The effect of anti-CTLA4 treatment on peripheral and intra-tumoral T cells in patients with hepatocellular carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

David Agdashian, Mei ElGindi, Changqing Xie, Milan Sandhu, Drew Pratt, David E. Kleiner, William D. Figg, Julie A. Rytlewski, Catherine Sanders, Erik C. Yusko, Bradford Wood, David Venzon, Gagandeep Brar, Austin G. Duffy, Tim F. Greten, Firouzeh Korangy

ABSTRACT

BACKGROUND: Checkpoint inhibitors have recently been approved for the treatment of patients with hepatocellular carcinoma (HCC). However, biomarkers, which will help identify patients responding to therapy, are missing. We recently tested the combination of anti-CTLA4 treatment (tremelimumab) with loco-regional therapy in patients with HCC and reported a partial response rate of 26%. METHODS: Here, we report updated survival analyses and results from our immune monitoring studies on peripheral blood mononuclear cells (PBMCs) and tumors from these patients. RESULTS: Tremelimumab therapy increased CD4+-HLA-DR+, CD4+PD-1+, CD8+HLA-DR+, CD8+PD-1+, CD4+ICOS+ and CD8+ICOS+ T cells in the peripheral blood of the treated patients. Patients with higher CD4+PD1+ cell frequency at baseline were more likely to respond to tremelimumab therapy. PD-1 expression was increased on alpha fetal protein (AFP) and survivin-specific CD8 T cells upon tremelimumab treatment. An increase of tumor infiltrating CD3+ T cells were also seen in these patients. Immunosequencing of longitudinal PBMC showed that one cycle of tremelimumab significantly decreased peripheral clonality, while no additional effects were seen after loco-regional therapy. CONCLUSION: In summary, we observed a clear activation of T cell responses in HCC patients treated with tremelimumab and identified potential biomarkers which will help identify patients responding to immunotherapy with anti-CTLA4. More... »

PAGES

1-10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-019-02299-8

DOI

http://dx.doi.org/10.1007/s00262-019-02299-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111682358

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30688989


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Agdashian", 
        "givenName": "David", 
        "id": "sg:person.0621654440.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621654440.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "ElGindi", 
        "givenName": "Mei", 
        "id": "sg:person.01232624033.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232624033.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xie", 
        "givenName": "Changqing", 
        "id": "sg:person.011005252133.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011005252133.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sandhu", 
        "givenName": "Milan", 
        "id": "sg:person.011020270642.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011020270642.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Laboratory of Pathology, Center for Cancer Research (CCR) National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pratt", 
        "givenName": "Drew", 
        "id": "sg:person.013345672337.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013345672337.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Laboratory of Pathology, Center for Cancer Research (CCR) National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kleiner", 
        "givenName": "David E.", 
        "id": "sg:person.0617046406.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617046406.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Figg", 
        "givenName": "William D.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Adaptive Biotechnologies (United States)", 
          "id": "https://www.grid.ac/institutes/grid.421940.a", 
          "name": [
            "Adaptive Biotechnologies, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rytlewski", 
        "givenName": "Julie A.", 
        "id": "sg:person.011725220613.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011725220613.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Adaptive Biotechnologies (United States)", 
          "id": "https://www.grid.ac/institutes/grid.421940.a", 
          "name": [
            "Adaptive Biotechnologies, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sanders", 
        "givenName": "Catherine", 
        "id": "sg:person.01212251417.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212251417.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Adaptive Biotechnologies (United States)", 
          "id": "https://www.grid.ac/institutes/grid.421940.a", 
          "name": [
            "Adaptive Biotechnologies, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yusko", 
        "givenName": "Erik C.", 
        "id": "sg:person.0734501735.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734501735.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Center for Interventional Oncology, Radiology and Imaging Sciences and Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wood", 
        "givenName": "Bradford", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Venzon", 
        "givenName": "David", 
        "id": "sg:person.01053630317.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053630317.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brar", 
        "givenName": "Gagandeep", 
        "id": "sg:person.01363572011.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363572011.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Duffy", 
        "givenName": "Austin G.", 
        "id": "sg:person.01073601541.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073601541.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, 20892, Bethesda, MD, USA", 
            "NCI CCR Liver Cancer Program, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Greten", 
        "givenName": "Tim F.", 
        "id": "sg:person.0644645350.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644645350.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health", 
          "id": "https://www.grid.ac/institutes/grid.94365.3d", 
          "name": [
            "Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Korangy", 
        "givenName": "Firouzeh", 
        "id": "sg:person.01301223015.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301223015.55"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jim.2011.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007937347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2016.10.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013332645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-04-217604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014830407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020455470", 
          "https://doi.org/10.1038/nature13954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri3158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021347928", 
          "https://doi.org/10.1038/nri3158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-15-1507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030866924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-1721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034680513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-012-1332-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039681130", 
          "https://doi.org/10.1007/s00262-012-1332-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdw181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042567831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00281-016-0614-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044941597", 
          "https://doi.org/10.1007/s00281-016-0614-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00281-016-0614-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044941597", 
          "https://doi.org/10.1007/s00281-016-0614-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3008211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047908959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-13-2648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049292569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrgastro.2017.7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083732764", 
          "https://doi.org/10.1038/nrgastro.2017.7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(17)31046-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084991554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(17)31044-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085020935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1002309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085592854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2017.06.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086043471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2017.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091842520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2017.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091842520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2017.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091842520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(18)30351-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104370126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(18)30351-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104370126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2018.36.4_suppl.475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111064552"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04", 
    "datePublishedReg": "2019-04-01", 
    "description": "BACKGROUND: Checkpoint inhibitors have recently been approved for the treatment of patients with hepatocellular carcinoma (HCC). However, biomarkers, which will help identify patients responding to therapy, are missing. We recently tested the combination of anti-CTLA4 treatment (tremelimumab) with loco-regional therapy in patients with HCC and reported a partial response rate of 26%.\nMETHODS: Here, we report updated survival analyses and results from our immune monitoring studies on peripheral blood mononuclear cells (PBMCs) and tumors from these patients.\nRESULTS: Tremelimumab therapy increased CD4+-HLA-DR+, CD4+PD-1+, CD8+HLA-DR+, CD8+PD-1+, CD4+ICOS+ and CD8+ICOS+ T cells in the peripheral blood of the treated patients. Patients with higher CD4+PD1+ cell frequency at baseline were more likely to respond to tremelimumab therapy. PD-1 expression was increased on alpha fetal protein (AFP) and survivin-specific CD8 T cells upon tremelimumab treatment. An increase of tumor infiltrating CD3+ T cells were also seen in these patients. Immunosequencing of longitudinal PBMC showed that one cycle of tremelimumab significantly decreased peripheral clonality, while no additional effects were seen after loco-regional therapy.\nCONCLUSION: In summary, we observed a clear activation of T cell responses in HCC patients treated with tremelimumab and identified potential biomarkers which will help identify patients responding to immunotherapy with anti-CTLA4.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00262-019-02299-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2724226", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1096240", 
        "issn": [
          "0340-7004", 
          "1432-0851"
        ], 
        "name": "Cancer Immunology, Immunotherapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "68"
      }
    ], 
    "name": "The effect of anti-CTLA4 treatment on peripheral and intra-tumoral T cells in patients with hepatocellular carcinoma", 
    "pagination": "1-10", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e7bc8644a8caa58c4f7f33c63003ec30e5411311e4305aaa918a921f02f9f7ec"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30688989"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8605732"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00262-019-02299-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111682358"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00262-019-02299-8", 
      "https://app.dimensions.ai/details/publication/pub.1111682358"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130801_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00262-019-02299-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00262-019-02299-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00262-019-02299-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00262-019-02299-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00262-019-02299-8'


 

This table displays all metadata directly associated to this object as RDF triples.

250 TRIPLES      21 PREDICATES      49 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00262-019-02299-8 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N381e7397f3f8456081f78134e890a829
4 schema:citation sg:pub.10.1007/s00262-012-1332-3
5 sg:pub.10.1007/s00281-016-0614-9
6 sg:pub.10.1038/nature13954
7 sg:pub.10.1038/nrgastro.2017.7
8 sg:pub.10.1038/nri3158
9 https://doi.org/10.1016/j.jhep.2016.10.029
10 https://doi.org/10.1016/j.jhep.2017.09.007
11 https://doi.org/10.1016/j.jim.2011.09.001
12 https://doi.org/10.1016/s0140-6736(17)31044-9
13 https://doi.org/10.1016/s0140-6736(17)31046-2
14 https://doi.org/10.1016/s1470-2045(18)30351-6
15 https://doi.org/10.1053/j.gastro.2017.06.007
16 https://doi.org/10.1093/annonc/mdw181
17 https://doi.org/10.1126/scitranslmed.3008211
18 https://doi.org/10.1158/1078-0432.ccr-13-1721
19 https://doi.org/10.1158/1078-0432.ccr-13-2648
20 https://doi.org/10.1158/1078-0432.ccr-15-1507
21 https://doi.org/10.1182/blood-2009-04-217604
22 https://doi.org/10.1200/jco.2018.36.4_suppl.475
23 https://doi.org/10.1371/journal.pmed.1002309
24 schema:datePublished 2019-04
25 schema:datePublishedReg 2019-04-01
26 schema:description BACKGROUND: Checkpoint inhibitors have recently been approved for the treatment of patients with hepatocellular carcinoma (HCC). However, biomarkers, which will help identify patients responding to therapy, are missing. We recently tested the combination of anti-CTLA4 treatment (tremelimumab) with loco-regional therapy in patients with HCC and reported a partial response rate of 26%. METHODS: Here, we report updated survival analyses and results from our immune monitoring studies on peripheral blood mononuclear cells (PBMCs) and tumors from these patients. RESULTS: Tremelimumab therapy increased CD4+-HLA-DR+, CD4+PD-1+, CD8+HLA-DR+, CD8+PD-1+, CD4+ICOS+ and CD8+ICOS+ T cells in the peripheral blood of the treated patients. Patients with higher CD4+PD1+ cell frequency at baseline were more likely to respond to tremelimumab therapy. PD-1 expression was increased on alpha fetal protein (AFP) and survivin-specific CD8 T cells upon tremelimumab treatment. An increase of tumor infiltrating CD3+ T cells were also seen in these patients. Immunosequencing of longitudinal PBMC showed that one cycle of tremelimumab significantly decreased peripheral clonality, while no additional effects were seen after loco-regional therapy. CONCLUSION: In summary, we observed a clear activation of T cell responses in HCC patients treated with tremelimumab and identified potential biomarkers which will help identify patients responding to immunotherapy with anti-CTLA4.
27 schema:genre research_article
28 schema:inLanguage en
29 schema:isAccessibleForFree false
30 schema:isPartOf N1cec2c4716414143ac6a90b0e3d4f568
31 Nb9cc9b5908ec42d78f08361f2aa0f6c0
32 sg:journal.1096240
33 schema:name The effect of anti-CTLA4 treatment on peripheral and intra-tumoral T cells in patients with hepatocellular carcinoma
34 schema:pagination 1-10
35 schema:productId N5bfa36cd999a49d5ab8b2de1995afe46
36 N8b31248596c949d090e3a01876d6237b
37 Na0e964cff6794f56a99452dd0718c8d1
38 Nc877af42980447ffbcc27018f98f74a6
39 Ne84c1d1d9d22428fb8387acbb6fa103c
40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111682358
41 https://doi.org/10.1007/s00262-019-02299-8
42 schema:sdDatePublished 2019-04-11T13:52
43 schema:sdLicense https://scigraph.springernature.com/explorer/license/
44 schema:sdPublisher N6dd049134b864b0ba8a85cd79c108de0
45 schema:url https://link.springer.com/10.1007%2Fs00262-019-02299-8
46 sgo:license sg:explorer/license/
47 sgo:sdDataset articles
48 rdf:type schema:ScholarlyArticle
49 N14676f35430a46b697f9434ed822eb90 rdf:first sg:person.01053630317.46
50 rdf:rest N2867cc26b4b949798466e56575fae36b
51 N1cec2c4716414143ac6a90b0e3d4f568 schema:issueNumber 4
52 rdf:type schema:PublicationIssue
53 N2867cc26b4b949798466e56575fae36b rdf:first sg:person.01363572011.41
54 rdf:rest N876c703749a2419db3fdf121bd1e6ad4
55 N29d50156174043a8a3f5cd883c9e2828 rdf:first sg:person.0617046406.93
56 rdf:rest Nc30856b08b0d468a837fbfdb2006eda3
57 N381e7397f3f8456081f78134e890a829 rdf:first sg:person.0621654440.87
58 rdf:rest N538ccf38beb24ef9aa9e306e4de387c1
59 N4e3220abd2f34d6894f3080ae0d3288f rdf:first sg:person.0644645350.74
60 rdf:rest Ne31241a8b6594c5dbc5dd9bc2b4ecf95
61 N538ccf38beb24ef9aa9e306e4de387c1 rdf:first sg:person.01232624033.79
62 rdf:rest Nf8ca596b0a034822aca884c7b0704892
63 N56fd0faf8bf6418598893a692db86e7f rdf:first sg:person.01212251417.17
64 rdf:rest Nec1504221f6843d4bf2efcbde0b026cb
65 N5bfa36cd999a49d5ab8b2de1995afe46 schema:name dimensions_id
66 schema:value pub.1111682358
67 rdf:type schema:PropertyValue
68 N6668219031cb4875b78a1768a964f3c1 rdf:first N68452281011d482ba335cb8566df756c
69 rdf:rest N14676f35430a46b697f9434ed822eb90
70 N68452281011d482ba335cb8566df756c schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
71 schema:familyName Wood
72 schema:givenName Bradford
73 rdf:type schema:Person
74 N6d17e389e9e542b5b014b5c585641ddc rdf:first sg:person.011725220613.93
75 rdf:rest N56fd0faf8bf6418598893a692db86e7f
76 N6dd049134b864b0ba8a85cd79c108de0 schema:name Springer Nature - SN SciGraph project
77 rdf:type schema:Organization
78 N876c703749a2419db3fdf121bd1e6ad4 rdf:first sg:person.01073601541.74
79 rdf:rest N4e3220abd2f34d6894f3080ae0d3288f
80 N8b31248596c949d090e3a01876d6237b schema:name readcube_id
81 schema:value e7bc8644a8caa58c4f7f33c63003ec30e5411311e4305aaa918a921f02f9f7ec
82 rdf:type schema:PropertyValue
83 Na0e964cff6794f56a99452dd0718c8d1 schema:name doi
84 schema:value 10.1007/s00262-019-02299-8
85 rdf:type schema:PropertyValue
86 Nb9cc9b5908ec42d78f08361f2aa0f6c0 schema:volumeNumber 68
87 rdf:type schema:PublicationVolume
88 Nb9d47b413edd409eb97e521874ab00a2 rdf:first sg:person.013345672337.16
89 rdf:rest N29d50156174043a8a3f5cd883c9e2828
90 Nc30856b08b0d468a837fbfdb2006eda3 rdf:first Nebed94cf46384091ba800838fae1a7dc
91 rdf:rest N6d17e389e9e542b5b014b5c585641ddc
92 Nc877af42980447ffbcc27018f98f74a6 schema:name nlm_unique_id
93 schema:value 8605732
94 rdf:type schema:PropertyValue
95 Nd07fd1553e0c4e47ab30c5f2373f08aa rdf:first sg:person.011020270642.93
96 rdf:rest Nb9d47b413edd409eb97e521874ab00a2
97 Ne31241a8b6594c5dbc5dd9bc2b4ecf95 rdf:first sg:person.01301223015.55
98 rdf:rest rdf:nil
99 Ne84c1d1d9d22428fb8387acbb6fa103c schema:name pubmed_id
100 schema:value 30688989
101 rdf:type schema:PropertyValue
102 Nebed94cf46384091ba800838fae1a7dc schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
103 schema:familyName Figg
104 schema:givenName William D.
105 rdf:type schema:Person
106 Nec1504221f6843d4bf2efcbde0b026cb rdf:first sg:person.0734501735.01
107 rdf:rest N6668219031cb4875b78a1768a964f3c1
108 Nf8ca596b0a034822aca884c7b0704892 rdf:first sg:person.011005252133.08
109 rdf:rest Nd07fd1553e0c4e47ab30c5f2373f08aa
110 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
111 schema:name Medical and Health Sciences
112 rdf:type schema:DefinedTerm
113 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
114 schema:name Immunology
115 rdf:type schema:DefinedTerm
116 sg:grant.2724226 http://pending.schema.org/fundedItem sg:pub.10.1007/s00262-019-02299-8
117 rdf:type schema:MonetaryGrant
118 sg:journal.1096240 schema:issn 0340-7004
119 1432-0851
120 schema:name Cancer Immunology, Immunotherapy
121 rdf:type schema:Periodical
122 sg:person.01053630317.46 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
123 schema:familyName Venzon
124 schema:givenName David
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053630317.46
126 rdf:type schema:Person
127 sg:person.01073601541.74 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
128 schema:familyName Duffy
129 schema:givenName Austin G.
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073601541.74
131 rdf:type schema:Person
132 sg:person.011005252133.08 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
133 schema:familyName Xie
134 schema:givenName Changqing
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011005252133.08
136 rdf:type schema:Person
137 sg:person.011020270642.93 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
138 schema:familyName Sandhu
139 schema:givenName Milan
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011020270642.93
141 rdf:type schema:Person
142 sg:person.011725220613.93 schema:affiliation https://www.grid.ac/institutes/grid.421940.a
143 schema:familyName Rytlewski
144 schema:givenName Julie A.
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011725220613.93
146 rdf:type schema:Person
147 sg:person.01212251417.17 schema:affiliation https://www.grid.ac/institutes/grid.421940.a
148 schema:familyName Sanders
149 schema:givenName Catherine
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212251417.17
151 rdf:type schema:Person
152 sg:person.01232624033.79 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
153 schema:familyName ElGindi
154 schema:givenName Mei
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232624033.79
156 rdf:type schema:Person
157 sg:person.01301223015.55 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
158 schema:familyName Korangy
159 schema:givenName Firouzeh
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301223015.55
161 rdf:type schema:Person
162 sg:person.013345672337.16 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
163 schema:familyName Pratt
164 schema:givenName Drew
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013345672337.16
166 rdf:type schema:Person
167 sg:person.01363572011.41 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
168 schema:familyName Brar
169 schema:givenName Gagandeep
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363572011.41
171 rdf:type schema:Person
172 sg:person.0617046406.93 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
173 schema:familyName Kleiner
174 schema:givenName David E.
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617046406.93
176 rdf:type schema:Person
177 sg:person.0621654440.87 schema:affiliation https://www.grid.ac/institutes/grid.94365.3d
178 schema:familyName Agdashian
179 schema:givenName David
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621654440.87
181 rdf:type schema:Person
182 sg:person.0644645350.74 schema:affiliation https://www.grid.ac/institutes/grid.48336.3a
183 schema:familyName Greten
184 schema:givenName Tim F.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644645350.74
186 rdf:type schema:Person
187 sg:person.0734501735.01 schema:affiliation https://www.grid.ac/institutes/grid.421940.a
188 schema:familyName Yusko
189 schema:givenName Erik C.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734501735.01
191 rdf:type schema:Person
192 sg:pub.10.1007/s00262-012-1332-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039681130
193 https://doi.org/10.1007/s00262-012-1332-3
194 rdf:type schema:CreativeWork
195 sg:pub.10.1007/s00281-016-0614-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044941597
196 https://doi.org/10.1007/s00281-016-0614-9
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/nature13954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020455470
199 https://doi.org/10.1038/nature13954
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/nrgastro.2017.7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083732764
202 https://doi.org/10.1038/nrgastro.2017.7
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/nri3158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021347928
205 https://doi.org/10.1038/nri3158
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.jhep.2016.10.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013332645
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.jhep.2017.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091842520
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.jim.2011.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007937347
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/s0140-6736(17)31044-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085020935
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s0140-6736(17)31046-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084991554
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/s1470-2045(18)30351-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104370126
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1053/j.gastro.2017.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086043471
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1093/annonc/mdw181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042567831
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1126/scitranslmed.3008211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047908959
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1158/1078-0432.ccr-13-1721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034680513
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1158/1078-0432.ccr-13-2648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049292569
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1158/1078-0432.ccr-15-1507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030866924
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1182/blood-2009-04-217604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014830407
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1200/jco.2018.36.4_suppl.475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111064552
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1371/journal.pmed.1002309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085592854
236 rdf:type schema:CreativeWork
237 https://www.grid.ac/institutes/grid.421940.a schema:alternateName Adaptive Biotechnologies (United States)
238 schema:name Adaptive Biotechnologies, Seattle, WA, USA
239 rdf:type schema:Organization
240 https://www.grid.ac/institutes/grid.48336.3a schema:alternateName National Cancer Institute
241 schema:name Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, 20892, Bethesda, MD, USA
242 NCI CCR Liver Cancer Program, Bethesda, MD, USA
243 rdf:type schema:Organization
244 https://www.grid.ac/institutes/grid.94365.3d schema:alternateName National Institutes of Health
245 schema:name Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
246 Center for Interventional Oncology, Radiology and Imaging Sciences and Center for Cancer Research, National Institutes of Health, Bethesda, MD, USA
247 Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
248 Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, 20892, Bethesda, MD, USA
249 Laboratory of Pathology, Center for Cancer Research (CCR) National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
250 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...