Immunotherapy after hematopoietic stem cell transplantation using umbilical cord blood-derived products View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-02

AUTHORS

Aurore Saudemont, J. Alejandro Madrigal

ABSTRACT

Umbilical cord blood (UCB) is being increasingly used as a source of hematopoietic stem cells (HSC) for transplantation. UCB transplantation (UCBT) has some advantages such as less stringent HLA-matching requirements, fast availability of the graft and reduced incidence and severity of graft-versus-host disease. However, UCBT is also associated with a higher incidence of infection, graft failure, slow engraftment and slow immune reconstitution. UCB is mainly used as a source of HSC; however, it is also rich in immune cells that could be used to treat some of the main complications post-UCBT as well as other diseases, thus implicating the use of UCB for immunotherapy. Here, we aim to describe some of the therapies currently developed that use UCB as a cell source, focusing in particular on regulatory T cells and natural killer cells. More... »

PAGES

215-221

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00262-016-1852-3

DOI

http://dx.doi.org/10.1007/s00262-016-1852-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045750268

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27271550


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