Unlocking the therapeutic potential of primary tumor-draining lymph nodes. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-03

AUTHORS

Jossie Rotman, Bas D Koster, Ekaterina S Jordanova, A Marijne Heeren, Tanja D de Gruijl

ABSTRACT

Lymph nodes draining the primary tumor are essential for the initiation of an effective anti-tumor T-cell immune response. However, cancer-derived immune suppressive factors render the tumor-draining lymph nodes (TDLN) immune compromised, enabling tumors to invade and metastasize. Unraveling the different mechanisms underlying this immune escape will inform therapeutic intervention strategies to halt tumor spread in early clinical stages. Here, we review our findings from translational studies in melanoma, breast, and cervical cancer and discuss clinical opportunities for local immune modulation of TDLN in each of these indications. More... »

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-019-02330-y

DOI

http://dx.doi.org/10.1007/s00262-019-02330-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113182335

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30944963


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