MDSCs in infectious diseases: regulation, roles, and readjustment View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-04

AUTHORS

Anca Dorhoi, Estibaliz Glaría, Thalia Garcia-Tellez, Natalie E. Nieuwenhuizen, Gennadiy Zelinskyy, Benoit Favier, Anurag Singh, Jan Ehrchen, Cornelia Gujer, Christian Münz, Margarida Saraiva, Yahya Sohrabi, Ana E. Sousa, Peter Delputte, Michaela Müller-Trutwin, Annabel F. Valledor

ABSTRACT

Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence supported by functional assays on the roles of different subsets of MDSCs in acute and chronic infections, including pathogen-associated malignancies, and discusses strategies to modulate MDSC dynamics to benefit the host. More... »

PAGES

1-13

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00262-018-2277-y

    DOI

    http://dx.doi.org/10.1007/s00262-018-2277-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110757790

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30569204


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