Cryptotanshinone has curative dual anti-proliferative and immunotherapeutic effects on mouse Lewis lung carcinoma. View Full Text


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Article Info

DATE

2019-04-10

AUTHORS

Shuo Liu, Zhen Han, Anna L Trivett, Hongsheng Lin, Sean Hannifin, De Yang, Joost J Oppenheim

ABSTRACT

Lung cancer is currently the leading cause of cancer-related mortality with very limited effective therapy. Screening of a variety of traditional Chinese medicines (TCMs) for their capacity to inhibit the proliferation of human lung cancer A549 cells and to induce the in vitro maturation of human DCs led to the identification of cryptotanshinone (CT), a compound purified from the TCM Salvia miltiorrhiza Bunge. Here, CT was shown to inhibit the proliferation of mouse Lewis lung carcinoma (LLC) cells by upregulating p53, downregulating cyclin B1 and Cdc2, and, consequently, inducing G2/M cell-cycle arrest of LLC cells. In addition, CT promoted maturation of mouse and human DCs with upregulation of costimulatory and MHC molecules and stimulated DCs to produce TNFα, IL-1β, and IL-12p70, but not IL-10 in vitro. CT-induced maturation of DCs depended on MyD88 and also involved the activation of NF-κB, p38, and JNK. CT was effective in the treatment of LLC tumors and, when used in combination with low doses of anti-PD-L1, cured LLC-bearing mice with the induction of subsequent anti-LLC long-term specific immunity. CT treatment promoted T-cell infiltration and elevated the expression of genes typical of Th1 polarization in LLC tumor tissue. The therapeutic effect of CT and low doses of anti-PD-L1 was reduced by depletion of CD4 and CD8 T cells. This paper provides the first report that CT induces immunological antitumor activities and may provide a new promising antitumor immunotherapeutic. More... »

References to SciGraph publications

  • 2017-12. Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors in SCIENTIFIC REPORTS
  • 2005-04. Immunosuppressive networks in the tumour environment and their therapeutic relevance in NATURE REVIEWS CANCER
  • 2010-09. Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer in CELLULAR & MOLECULAR IMMUNOLOGY
  • 2012-09. Cryptotanshinone induces cell cycle arrest and apoptosis of multidrug resistant human chronic myeloid leukemia cells by inhibiting the activity of eukaryotic initiation factor 4E in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2008-06. Inhibitory B7-family molecules in the tumour microenvironment in NATURE REVIEWS IMMUNOLOGY
  • 1998-03. Dendritic cells and the control of immunity in NATURE
  • 2015-08. Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2012-06. Tanshinones from Chinese Medicinal Herb Danshen (Salvia miltiorrhiza Bunge) Suppress Prostate Cancer Growth and Androgen Receptor Signaling in PHARMACEUTICAL RESEARCH
  • 2003-12. Dendritic-cell control of pathogen-driven T-cell polarization in NATURE REVIEWS IMMUNOLOGY
  • 2013-10. Inactivation of tumor-specific CD8+ CTLs by tumor-infiltrating tolerogenic dendritic cells in IMMUNOLOGY AND CELL BIOLOGY
  • 2003-02. Interleukin-12 and the regulation of innate resistance and adaptive immunity in NATURE REVIEWS IMMUNOLOGY
  • 2002-08. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion in NATURE MEDICINE
  • 2001-04. Regulation of the G2/M transition by p53 in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00262-019-02326-8

    DOI

    http://dx.doi.org/10.1007/s00262-019-02326-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113356134

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30972427


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