Ontology type: schema:ScholarlyArticle
2019-04
AUTHORSRyungsa Kim, Ami Kawai, Megumi Wakisaka, Yuri Funaoka, Naomi Yasuda, Masayuki Hidaka, Yukitaka Morita, Shoichro Ohtani, Mitsuya Ito, Koji Arihiro
ABSTRACTTumor-infiltrating lymphocytes are an important prognostic factor after neoadjuvant chemotherapy (NAC) in patients with breast cancer. Natural killer (NK) cells play critical roles in antitumor immune surveillance. Here, we assessed the relationship between peripheral natural killer (pNK) cell activity, tumor microenvironmental factors (TMEFs), and the therapeutic efficacy of preoperative chemotherapy in patients with breast cancer. In a cohort of 39 patients diagnosed with stage II-IV breast cancer who received NAC, we measured pNK cell activity by chromium release assay and assessed TMEF levels by next-generation sequencing. Following NAC, pNK cell activity was increased in 24/39 patients but decreased in 15/39 patients. Increased pNK cell activity following preoperative chemotherapy was associated significantly with the disappearance of axillary lymph node metastasis (Ax+; p = 0.0235). Increased pNK cell activity remained significantly associated with the disappearance of Ax+ in multivariate logistic regression analysis (OR 5.41, 95% CI 1.19-24.52, p = 0.0283). A Grade 2 or higher effect of NAC was associated with high pre-NAC cytotoxic T lymphocyte-associated protein 4 (CTLA-4) levels (p = 0.0281) and elevated post-NAC NK (p = 0.0005) cells and transforming growth factor-beta (TGF-β; p = 0.0350) levels. The disappearance of Ax+ was associated with high pre-NAC CTLA-4 levels (p = 0.0278) and elevated CD4 levels after NAC (p = 0.0250). The systemic activation of pNK cells after NAC may improve metastatic tumor elimination in patients with breast cancer owing to a release from local immunosuppression, and immune activation in the tumor microenvironment. More... »
PAGES1-9
http://scigraph.springernature.com/pub.10.1007/s00262-019-02305-z
DOIhttp://dx.doi.org/10.1007/s00262-019-02305-z
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1111626863
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30673828
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"name": [
"Breast Surgery, Hiroshima Mark Clinic, 1-4-3F, 2-Chome, Ohte-machi, Naka-ku, 730-0051, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Ryungsa",
"id": "sg:person.0760057273.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760057273.47"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Breast Surgery, Hiroshima Mark Clinic, 1-4-3F, 2-Chome, Ohte-machi, Naka-ku, 730-0051, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Kawai",
"givenName": "Ami",
"id": "sg:person.012311262227.80",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012311262227.80"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Breast Surgery, Hiroshima Mark Clinic, 1-4-3F, 2-Chome, Ohte-machi, Naka-ku, 730-0051, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Wakisaka",
"givenName": "Megumi",
"id": "sg:person.013106642627.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013106642627.49"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Breast Surgery, Hiroshima Mark Clinic, 1-4-3F, 2-Chome, Ohte-machi, Naka-ku, 730-0051, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Funaoka",
"givenName": "Yuri",
"id": "sg:person.013704223227.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013704223227.49"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Breast Surgery, Hiroshima Mark Clinic, 1-4-3F, 2-Chome, Ohte-machi, Naka-ku, 730-0051, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Yasuda",
"givenName": "Naomi",
"id": "sg:person.012522551046.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012522551046.40"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Genetic Testing Gene Research, 1-4-5F, 2-Chome, Ohte-machi, Naka-ku, 730-0051, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Hidaka",
"givenName": "Masayuki",
"id": "sg:person.014023066730.77",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014023066730.77"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Genetic Testing Gene Research, 1-4-5F, 2-Chome, Ohte-machi, Naka-ku, 730-0051, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Morita",
"givenName": "Yukitaka",
"id": "sg:person.014620447330.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014620447330.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima City Asa Hospital",
"id": "https://www.grid.ac/institutes/grid.414157.2",
"name": [
"Department of Breast Surgery, Hiroshima City Hospital, 7-33, Moto-machi, Naka-ku, 730-8518, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Ohtani",
"givenName": "Shoichro",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima City Asa Hospital",
"id": "https://www.grid.ac/institutes/grid.414157.2",
"name": [
"Department of Breast Surgery, Hiroshima City Hospital, 7-33, Moto-machi, Naka-ku, 730-8518, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Ito",
"givenName": "Mitsuya",
"id": "sg:person.0620605031.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620605031.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University Hospital",
"id": "https://www.grid.ac/institutes/grid.470097.d",
"name": [
"Department of Anatomical Pathology, Hiroshima University Hospital, 2-3, 1-Chome Kasumi, Minami-ku, 734-8551, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Arihiro",
"givenName": "Koji",
"id": "sg:person.0760545744.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760545744.50"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/s12967-015-0535-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000959769",
"https://doi.org/10.1186/s12967-015-0535-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc3603",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007099448",
"https://doi.org/10.1038/nrc3603"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-13-1642",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015811873"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci45816",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015962604"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20130960",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016698866"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2325/jbcs.13.254",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020254423",
"https://doi.org/10.2325/jbcs.13.254"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00262-011-1053-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021388653",
"https://doi.org/10.1007/s00262-011-1053-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.2013.634",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023376159",
"https://doi.org/10.1038/bjc.2013.634"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12967-015-0567-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025710529",
"https://doi.org/10.1186/s12967-015-0567-0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20051511",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030092909"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20051511",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030092909"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-016-5339-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038577464",
"https://doi.org/10.1245/s10434-016-5339-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-016-5339-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038577464",
"https://doi.org/10.1245/s10434-016-5339-4"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2016.12.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053981356"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2016.12.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053981356"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2002.20.5.1304",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083941982"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.clbc.2017.09.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092059793"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.clbc.2017.09.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092059793"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(17)30904-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1099620115"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-04",
"datePublishedReg": "2019-04-01",
"description": "Tumor-infiltrating lymphocytes are an important prognostic factor after neoadjuvant chemotherapy (NAC) in patients with breast cancer. Natural killer (NK) cells play critical roles in antitumor immune surveillance. Here, we assessed the relationship between peripheral natural killer (pNK) cell activity, tumor microenvironmental factors (TMEFs), and the therapeutic efficacy of preoperative chemotherapy in patients with breast cancer. In a cohort of 39 patients diagnosed with stage II-IV breast cancer who received NAC, we measured pNK cell activity by chromium release assay and assessed TMEF levels by next-generation sequencing. Following NAC, pNK cell activity was increased in 24/39 patients but decreased in 15/39 patients. Increased pNK cell activity following preoperative chemotherapy was associated significantly with the disappearance of axillary lymph node metastasis (Ax+; p\u2009=\u20090.0235). Increased pNK cell activity remained significantly associated with the disappearance of Ax+ in multivariate logistic regression analysis (OR 5.41, 95% CI 1.19-24.52, p\u2009=\u20090.0283). A Grade 2 or higher effect of NAC was associated with high pre-NAC cytotoxic T lymphocyte-associated protein 4 (CTLA-4) levels (p\u2009=\u20090.0281) and elevated post-NAC NK (p\u2009=\u20090.0005) cells and transforming growth factor-beta (TGF-\u03b2; p\u2009=\u20090.0350) levels. The disappearance of Ax+ was associated with high pre-NAC CTLA-4 levels (p\u2009=\u20090.0278) and elevated CD4 levels after NAC (p\u2009=\u20090.0250). The systemic activation of pNK cells after NAC may improve metastatic tumor elimination in patients with breast cancer owing to a release from local immunosuppression, and immune activation in the tumor microenvironment.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00262-019-02305-z",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1096240",
"issn": [
"0340-7004",
"1432-0851"
],
"name": "Cancer Immunology, Immunotherapy",
"type": "Periodical"
},
{
"issueNumber": "4",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "68"
}
],
"name": "A potential role for peripheral natural killer cell activity induced by preoperative chemotherapy in breast cancer patients",
"pagination": "1-9",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"9fe9d2e3f69336c806573edae79b28c25af861e1bd5ec19d3e355c127e62d825"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30673828"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8605732"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00262-019-02305-z"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1111626863"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00262-019-02305-z",
"https://app.dimensions.ai/details/publication/pub.1111626863"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:48",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130792_00000006.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs00262-019-02305-z"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-019-02305-z'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-019-02305-z'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-019-02305-z'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-019-02305-z'
This table displays all metadata directly associated to this object as RDF triples.
200 TRIPLES
21 PREDICATES
44 URIs
21 LITERALS
9 BLANK NODES