Tumor-associated myeloid cells as guiding forces of cancer cell stemness View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-04-11

AUTHORS

Antonio Sica, Chiara Porta, Alberto Amadori, Anna Pastò

ABSTRACT

Due to their ability to differentiate into various cell types and to support tissue regeneration, stem cells simultaneously became the holy grail of regenerative medicine and the evil obstacle in cancer therapy. Several studies have investigated niche-related conditions that favor stemness properties and increasingly emphasized their association with an inflammatory environment. Tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) are major orchestrators of cancer-related inflammation, able to dynamically express different polarized inflammatory programs that promote tumor outgrowth, including tumor angiogenesis, immunosuppression, tissue remodeling and metastasis formation. In addition, these myeloid populations support cancer cell stemness, favoring tumor maintenance and progression, as well as resistance to anticancer treatments. Here, we discuss inflammatory circuits and molecules expressed by TAMs and MDSCs as guiding forces of cancer cell stemness. More... »

PAGES

1025-1036

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00262-017-1997-8

    DOI

    http://dx.doi.org/10.1007/s00262-017-1997-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084765465

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28401258


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