      "https://app.dimensions.ai/details/publication/pub.1113283274"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13093_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00262-019-02337-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-019-02337-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-019-02337-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-019-02337-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-019-02337-5'


 

This table displays all metadata directly associated to this object as RDF triples.

183 TRIPLES      20 PREDICATES      52 URIs      16 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00262-019-02337-5 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N13531b6db454497284e7c852fec9df08
4 schema:citation sg:pub.10.1007/s12035-018-1058-0
5 sg:pub.10.1038/cmi.2016.28
6 sg:pub.10.1038/onc.2013.344
7 sg:pub.10.1038/s41590-018-0044-z
8 https://doi.org/10.1002/eji.201747281
9 https://doi.org/10.1016/j.coi.2017.01.003
10 https://doi.org/10.1016/j.coi.2018.03.013
11 https://doi.org/10.1016/j.jaci.2009.09.045
12 https://doi.org/10.1016/j.ymthe.2017.06.012
13 https://doi.org/10.1016/j.ymthe.2017.12.012
14 https://doi.org/10.1073/pnas.0611655104
15 https://doi.org/10.1080/15384101.2016.1189041
16 https://doi.org/10.1093/abbs/gmt151
17 https://doi.org/10.1096/fj.201600410rr
18 https://doi.org/10.1111/imm.12224
19 https://doi.org/10.1128/mcb.01206-10
20 https://doi.org/10.1172/jci38902
21 https://doi.org/10.1371/journal.pone.0019047
22 https://doi.org/10.1371/journal.pone.0075139
23 https://doi.org/10.1681/asn.2014030226
24 https://doi.org/10.3389/fimmu.2015.00578
25 https://doi.org/10.3389/fnagi.2014.00333
26 https://doi.org/10.3892/ijo.2015.3275
27 https://doi.org/10.4049/jimmunol.0900907
28 https://doi.org/10.4049/jimmunol.1100903
29 https://doi.org/10.4049/jimmunol.1600789
30 https://doi.org/10.4049/jimmunol.165.4.1782
31 https://doi.org/10.4049/jimmunol.180.6.3739
32 schema:datePublished 2019-04-06
33 schema:datePublishedReg 2019-04-06
34 schema:description Hepatocellular carcinoma (HCC) is the third most lethal cancer in the world. Natural killer (NK) cell-mediated immunity is crucial for tumor surveillance and therapy. Characterization of the regulatory mechanisms of NK cell function is important for developing novel immunotherapies against HCC. In this study, we used a chemical-induced mouse HCC model to identify the upregulation of Sirtuin2 (SIRT2) in liver NK cells. In particular, SIRT2 was predominantly expressed in liver CD94<sup>+</sup> NK cells. The HCC liver microenvironment induced SIRT2 expression in NK cells. In addition, overexpression of exogenous SIRT2 significantly upregulated the production of cytokines and cytotoxic mediators in activated NK cells. Consistently, SIRT2-overexpressing NK cells showed a stronger tumoricidal effect on hepatoma cells. Moreover, SIRT2 remarkably promoted the phosphorylation of Extracellular-signal-regulated kinase 1/2 (Erk1/2) and p38 Mitogen-activated protein kinases (MAPK) in activated NK cells. SIRT2 knockdown in liver CD94<sup>+</sup> NK cells impaired their cytotoxic effect on hepatoma cells. Our study indicates that SIRT2 enhances the tumoricidal activity of liver NK cells in HCC.
35 schema:genre research_article
36 schema:inLanguage en
37 schema:isAccessibleForFree false
38 schema:isPartOf sg:journal.1096240
39 schema:name Sirtuin2 enhances the tumoricidal function of liver natural killer cells in a mouse hepatocellular carcinoma model.
40 schema:productId N195168ff1a284329a1c32db01bfeab79
41 N3260769889254d469c370e1a41a22c1b
42 N6e3cd2f6743045c49cb92a97fdd72392
43 Nb5af78800b8243d6ba30f21413b7a269
44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113283274
45 https://doi.org/10.1007/s00262-019-02337-5
46 schema:sdDatePublished 2019-04-11T14:31
47 schema:sdLicense https://scigraph.springernature.com/explorer/license/
48 schema:sdPublisher N207820e5e66d4e99ad06b2f801094dd1
49 schema:url http://link.springer.com/10.1007/s00262-019-02337-5
50 sgo:license sg:explorer/license/
51 sgo:sdDataset articles
52 rdf:type schema:ScholarlyArticle
53 N0b7ed2c2dade4227aedc28995813e494 rdf:first Nd9dff5e43b6449448fc2984ca6888fcd
54 rdf:rest N290ab58d8e8a47649a7098434dbabb2c
55 N0e9d553a466f4c90848b9fda058d1ba5 schema:affiliation https://www.grid.ac/institutes/grid.413247.7
56 schema:familyName Zhou
57 schema:givenName Feng
58 rdf:type schema:Person
59 N13531b6db454497284e7c852fec9df08 rdf:first N945d3fdcebed49ca84b4cdfa1f16c19b
60 rdf:rest N578e112c6a9b4933ad7755d8d4d725a5
61 N195168ff1a284329a1c32db01bfeab79 schema:name pubmed_id
62 schema:value 30955067
63 rdf:type schema:PropertyValue
64 N207820e5e66d4e99ad06b2f801094dd1 schema:name Springer Nature - SN SciGraph project
65 rdf:type schema:Organization
66 N290ab58d8e8a47649a7098434dbabb2c rdf:first N4fb2e4cd900b46eeae8c41c6059b1dca
67 rdf:rest N2a7a73043b984d31ad3ad8aa74ecd067
68 N2a7a73043b984d31ad3ad8aa74ecd067 rdf:first N0e9d553a466f4c90848b9fda058d1ba5
69 rdf:rest rdf:nil
70 N3260769889254d469c370e1a41a22c1b schema:name dimensions_id
71 schema:value pub.1113283274
72 rdf:type schema:PropertyValue
73 N4fb2e4cd900b46eeae8c41c6059b1dca schema:affiliation https://www.grid.ac/institutes/grid.413247.7
74 schema:familyName Zhao
75 schema:givenName Qiu
76 rdf:type schema:Person
77 N578e112c6a9b4933ad7755d8d4d725a5 rdf:first Na03f12e864814ba68985a4fa0e2b1b21
78 rdf:rest Nb8464b5a34c64995ad1dd88441c0d0e2
79 N6e3cd2f6743045c49cb92a97fdd72392 schema:name nlm_unique_id
80 schema:value 8605732
81 rdf:type schema:PropertyValue
82 N945d3fdcebed49ca84b4cdfa1f16c19b schema:affiliation https://www.grid.ac/institutes/grid.413247.7
83 schema:familyName Chen
84 schema:givenName Ming
85 rdf:type schema:Person
86 N9ac9aa10ee2540a0bda47fcf1e81c51c schema:affiliation https://www.grid.ac/institutes/grid.412632.0
87 schema:familyName Zhu
88 schema:givenName Chengliang
89 rdf:type schema:Person
90 Na03f12e864814ba68985a4fa0e2b1b21 schema:affiliation https://www.grid.ac/institutes/grid.33199.31
91 schema:familyName Xu
92 schema:givenName Min
93 rdf:type schema:Person
94 Nb5af78800b8243d6ba30f21413b7a269 schema:name doi
95 schema:value 10.1007/s00262-019-02337-5
96 rdf:type schema:PropertyValue
97 Nb8464b5a34c64995ad1dd88441c0d0e2 rdf:first N9ac9aa10ee2540a0bda47fcf1e81c51c
98 rdf:rest N0b7ed2c2dade4227aedc28995813e494
99 Nd9dff5e43b6449448fc2984ca6888fcd schema:affiliation https://www.grid.ac/institutes/grid.413247.7
100 schema:familyName Wang
101 schema:givenName Hongling
102 rdf:type schema:Person
103 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
104 schema:name Medical and Health Sciences
105 rdf:type schema:DefinedTerm
106 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
107 schema:name Immunology
108 rdf:type schema:DefinedTerm
109 sg:journal.1096240 schema:issn 0340-7004
110 1432-0851
111 schema:name Cancer Immunology, Immunotherapy
112 rdf:type schema:Periodical
113 sg:pub.10.1007/s12035-018-1058-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103248527
114 https://doi.org/10.1007/s12035-018-1058-0
115 rdf:type schema:CreativeWork
116 sg:pub.10.1038/cmi.2016.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043364562
117 https://doi.org/10.1038/cmi.2016.28
118 rdf:type schema:CreativeWork
119 sg:pub.10.1038/onc.2013.344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012096644
120 https://doi.org/10.1038/onc.2013.344
121 rdf:type schema:CreativeWork
122 sg:pub.10.1038/s41590-018-0044-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1100671496
123 https://doi.org/10.1038/s41590-018-0044-z
124 rdf:type schema:CreativeWork
125 https://doi.org/10.1002/eji.201747281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100394339
126 rdf:type schema:CreativeWork
127 https://doi.org/10.1016/j.coi.2017.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083906181
128 rdf:type schema:CreativeWork
129 https://doi.org/10.1016/j.coi.2018.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101837116
130 rdf:type schema:CreativeWork
131 https://doi.org/10.1016/j.jaci.2009.09.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012815377
132 rdf:type schema:CreativeWork
133 https://doi.org/10.1016/j.ymthe.2017.06.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090283765
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1016/j.ymthe.2017.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099712744
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1073/pnas.0611655104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046757744
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1080/15384101.2016.1189041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006239774
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1093/abbs/gmt151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009797816
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1096/fj.201600410rr schema:sameAs https://app.dimensions.ai/details/publication/pub.1052135531
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1111/imm.12224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010100326
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1128/mcb.01206-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049815904
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1172/jci38902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031678995
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1371/journal.pone.0019047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048316550
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1371/journal.pone.0075139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001978085
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1681/asn.2014030226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009638921
156 rdf:type schema:CreativeWork
157 https://doi.org/10.3389/fimmu.2015.00578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041465049
158 rdf:type schema:CreativeWork
159 https://doi.org/10.3389/fnagi.2014.00333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013756149
160 rdf:type schema:CreativeWork
161 https://doi.org/10.3892/ijo.2015.3275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071514139
162 rdf:type schema:CreativeWork
163 https://doi.org/10.4049/jimmunol.0900907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077966315
164 rdf:type schema:CreativeWork
165 https://doi.org/10.4049/jimmunol.1100903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006463271
166 rdf:type schema:CreativeWork
167 https://doi.org/10.4049/jimmunol.1600789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090695075
168 rdf:type schema:CreativeWork
169 https://doi.org/10.4049/jimmunol.165.4.1782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074678970
170 rdf:type schema:CreativeWork
171 https://doi.org/10.4049/jimmunol.180.6.3739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077616239
172 rdf:type schema:CreativeWork
173 https://www.grid.ac/institutes/grid.33199.31 schema:alternateName Huazhong University of Science and Technology
174 schema:name Department of Hematology and Oncology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
175 rdf:type schema:Organization
176 https://www.grid.ac/institutes/grid.412632.0 schema:alternateName Renmin Hospital of Wuhan University
177 schema:name Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.
178 rdf:type schema:Organization
179 https://www.grid.ac/institutes/grid.413247.7 schema:alternateName Zhongnan Hospital of Wuhan University
180 schema:name Department of Blood Transfusion, Zhongnan Hospital of Wuhan University, Wuhan, China.
181 Hubei Clinical Center and Key Laboratory for Intestinal and Colorectal Disease, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, 169 East Lake Road, Wuchang District, Wuhan City, Hubei Province, China.
182 Hubei Clinical Center and Key Laboratory for Intestinal and Colorectal Disease, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, 169 East Lake Road, Wuchang District, Wuhan City, Hubei Province, China. fengzhou@whu.edu.cn.
183 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...