How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-04

AUTHORS

Annika M. Bruger, Anca Dorhoi, Gunes Esendagli, Katarzyna Barczyk-Kahlert, Pierre van der Bruggen, Marie Lipoldova, Tomas Perecko, Juan Santibanez, Margarida Saraiva, Jo A. Van Ginderachter, Sven Brandau

ABSTRACT

Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of mononuclear and polymorphonuclear myeloid cells, which are present at very low numbers in healthy subjects, but can expand substantially under disease conditions. Depending on disease type and stage, MDSC comprise varying amounts of immature and mature differentiation stages of myeloid cells. Validated unique phenotypic markers for MDSC are still lacking. Therefore, the functional analysis of these cells is of central importance for their identification and characterization. Various disease-promoting and immunosuppressive functions of MDSC are reported in the literature. Among those, the capacity to modulate the activity of T cells is by far the most often used and best-established read-out system. In this review, we critically evaluate the assays available for the functional analysis of human and murine MDSC under in vitro and in vivo conditions. We also discuss critical issues and controls associated with those assays. We aim at providing suggestions and recommendations useful for the contemporary biological characterization of MDSC. More... »

PAGES

1-14

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00262-018-2170-8

    DOI

    http://dx.doi.org/10.1007/s00262-018-2170-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104134617

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29785656


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